Talking Points

The PROCTOR Trial Jun 3, 2026 00:08:35 Ruben de Winter and C. Michael Gibson compare clinical outcomes of native vessel versus SVG PCI for patients with prior CABG.

The SELUTION DeNovo Trial May 20, 2026 00:05:08 Christian M. Spaulding and C. Michael Gibson look at the 1-year results from the study comparing sirolimus-eluting DCB with DES for de novo coronary lesions.

The VESALIUS-CV Trial May 6, 2026 00:07:21 Paul Burton and C. Michael Gibson discuss the effects of adding evolocumab for patients at high risk for CV events but without prior MI or stroke.

The META-AF Trial Apr 22, 2026 00:04:42 Amrish Deshmukh talks to C. Michael Gibson about the use of metformin as an adjunctive therapy to catheter ablation of AF.

Evolution of Pharmacotherapy in STEMI Apr 1, 2026 00:08:17 How has the pharmacotherapy for STEMI changed over the past 46 years? Ginger Jiang and C. Michael Gibson discuss treating patients with zalunfiban at first medical contact.

The CorCMR Trial Mar 4, 2026 00:05:50 Colin Berry and C. Michael Gibson discuss whether stress CMR imaging is helpful in patients with angina and no obstructive CAD.

The TUXEDO-2 Trial Feb 4, 2026 00:03:56 Sripal Bangalore and C. Michael Gibson discuss whether ticagrelor is noninferior to prasugrel in patients with diabetes and multivessel CAD undergoing PCI.

The FLOW Trial Jan 7, 2026 00:05:33 C. Michael Gibson talks to Katherine Tuttle about semaglutide's positive effects in patients with diabetes and chronic kidney disease.

The 2024 ESC CCS Guidelines Dec 17, 2025 00:15:59 Mamas Mamas, Nieves Gonzalo, and Erick Schampaert take a look at the latest guidelines for chronic coronary syndromes and how they relate to complex PCI.

The My Heart Your Heart Trial Dec 10, 2025 00:06:26 Thomas Crawford meets with C. Michael Gibson to discuss the role of reconditioned pacemakers in low- and middle-income countries.

The FAVOR III Europe Trial Dec 3, 2025 00:14:19 Mamas Mamas, Birgitte Krogsgaard Andersen, and Niels Ramsing Holm discuss QFR versus FFR for guiding resvascularization in patients with coronary stenoses.

The FLOW Trial Dec 3, 2025 00:05:33 C. Michael Gibson talks to Katherine Tuttle about semaglutide's positive effects in patients with diabetes and chronic kidney disease.

STORM-PE TRIAL Nov 19, 2025 00:14:24 James Benenati, Robert Lookstein, and Rachel Rosovsky discuss the STORM-PE trial, the first-of-its-kind RCT for acute intermediate-high risk pulmonary embolism (PE).

The EARLY TAVR and TAVR UNLOAD Trials Nov 12, 2025 00:15:25 For patients with aortic stenosis, is earlier intervention beneficial? Mamas Mamas, Philippe Généreux, Nicolas Van Mieghem, and Bernard Prendergast discuss.

The EPIC-CAD Trial Oct 29, 2025 00:14:27 Mamas Mamas and Gi-byoung Nam discuss edoxaban monotherapy in patients with high-risk AF and stable CAD.

The ECLIPSE Trial Oct 1, 2025 00:07:38 Ajay Kirtane and C. Michael Gibson discuss how orbital atherectomy compares with balloon angioplasty for severely calcified coronary arteries before DES implantation.

The CLEAR SYNERGY (OASIS 9) Trial Sep 17, 2025 00:07:45 Does long-term colchicine benefit patients after acute MI? C. Michael Gibson and Sanjit Jolly discuss. 097245

The NOTION-3 Trial Sep 3, 2025 00:17:21 Mamas Mamas talks to Jacob Thomsen Lønborg about how PCI affects outcomes for patients with stable CAD undergoing TAVI.

TMVR in the Heart Failure Paradigm Aug 15, 2025 00:14:12 Transcatheter devices are new to the heart failure (HF) community and treatment armamentarium for severe MR. This discussion focuses on the impact of transcatheter devices on HF patients and current barriers faced by referring specialists.

The ABYSS Trial Aug 13, 2025 00:06:02 Johanne Silvain, Gilles Montalescot, and C. Michael Gibson discuss the effects of beta-blocker interruption in post-MI patients.

Patient Selection and Treatment Goals Aug 11, 2025 00:15:20 Patient selection is important for transcatheter interventions and impacts result success. This discussion focuses on defining what treatment goals should be, limitations of current interventions, and identifying appropriate transcatheter patients.

