Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
Each week, Sean Carroll hosts conversations with some of the most interesting thinkers in the world, covering topics from neuroscience and engineering to philosophy and culture. The podcast explores how music affects the brain, the nature of quantum mechanics, the workings of black holes, and the design of video games. It aims to delve into the biggest ideas in science, philosophy, culture, and more.
Episodes
356 | Andrea Wulf on Enlightenment, Nature, Romanticism, and Modernity
All ideas have a history, no matter how inevitable and well-entrenched they may seem to us today. The later Enlightenment was a heady time when people were exploring new conceptions of nature, humanity, and the self. Andrea Wulf is a writer of narrative histories, examining the origins of ideas through the lives of the people who explored them. In this episode we discuss three of her books:
AMA | June 2026
Welcome to the June 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them
355 | Solo: Looking Quantum Mechanics in the Eyeball
One of the major obstacles to understanding quantum mechanics is the difficulty we have in simply accepting what the theory itself is telling us. The problem is that we know what the everyday world looks like -- stuff, arranged in space, evolving through time. So we can't resist the temptation to impose that picture on the quantum description, even if it's not actually there. In this solo ep
354 | Christian List on Free Will and Levels of Reality
Did I have any freedom in choosing this particular podcast guest? At the level of particles, fields, and the fundamental laws of physics; no. At the level of human agents navigating the world, yes. Today's guest, Christian List, is a philosopher and political scientist who has arguably done the most to articulate the "compatibilist" perspective on free will, according to which the freedom of
353 | Alvin Roth on the Economics of Morally Contested Markets
Economic markets are efficient ways of deciding fair prices, at least in ideal circumstances of perfect competition, information, and choice. But there is more to life than fair prices. Two people might decide on a fair price to carry out a contract killing, but society generally frowns on the idea. Many examples of morally contestable markets feature less consensus than that one: sex work,
AMA | May 2026
Welcome to the May 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them
352 | Bing Brunton on Connecting the Connectome to the Body
The connectome is the wiring diagram of a brain, a big matrix that tells us what neurons talk to what other neurons. Understanding it is an important step to understanding how brains work, but a long way from the final answer. A big next step is understanding how neuronal circuits connect to and guide bodily behavior. Very recent work on mapping the fruit-fly connectome has brought us closer
351 | Peter Singer on Maximizing Good for All Sentient Creatures
Peter Singer has been an influential philosopher for a number of decades. He was a significant early voice in animal rights, has been a leading thinker of utilitarianism, and helped inspire the effective altruism movement. In this podcast episode, we try our best to talk about all of those things -- working from metaethical questions of consequentialism vs. other approaches, to specific flav
350 | J. Eric Oliver on the Self and How to Know It
We are more familiar with ourselves than with anything else in the universe, but we generally don't come very close to really understanding what our "self" is. That's not too surprising, as selves are very complicated and we are burdened by all sorts of biases. Today's guest is J. Eric Oliver, who has been teaching a popular course at the University of Chicago called "The Intelligible Self."
