Home Podcasts Biohacking Beauty: The Anti-Aging Skincare Podcast
Biohacking Beauty: The Anti-Aging Skincare Podcast

Biohacking Beauty: The Anti-Aging Skincare Podcast

Young Goose 255 episodes Latest Jun 3, 2026

Biohacking Beauty is a podcast that explores skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, it delves into multi-mechanism protocols for optimizing the skin. The show features world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, translating complex research into actionable strategies. Topics include the 12 Hallmarks of Aging and bio-harmonizing lifestyle shifts for biological recalibration.

Episodes

The Mitochondria Problem Behind Aging Skin + How to Recharge Your Skin and Look Younger Jun 10, 2026 34:30 Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.In this solo episode, Young Goose co-founder Amitay Eshel breaks
Dr. Tyler Panzner: Hidden Trade-Offs of Longevity Supplements and the Advantage of Topical Delivery Jun 3, 2026 01:09:30 Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation
The Death of Anti-Aging Skincare & The Longevity Framework That Replaces It May 29, 2026 45:47 Your skin has a biological age and for most people, it's not the same as their chronological one. Mayo Clinic published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue.This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is t
The Overlooked Side of Autophagy Causing Aging - Part 2 May 27, 2026 31:03 The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body
The Overlooked Side of Autophagy Causing Aging - Part 1 May 20, 2026 26:17 What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most peo
Chris Mirabile: Why One Ingredient Will Never Stop You From Aging (And What Actually Does) May 13, 2026 51:18 Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years.We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem,
Biohackers React To Viral SkinTok Videos on Dermaroller, Red Light Therapy Wands & Tretinoin May 6, 2026 33:04 Most of what goes viral on SkinTok is missing one thing. The part where someone actually checks if it works.In this bonus episode, Amitay and Anastasia break down three of the most viral skincare trends circulating today, red light therapy wands, at-home dermarolling, and tretinoin, and run each one through a biohacker's lens. Not to dismiss them outright. But to ask the questions the original vid
Real Talk on Motherhood, Postpartum Skin, and Rebuilding from the Inside Out with Anastasia Khodzhaeva Apr 29, 2026 01:01:18 Mothers sacrifice so much of themselves to carry another human being in their body for nine months. Even after childbirth, there's a phase called the fourth trimester because babies are still heavily dependent on moms for their survival.Motherhood looks different for every woman. For Anastasia, who is a first-time mom, motherhood looked particularly different since her family is overseas and she's
Why Niacinamide Is Not the NAD+ Hero You Think It Is Apr 22, 2026 59:44 Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the m
Dr. Alan Bauman: Why Biohackers Are Losing Their Hair Faster Than Everyone Else Apr 15, 2026 01:17:55 A lot of us treat hair loss the way skincare treats wrinkles, as a cosmetic problem to cover up. But almost every case of thinning, recession, or shedding has something deeper driving it, and by the time it shows up in the mirror, a significant amount of density is already gone.We at Young Goose believe that beauty is whole body care, and hair is one of the most metabolically active tissues in the
The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the Decline Apr 8, 2026 32:20 Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of
Dani Conway: The Gut-Liver Detox Connection & How Gut Issues Show Up As Skin Issues Apr 1, 2026 57:37 Most people treat their skin like a surface problem. But almost every persistent skin issue, from rosacea to eczema to accelerated aging, has something deeper driving it.That deeper driver is almost always the gut, the liver, or a backed-up detox pathway. We at Young Goose, always believe that skincare is whole body care and we want our community to identify the deeper causes of skin issues that p

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