Fortune 500: Titans and Disruptors of Industry
Hosted by Fortune Editor-in-Chief Alyson Shontell, this podcast features in-depth conversations with powerful thought leaders who are shaping the business world and the way we live. Each episode delves into the strategies, insights, and disruptions of industry titans. Listeners gain a closer look at the minds behind major corporate and economic trends. The show aims to uncover what drives success and innovation in modern business.
Episodes
Workday CEO Predicts AI Job Displacement And Which Roles May Be Safe
Workday cofounder Aneel Bhusri returned to the CEO position for what he calls a “refounding moment.” Bhusri is steering the enterprise software giant toward an AI-native future built around AI agents that may reshape how companies build, hire and manage.
In this episode, Fortune Editor-in-Chief Alyson Shontell speaks with Bhusri about why he believes AI-driven job displacement is coming within
Sam Altman: AI Beyond Human Control “Absolutely Possible”
OpenAI CEO Sam Altman sits down with Fortune's Editor-in-Chief Alyson Shontell to discuss the high-stakes balancing act of AI: pushing the boundaries of scientific discovery while confronting the existential risks of loss of control.
In this episode, Altman addresses the reality of AI alignment, the Hugging Face incident, and OpenAI's commitment to halting training runs if safety thresholds
Why GM's CEO Mary Barra is Still Bullish on Electric Vehicles
Mary Barra has spent more than four decades at General Motors, rising from an 18-year-old co-op student training on the factory floor to CEO. In her 12-year tenure, she’s steered the company through a near-catastrophic safety crisis and helped turn the century-old automaker into an innovation powerhouse that currently ranks No. 23 on the Fortune 500.
In this episode, Fortune’s Editor-in-Chief Aly
Bill Ackman's takes on Mamdani, Trump and investing in the AI era
Pershing Square Founder and CEO Bill Ackman got his start by cold-calling multi-millionaires and billionaires for startup capital. Today, the billionaire hedge fund manager is a leading voice both on Wall St. and online, where he frequently shares candid opinions about investing, politics, and culture to about 2.7 million X followers.
In this episode, Fortune’s Editor-in-Chief Alyson Shonte
FedEx CEO: AI Could Help Fix A $1.8 Trillion Global Supply Chain Problem
For the first time in the company's history, FedEx has surpassed UPS in market value. Handling roughly 18 million packages a day, FedEx is acutely aware of how tariffs and geopolitical tensions have disrupted the global supply chain. As it enters its AI era, the company is leveraging artificial intelligence to predict and address these obstacles head-on.
In this episode, Fortune Editor-in-Chief A
$4 Trillion Savings Gap: TIAA’s CEO on The Retirement Crisis
For more than 100 years, TIAA has helped millions of Americans — from educators to healthcare workers to public servants — turn their savings into guaranteed income they cannot outlive. Today, the company is expanding beyond its traditional 403(b) roots, pioneering lifetime income solutions inside 401(k) plans and using AI to better protect and serve participants.
In this episode, Fortune’s Editor
AI Takeover: Qualcomm’s Big Bet on AI Agents, Robots and 6G | Titans and Disruptors
For over 40 years, Qualcomm technology has powered some of the world’s most transformational technological advancements. Today, the company is moving beyond smartphones, building a future with wearable AI, humanoid robots, and a 6G cellular network.
In this episode, Fortune’s Editor-in-Chief Alyson Shontell speaks with Qualcomm’s President and CEO Cristiano Amon to discuss the company’s commitmen
The $8+ Billion Partnership: How Delta and Amex Redefined the Business of Flying | Titans and Disruptors
From one of the largest bankruptcies in U.S. history to leading the industry in market capitalization and premium customer satisfaction, Delta Air Lines has rewritten the business of flying in the last two decades.
In this episode, Fortune's Editor-in-Chief Alyson Shontell sits down with CEO Ed Bastian at Delta’s Atlanta headquarters to discuss the strategic maneuvers behind the airline’s resurg
The end of work: Vinod Khosla's bold AI prediction | Titans and Disruptors
What if AI made your paycheck optional? Vinod Khosla, one of the world's greatest venture capitalists and an early backer of AI, believes the technology will take over 80% of labor, freeing humans to live on passion instead.His track record backs up the boldness, as early bets on OpenAI, DoorDash, Instacart, and Square have made him one of the most consequential investors of our time.In this episo
Google’s AI boss made OpenAI issue code red. Now he wants to solve disease. | Titans and Disruptors
Google DeepMind founder and CEO Sir Demis Hassabis is a master chess player, a recipient of the Nobel Prize in Chemistry, and - as of 2024 - a Knight. Today, as a leader within Google’s booming AI team, Hassabis wants to make AI the “engine” driving the entire company.In this episode of Fortune 500: Titans and Disruptors of Industry, Fortune’s Editor-in-Chief Alyson Shontell sits down with Hassabi
Pfizer CEO took on COVID. Now he wants to cure cancer | Titans and Disruptors
Dr. Albert Bourla became Pfizer’s CEO months before the COVID-19 pandemic took hold of the US. Under his leadership, Pfizer manufactured 3 billion doses of the first FDA-approved vaccine in the first year, which led to record-breaking earnings. Yet over the past few years, post-pandemic sales slumps, patent cliffs and vaccine skepticism have driven down Pfizer’s earnings. In this episode of Fortun
Kamala Harris says the ‘Glass Cliff’ Suggests Finality: “I’m Not Into That”
It’s been one year since Vice President Kamala Harris and then-Democratic nominee was coming down to her final days of the 2024 presidential campaign against Donald Trump. She spent 107 days on the road in a bid to earn their vote, but it wasn’t enough. Almost one year later, she’s had time to reflect. In a wide-ranging conversation at Fortune’s Most Powerful Women summit, Harris joined Fortune’s
Jamie Dimon on What Kills Companies and the Key to Business Leadership
JPMorgan Chase CEO Jamie Dimon has led the nation's largest financial institution through times of disruption for two decades. As Dimon navigates today's world of generative AI, President Trump's policies, and the effects on the global economy, Dimon sat down with Fortune's Editor-in-Chief, Alyson Shontell, to discuss these topics at the Most Powerful Women Summit in Washington, D.C. Dimon shares
How Ramp's Eric Glyman Built a $22.5 Billion Startup in 2,367 Days
Ramp CEO Eric Glyman has helped build one of fintech’s fastest-growing startups — hitting $1 billion in annualized revenue, serving 45,000 businesses, and soaring to a $22.5 billion valuation in just 2,367 days. In this episode of Fortune 500: Titans and Disruptors of Industry, he sits down with Fortune’s Editor-in-Chief Alyson Shontell to break down Ramp’s meteoric rise, the business model flippi
Julie Sweet’s Path From Lawyer to Leading 770,000 People
AI is rewriting the rules of business — and Accenture CEO Julie Sweet says reinvention is the only way Fortune 500s will survive. In the debut episode of Fortune 500: Titans and Disruptors of Industry, Sweet sits down with Fortune’s Editor-in-Chief Alyson Shontell to reveal how she’s nearly doubled Accenture’s value, grown its workforce to 770,000, and kept the company thriving through disruption.
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