AMA | April 2026
Welcome to the April 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes gro
349 | Daniel Harlow on What Quantum Gravity Teaches Us About Quantum Mechanics
There is something special about gravity. After decades of effort, there is still no convergence on the right way to reconcile Einstein's theory of general relativity with the framework of quantum mechanics. But a number of intriguing ideas have arisen along the way, including black hole radiation, the wave function of the universe, the AdS/CFT correspondence, and the role of quantum informa
348 | Jessica Riskin on Jean-Baptiste Lamarck and Life as Creative Agency
"Lamarkism" is a term often attached to a seemingly discredited idea in evolutionary biology: that one organism could acquire characteristics (e.g., becoming stronger through exercise) that would then be inherited by its descendants. This is a different story than the one ultimately told by the modern synthesis of evolutionary biology, according to which inheritance passes through our genome
347 | Andrew Guthrie Ferguson on How Your Data Will Be Used Against You
In the 18th century, philosopher Jeremy Bentham suggested the Panopticon as a model of a prison where inmates could be constantly observed by just a single prison guard. Although his original idea was never built, the word has come to indicate any system of social control through constant surveillance. Nowadays, we are close to creating such a system, not for prisons, but for our everyday li
346 | Erica Cartmill on How Human and Animal Minds Think and Play
Intelligence is a many splendored thing, especially when it comes to comparisons between species. Chimpanzees are better than humans at some numerical tasks, but less good at understanding what numbers actually mean. One window on the ways that species differ is how they play amongst themselves. I talk with anthropologist and cognitive scientist Erica Cartmill about modes of play and other s
AMA | March 2026
Welcome to the March 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes gro
345 | Adam Elga on Being Rational in a Very Large Universe
Behaving rationally involves facing up to conditions of uncertainty; we never navigate the world with perfect confidence. Sometimes we are uncertain about the way the world is, but we can also be uncertain about our place within the world. This kind of situation arises in cosmology (where the relevant world can extend very far in space or time), and also in quantum mechanics (where new world
344 | Adam Gurri on Liberal Democracy and How to Fight For It
It's possible to look at the course of history over the past few centuries and discern a movement toward increasing democracy, freedom, and individual rights -- "liberalism," in the political-philosophy sense of the term. But such movement isn't inevitable or irreversible, and in very recent times there have been both intellectual arguments explicitly pushing back against the liberal consens
343 | Tom Griffiths on The Laws of Thought
For all that human beings spend a lot of their time thinking, it's far from obvious what that process actually entails. Part of it amounts to classical logical reasoning. But an even bigger part involves reasoning with probability and uncertainty. And some of it is governed by unavoidable limitations on time and accuracy. Psychologist and computer scientist Tom Griffiths suggests that we hav
AMA | Feb 2026
Welcome to the February 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group
342 | Rachell Powell on Evolutionary Convergence, Morality, and Mind
Evolution with natural selection involves an intricate mix of the random and the driven. Mutations are essentially random, while selection pressures work to prefer certain outcomes over others. There is tremendous divergence of species over time, but also repeated convergence to forms and mechanisms that are unmistakably useful. We see this clearly in eyes and fins, but the basic pattern also hold
341 | Stewart Brand on Maintenance as an Organizing Principle
"Things fall apart; the centre cannot hold," wrote W.B. Yeats. I don't know about the centre, but the tendency of things to fall apart is pretty universal, ultimately due to the Second Law of Thermodynamics. Anyone living in a society or involved with technology must therefore be interested in the concept of maintenance -- keeping systems working. In his book Maintenance: Of Everything, Part One,
340 | Rebecca Newberger Goldstein on What Matters and Why It Matters
At any given moment, an uncountable number of events are happening, but only some of them matter to us. What does it mean for something to matter, and more importantly, what does it mean for us to matter -- to ourselves as well as to others? The need to matter can be motivation to do great things, but it can also be a reason for people to come into conflict. Philosopher/novelist Rebecca Newberger
339 | Ned Block on Whether Consciousness Requires Biology
It's become increasingly clear that the Turing Test -- determining whether human interlocutors can tell whether a conversation is being carried out by a human or a machine -- is not a good way to think about consciousness. Modern LLMs can mimic human conversation with extraordinary verisimilitude, but most people would not judge them to be conscious. What would it take? Is it even possible for a c
