Talking Biotech with Dr. Kevin Folta
Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.
Episodes
New Strategies in Early ALS Detection
This episode explores the cutting-edge advancements in ALS diagnostics and treatment, highlighting how AI and digital health are transforming patient care and research. Guest Indo Navar shares her journey from Silicon Valley entrepreneurship to pioneering innovative solutions for ALS and other neurodegenerative diseases.
A new strategy in the war on obesity
In this episode, Kevin Folta interviews Dr. Erik Ingelsson about innovative RNA-based therapies for obesity, focusing on the potential of silencing RNA and gene editing to target visceral fat and improve metabolic health.
Cameron English-The Debate on Conventional vs Organic Farming
The debate continues on organic vs conventional farming. Cameron and Kevin give their views on this growing subject!
Stop Political Interference in Federal Science Grants! With Dr. Colette Delawalla
In this episode, Kevin Folta interviews Dr. Colette Delawalla about the threats to scientific integrity posed by recent political and administrative changes. They discuss the importance of federal funding, the impact of proposed policies, and how the scientific community can respond to defend science and democracy. You Can Help Change the Federal Government views!!
The Future of Agriculture -- Dr. Scott Angle
Celebrating 500 episodes of Talking Biotech, Kevin Folta interviews Dr. Scott Angle, University of Florida Senior Vice President for Agriculture and Natural Resources, to explore the future of agriculture, AI innovations, and Florida's agricultural landscape. Discover insights on technology, workforce development, and sustainable farming practices.
Biotech Mold Detection and Health - Brian Karr
In this episode of Talking Biotech, we explore cutting-edge biotech tools that are transforming how we detect and address indoor environmental health issues, particularly mold and microbes. With new, highly sensitive methods, we're moving beyond traditional inspection techniques to more precise, source-level detection—crucial for health outcomes.
Dr. Neil Stewart-Radiation Sensing Potatoes
Plants can't get up and walk away from stress or predators, so they've evolved sensitive systems to sense and in some cases anticipate changes in their environment. Now, there's sensors to light, to humidity, to touch, to gravity, to dozens of other prevailing factors that push information from the external environment into the nucleus, shaping gene expression and adapting. To that change
Milk Proteins without the Dairy - Adam Tarshis and Dr. Cory Tobin
The proteins that give cheese its unique elasticity and eating quality are challenging to create outside of the cow. However, the team at Mozza has developed a method to generate the milk proteins in soybeans, exploiting the potential massive scale of field crop production, and providing a dairy-free source of these important proteins. Today's podcast interviews Adam Tarshis and Dr. Cory
New Technology in Severe Burn Care - Dr. Katie Bush
Severe burns require specialized care and long healing times at great expense. This week's Talking Biotech podcast explores the latest advancements in burn treatment technology with Dr. Katie Bush from Aveda Medical. Discover how innovative cell therapies and regenerative techniques are transforming wound healing, reducing hospital stays, and improving cosmetic outcomes.00:00Introduction
Molecular Residue Cancer Detection - Dr. Nate Montgomery
This episode explores the latest advancements in personalized DNA and RNA technologies for early cancer detection, diagnostics, and treatment monitoring. New technologies identify molecular signatures of tumors that help predict onset and re-occurrence of disease. Dr. Nathan Montgomery from Neo Genomics Laboratories discusses how molecular residual disease testing, liquid biopsies, and ge
Strategies in Combating Chronic Kidney Disease - Dr. Salvatore Viscomi
Chronic kidney disease (CKD) is a pressing health issue that affects over a billion people worldwide, yet it often goes unnoticed until it's too late. In this post, we'll explore insights from Dr. Salvatore Viscomi, the CEO and founder of Carna Health, who sheds light on the alarming prevalence of CKD, its underlying causes, and the innovative solutions being implemented to address this g
AI and the Future of Healthcare -- Dr. Emilia Javorsky
This week's Talking Biotech Podcast examines the realistic potential of AI in cancer research and healthcare, emphasizing data quality, individualization, and system reform. Guest: Dr. Emilia Javorsky, Future of Life Institute. Future of Life InstituteAI and Cancer: A New Frontier
The First Environmental GE Organism Release - almost! Dr. Steven Lindow
This episode explores the pioneering work on ice minus bacteria and their role in frost damage prevention in plants. Dr. Steven Lindow shares insights into early biotech innovations, regulatory challenges, and the potential for modern applications of this technology.