Women's Health Study: Biomarkers Aug 6, 2025 00:09:51 Paul Ridker and C. Michael Gibson discuss 30-year data hinting at how three modifiable factors—LDL, hs-CRP, and Lp(a)—might be leveraged to reduce long-term risk. 06f763f0-76e5-11f0-bb7c-8557ae1d8a8b

Echocardiography and Quality Data Aug 4, 2025 00:22:10 Clinical trials face challenges with variability in echo images, protocol adherence, and data quality. This discussion focuses on strategies to improve trial integrity, operational efficiency, and regulatory approval of transcatheter devices.

Insights on Intrepid 2-Yr Mitral TF EFS Jul 30, 2025 00:16:01 The Intrepid TMVR system just released 2-year transfemoral EFS outcomes at NY Valves. This discussion provides a deeper dive into what this data means for the Intrepid mitral program and perspectives on the transcatheter landscape.

New ESC Guidelines for AF Jul 23, 2025 00:20:07 Renate Schnabel, Ruben Casado Arroyo, and Mamas Mamas discuss the atrial fibrillation recommendations unveiled at ESC Congress 2024.

The STEEER-AF Trial Jul 9, 2025 00:05:57 Dipak Kotecha talks to C. Michael Gibson about whether educating healthcare providers on rhythm-control therapy affects guideline adherence and stroke outcomes.

The EPIC-CAD Trial Jul 2, 2025 00:12:08 Gi-Byoung Nam, Duk-Woo Park, and C. Michael Gibson weigh edoxaban monotherapy vs dual antithrombotic therapy for patients with AF and stable coronary artery disease.

Acute Coronary Care in Ethiopia Jun 18, 2025 00:12:08 Mamas Mamas talks to Tesfaye Telila about the landscape of acute coronary care in Ethiopa, where just a few dozen cardiologists contend with a population of 120 million people.

The POPular PAUSE TAVI Trial Jun 4, 2025 00:04:47 Should we stop anticoagulation therapy before TAVI in patients with aortic stenosis? Dirk-Jan van Ginkel and C. Michael Gibson discuss.

The SENIOR-RITA Trial May 21, 2025 00:10:10 Vijay Kunadian talks to C. Michael Gibson about using an invasive or conservative strategy for older patients with NSTEMI.

The REDUCE-AMI Trial May 7, 2025 00:12:50 Troels Yndigegn, Sripal Bangalore, and Mamas Mamas discuss whether beta-blockers still benefit patients with acute MI and preserved ejection fraction.

The EARTH-STEMI Trial Apr 16, 2025 00:06:16 Gianluca Campo and C. Michael Gibson compare complete versus culprit-only revascularization in older STEMI patients.

The SCOFF Trial Apr 9, 2025 00:07:23 David Ferreira talks to C. Michael Gibson about the latest data showing patients don't need to fast ahead of cardiac catheterization.

The RESHAPE-HF2 and MATTERHORN Trials Apr 2, 2025 00:16:50 Mamas Mamas, Stefan Anker, and Volker Rudolph talk about their studies of MitraClip for functional MR in patients with heart failure.

The EMPACT-MI Trial Mar 19, 2025 00:06:23 Javed Butler and C. Michael Gibson discuss the trial testing early empagliflozin after acute MI.

The PROACT Trial Mar 5, 2025 00:04:24 Talking with C. Michael Gibson, David Austin reviews the phase III trial of enalapril for anthracycline-induced cardiotoxicity in lymphoma and breast cancer patients.

The ORBITA-COSMIC Trial Feb 10, 2025 00:12:45 Rasha Al-Lamee and Michael Foley sit down with Mamas Mamas to discuss data on an implantable coronary sinus reducer that can ease symptoms in patients with refractory angina.

The REVIVED-BCIS2 Randomized Trial Feb 4, 2025 00:06:16 Looking at the REVIVED-BCIS2 results, Divaka Perera and C. Michael Gibson discuss the relationship between myocardial viability, PCI, and outcomes.

Ketogenic Diet and Cardiovascular Risk Jan 15, 2025 00:06:26 Iulia Iatan talks to C. Michael Gibson about how a low-carbohydrate, high-protein diet can increase plasma lipid levels and cardiovascular risk.

The CLEAR Outcomes Trial Jan 8, 2025 00:07:03 Steven Nissen and C. Michael Gibson discuss using bempedoic acid to reduce MACE in statin-intolerant patients with high cardiovascular risk.

