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The Metabolic Link

The Metabolic Link

Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field 95 Episodes Oct 6, 2026

The Metabolic Link is a medical and science podcast that explores the common thread of metabolism in health and disease. Hosted by Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, it dives into the latest research on metabolic health and therapy alongside leading experts. The podcast also discusses how this science is applied in the real world, bridging the gap between research and practical application.

Episodes

Rethinking Preventive Testing: Whole-Body MRI, VO2 Max & Organ Aging | Dr. Michael Doney, MD | The Metabolic Link Ep. 105
Rethinking Preventive Testing: Whole-Body MRI, VO2 Max & Organ Aging | Dr. Michael Doney, MD | The Metabolic Link Ep. 105 Oct 6, 2026 5123 What would an emergency physician tell his patients if he could have met them 20 years before their crisis?Dr. Michael Doney, MD, MPH, MS, spent years as a board-certified emergency physician managing the acute consequences of chronic disease. Today he is Executive Medical Director of Biograph, a preventive health clinic that combines whole-body MRI, cardiovascular imaging, DEXA, VO2 max testing,
Ketosis in the Real World: Sardine Fasting, Low-Dose GLP-1s & Carb Addiction | Dr. Annette Bosworth, MD | The Metabolic Link Ep. 104
Ketosis in the Real World: Sardine Fasting, Low-Dose GLP-1s & Carb Addiction | Dr. Annette Bosworth, MD | The Metabolic Link Ep. 104 Sep 22, 2026 4915 Join us for a FREE live Q&A with Dr. Boz on October 14 at 9:00 AM PT / 12:00 PM ET and ask her your questions directly. No membership required. Register here.What happens when an internist teaches ketogenic nutrition to 200 students at the same time and tracks every one of their glucose and ketone readings on shared dashboards?Dr. Annette Bosworth, MD, known to her audience as Dr. Boz, is an i
Metabolic Gynecology: Insulin, Inflammation, and the Uterus as an End Organ | Dr. Andréa Salcedo, DO | The Metabolic Link Ep. 103
Metabolic Gynecology: Insulin, Inflammation, and the Uterus as an End Organ | Dr. Andréa Salcedo, DO | The Metabolic Link Ep. 103 Sep 8, 2026 3856 Join us for a FREE live Q&A with Dr. Salcedo on September 10 at 9:00 AM PT / 12:00 PM ET and ask her your questions directly. Register here.What if the uterus is an end organ, responding to insulin and inflammation the same way the heart, kidneys, and liver do?Dr. Andréa Salcedo is a board-certified OBGYN (DO, MPH, FACOG) and associate professor at Loma Linda University School of Medicine whos
You Asked, Ben Bikman Answered: GLP-1 Muscle Loss, Ketone Targets & Cancer Metabolism | The Metabolic Link Ep. 102
You Asked, Ben Bikman Answered: GLP-1 Muscle Loss, Ketone Targets & Cancer Metabolism | The Metabolic Link Ep. 102 Aug 25, 2026 4084 Today we are doing something we have never done before.Once a month, members of The Metabolic Initiative get an hour to put their own questions directly to the scientists and clinicians at the forefront of metabolic health. Those sessions stay inside the platform. This one does not.After Dr. Ben Bikman joined us for episode 100, the questions kept coming. So we invited him back to sit with Dr. Dom
Implementation of Ketogenic and Low Carbohydrate Therapies for Metabolic Disease | Franziska Spritzler, RD, CDE | The Metabolic Link Ep. 101
Implementation of Ketogenic and Low Carbohydrate Therapies for Metabolic Disease | Franziska Spritzler, RD, CDE | The Metabolic Link Ep. 101 Aug 11, 2026 3320 Ketogenic and low-carbohydrate diets often focus on a specific carbohydrate target: keep your net carbs under 30 grams. But as registered dietitian and certified diabetes educator Franziska Spritzler demonstrates in this presentation from Metabolic Health Summit, a carbohydrate target is not a therapy. Effective implementation means a full assessment of medical history, medications, labs, food pre
Ben Bikman, PhD | Rethinking Metabolic Health: Insulin, Ketones, and What Comes Next | The Metabolic Link Ep. 100
