OpenAI Podcast
Hosted by Andrew Mayne, The OpenAI Podcast features conversations with the people building with and working at OpenAI. Topics range from how new features are developed to what users are doing with the technology. It’s a practical look at how AI is made and where it’s going, told by the people closest to the work.
Episodes
How a reasoning model cracked an 80-year-old math problem - Episode 20
Last month AI found something mathematicians had missed for decades. Reasoning researchers Alexander Wei, Hongxun Wu, and Lijie Chen join the podcast to discuss how a general-purpose model helped disprove an 80-year-old conjecture from famed mathematician Paul Erdős. They walk through the moment the result started looking real, what it took to verify the proof, and what’s happened since sharing th
Inside image generation’s Renaissance moment - Episode 19
People are generating over 1.5 billion images a week in ChatGPT. In this episode, Product lead Adele Li and researcher Kenji Hata share some of the new use cases and trends since the launch of Images 2.0. Together with host Andrew Mayne, they trace the progress from the early DALL-E days and dive into the latest capabilities, including better text rendering, photorealism, multilingual support, wor
Why AI needs a new kind of supercomputer network - Episode 18
Training frontier models isn’t as simple as adding more GPUs—one small problem and the whole coordinated dance falls apart. OpenAI’s Mark Handley and Greg Steinbrecher discuss how a new supercomputer network design, used to train some of the company’s latest models, keeps the whole system moving in lockstep, even with record numbers of GPUs. They break down Multipath Reliable Connection, a new pro
What happens now that AI is good at math? - Episode 17
Math is one of the clearest ways to see how far AI has come in a short span. OpenAI researchers Sébastien Bubeck and Ernest Ryu join host Andrew Mayne to explain what changed and what it could mean for the future of research. They reflect on how Ernest used ChatGPT to help solve a 42-year-old open problem, the difference between deep literature search and original mathematical discovery, and what
Building AI for Life Sciences - Episode 16
What does it take to build AI systems that can actually help scientists? Research lead Joy Jiao and product lead Yunyun Wang discuss how OpenAI is developing models for life sciences and what responsible deployment means in a field with real biosecurity stakes. They explore how AI is already improving research workflows and where it could lead in drug discovery and more autonomous labs — including
Inside the Model Spec - Episode 15
The more AI can do, the more we need to ask what it should and shouldn’t do. In this episode, OpenAI researcher Jason Wolfe joins host Andrew Mayne to talk about the Model Spec, the public framework that defines intended model behavior. They discuss how the Model Spec works in practice, including how the chain of command handles conflicts between instructions, and how OpenAI evolves it based
Building AI for better healthcare - Episode 14
Healthcare systems around the world are under strain, and both patients and clinicians are feeling the impact. OpenAI's Head of Health Dr. Nate Gross and Karan Singhal, who leads Health AI Research, discuss how AI can help address the biggest challenges. They cover how OpenAI is training models to handle sensitive health questions in collaboration with physicians, and how that foundation is unlock
The Thinking Behind Ads in ChatGPT - Episode 13
How should advertising work in an AI product? Asad Awan, one of the ad leads at OpenAI, walks through how the company is approaching this decision and why it’s testing ads in ChatGPT at all. He explains how ads are built to stay separate from the model response, keep conversations with ChatGPT private from advertisers, and give people control over their experience.Chapters00:00:29 — Mission and pr
State of the AI Industry - Episode 12
OpenAI CFO Sarah Friar and Khosla Ventures founder Vinod Khosla argue the greatest challenges in AI right now are keeping up with demand and making sure more people get the benefit. They unpack what's driving big investments in compute and why this moment is different from other technology cycles — with meaningful advances in health, agents, and robotics still ahead. Chapters00:00:00 — What’s
Shaping Model Behavior in GPT-5.1 - Episode 11
What does it mean for an AI model to have "personality"? Researcher Christina Kim and product manager Laurentia Romaniuk talk about how OpenAI set out to build a model that delivers on both IQ and EQ, while giving people more flexibility in how ChatGPT responds. They break down what goes into model behavior and why it's an important, but still imperfect blend of art and science.Chapters:- 00:00:43
