This Week in Neuroscience
A podcast about the nervous system, hosted by Vincent Racaniello. It covers recent research and developments in neuroscience.
Episodes
TWiN 73: The price of a bigger brain
TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Expansion of outer cortical CUX2 neuron
TWiN 72: What cesarean babies miss
TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin. .Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Vaginal microbiota transfer ameliorates cesare
TWiN 71: Psychedelics rewire the brain from within
TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Psychedelics rewire the b
TWiN 70: Unraveling the axon wrap
TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Gut microbiome promotes pain in fibromyalgia (Neuron) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenk
TWiN 69: Fibromyalgia and the microbiome
TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation, metabolomic changes, and reduced skin innervation. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Microb
TWiN 68: Firewall for the brain
TWiN explores the use of speech brain-computer interfaces to restore communication to people with paralysis, and reveals strategies for protecting private inner speech. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Keeping private inner speech from brain-computer interfaces (Cell
TWiN 67: Interpreting situation-specific facial signals
TWiN explores how theta phase shifts mediate contextual perception of facial expressions during everyday social interactions. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Neural computations underlying contextual processing in humans (Cell Rep) Previous experience shapes percept
TWiN 66: Neuroscience of overeating
TWiN reviews the underlying neurobiological mechanisms of overeating and obesity, the role of the hypothalamus and reward systems in controlling food intake and energy balance, and how dysregulation in these systems leads to overeating. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Serv
TWiN 65: Air pollutants promote dementia
TWiN explains epidemiological data showing that exposure to air pollution was associated with an increased risk of developing Lewy body dementia, and nasal administration of air pollution in mice led to brain atrophy and impaired cognition and motor function. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
TWiN 64: How the brain decides what we see
TWiN explains how visual neurons show functional flexibility by selectively responding to subsets of inputs representing attended objects while ignoring those conveying information about irrelevant objects. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Gamma-band synchronization
TWiN 63: Microbiome-targeted neurotherapy
TWiN discusses research showing that Lactobacillus acidophilus promotes cognitive function recovery after cerebral ischemia, by regulating microglial peroxisomal function. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Arc is pdb molecule of the month (PDB) Probiotics after stroke
TWiN 62: Memories of bad food
TWiN explains research which identifies the regions of the brain that register a long-lasting aversion to potentially poisonous food even with meal to illness delays of several days. Hosts: Vincent Racaniello, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server A neural mechanism for post-ingestion feedback (Nature) Timestamps by
TWiN 61: Blood to the brain
TWiN reveals that proteins travel from the blood to the brain where they are taken up by microglia, revealing a new mode of communication between the brain and the periphery. Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Circulatory proteins taken up by brain microglia (bioRxiv)
TWiN 60: You get the gist of it?
TWiN discusses experiments which show that high-fidelity memories that lose their precision with time depends on reorganization of hippocampal circuitry. Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Loss of precision memory and the hippocampus (Nature) Changes in hippocampi of cab
TWiN 59: AI co-scientist
Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries. Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server AI cracks superbug problem (B
TWiN 58: Tongue-dragging rescue behavior
TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection. Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Tongue-dragging in mice (Sci Adv)
TWiN 57: Repetitive injury, herpes, and Alzheimer's
TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer's disease. Hosts: Vincent Racaniello and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Repetitive injury, herpes, and Alzheimers (Sci Signal) The tau of herpesvirus (TWiV 1187) Fi
TWiN 56: Astrocytes help neurons remember
TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall. Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Disc
TWiN 55: A brain circuit for day/night balance
TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change. Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Brain circuit for photoperiod adaptation (Nature) Timestamps by Jole
TWiN 54: How pregnancy transforms the brain
TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting. Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Pregnancy transforms the brain (Nature) Hormone-mediated neural remodeling during pregnancy (Science) Ef
TWiN 53: Slowing time by cooling the brain
Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Joseph J. Paton and F
TWiN 52: Probiotic improves social behavior in children with ASD
Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD. Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server P
TWiN 51: Sensory processing dysfunction in autism spectrum disorders
TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Go
TWiN 50: Neurological sequelae after COVID-19
TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google
TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?
TWiN welcomes mice to the elite club of 'self-aware' animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Mice are self-aware (Neuron) Mirror self-recognition in
TWiN 48: Traumatic brain injury and retroviruses
TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Activation of endogenous retroviruses in TBI oligodendroglia (Cell Rep) Timestamps by Jolene. Tha
TWiN 47: Walking after spinal cord injury
TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Walking naturally after spinal cord injury (Nature) The paral
TWiN 46: Neuronal activity promotes glioma progression
TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Glioma synapses recruit
TWiN 45: Acupuncture modulates the immune system
TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free):
TWiN 44: ADHD and persistent pain
TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Pain hypersensitivity in ADHD model (PNAS) Timestamps by Jolene. Thanks!