New Frontiers in Therapeutic Peptides - Dr. Karsten Eastman
In this episode of the Talking Biotech podcast, Dr. Karsten Eastman discusses the significance of peptides in biology and their therapeutic potential. He explains the roles of peptides, particularly GLP-1 therapeutics, and the challenges associated with their stability and bioavailability. The conversation delves into nature's strategies for enhancing peptide stability and how Sathera The
Genetic Variation in Vegetative Propagation - Dr. Danelle Seymour
In this episode of the Talking Biotech podcast, Dr. Danelle Seymour discusses the genetic anomoliies observed in the vegetative propagation of tree crops, particularly citrus. The conversation delves into the importance of preserving genetic material through grafting, the challenges of genetic variation in vegetatively propagated plants, and the role of mutations in these processes. Dr. S
Conditionally Active Therapeutics - Dr. Neela Patel, Dr. Diane Hollenbaugh
In this episode of the Talking Biotech podcast, Dr. Kevin Folta speaks with Dr. Neela Patel and Dr. Diane Hollenbaugh from Bonum Therapeutics about the emerging field of conditionally active biologics. They discuss the challenges of current therapies, the innovative mechanisms behind their drug development, and the potential of immuno-oncology to revolutionize cancer treatment. The conver
A Plasmid-Based Cancer Therapy - Dr. Alexander Schneider
In this episode of the Talking Biotech podcast, host Dr. Kevin Folta engages with Dr. Alex Schneider, CEO and founder of CureLab, to discuss innovative approaches to cancer treatment, particularly focusing on the challenges posed by refractory cancers such as triple-negative breast cancer and platinum-resistant ovarian cancer. Dr. Schneider emphasizes the evolution of cancer therapies fro
Biotech in Beauty Products - Nicholas Brideau
This conversation explores the intersection of biotechnology and the beauty industry, highlighting how biotech is revolutionizing the production of cosmetic ingredients. The discussion covers the slow pace of innovation in beauty, the debate between natural and synthetic ingredients, and the role of AI in discovering new active compounds. The conversation also delves into specific example
Molecular Biology Giants that Left Us In 2025
2025 saw some of the giants in molecular biology leave us. Those that made seminal discoveries in DNA science to those that put it to work in describing the underpinnings of life left an indelible mark on history, and it is fitting that we commemorate their discoveries and contributions.
TB Throwback- Correcting the Veritasium Episode on Glyphosate
This is a throwback to episode 484, a very important correction of their episode on glyphosate. With so much controversy around this compound it is critical to keep the information correct and consistent with a 50 year body of evidence when discussing risk and benefit. Veritassium made some mistakes, so here they are corrected so that you can participate effectively in these discussions.
TB Throwback: Gliblastoma and Cindy's Gift
This episode originally aired on December 18, 2021. Cindy Graham was diagnosed with glioblastoma in her late 40s. She fought the disease, and ultimately donated her tissues to research to study the nature of glioblastoma and identify potential vulnerabilities that could underlie a cure. This episode first features Dr. Shiela Singh, glioblastoma expert who has performed analysis of Cindy'
TB Throwback: Dr. Avindra Nath and HERV-based Diseases
In today's throwback to 2022, Dr. Avindra Nath of the NIH reviews research efforts in proteins expressed from human endogenous retroviruses. It is a fascinating discussion of how genome relics may be contributing to insidious human disease.
482 Dr. Maxine Thompson, Episode 117, Jan 18, 2015
This throwback episode to 2018 is an interview with plant breeding pioneer Dr. Maxine Thompson.