Holiday Message 2025 | The Romance of the University
Time for the holiday message! Rounding off the year with a brief and casual reflection on some issue that doesn't quite rise to the level of a full solo podcast. And hopefully something uplifting. This year, I offer a short apologia for higher education in the liberal arts and sciences, focusing not on the down-to-earth economic/occupational benefits of a college degree, but on the very real ways
AMA | December 2025
Welcome to the December 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group
338 | Ryan Patterson on the Physics of Neutrinos
The story goes that Wolfgang Pauli, who first proposed the existence of neutrinos, was embarrassed to have done so, as it was considered uncouth to hypothesize new particles that could not be detected. Modern physicists have no such scruples, of course, but more importantly neutrinos turn out to be very detectable, given sufficient resources and experimental technique. I talk with neutrino physici
337 | Kevin Zollman on Game Theory, Signals, and Meaning
Game theory is a way of quantitatively describing what happens any time one thing interacts with another thing, when both things have goals and potential rewards. That's a pretty broad class of interesting events, so it is unsurprising that game theory is a useful way of thinking about everything from international relations to the evolution of peacock feathers. I talk with philosopher Kevin Zollm
336 | Anil Ananthaswamy on the Mathematics of Neural Nets and AI
Machine learning using neural networks has led to a remarkable leap forward in artificial intelligence, and the technological and social ramifications have been discussed at great length. To understand the origin and nature of this progress, it is useful to dig at least a little bit into the mathematical and algorithmic structures underlying these techniques. Anil Ananthaswamy takes up this challe
AMA | November 2025
Welcome to the November 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group
335 | Andrew Jaffe on Models, Probability, and the Universe
Science has an incredibly impressive track record of uncovering nonintuitive ideas about the universe that turn out to be surprisingly accurate. It can be tempting to think of scientific discoveries as being carefully constructed atop a rock-solid foundation. In reality, scientific progress is tentative and fallible. Scientists propose models, assign them probabilities, and run tests to see whethe
334 | Daniel Whiteson on the Physics of and by Aliens
The universe as revealed by physics is objective: it's out there, existing and behaving in ways that are completely independent of human thought. But the process by which we learn about the universe, and the language with which we talk about it, is extremely human-dependent. Does that mean that aliens would do science differently, and even think differently about physics, even if we all live in th
333 | Gordon Pennycook on Unthinkingness, Conspiracies, and What to Do About Them
Why are people wrong all the time, anyway? Is it because we human beings are too good at being irrational, using our biases and motivated reasoning to convince ourselves of something that isn't quite accurate? Or is it something different -- unmotivated reasoning, or "unthinkingness," an unwillingness to do the cognitive work that most of us are actually up to if we try? Gordon Pennycook wants to
332 | Dmitri Tymoczko on the Mathematics Behind Music
Music is math that you can dance to. The fact that certain notes sound good when played together, or in succession, is related to the mathematical properties of the frequencies to which they correspond, an idea that goes back as far as Pythagoras himself. These days we have a much more intricate understanding of these relationships and how to manipulate them. I talk to composer and music theorist
AMA | October 2025
Welcome to the October 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group t
331 | Solo: Fine-Tuning, God, and the Multiverse
Certain features of our universe seem unnatural to us. These include "constants of nature" such as the cosmological constant and the mass of the Higgs boson, as well as features of the initial conditions like the curvature of space and the initial entropy. But they can't truly be "unnatural" -- they are literally features of Nature itself. Some have turned to the anthropic principle and the multiv
330 | Petter Törnberg on the Dynamics of (Mis)Information
A characteristic of complex systems is that individual components combine to exhibit large-scale emergent behavior even when the components were not specifically designed for any particular purpose within the collective. Sometimes those individual components are us -- people interacting within societies or online communities. Studying the dynamics of such interactions is interesting both to better
329 | Steven Pinker on Rationality and Common Knowledge
