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Talk Python To Me

Talk Python To Me

Michael Kennedy 549 episodes Latest May 30, 2026

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. It dives deep into popular Python packages and features interviews with software developers, data scientists, and hobbyists doing amazing things with Python. Newcomers to Python can quickly learn the ins and outs of the community by hearing from leaders, while experienced Python users can learn about their favorite packages and new open-source releases.

Episodes

#551: Stroll Down Startup Lane - 2026 Jun 11, 2026 6534 If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share
#550: AI Contributions and Maintainer Load in Open Source May 30, 2026 3762 You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue filed first. No discussion. Just "here, please review this for me." Over the past year, GitHub activity has spiked roughly twelve times in a few short months, and a huge chunk of that signal is landing on the same small group of m
#549: Great Docs May 25, 2026 4020 Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Michael Chow from Posit are back on Talk Python with a brand new Python documentation tool called Great Docs that takes both seriously. Rich is the creator of Great Tables, and before that the R package GT, the man has a serious eye for
#548: Event Sourcing Design Pattern May 11, 2026 4129 What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row that quietly forgets its own history. That's event sourcing, and Chris May is back on Talk Python, fresh off our Datastar panel, to walk us through what it actually looks like in Python. We'll cover the core patterns, the libraries to reach for,
#547: Parallel Python at Anyscale with Ray May 6, 2026 3556 When OpenAI trained GPT-3, they didn't roll their own orchestration layer. They used Ray, an open source Python framework born out of the same Berkeley research lab lineage that gave us Apache Spark. And here's the twist: Ray was originally built for reinforcement learning research, then quietly faded as RL hit a wall. Until ChatGPT showed up. Suddenly reinforcement learning was b
#546: Self hosting apps for Python people Apr 27, 2026 3792 The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you read about a family that lost their entire Google account over a medical photo sent to a doctor. At some point, the question shifts from "why would I run this myself?" to "why aren't I?" My guest this week is Alex Kretzschmar, head
#545: OWASP Top 10 (2025 List) for Python Devs Apr 16, 2026 3963 The OWASP Top 10 just got a fresh update, and there are some big changes: supply chain attacks, exceptional condition handling, and more. Tanya Janca is back on Talk Python to walk us through every single one of them. And we're not just talking theory, we're going to turn Claude Code loose on a real open source project and see what it finds. Let's do it. Episode sponsors Tempora
#544: Wheel Next + Packaging PEPs Apr 10, 2026 4277 When you pip install a package with compiled code, the wheel you get is built for CPU features from 2009. Want newer optimizations like AVX2? Your installer has no way to ask for them. GPU support? You're on your own configuring special index URLs. The result is fat binaries, nearly gigabyte-sized wheels, and install pages that read like puzzle books. A coalition from NVIDIA, Astr
#543: Deep Agents: LangChain's SDK for Agents That Plan and Delegate Apr 1, 2026 3833 When you type a question into ChatGPT, the model only has what you typed to work with. But tools like Claude Code can plan, iterate, test, and recover from mistakes. They work more like we do. The difference is the agent harness: Planning tools, file system access, sub-agents, and carefully crafted system prompts that turn a raw LLM into something genuinely capable. Sydney Runk
#542: Zensical - a modern static site generator Mar 25, 2026 3843 If you've built documentation in the Python ecosystem, chances are you've used Martin Donath's work. His Material for MKDocs powers docs for FastAPI, uv, AWS, OpenAI, and tens of thousands of other projects. But when MKDocs 2.0 took a direction that would break Material and 300 ecosystem plugins, Martin went back to the drawing board. The result is Zensical: A new static site gene
#541: Monty - Python in Rust for AI Mar 19, 2026 3944 When LLMs write code to accomplish a task, that code has to actually run somewhere. And right now, the options aren't great. Spin up a sandboxed container and you're paying a full second of cold start overhead plus the complexity of another service. Let the LLM loose on your actual machine and... well, you'd better be watching. On this episode, I sit down with Samuel Colvin, cr
#540: Modern Python monorepo with uv and prek Mar 13, 2026 3733 Monorepos -- you've heard the talks, you've read the blog posts, maybe you've seen a few tantalizing glimpses into how Google or Meta organize their massive codebases. But it's often in the abstract and behind closed doors. What if you could crack open a real, production monorepo, one with over a million lines of Python and over 100 of sub-packages, and actually see how it's built

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