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Lightcone Podcast

Lightcone Podcast

Y Combinator 37 Episodes Dec 3, 2025

Lightcone Podcast is a show for technical founders, focusing on techno-optimism and the challenges of building startups. Hosted by Y Combinator, it features insights from experienced entrepreneurs and investors. The podcast aims to inspire and educate founders on their journey.

Episodes

What Founders Have To Unlearn To Become Great CEOs Dec 3, 2025 00:44:21 Spenser Skates has spent more than a decade building Amplitude from a YC startup into a public company, and in that time, he's had to reinvent himself just as much as the product.Joining the Lightcone pod, he talks through the shift from founder to large-company CEO, the skepticism his team initially had toward AI, and the moment they realized the next wave of analytics would require a full re
AI Is Eating Logistics Nov 14, 2025 00:33:40 Logistics is a multi-trillion-dollar industry that quietly powers the entire global economy — and it's shockingly manual.Ryan Petersen, founder & CEO of Flexport, joins the Lightcone to break down how AI is finally touching the physical world: making shipping cheaper, speeding up global trade, and automating work that used to live inside emails, spreadsheets, and phone calls.
Inside The MIT AI Study Everyone Misunderstood (And What It Means For Startups) Oct 30, 2025 00:21:43 MIT's new State of AI in Business report went viral for claiming that 95% of enterprise AI projects fail. But the real story isn't that AI doesn't work — it's just big companies can't build it.In this episode of the Lightcone, Garry, Harj, Diana, and Jared break down what the study really says, why in-house enterprise AI efforts keep stalling, and how startups are filling the g
Unpopular Ideas That Became Billion-Dollar Businesses Oct 17, 2025 00:37:42 Nine out of ten people might tell you you're crazy. The tenth might see what you see.Garry, Harj, Jared, and Diana talk about contrarian bets — the ideas that look impossible until they work. From Uber and Coinbase to DoorDash and Flock Safety, they share how founders find opportunity where others see dead ends.
The 7 Most Powerful Moats For AI Startups Oct 3, 2025 00:45:05 In the early days, the only moat that startups have is speed. Once you make something people want, the question becomes what deeper moats can you build on to defend against the competition?Garry, Harj, Diana, and Jared dive into Hamilton Helmer’s Seven Powers framework to find out how these moats show up in practice today in AI startups.
The FDE Playbook for AI Startups with Bob McGrew Sep 12, 2025 00:50:42 Bob McGrew helped build some of the most influential technologies of the past two decades. Bob was an early engineer at PayPal, an early executive at Palantir, and was recently Chief Research Officer at OpenAI - where he led the development of ChatGPT, GPT-4 ,and the o1 reasoning model.During his time at Palantir, he was a pioneer of the Forward Deployed Engineer (FDE) model, a strategy that is at
Anthropic Co-founder: Building Claude Code, Lessons From GPT-3 & LLM System Design Aug 21, 2025 00:35:56 Tom Brown co-founded Anthropic after helping build GPT-3 at OpenAI. A self-taught engineer, he went from getting a B-minus in linear algebra to becoming one of the key people behind AI's scaling breakthroughs. And his work is paying off.Today, Anthropic's Claude is the go-to choice for developers, and his team is overseeing what he calls "humanity's largest infrastructure buildout
How to Spend Your 20s in the AI Era Jul 8, 2025 00:38:55 AI has upended the once "safe" CS career path.New grads are facing unemployment rates twice those of art history majors, and a CS degree is no longer a surefire ticket to wealth. At the same time, small, focused teams are scaling from zero to eight-figure revenue in months.In a special Lightcone Live at AI Startup School, Garry, Diana, Harj, and Jared discuss why it's now more import
Alexandr Wang: Building Scale AI, Transforming Work with Agents & Competing With China Jun 18, 2025 01:01:12 Alexandr Wang started Scale AI to help machine learning teams label data faster.It started as a simple API for human labor, but behind the scenes, he was tackling a much bigger problem: how to turn messy, real-world data into something AI could learn from. Today, that early idea powers a multi-hundred-million-dollar engine behind America's AI infrastructure—fueling everything from Fortune 500
State-Of-The-Art Prompting For AI Agents May 30, 2025 00:31:26 At first, prompting seemed to be a temporary workaround for getting the most out of large language models. But over time, it's become critical to the way we interact with AI.On the Lightcone, Garry, Harj, Diana, and Jared break down what they've learned from working with hundreds of founders building with LLMs: why prompting still matters, where it breaks down, and how teams are making it
Startups Ideas You Can Now Build With AI May 16, 2025 00:40:46 There's never been a better time to start an AI company. Not just because there are new ideas, but because the tech finally makes old ones actually work.On the Lightcone, Garry, Harj, Diana, and Jared talk through the kinds of startups that are suddenly viable thanks to LLMs—from full-stack law firms to personalized tutors to recruiting platforms that can finally scale. They share the patterns the
Windsurf CEO: Betting On AI Agents, Pivoting In 48 Hours, And The Future of Coding May 2, 2025 00:52:35 Varun Mohan didn't set out to build one of the fastest-growing AI developer tools. He just knew his company had to change, or die.After initially betting on GPU virtualization, he saw the writing on the wall: if there was a future for his company, it would be at the AI application layer, not infra. Over a single weekend, he and his team pivoted to building Windsurf— a tool to help everyone, bo

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