Getting along in society requires that we mostly adhere to certainly shared norms and customs. Often it's not enough that we all know what the rules are, but also that everyone else knows the rules, and that they know that we know the rules, and so on. Philosophers and game theorists refer to this as common knowledge. In Steven Pinker's new book, When Everyone Knows That Everyone Knows..., he expl
328 | Mary Roach on Replacing Parts of Our Bodies
Like any machine, bodies occasionally break down, and it's natural to go in search of a replacement part. Ancient societies featured simple prosthetics for teeth, noses, and limbs, while modern medicine pursues more advanced ways of replacing internal organs and microbiomes. But what is striking is not just the impressive ingenuity of our attempts to replicate human anatomy, but the surprising lev
AMA | September 2025
Welcome to the September 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group
327 | Cass Sunstein on Liberalism
"Liberalism," divorced from its particular connotations in this or that modern political context, refers broadly to a philosophy of individual rights, liberties, and responsibilities, coupled with respect for institutions and rule of law over personalized power. As Cass Sunstein construes the term, liberalism encompasses a broad tent, from Ronald Reagan and Margaret Thatcher to Martin Luther King
326 | Natalie Batalha on What We Know and Will Learn About Exoplanets
In a relatively short period of time, exoplanets (planets around stars other than our Sun) have gone from an intriguing conjecture to an active field of scientific study, with over 5,000 confirmed discoveries. The task now is to move beyond merely accumulating new examples, and embarking on systematic studies of their properties. What fraction of stars have planets, how are they distributed in siz
325 | Alvy Ray Smith on Pixar, Pixels, and the Great Digital Convergence
The world is becoming pixelated. As computers and other digital devices become ubiquitous, human knowledge and communication and information is gradually being converted into, and manipulated as, strings of bits. What does that really mean, and what are the ramifications going forward? Alvy Ray Smith is a computer scientist, co-founder of Pixar, and author of A Biography of the Pixel. We go throug
324 | Elizabeth Mynatt on Universities and the Importance of Basic Research
It is not manifestly obvious that universities should be where most scholarly research is performed. One could imagine systems that separated out the tasks of "teaching students" and "generating new knowledge." But it turns out that combining them yields spectacular synergies, both from letting students experience cutting-edge research and from keeping researchers inspired by interacting with brig
AMA | August 2025
Welcome to the August 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group th
323 | Jacob Barandes on Indivisible Stochastic Quantum Mechanics
The search for a foundational theory of quantum mechanics that all physicists can agree on remains active. Over the last century a number of contenders have emerged, including Many-Worlds, pilot-wave theories, and others, but all of them have aspects that many people object to. Jacob Barandes has taken up the challenge, proposing a new formulation of quantum theory in which there is no wave functi
322 | Philip Pettit on Language, Agency, Politics, and Freedom
When we think of the capacities that distinguish humans from other species, we generally turn to intelligence and its byproducts, including our technological prowess. But our intelligence is highly connected to our ability to use language, which is in turn closely related to our capacities as social creatures. Philosopher Philip Pettit would encourage us to think of those social capacities, as ena
321 | David Tong on Open Questions in Quantum Field Theory
Quantum field theory is the basis for our most successful theories of fundamental physics. And yet, there are things we don't understand about it. Some of these puzzles are relatively well-known, while others are less celebrated. David Tong joins us to talk about some of the more interesting and perplexing aspects of quantum field theory. He also discusses his new project to write a series of text
AMA | July 2025
Welcome to the July 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them
320 | Solo: Complexity and the Universe
Our universe started out looking very simple: hot, dense, smooth, rapidly expanding. According to our best current model, it will end up looking simple once again: cold, dark, empty. It's in between -- now, roughly speaking -- that things look complex. I have been working to understand the stages by which complexity comes into existence, thrives, and eventually disappears. Without going into techn
319 | Bryan Van Norden on Philosophy From the Rest of the World
It is common to refer to philosophy as "a series of footnotes to Plato." But in the original quote, Alfred North Whitehead was more careful: he limited his characterization to "the European philosophical tradition." There are other traditions, both ancient and ongoing: Chinese philosophy, Indian philosophy, Africana philosophy, and various indigenous philosophies. For the most part, these do not g