Inflammatory Risk in Statin-Treated Patients Dec 11, 2024 00:11:58 Pooling data from the PROMINENT, REDUCE-IT, and STRENGTH trials, Paul Ridker and C. Michael Gibson discuss the residual inflammatory risks for patients treated with statins.

The BUDAPEST CRT Upgrade Trial Dec 4, 2024 00:12:49 Béla Merkely and C. Michael Gibson discuss the results of a CRT-D upgrade versus ICD alone for HFrEF patients with right ventricular pacing.

The HEART-FID Trial Nov 20, 2024 00:04:58 Robert Mentz and C. Michael Gibson discuss the latest trial to address whether iron supplementation, this time with ferric carboxymaltose, improves outcomes for patients with HF and iron deficiency.

The FIRE Study Nov 6, 2024 00:07:59 Simone Biscaglia and C. Michael Gibson discuss physiology-guided complete revascularization versus culprit-only PCI for elderly patients with acute MI.

The ECLS-SHOCK Trial Oct 23, 2024 00:10:15 Holger Thiele and C. Michael Gibson discuss the impact of VA-ECMO on patients with acute MI and advanced cardiogenic shock.

The STOPDAPT-3 Trial Oct 9, 2024 00:09:03 Masahiro Natsuaki and C. Michael Gibson discuss this latest randomized comparison of prasugrel monotherapy and DAPT with aspirin for patients undergoing PCI.

The ILUMIEN IV Trial Oct 2, 2024 00:11:56 Ziad Ali and C. Michael Gibson take a deeper dive into this comparison of OCT- and angiography-guided PCI.

OCT vs IVUS vs Angiography: A Meta-analysis Sep 11, 2024 00:08:05 Gregg Stone and C. Michael Gibson discuss an updated meta-analysis addressing intravascular imaging in DES implantation.

The ATTRibute-CM Trial Sep 4, 2024 00:06:52 Julian Gillmore and C. Michael Gibson discuss the efficacy of acoramidis for patients with transthyretin amyloid cardiomyopathy.

The ADVENT Trial Aug 14, 2024 00:10:28 Vivek Reddy and C. Michael Gibson compare pulsed field ablation versus thermal ablation for patients with paroxysmal atrial fibrillation.

The ARAMIS Trial Aug 7, 2024 00:07:48 Mathieu Kerneis and C. Michael Gibson compare outcomes of patients treated with anakinra, a new therapy for acute myocarditis, or placebo.

The NITRATE-CIN Trial Jul 31, 2024 00:09:50 Dan Jones and C. Michael Gibson discuss whether inorganic nitrate reduces contrast-induced nephropathy after angiography in ACS patients.

The DICTATE-AHF Trial Jul 10, 2024 00:09:33 Zachary Cox and C. Michael Gibson discuss whether early dapagliflozin initiation is safe and effective for patients with acute heart failure.

The RIGHT Trial Jul 3, 2024 00:08:14 Shaoping Nie, Gilles Montalescot, and C. Michael Gibson discuss prolonged anticoagulation after primary PCI for patients with MI.

Four-Year Results: The EVOLUT Low Risk Trial Jun 12, 2024 00:05:51 Michael J. Reardon and C. Michael Gibson discuss the trial's 4-year results in low-surgical-risk patients with severe aortic stenosis randomized to self-expanding TAVI or SAVR.

The AGENT IDE Trial Jun 5, 2024 00:10:29 Robert W. Yeh and C. Michael Gibson discuss the primary outcomes of this eagerly awaited trial comparing the AGENT paclitaxel-coated balloon with conventional balloon angioplasty for in-stent restenosis.

The TRISCEND II Trial May 22, 2024 00:06:50 Susheel K. Kodali and C. Michael Gibson discuss transcatheter tricuspid valve replacement in patients with severe tricuspid regurgitation.

The VIVA Trial May 15, 2024 00:05:00 Josep Rodés-Cabau and C. Michael Gibson discuss the benefits of TAVI versus SAVR in patients with severe aortic stenosis and small aortic annuli.

The SELECT Trial May 1, 2024 00:12:55 A. Michael Lincoff and C. Michael Gibson discuss the cardiovascular impact of semaglutide in patients with overweight or obesity but without diabetes.

The MINT Trial Apr 17, 2024 00:10:44 Jeffrey Carson and Serge Korjian discuss restrictive versus liberal blood transfusion in patients with MI and anemia.

The ORBITA-2 Trial Apr 3, 2024 00:21:21 Christopher Rajkumar, Rasha Al-Lamee, and C. Michael Gibson discuss this randomized trial of PCI versus a placebo procedure for stable angina.