Ben Bikman, PhD | Rethinking Metabolic Health: Insulin, Ketones, and What Comes Next | The Metabolic Link Ep. 100 Jul 28, 2026 3974 Join us for a live Q&A with Dr. Ben Bikman here.For the 100th episode of The Metabolic Link, Ben Bikman, PhD, professor of cell biology and physiology at Brigham Young University and author of Why We Get Sick, returns for a milestone conversation with co-hosts Dominic D’Agostino, PhD, and Victoria Field. Together, they examine what clinicians are measuring, what conventional approaches may be
Type 1 Diabetes on a Ketogenic Diet: What a 1,000-Mile Bike Ride Revealed | Dr. Ian Lake | The Metabolic Link Ep. 99
Type 1 Diabetes on a Ketogenic Diet: What a 1,000-Mile Bike Ride Revealed | Dr. Ian Lake | The Metabolic Link Ep. 99 Jul 14, 2026 4109 What can 21 days of continuous glucose and ketone data, recorded during a 1,000-mile cycling journey, reveal about managing type 1 diabetes on a ketogenic diet?Dr. Ian Lake is a UK-based primary care physician who has lived with type 1 diabetes for more than 30 years. After two decades of conventional high-carbohydrate management, he adopted a very low-carbohydrate, ketogenic approach and began ex
Ozempic, Insulin Resistance, and Type 2 Diabetes: What Are We Missing? | Dr. Mariela Glandt | The Metabolic Link Ep. 98
Ozempic, Insulin Resistance, and Type 2 Diabetes: What Are We Missing? | Dr. Mariela Glandt | The Metabolic Link Ep. 98 Jun 30, 2026 3908 Attend a Live Q&A with Dr. Glandt. Reigster here.What if the way we treat type 2 diabetes is fundamentally backwards?Dr. Mariela Glandt is an endocrinologist and obesity medicine specialist who spent 15 years practicing conventional medicine before concluding, in her words, that how we treat diabetes “is actually upside down.” As co-founder of OwnaHealth, she focuses on addressing the insulin
Treating PTSD When Standard Care Falls Short: A Hyperbaric Oxygen Protocol | Dr. Keren Doenyas-Barak, MD | The Metabolic Link Ep. 97
Treating PTSD When Standard Care Falls Short: A Hyperbaric Oxygen Protocol | Dr. Keren Doenyas-Barak, MD | The Metabolic Link Ep. 97 Jun 16, 2026 4646 Fewer than 40% of people with PTSD respond to standard care. For the intrusive symptoms at the core of the disorder, response rates may be lower than 15%. So what options remain for patients who have not responded to existing treatments?Dr. Keren Doenyas-Barak, director of the PTSD program at the Sagol Center for Hyperbaric Medicine and Research and a faculty member at Tel Aviv University, has tre
Inflammation and Glycation: The Two Heads of Chronic Disease | Dr. Paul Reynolds, PhD | The Metabolic Link Ep. 96
Inflammation and Glycation: The Two Heads of Chronic Disease | Dr. Paul Reynolds, PhD | The Metabolic Link Ep. 96 Jun 2, 2026 4450 Dr. Paul Reynolds has spent his career studying what he calls “two heads of the same beast”: inflammation and glycation — two interlocking processes that may help explain why so many chronic diseases are connected, even when they are treated as separate conditions.Dr. Reynolds is a professor and research scientist at Brigham Young University whose NIH-funded research program studies inflammation,
Metabolic Psychiatry in Clinical Practice: Brain Energy, Common Pitfalls, & Precision Nutrition | Dr. Bret Scher, MD | The Metabolic Link Ep. 95
Metabolic Psychiatry in Clinical Practice: Brain Energy, Common Pitfalls, & Precision Nutrition | Dr. Bret Scher, MD | The Metabolic Link Ep. 95 May 19, 2026 3119 In people with severe depression and cognitive decline, brain glucose metabolism has been shown in some studies to decline measurably. Ketone metabolism, by contrast, appears relatively preserved. That single observation is reshaping how researchers think about psychiatric illness.In this episode, Dominic D'Agostino sits down with Bret Scher, a cardiologist who pivoted to metabolic psychiatry
Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94
Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94 May 5, 2026 5207 A gene mutation that reduces ketone production in the fasted state is associated with sudden infant death in modern populations. But in the ancestral context where it evolved alongside an omega-3-rich diet, it may have been part of what kept infants alive.Dr. Gideon Mailer and Nicola Hale join The Metabolic Link to present their hypothesis that the CPT1A L479 Arctic variant is not anti-ketogenic b

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