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Endocrine Feedback Loop

Endocrine Feedback Loop

Endocrine Society 74 Episodes Sep 18, 2026

Endocrine Feedback Loop is a monthly journal club podcast series brought to you by the Endocrine Society. Hosted by endocrinologist Chase Hendrickson, MD, from Vanderbilt University, each episode features an expert educator and a topical specialist dissecting recently published journal articles and discussing implications for clinical practice.

Episodes

EFL077 - Inflammation vs. Immune-System Dysfunction in PCOS
EFL077 - Inflammation vs. Immune-System Dysfunction in PCOS Sep 18, 2026 1681 For our 77th episode, we discuss a study in the Journal of Clinical Endocrinology & Metabolism investigating the role of immune signaling in polycystic ovary syndrome (PCOS), now renamed polyendocrine metabolic ovarian syndrome (PMOS). Using a multiracial case-control design, the authors examined whether PCOS is characterized by chronic inflammation or whether immune dysregulation plays a more
EFL076 - Pregnancy Outcomes in PCOS and GDM
EFL076 - Pregnancy Outcomes in PCOS and GDM Aug 25, 2026 2795 For our 76th episode, we discuss a recent Journal of Clinical Endocrinology & Metabolism secondary analysis examining pregnancy outcomes among women with polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM). Drawing on data from the DiGest randomized clinical trial, the study explores whether PCOS influences maternal and neonatal outcomes and whether a reduced-calorie dieta
EFL075 - Methimazole Titration and Initial Disease Severity in Graves' Disease
EFL075 - Methimazole Titration and Initial Disease Severity in Graves' Disease Jul 16, 2026 2214 How does the severity of Graves disease at presentation affect subsequent methimazole dose titration? Find out more in this month's episode!For our 75th episode, we review a forthcoming Journal of Clinical Endocrinology & Metabolism study examining whether the severity of Graves disease at presentation influences methimazole titration and treatment management. Drawing on a retrospective longit
EFL074 - Taking Levothyroxine Fasting vs. With Breakfast
EFL074 - Taking Levothyroxine Fasting vs. With Breakfast Jun 18, 2026 1954 For our 74th episode, recorded live at ENDO 2026 in Chicago, we review a recent JCEM study that addresses a common clinical question: does levothyroxine need to be taken on an empty stomach?This randomized clinical trial evaluates a dose-adjusted, non-fasting regimen and finds that a 15% increase with breakfast ingestion achieves TSH stability similar to that with standard fasting dosing. The resu
EFL073 - Infrequent Zoledronate in Low Fracture Risk
EFL073 - Infrequent Zoledronate in Low Fracture Risk May 21, 2026 2287 For our 73rd episode and the start of the seventh season, we review a recent study examining the long-term anti-fracture efficacy of infrequent zoledronate dosing in women with osteopenia. While current clinical approaches typically focus on treating individuals at higher fracture risk, this study explores whether earlier intervention in lower-risk populations may help reduce fracture risk over ti
EFL072 - Pre-Operative Use of Mineralocorticoid-Receptor Antagonists in Primary Aldosteronism
EFL072 - Pre-Operative Use of Mineralocorticoid-Receptor Antagonists in Primary Aldosteronism Apr 22, 2026 2628 For our 72nd episode and the final episode of the sixth season, we review a recent study examining the perioperative medical management of primary aldosteronism, with a focus on the use of mineralocorticoid receptor antagonists before adrenalectomy. Primary aldosteronism is increasingly recognized as a common and clinically important cause of secondary hypertension, yet questions remain about opti
EFL071 – Taste Changes with Semaglutide
EFL071 – Taste Changes with Semaglutide Mar 27, 2026 1854 For our 71st episode, we review a randomized, placebo-controlled clinical trial that explores how semaglutide may influence taste perception in women with obesity and polycystic ovary syndrome. While GLP‑1 receptor agonists are widely used for weight loss, the mechanisms underlying changes in food preference remain less well understood. This study takes a multimodal approach to examine whether sem
EFL070 – Dosing Strategies for Remission in Graves Disease
EFL070 – Dosing Strategies for Remission in Graves Disease Feb 19, 2026 2112 For our 70th episode, we review a paper that tries to improve our understanding of remission in Graves’ disease. Long-term thionamide treatment has long been the preferred approach internationally in Graves’ disease, and only more recently here in the U.S. So, the more we know about dosing and how that might encourage or predict remission, the better. This report is an observational study, as is o
EFL069 - The Gut Microbiome in Type 1 Diabetes and Obesity
EFL069 - The Gut Microbiome in Type 1 Diabetes and Obesity Jan 15, 2026 2460 For our 69th episode, we review a paper in The Journal of Clinical Endocrinology & Metabolism on the gut microbiome of adolescents with type 1 diabetes, which hopes to understand differences between those with a normal body mass index compared to obesity. Studying gut microbiomes has been a “hot topic” for several years now, and we are excited to take the opportunity to unpack this work and se
EFL068 - Hypocalcemia in CKD after Denosumab
EFL068 - Hypocalcemia in CKD after Denosumab Dec 18, 2025 2154 For our 68th episode, we look at a paper in The Journal of Clinical Endocrinology & Metabolism that compares the effect on calcium of initial and subsequent doses of denosumab in people with chronic kidney disease (CKD). Though concerns have arisen over the years about the problems with stopping denosumab therapy, it remains an appealing medication for some of our patients with CKD. So we thou
EFL067 - Bariatric Surgery and Changes in Body Composition and Musculoskeletal Health
EFL067 - Bariatric Surgery and Changes in Body Composition and Musculoskeletal Health Nov 20, 2025 2581 For our 67th episode, we look at a study in The Journal of Clinical Endocrinology & Metabolism that reports the impact of different types of weight-loss surgery on body composition, muscle strength, and bone density. Our patients frequently ask questions about these changes with surgical and medical weight loss, so we thought it highly worthwhile to review these findings with you all. Host Cha
EFL066 - Islet Autoantibodies
EFL066 - Islet Autoantibodies Oct 16, 2025 2140 For our 66th episode, we review a recent Journal of the Endocrine Society (JES) article that looks at the frequency of positive islet antibodies in a population of adults without diabetes. While that may initially seem like an unusual article choice, we found it to be quite helpful in an era where we now have a therapeutic option to delay the onset of clinical type 1 diabetes when we can identify

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