318 | Edward Miguel on the Developing Practice of Development Economics
Economics is seeing an upsurge in the importance of controlled, reproducible empirical studies. One area where this has had a great impact is on development economics, which studies the economies of low- and middle-income societies. Edward Miguel has been at the forefront of both the revolution in empirical methods, and in applying those techniques to alleviating poverty in sub-Saharan Africa and
317 | Nicole Rust on Why Neuroscience Hasn't Solved Brain Disorders
The human brain is extremely complicated, but decades of careful neuroscientific research have revealed quite a bit about how it works, including how certain genes affect particular brain behaviors. Nevertheless, this progress has not led to quite as much improvement in the treatment of brain disorders as we might expect. I talk with neuroscientist Nicole Rust about why this is and how to improve
AMA | June 2025
Welcome to the June 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them
316 | Niayesh Afshordi and Phil Halper
Einstein's general theory of relativity, plus some reasonable assumptions about the universe and what it's made of, has a remarkable implication: that as we trace cosmic evolution into the far past, we ultimately hit a singularity of infinite density and curvature, the Big Bang. Did that really happen? Einstein's theory is classical, after all, and the world is quantum. And whose to say what assum
315 | Branden Fitelson on the Logic and Use of Probability
Every time you see an apple spontaneously break away from a tree, it falls downward. You therefore claim that there is a law of physics: apples fall downward from trees. But how can you really know? After all, tomorrow you might see an apple that falls upward. How is science possible at all? Philosophers, as you might expect, have thought hard about this. Branden Fitelson explains how a better und
314 | Karen Lloyd on the Deep Underground Biosphere
There are living creatures dwelling deep below the surface of the Earth, as deep as we are able to drill. These hearty microorganisms are related to more familiar life forms on land and under water, but the operate and survive in ways that are quite different from what we're familiar with. They live off of nutrients that have penetrated from the surface, or sometimes off of pure electrons. Karen L
313 | Eric Topol on the Changing Face of Medicine and Aging
Medical science is advancing at an astonishing rate. Today we talk with leading expert Eric Topol about two aspects of this story. First, the use of artificial intelligence in medicine, especially in diagnostics. This is an area that is a perfect match between an important question and the capabilities of machine learning, to the point where AI can out-perform human doctors. And second, our unders
AMA | May 2025
Welcome to the May 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them
312 | Thomas Levenson on the Mutual History of Humans and Germs
The germ theory of disease is a crowning achievement of science, up there with modern physics, continental drift, and evolution via natural selection. (Even if there will always be cranky skeptics.) But the road to widespread acceptance isn't always an easy one. Why did it take so long between Anton van Leeuwenhoek seeing "animalcules" in a microscope (1670s) to Louis Pasteur's work on pasteurizat
311 | Annaka Harris on Whether Consciousness is Fundamental
Questions about consciousness range from the precise and empirical -- what neurons fire when I have some particular experience -- to the deeply profound -- does consciousness emerge from matter, or does matter emerge from consciousness? While it might be straightforward to think that consciousness arises from the collective behavior of atoms in the brain, Annaka Harris and others argue that consci
AMA | April 2025
Welcome to the April 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group the
310 | Marc Kamionkowski on Dark Energy and Cosmic Anomalies
Cosmologists were, let us be honest, pretty stunned in 1998 when observations revealed that the universe is accelerating. There was an obvious plausible explanation, the cosmological constant proposed by Einstein, which is equivalent to a constant vacuum energy pervading space. But the cosmological constant was known to be enormously smaller than its "natural" value, and it seems fine-tuned for it
309 | Christof Koch on Consciousness and Integrated Information
Consciousness is easier to possess than to define. One thing we can do is to look into the brain and see what lights up when conscious awareness is taking place. A complete understanding of this would be known as the "neural correlates of consciousness." Once we have that, we could hopefully make progress on developing a theoretical picture of what consciousness is and why it happens. Today's gues
308 | Alison Gopnik on Children, AI, and Modes of Thinking