TWiN 43: Pavlovian opioid tolerance
TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Associative opioid analgesic tolerance (Sci Adv) Pavlov
TWiN 42: Therapeutic effects of psychedelic drugs
TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Click arrow to play Download TWiN 042 (34 MB .mp3, 57 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this ep
TWiN 41: Alzheimer's and melanin-concentrating hormone
Vivianne explains how early in Alzheimer's disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for thi
TWiN 40: Dopamine organizes behavior's syllables
Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subs
TWiN 39: Virus-like capsids trigger paraneoplastic disease
Junjie from Jason's lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Virus-like capsids in paran
TWiN 38: Bacterial immunity heals sensory neurons
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A. Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Immunity to the microbiota promotes sensory neuron regeneration (Cell) Timestamps
TWiN 37: Microglia at the crossroads
TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Microglia states and nomenclature (Nature) Timestamps by Jolene. T
TWiN 36: Unbearable neurologists
TWiN answers listener questions about Alzheimer's disease, glaucoma and the microbiota, Dravet's Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Letters read on TWiN 36 Timestamps by Jolene. Thanks! Musi
TWiN 35: Neuromodulation in treatment-resistant depression
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. Hosts: Jason Shepherd and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Closed-loop neuromodulation for depression (Nat Med) Timestam
TWiN 34: Microglia vital after spinal cord injury
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Microglia coordinate spinal cord repair (Nat Commun) Timestamps by Jolene. Thanks!
TWiN 33: Viruses leaving the brain
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Meningeal lymph vessels and viral exit from brain (Nature Neuroscience) Clearing mouse brain video (Y
TWiN 32: Relearning how to move after stroke
TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together. Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Recovery after stroke in mice (Cell Rep) Timestamps by Jolene. Thanks! Music is by Ronald Jen
TWiN 31: HIV-1 co-receptor shapes window for memory linking
TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode CCR5 and memory linking (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your n
TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson's disease. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this epi
TWiN 29: Astrocytes close the critical period
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Astrocytes close the critical period (Science) Timestamps by Jolene
TWiN 28: Oligodendrocyte performance enhancing exosomes
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Click arrow to play Download TWiN 028 (77 MB .mp3, 64 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Glia 101
TWiN 27: Eyes wired to the auditory cortex
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex. Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Remapping retinal projections (Na
TWiN 26: Immunological memory in the brain
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Become a patron of TWiN! Links for this episode Memory of immunity (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
TWiN 25: Thanks for listening
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Males and females in neuroscience studies (New Scientist) Br
TWiN 24: Social transmission of maternal behavior with Ioana Carcea and Robert Froemke
Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin. Hosts: Vincent Racaniello and Timothy Cheung Guests: Ioana Carcea and Robert Froemke Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this
TWiN 23: Peripheral nervous system with Bruce Carter
Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Guest: Bruce Carter Su
TWiN 22: It's never lupus
TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Lupus autoantibodies bind Glu
TWiN 21: How do we know if a mouse is hallucinating?
TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Listener poll - please take it Striatal dopamine
TWiN 20: Drifting aromas in the brain
While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
TWiN 19: Glia 101
On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Music is by Ronald Jenkees Send your
TWiN 18: Autism and the gut microbiome with Mauro Costa-Mattioli
Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN!
TWiN 17: Worms see the light with Michael Nitabach
Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Michael Nitabach Subscribe (free): iTunes, Google Podcas
TWiN 15: Microbiome and neurodevelopment with Helen Vuong
Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello Guest: Helen Vuong Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Maternal microbiome influences fetal neurodevelopment (Nature) Timestamps b
TWiN 14: Reducing Alzheimer-like pathology in mice
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer's disease may be a late manifestation of earlier pathogenic seed formation. Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become
TWiN 13: mRNAs for long-term memory
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Transcriptional programs associa
TWiN 12: A gene for short-term memory
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell. Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Thalamic orphan receptor in short term memory (Cell) An
TWiN 11: A dollar per neuron
Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron. Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello Guest: Maria Tosches Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Single-cell transcriptomics of reptile cortex (Science) Innovations
TWiN 10: Remodeling synapses with a cytokine
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation. Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode IL-33 promotes synaptic plasticity (Cell) T
TWiN 9: COVID-19 neurology with Genna Waldman
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello Guest: Genna Waldman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Preparing a neur
TWiN 8: Replacing lost neurons
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Converting glia to neurons (Cell) Reversing Parkinson
TWiN 7: Stress, the good, bad and beautiful
The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses. Hosts: Ori Lieberman, Jason Shepherd, Erin Calipari and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for the episode The hair cycle (J Cell Sci) Hyperactivation of sympathetic nerves drives hair greying (Nature)
TWiN 6: Neural control of sexual behavior
Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes. Hosts: Ori Lieberman, Andres Bendesky, andJason Shepherd Guest: Nirao Shah Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Nirao Shah laboratory Neural circuit remodeling and sexual behavior (Cell) Timestam
TWiN 5: Anosmia and COVID-19
Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, Erin Calipari and Vincent Racaniello Guest: Bob Datta Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
TWiN 4: It's a trap!
Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons. Hosts: Andres Bendesky, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Arc is a repurposed retrotransposon gag protein that mediates intercellular RNA trans
TWiN 3: Gambling on dopamine
Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction. Hosts: Ori Lieberman, Erin Calipari,Jason Shepherd, and Vincent Racaniello Click arrow to play Download TWiN 003 (52 MB .mp3, 86 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN!
TWiN 2: Cells that fire together wire together
The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing. Hosts: Ori Lieberman, Andres Bendesky,Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links
TWiN 1: The ultimate challenge
The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello Become a patron of TWiN! Links for this episode Lieberman lab Calipari lab Shepherd lab Image credit Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.t
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