The ARIE-HM3 Trial Mar 14, 2024 00:14:49 Mandeep Mehra and C. Michael Gibson discuss whether or not aspirin is needed for patients with left ventricular assist devices in advanced heart failure.

The AZALEA - TIMI Trial Mar 11, 2024 00:13:15 Christian T. Ruff and C. Michael Gibson discuss the primary results of a randomized trial testing the efficacy of abelacimab versus rivaroxaban for stroke prevention in atrial fibrillation.

The heart-1 Trial of VERVE-101 Feb 21, 2024 00:05:16 Andrew Bellinger, Sek Kathiresan, and C. Michael Gibson talk about the phase 1b trial of what investigators hope may be a one-time genetic fix for hyperlipidemia.

Lepodisiran Phase I Trial Feb 7, 2024 00:05:22 Steven Nissen and C. Michael Gibson discuss the efficacy and safety of lepodisiran, an extended duration short-interfering RNA meant to reduce lipoprotein (a).

CLEAR Outcomes Subanalysis Jan 24, 2024 00:10:15 Paul Ridker and C. Michael Gibson discuss whether residual inflammatory risk or residual cholesterol risk is a more effective predictor of CV events among patients treated with statins.

The AXIOMATIC - SSP Trial Jan 10, 2024 00:08:35 Mike Sharma and C. Michael Gibson discuss managing acute thromboembolic events in secondary stroke using antithrombotic treatment with factor XIa inhibition.

The EBRAVE - AF Trial Jan 3, 2024 00:09:01 Axel Bauer and C. Michael Gibson talk about whether smartphone-based screening can effectively detect atrial fibrillation in elderly, at-risk patients.

The INVICTUS Trial Dec 7, 2023 00:17:01 Ganesan Karthikeyan and C. Michael Gibson compare the efficacy of rivaroxaban versus vitamin K agonists for patients with rheumatic heart disease associated atrial fibrillation

The FRAME-AMI Trial Oct 4, 2023 00:09:07 Joo-Yong Hahn and C. Michael Gibson compare FFR with angiography-guided PCI for patients with acute myocardial infarction and multivessel disease.

MASTER DAPT: Long-Term Results Sep 13, 2023 00:05:58 Marco Valgimigli and C. Michael Gibson discuss the long-term follow-up results from MASTER DAPT, which compared the outcomes of high bleeding risk patients randomized to either abbreviated or standard antiplatelet therapy.

Episode 180: The PANTHER Trial Sep 6, 2023 00:08:19 Marco Valgimigli and C. Michael Gibson discuss the PANTHER trial, which compared P2Y12 inhibitor monotherapy with aspririn monotherapy in patients with coronary artery disease.

Radial vs. Femoral Access for PCI: Meta-Analysis Aug 24, 2023 00:09:44 Giuseppe Gargiulo and C. Michael Gibson discuss whether the choice of radial or femoral artery access impacts the risk of mortality and major bleeding for patients undergoing coronary procedures.

Episode 181: ACT Outpatient and Inpatient Trials Aug 9, 2023 00:05:39 Sanjit Jolly and C. Michael Gibson discuss if colchicine and rivaroxaban plus aspirin can slow disease progression in patients hospitalized with COVID-19.

Episode 180: The VALOR-HCM Trial Aug 2, 2023 00:09:35 Milind Desai and C. Michael Gibson compare the results of mavacamten for severe obstructive hypertropic cardiomyopathy with the typical treatments of surgical septal myectomy or alcohol ablation.

Episode 179: The SODIUM-HF Study Jul 12, 2023 00:10:57 Justin Ezekowitz and C. Michael Gibson look at a sodium-reducing dietary intervention and its effects on patients with HF.

Episode 178: The COMPLETE Trial Jul 5, 2023 00:07:44 Shamir Mehta and C. Michael Gibson discuss how complete revascularization affects angina-related quality of life in patients with STEMI.

Episode 177: The EDIT-CMD Trial Jun 14, 2023 00:10:45 Tijn Jansen, Suzette Elias-Smale, and C. Michael Gibson discuss whether diltiazem improves coronary vasomotor dysfunction in patients with angina and nonobstructive coronary artery disease.

Episode 176: The IVVE Trial May 24, 2023 00:07:21 Mark Loeb and C. Michael Gibson discuss whether the influenza vaccine can reduce adverse vascular events among patients with HF.

Episode 175: The METEORIC-HF Trial May 17, 2023 00:08:53 Gregory Lewis and C. Michael Gibson discuss how omecamtiv mecarbil affects exercise tolerance in patients with chronic HFrEF.

Episodes

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