Home Podcasts Machine Learning Street Talk (MLST)
Machine Learning Street Talk (MLST)

Machine Learning Street Talk (MLST)

Machine Learning Street Talk (MLST) 252 Episodes Jul 1, 2026

Machine Learning Street Talk (MLST) features in-depth conversations with leading figures in artificial intelligence, cognitive science, neuroscience, and philosophy of mind. The show covers current affairs in AI with rigorous analysis, aiming to cut through hype and explore diverse intellectual perspectives. Hosted by Tim Scarfe, Ph.D., with regular contributions from MIT Ph.D. Keith Duggar.

Episodes

The Benchmark With No Instructions — ARC-AGI-3 (winning team!) Jul 1, 2026 01:24:34 Tim Scarfe travels to Zurich to sit down with the Tufa Labs ARC-AGI-3 team — founder Benjamin Crouzier, with Jeroen Cottaar, Dries Smit, Stefano Viel and Michal Tesnar — to work out what their leaderboard-topping system does and what the benchmark is really testing.The cut opens on the games: a walkthrough of the Locksmith game, where you read the rules of an unfamiliar world straight from raw fra
The Thermodynamic AI Computing Chip - Thomas Ahle Jun 28, 2026 01:02:59 Thomas Ahle wants Normal Computing to be the Lovable for chip design: type your intent, and a swarm of agents carries it from design through optimisation, formalisation and verification to tape-out. To get there, his team at wrote their own open-source Verilog simulator, 580,000 lines in 43 days, because commercial EDA verifiers run about $10,000 per core and there are no decent open-source compil
He won a Nobel here for AlphaFold. Then he left. - John Jumper Jun 22, 2026 00:53:05 This episode is sponsored by Notion. Learn more about Notion's Developer Platform today at https://notion.com/mlstProtein folding stalled biology for fifty years. A sequence of amino acids dictates a three-dimensional shape, but reading that shape meant a year and roughly $100,000 of crystallography per structure. Then AlphaFold 2 won CASP14 so decisively the organizers called the problem esse
When AI Decides You're a Threat — Brad Carson May 31, 2026 01:20:51 Brad Carson was the Army's General Counsel, served two terms in Congress and was Acting Under Secretary of Defense for Personnel and Readiness. He now heads Americans for Responsible Innovation, the AI-policy advocacy group he co-founded. Keith Duggar spends roughly eighty minutes pushing back.SPONSOR:---Cyber Fund built the Monastery to help founders ship products that were impossible a year ago.
Intelligence is collective, not artificial — Prof. Michael I. Jordan (UC Berkeley / Inria) May 21, 2026 01:17:09 Michael I. Jordan, described by Science magazine as the most influential computer scientist alive, has never thought of himself as an AI researcher. In this conversation he explains why that distinction matters.SPONSOR:---Cyber Fund built the Monastery to help founders ship products that were impossible a year ago. Applications for Batch 1 are now open.Apply now: https://cyber.fund---Jordan traine
The AI Models Smart Enough to Know They're Cheating — Beth Barnes & David Rein [METR] May 4, 2026 01:53:26 Beth Barnes and David Rein on the one graph that ate the AI timelines discourse, and why the two people who built it are the most careful about how you read it.**SPONSOR**Prolific - Quality data. From real people. For faster breakthroughs.https://www.prolific.com/?utm_source=mlstInterview: https://youtu.be/cnxZZTl1tkk---Beth Barnes and David Rein from METR on the one graph that ate the AI timeline
When AI Discovers The Next Transformer - Robert Lange (Sakana) Mar 13, 2026 01:18:06 Robert Lange, founding researcher at Sakana AI, joins Tim to discuss *Shinka Evolve* — a framework that combines LLMs with evolutionary algorithms to do open-ended program search. The core claim: systems like AlphaEvolve can optimize solutions to fixed problems, but real scientific progress requires co-evolving the problems themselves.GTC is coming, the premier AI conference, great opportunity to
"Vibe Coding is a Slot Machine" - Jeremy Howard Mar 3, 2026 01:26:39 Dive into the realities of AI-assisted coding, the origins of modern fine-tuning, and the cognitive science behind machine learning with fast.ai founder Jeremy Howard. In this episode, we unpack why AI might be turning software engineering into a slot machine and how to maintain true technical intuition in the age of large language models.GTC is coming, the premier AI conference, great opportunity
Evolution "Doesn't Need" Mutation - Blaise Agüera y Arcas Feb 16, 2026 00:55:48 What if life itself is just a really sophisticated computer program that wrote itself into existence?Blaise Agüera y Arcas presenting at ALife 2025 — the most technically detailed public walkthrough of the ideas in his *What is Life?* and *What is Intelligence?* books that we've come across.He covers the BFF experiments (self-replicating programs emerging spontaneously from random noise), the
VAEs Are Energy-Based Models? [Dr. Jeff Beck] Jan 25, 2026 00:46:56 What makes something truly *intelligent?* Is a rock an agent? Could a perfect simulation of your brain actually *be* you? In this fascinating conversation, Dr. Jeff Beck takes us on a journey through the philosophical and technical foundations of agency, intelligence, and the future of AI.Jeff doesn't hold back on the big questions. He argues that from a purely mathematical perspective, there&
Abstraction & Idealization: AI's Plato Problem [Mazviita Chirimuuta] Jan 23, 2026 00:53:37 Professor Mazviita Chirimuuta joins us for a fascinating deep dive into the philosophy of neuroscience and what it really means to understand the mind.*What can neuroscience actually tell us about how the mind works?* In this thought-provoking conversation, we explore the hidden assumptions behind computational theories of the brain, the limits of scientific abstraction, and why the question of ma
Why Every Brain Metaphor in History Has Been Wrong [SPECIAL EDITION] Jan 23, 2026 00:42:04 What if everything we think we know about the brain is just a really good metaphor that we forgot was a metaphor?This episode takes you on a journey through the history of scientific simplification, from a young Karl Friston watching wood lice in his garden to the bold claims that your mind is literally software running on biological hardware.We bring together some of the most brilliant minds we&#

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