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Some Work, All Play

Some Work, All Play

David Roche and Megan Roche 317 episodes Latest May 26, 2026

Five to ten topics, sometimes about running, with lots of love and enthusiasm and science. The hosts dig deep into training, races, studies, pop culture, and much more. Featuring Megan Roche, M.D. and David Roche.

Episodes

314. Carbs and Bone Health, A Reproducibility Crisis in Training Science, Wild Data on Post-Exercise Ketones, and Trail Supershoe Data! Jun 9, 2026 01:34:04 We removed all the cutlery from our house before this great episode! The main science discussion was on a new study looking at reproducibility of adaptations in individual athletes. The relatively surprising finding is that there was no significant correlation in how the same athlete responds to the same intervention across time. We discuss what that means for training science. The word “holistic”
313. Marathons v. Ultras, Fatigue Resistance Debates, Gene Editing Breakthrough, and Posture Impact on Blood Volume! Jun 2, 2026 01:33:31 We put some cinder blocks under the head of our bed (for science!) before this great episode. A weird study just came out finding that head-up sleeping may increase red blood cell totals. We talk about what it means and what it doesn’t mean. Excuse us while we launch a cinderblock start-up.We also discussed a breakthrough in gene editing for cholesterol, and what that could mean for the future. Th
312. How Blood Volume Impacts Performance and Adapts Fast, The Scary Potential of Lactate Supplementation, The True GOAT, and The Circle Pit! May 26, 2026 01:23:14 We basked in some amazing news before this great episode! The main topic was a breakdown of one of the most important elements of performance and health: blood volume. Studies show that blood volume can seem to act as a synonym for fitness, with one finding that 6 weeks of training gains can be reversed with a phlebotomy that returns blood volume to baseline levels. Positive adaptations can happen
311. The Science Episode! How To Stop Cramps, Fat Oxidation Changes, Missing Link Heat Training, The Difficulty of Physiology Data, and More May 19, 2026 01:41:56 We talked about some of the strangest and coolest research topics in endurance sports for this episode! Basically, the science discussions went long, so we just ran with it.The main discussion was on how to stop cramps, laying out 10 theories. But put on your tin foil hats, because we think the cramping conspiracy runs deep. Our theory: cramping is connected to fatigue resistance is connected to a
310. The Fatigue Resistance Episode! Rachel Entrekin Makes History at Cocodona, Women v. Men Durability, Fueling and the Central Nervous System, Brain Changes, and More May 12, 2026 01:34:02 We had some HYPOTHESES for this amazing episode! The main topics all revolved around fatigue resistance (often called “durability” in the literature), which we think is the most exciting area of training theory and physiology. It started with Rachel Entrekin’s legendary overall win at the Cocodona 250, an event that explores some of the strangest and coolest parts of endurance.Our big theory: what
309. The Marathon that Changed Running, Ultra GOAT to Western States, Misconceptions about Training Volume, A Supershoe Lawsuit, and A Hydration Study! May 5, 2026 01:21:11 We violated the warranty on ankle tape before this great episode! A main topic involved taking a step back to understand the historic context of Vinny Mauri’s 2:05 debut marathon. We think it’s a performance that signals a fundamental shift in the future of the sport for everyone, and we discuss why.We also talked about the exciting news that Jim Walmsley is heading to Western States with a sponso
308. Sub-2 Hour Marathon Fueling, The High Carb Plus Bicarb Era, Strides v. Plyometrics Study, Supershoe Evolution, and Iron Theories! Apr 28, 2026 01:39:23 We made an unfortunate impulse purchase (you'll see) before this great episode! The main topic revolved around the world records at the London Marathon, including Sebastian Sawe’s 1:59:30 winning time. We discuss his mid-race fueling, bicarb use, shoes, and so much more. Plus, there was an important study measuring the differences in mechanical output between sprints, strides, and plyometrics.
307. A Mind-Blowing Boston Marathon, Jess McClain Runs 2:20 (!!!), and Studies on What Improves Endurance Performance! Apr 21, 2026 01:29:58 We had just the right amount of Dunkin’ coffee (a barrel) before this great episode! The main topic was everything we learned at the Boston Marathon, highlighted by Jess McClain running 2:20:49 to break the American Course Record by over a minute. We break down our experience the most magical weekend!The most memorable moment for us: Around 30k, Jess fumbled a bottle (with a gel on it) right at th
306. How the GOAT Fuels, Single v. Double Workouts, Heat and Altitude Study, Caffeine Genotypes, and Building Bone Density! Apr 14, 2026 01:33:44 We got overconfident with a shoe experiment before this great episode! It started with a discussion of race-day fueling of Tadej Pogacar (who might be the greatest endurance athlete ever). 250 grams of carbs and 1430 calories for breakfast?! We zoom out to talk about cycling fueling generally, along with possible gender differences.Then it was a big science discussion on a new study on heat and al
305. The Theory of Downhills for Strength and Speed, AM v. PM Training Study, Bicarb Poisoning on Mt. Everest, and Moon Shots! Apr 7, 2026 01:26:20 We listened to a troubling amount of Noah Kahan music before this great episode! The main topic outlined our theory on using downhill training for strength and speed. The repeated bout effect from downhill-induced eccentric muscle contractions causes rapid improvements in muscular strength and running economy. We think that harnessing those principles is a pathway to fatigue resistance. Did we get
304. The Art of Steady Running, Pregnancy and Sponsorships, A Shocking TUE Dashboard, Heat and Heart Rate, Post-Exercise Ketones, and Bicarb! Mar 31, 2026 01:33:31 We imagined doing PG-13 things to a very tasty gel before this great episode! The main training topic was a discussion of steady running. Lots of theory talks about “hard days hard and easy days easy.” But we think there’s a place for an addition: “medium days medium.” We discuss the rationale and timing of how to work steady running into a typical week.We also had a big discussion of pregnancy an
303. The Weird Science of Carb Mouth Rinses, VO2 Max Limits, Fueling for Performance, Cross Training, and Cramp Prevention! Mar 24, 2026 01:31:50 We put on our spacesuits for this great episode! The main topic was a study finding that just putting a dissolvable carb strip on the tongue could improve performance by 3% in a short time trial. What?! How can carb strips and mouth rinses improve performance? We discuss the weird implications of cephalic-phase responses. And this one was full of amazing topics! Other topics: our first movie theat

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