We often study cognition in other species, in part to learn about modes of thinking that are different from our own. Today's guest, psychologist/philosopher Alison Gopnik, argues that we needn't look that far: human children aren't simply undeveloped adults, they have a way of thinking that is importantly distinct from that of grownups. Children are explorers with ever-expanding neural connections
AMA | March 2025
Welcome to the March 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group the
307 | Kevin Peterson on the Theory of Cocktails
A lot of science goes into crafting the perfect cocktail. Balancing sweet and bitter notes, providing the right amount of aeration and dilution, getting it to just the right temperature and keeping it that way. And even if you have no interest in cocktails as such, the general principles extend to other activities in art and in life. I talk to scientist-turned-mixologist Kevin Peterson about how t
306 | Helen Czerski on Our Energetic Oceans
It is commonplace to refer to the Earth's oceans as vast and largely unexplored. But we do understand some aspects, and improving that understanding is crucial to ensuring the continued viability and success of life on this planet. The oceans are a paradigmatic complex system: there are many components, distinct but mutually interacting, that add up to a nuanced whole. We talk with ocean physicist
305 | Lilliana Mason on Polarization and Political Psychology
Political outcomes would be relatively simple to predict and understand if only people were well-informed, entirely rational, and perfectly self-interested. Alas, real human beings are messy, emotional, imperfect creatures, so a successful theory of politics has to account for these features. One phenomenon that has grown in recent years is an alignment of cultural differences with political ones,
Bonus | Cuts to Science Funding and Why They Matter
The Trump administration, led by Elon Musk and his Department of Government Efficiency, has proposed sweeping cuts to spending on science research here in the US, in particular at the National Institutes of Health and the National Science Foundation. I explain a little about what is being cut and why these funds are important to scientific progress. I try, for what it's worth, to provide these exp
304 | James Evans on Innovation, Consolidation, and the Science of Science
It is a feature of many human activities - sports, cooking, music, interpersonal relations - that being able to do them well doesn't necessarily mean you can accurately describe how to do them well. Science is no different. Many successful scientists are not very good at explaining what goes into successful scientific practice. To understand that, it's necessary to study science in a scientific fa
AMA | February 2025
Welcome to the February 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group
303 | James P. Allison on Fighting Cancer with the Immune System
A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security pat
302 | Chris Kempes on the Biophysics of Evolution
Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but ho
301 | Tina Eliassi-Rad on Al, Networks, and Epistemic Instability
Big data is ruling, or at least deeply infiltrating, all of modern existence. Unprecedented capacity for collecting and analyzing large amounts of data have given us a new generation of artificial intelligence models, but also everything from medical procedures to recommendation systems that guide our purchases and romantic lives. I talk with computer scientist Tina Elassi-Rad about how we can sif
300 | Solo: Does Time Exist?
A new year, and a new centennial -- 300 (regularly-numbered) episodes of Mindscape! Our tradition is to have a solo episode, and what better topic than the nature of time? Physicists and philosophers have so frequently suggested that time is some kind of illusion that it's become almost passé to believe that it might be fundamental. This is an issue where, despite the form of the question, physics
Holiday Message | Hits and Misses
It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. Bu
299 | Michael Wong on Information, Function, and the Origin of Life
Living organisms seem exquisitely organized and complex, with features clearly adapted to serving certain functions needed to survive and procreate. Natural selection provides a compelling explanation for why that is so. But is there a bigger picture, a more general framework that explains the origin and evolution of functions and complexity in a world governed by uncaring laws of physics? I talk
298 | Jeff Lichtman on the Wiring Diagram of the Brain
The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a maj
AMA | December 2024
Welcome to the December 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group
297 | Emily Wilson on Homer, Poetry, and Translation
Not too long ago, Brad Pitt and Eric Bana starred in a (loose) adaptation of Homer's epic poem The Iliad; next month, Ralph Fiennes and Juliette Binoche will headline a film based on The Odyssey. Given that the originals were written (or at least written down) in the 8th century BCE, that is some impressive staying power. But they were also written in a very different time than ours, with differen
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