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Probably Science

Probably Science

Andy Wood, Matt Kirshen, Jesse Case 623 Episodes Aug 8, 2026

Professional comedians with so-so STEM pedigrees take you through this week in science. Incompetently. Featuring hosts Matt Kirshen, Andy Wood (and sometimes Jesse Case or Brooks Wheelan) along with a rotating cast of special guests from the worlds of comedy and science.

Episodes

Episode 613 - Dave Holmes
Episode 613 - Dave Holmes Aug 8, 2026 01:18:23 Writer/podcaster/host Dave Holmes (@daveholmes) returns to the show to talk with Jesse, Matt and Andy about his new Substack Cocksure, his memoir Party of One, the waning days of monoculture at MTV, Dave's excellent MTV history podcast Who Killed The Video Star?, Helen Twelvetrees, the band Rocket, Dan Taberski's Manifesto podcast, blocking out your inner cynical friend, the movie Ghost Dad, Dave'
Episode 612 - Alison Leiby
Episode 612 - Alison Leiby Jul 26, 2026 01:09:19 Comedian/writer Alison Leiby (@alisonleiby) joins Jesse, Andy and Matt to talk about her new memoir I'm A Lot, AI promotional scams, chronic back pain, how happiness can literally break your heart, takotsubo octopus traps, a breatkthrough in Alzheimer's-related sleep loss, plaque talk, inhaling CO2 to help with Alzheimer's, debunking the electric pangolin, giraffe math and ranking the intelligence
Episode 611 with Hannah Roeschlein
Episode 611 with Hannah Roeschlein Jul 16, 2026 57:47 Hannah Roeschlein (@handerpumprules) joins Jesse and Matt for half the episode before the computer gods get angry, forcing the two guys to finish the show solo. But between us we talk about Filipino divers! Synthetic cells! And Hobbits and Komodo dragons! In the Patreon bonus, we get into space fires, and hear how Matt got served by a legendary astronaut and Jesse angered BBQ fans. Click here to
Episode 610 - Kirk Smith
Episode 610 - Kirk Smith Jul 6, 2026 01:13:39 Comedian Kirk Smith (@kirksmithcomedy) joins Jesse, Andy and Matt to talk about his books Rice Krispies with Ketchup and Movin, pools and jacuzzis, competitive eating champions, the science of fireworks, the lack of rap in the Billboard Hot 100 and Andy's upcoming Oregon tour.
Episode 609 - Ryan Conner
Episode 609 - Ryan Conner Jun 26, 2026 01:17:46 Comedian/author Ryan Conner (@ryanconnercomedy) returns to the show to talk with Jesse, Andy and Matt about his new memoir 12 Guys Walk Into a Kitchen, Vietnamese refugees, Tippi Hedren's nail salon legacy, British soccer fans cleaning up in the US, the worst year to be alive, 2020 vs. 1968, hipster nostalgia, stomp clap tall bikes and nuclear (not atomic) clocks.
Episode 608 - Laura Sams Jordan
Episode 608 - Laura Sams Jordan Jun 18, 2026 01:16:47 Zoologist/producer/composer/podcaster Laura Sams (@lauramsams) Jordan joins Jesse, Matt and Andy to talk about fliming grizzly bears in Alaska, studying hyenas in Africa, Laura's kid-friendly wildlife podcast The Happiest Animal Show, starting a production company with your sibling, interviewing six-year-olds, Laura's inflatable basking shark, the shocking actual appearance of basking sharks, the
Episode 607 - Diana Hong
Episode 607 - Diana Hong Jun 4, 2026 01:12:28 Comedian Diana Hong (@dhongcomedy) joins Jesse, Andy and Matt to discuss cat ownership, Shadow Force, Sawbones and the McElroy-iverse, Diana's golf career, outsider commemorative art, a new way to get your lithium, battery types, alkali metals reacting with water, Lithium Valley, bottle recycling in the US, Sonny Bono's Palm Springs legacy, awful bronze statues, RIP Primm (maybe), an optimal robot
Episode 606 - Charles Star
Episode 606 - Charles Star May 29, 2026 01:06:58 Lawyer-turned-comedian and self-professed podcast slut Charles Star (@ugarles) returns to the show to talk about his podcast No Homework, celebrity roasts, Wings album covers, bad abbreviations, contact lenses that ease depression in mice, the insect with the biggest nuts, self-recognition in beluga whales and the link between sleep duration and accelerated aging.
Episode 605 - James Frey
Episode 605 - James Frey May 18, 2026 01:02:36 Comedian and former paramedic James Frey (@jamesfreycomedy) joins Andy, Jesse and Matt to talk about firefighter dreams and emergency medicine reality, James' Ventura comedy show, giving CPR in civilian life, a woman (well, women) who couldn't burp, getting fobbed off, sucker fish hiding in manta rays' butts, a quantum battery breakthrough and missing scientist conspiracy theories.
Episode 604 - Shane Mauss
Episode 604 - Shane Mauss May 11, 2026 01:12:05 Comedian Shane Mauss (@shane_mauss) returns to the show to talk about his upcoming comedy special TRIPS: The First Dose, how LSD affects blind people, misophonia's link to anxiety and depression, the goring of a matador's ass, plants 'hearing' rain coming and Shane's comedy/science podcast Here We Are.
Episode 603 - Brandie Posey
Episode 603 - Brandie Posey May 3, 2026 01:17:02 Comedian Brandie Posey (@brandazzle) returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label Burn This Records and her new comedy special Milk Job, Andy's other ska band, why humans can't regenerate limbs, a huge volcano refilling with magma, the dude who got both his arms reattached in 1992, whether Yellowstone is due for an eruption and Fruit Love Isl
Episode 602 - Chandler Dean
Episode 602 - Chandler Dean Apr 25, 2026 01:16:36 Comedian/speechwriter Chandler Dean (@chandlerjdean) joins Jesse, Andy and Matt to talk about his show Abolish Everything!, Jesse's over-the-top stuffed animal purchase, poop speed as a health indicator, the Bristol Stool Chart, medical fake poo, Jesse's obsessions with fake foods, giant stuff and really tiny stuff, Artemis II's avatar crewmates, the magic of Tiny Empath Babies, videos of Tiny Emp

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