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Longevity Optimization with Kayla Barnes-Lentz

Longevity Optimization with Kayla Barnes-Lentz

Kayla Barnes-Lentz 158 episodes Latest May 28, 2026

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

Episodes

Dr. Martha Gulati, MD: Women's Heart Disease, Female-Specific Risk Factors, and What Medicine Gets Wrong About Cardiovascular Health Jun 11, 2026 01:01:06 Heart disease is not only a man's disease. It is the number one killer of women, responsible for ten times more deaths than breast cancer. And yet most women have never had a real conversation about their cardiovascular risk, because the medical system was not built to catch it in them.Dr. Martha Gulati is the Director of Preventive Cardiology and Associate Director of the Barbra Streisand Wom
Dr. Jolene Brighten, ND - Endometriosis, Adenomyosis, PMDD, PMOS and Postpartum Hormones Jun 4, 2026 01:47:49 Women are often told that painful periods, irregular cycles, bloating, mood changes, fatigue, brain fog, postpartum symptoms, and hormonal shifts are “normal.”But common does not mean something should be ignored.In this episode, Dr. Jolene Brighten, ND joins me for a practical deep dive into female-specific conditions that are too often missed, minimized, or treated in isolation, including endomet
Dr. Izabella Wentz: IBS Root Causes, Leaky Gut, Autoimmunity, and How To Start Healing Your Gut May 28, 2026 00:56:08 Less than 25% of people with IBS get real relief from conventional medicine. That number tells you everything about how the current approach is failing.Most people with IBS have been told it is stress, told to take medication, and sent home. But irritable bowel syndrome is not one condition, it is a label applied to a cluster of symptoms that can have 20 to 40 completely different root causes. And
Dr. Scott Sherr, MD: Why Stress Blocks Healing: Mitochondria, Immune Aging, Hyperbaric Oxygen, and Methylene Blue May 21, 2026 01:31:45 There is a state where the body gets locked in sympathetic activation and mitochondrial dysfunction at the same time and no matter what supplements you take, no matter what protocols you run, nothing actually works. Dr. Scott Sherr calls it the sympathetic spiral of doom, and in this episode we break down exactly what it is, why so many people are stuck in it without knowing it, and the right sequ
Dr. Poonam Desai: The 5 Labs Women Need, Heart Disease Risk, Microplastics, and Perimenopause May 14, 2026 01:02:30 Most women have had bloodwork done. What most women haven't had is the right bloodwork. In this episode, Dr. Poonam Desai, double board certified in lifestyle and emergency medicine, NAM certified in menopause care, and founder of Longevity Place and Her Longevity, breaks down the five labs she runs on every female patient, the optimal values most physicians aren't targeting, and why the s
Prof. Belinda Beck, PhD: Bone Health: Building Strong Bones, Preventing Age-Related Loss, And Reversing Osteoporosis With Evidence-Based Exercise May 7, 2026 01:10:54 Most women are not thinking about their bones until a fracture happens or a scan comes back alarmingly. By then, the window for the most impactful intervention has often been narrowing for decades. Bone density peaks around age 18, not 30 as widely believed and the slow decline that follows is largely silent until it isn't.Professor Belinda Beck, PhD has spent more than two decades studying ex
Dr. Dawn Mussallem, DO: Cancer Prevention, Early Detection, Exercise, Metabolic Health and Breast Cancer Screening Apr 30, 2026 01:24:35 In this episode, I’m joined by Dr. Dawn Mussallem, DO, an integrative oncologist, lifestyle medicine specialist, cancer survivor, heart transplant recipient, and the newly appointed Chief Medical Officer of Fountain Life.We talk about why cancer rates are rising, what we actually know about prevention, and why early detection matters so much when it comes to long-term outcomes. We also discuss the
Dr. Brian Kennedy, PhD: The Real Science of Longevity: mTOR, Rapamycin & How to Measure Biological Age Apr 23, 2026 02:33:56 Brian Kennedy is one of the world’s leading researchers studying the biology of aging.In this conversation, we break down what longevity science actually shows about extending healthy lifespan and the everyday habits that appear to influence how we age.Dr. Brian shares insights from decades of aging research, explaining how scientists study longevity, how interventions like rapamycin and biologica
GLP-1 Crisis for Women, Gut Health, Bone Loss with Dr. Sara Szal, MD Apr 16, 2026 01:13:03 We're back with Dr. Szal! Today we are discussing a variety of topics: Gut health, peptides, hormone health , GLP-1's, bone health and so much more!In this conversation, Dr. Sara G dives into the gut-brain connection and explains how disrupting the microbiome can directly affect mood, anxiety, and overall mental resilience. She breaks down why even a single course of antibiotics can shift
Dr. Bérénice Benayoun, PhD: Why Your Ovaries Age (And the Gut Connection) Apr 9, 2026 01:32:32 Bérénice Benayoun, PhD, explains why ovarian aging may be one of the earliest and most important drivers of female aging, influencing the brain, immune system, metabolism, and long-term disease risk far beyond reproduction. She breaks down what we actually know so far, including DNA damage, mitochondrial dysfunction, fibrosis, hormonal signaling, and why the ovary appears to age faster than other
Dr. Deb Rivera, PhD: The Missing Link Between Stress, Aging, and Resilience Apr 2, 2026 01:32:51 Most people can feel when stress is affecting them. Far fewer know whether their body is adapting well or quietly being pushed toward dysfunction.In this episode, Dr. Deb Rivera, PhD in neuroengineering, explains the hidden biological system that helps determine how well your body handles stress. Her research focuses on redox balance and the glutathione ratio, a biomarker that may reveal whether y
Dr. Eboni Cornish, MD: Brain Longevity, Neuroinflammation, and What Quietly Damages the Brain Mar 26, 2026 01:39:12 Brain health problems rarely begin where most people look. Memory issues, low mood, poor focus, anxiety, and even early cognitive decline can be driven by hidden inflammation and root-cause imbalances long before they show up the way most people expect.In this episode, Dr. Eboni Cornish explains how chronic infections, mold, toxins, hormones, gut dysfunction, and oral or nasal microbial imbalances

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