How AI Is Accelerating Scientific Discovery Today and What's Ahead - Episode 10
AI is beginning to change how science gets done. Head of OpenAI for Science Kevin Weil and OpenAI research scientist Alex Lupsasca talk about the early signs of acceleration researchers are seeing with GPT-5—from surfacing literature across fields and languages, to speeding up complex calculations, to designing follow-up experiments. They unpack what’s possible today, what doesn’t work yet, and wh
ChatGPT Atlas and the next era of web browsing - Episode 9
How will the internet feel when your browser can actually help do things for you? OpenAI’s Ben Goodger and Darin Fisher, whose past work shaped some of the most popular modern browsers, dive into the making of ChatGPT Atlas. They explore how AI changes what a browser can be, from tabs you can talk to, to agents that take over tedious tasks. Learn more about the decisions they made along the way an
OpenAI x Broadcom and the future of compute - Episode 8
Sam Altman and Greg Brockman from OpenAI sit down with Broadcom’s Hock Tan and Charlie Kawwas to discuss their new partnership—and what it means for the future of AI. From custom silicon to global-scale infrastructure, they share how compute innovation is shaping the road to AGI. 00:00 Announcing the partnership03:06 The scale of AI infrastructure06:03 Collaboration and innovation in chip design08
Live from DevDay - Episode 7
The OpenAI Podcast is live for the first time. Host Andrew Mayne sits down with startups Cursor, Abridge, SchoolAI, and Jam.dev—each reimagining how AI can transform their industries. From healthcare and education to coding and collaboration, we explore how these builders are putting AI to work in the real world.00:23 Caleb Hicks (SchoolAI)14:14 Dani Grant (Jam.dev)26:20 Zach Lipton (Abridge)
The future of coding with AI - Episode 6
What happens when AI becomes a true coding collaborator? OpenAI co-founder Greg Brockman and Codex engineering lead Thibault Sottiaux talk about the evolution of Codex—from the first glimpses of AI writing code, to today’s GPT-5 Codex agents that can work for hours on complex refactorings. They discuss building “harnesses,” the rise of agentic coding, code review breakthroughs, and how AI may tran
Defining AGI and the road ahead - Episode 5
How close are we to automating scientific discovery? What do AI competition wins really tell us about progress toward AGI? OpenAI Chief Scientist Jakub Pachocki and researcher Szymon Sidor share inside stories—from gold medals at the International Math Olympiad to surprising leaps in reasoning—that reveal where AI is headed next.1:20 – From high school in Poland to AI research leaders4:50 – Explai
How AI is transforming education - Episode 4
AI is redefining how we learn — from personalized tutoring to entirely new teaching models. OpenAI’s Head of Education, Leah Belsky, joins host Andrew Mayne to discuss what this shift means for students, educators, and society. Special guests include college students Yabsera and Alaap, who share their perspectives on learning in the AI era.00:22 – Leah’s path to OpenAI & the moonshot01:40 – Ch
Jobs, growth, and the AI economy - Episode 3
The future of work is arriving faster than expected. In this episode, OpenAI COO Brad Lightcap and Chief Economist Ronnie Chatterji join Andrew Mayne to discuss the impacts of AI on software, science, small business, education, and jobs.00:00 Intro01:00 Brad Lightcap on OpenAI’s deployment mission02:00 Birth of ChatGPT: from playground to product06:15 AI’s impact on work & productivity08:55 Su
Inside ChatGPT, AI assistants, and building at OpenAI - Episode 2
Why was OpenAI surprised by ChatGPT’s success? What does it really mean to “reason” in an AI system? And what’s next for agentic coding and multimodal assistants? OpenAI Head of ChatGPT Nick Turley and Chief Research Officer Mark Chen unpack it all in a conversation that pulls back the curtain on the making of OpenAI’s most iconic product.00:00 – Intro: Meet Nick Turley and Mark Chen00:40&nbs
Sam Altman on AGI, GPT-5, and what’s next - Episode 1
On the first episode of the OpenAI Podcast, Sam Altman joins host Andrew Mayne to talk about the future of AI: from GPT-5 and AGI to Project Stargate, new research workflows, and AI-powered parenting.00:00Welcome to the OpenAI Podcast01:00ChatGPT & parenthood04:10AGI, superintelligence & scientific progress07:10Operator, Deep Research & productivity10:30GPT-5 & how we name models13
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