A Biotech Probiotic to Enhance Fiber - Dr. Zack Abbott
In this episode of the Talking Biotech podcast, Dr. Kevin Folta and Dr. Zack Abbott discuss the critical role of dietary fiber in human health, the alarming statistics regarding fiber deficiency in the population, and the innovative solutions being developed by Zbiotics to address this issue. They delve into the science behind genetically engineered probiotics that can convert sugars into
Peer Review and Rigor in Controversial Science - Cam English, Dr. Liza Lockwood
This cross-platform podcast is shared on Science Facts and Fallacies as well as Talking Biotech. Cameron English, Dr. Liza Lockwood and Dr. Kevin Folta discuss the comments made during a rant on the Science Facts and Fallacies podcast concerning the rigor of peer review and alledged lack of self policing in academic publishing. They discuss several papers in the recent public eye, with
Everyone Else is Lying to You - Pandemic Disinformation - Dr. Jonathan Howard
In this episode of the Talking Biotech podcast, Dr. Jonathan Howard discusses his experiences during the COVID-19 pandemic, the rise of disinformation, and the anti-vaccine movement. He reflects on his role as a physician at Bellevue Hospital, the impact of misinformation on public health, and the key players who have influenced the narrative surrounding vaccines and COVID-19. Dr. Howard
Targeting RNA with Therapeutics - Dr. Matthew Disney
SummaryIn this episode of the Talking Biotech Podcast, Dr. Matthew Disney discusses the potential of RNA as a therapeutic target, exploring its historical context, pathogenic roles in diseases, and the challenges and innovations in drug design. The conversation delves into specific diseases like myotonic dystrophy, ALS, and various cancers, highlighting the advantages of small molecules i
Biotech Takes On the Screw Worm - Dr. Max Scott
In this episode of the Talking Biotech podcast, Dr. Max Scott discusses the significant threat posed by screw worms, a parasitic insect that lays eggs in live animals, leading to severe economic and health impacts on livestock. The conversation covers the historical eradication efforts using the sterile insect technique, the current resurgence of screw worms in North America, and the inno
Attacking Cancers through Neoantigens - Dr. Jackie Douglass
In this episode of the Talking Biotech podcast, Dr. Jackie Douglas discusses the emerging field of neoantigens and their significance in cancer immunotherapy. Neoantigens, which are unique to cancer cells, offer a promising target for personalized immunotherapies. The conversation covers the formation of neoantigens, the role of HLA alleles in their presentation, recent advances in resear
Drug Discovery in the Synapse - Derek Small
In this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Derek Small, co-founder and CEO of Syndeoo, focusing on the increasing prevalence of neurological disorders and the challenges in developing effective therapies. They discuss the importance of synaptic function in mental health and neurodegenerative diseases, the innovative Boost platform for drug development, and
Correcting the Veratasium Glyphosate - Monsanto Episode
Listener Request! The YouTube channel Veritasium has been recognized by scientists and the public as a great source for scientific information. So what happened in the recent episode? The episode originally entitled "Exposing the Monsanto Conspiracy" attempts to link the historic horrors of Agent Orange and contaminated herbicides with current claims against the herbicide glyphosate. To
Unintended Effects of HPV and Shingles Vaccines - Dr. Kevin Folta
Anti-vaccination activists, including the US Health and Human Services Secretary, decry the risk of vaccination. In two recently developed vaccines the emerging story is that there is risk in not being vaccinated. Analysis of large data sets shows that over the last 20 years, those vaccinated with the HPV vaccine have a lower incidence of cervical, penile and anal cancers, as they should
Revolutionizing Agriculture with RNA Technology - Dr. Andrey Zarur
In this episode of the Talking Biotech podcast, Dr. Andrey Zarur, CEO of Greenlight Biosciences, discusses the innovative applications of RNA technology in agriculture. The conversation covers the challenges of food security, the role of RNA in pest control, and the regulatory advantages of RNA-based products. Dr. Zarur highlights the efficacy and safety of RNA insecticides, fungicides, a
Glyphosate 10 Years After IARC - Dr. Robert Tarone
SummaryIn this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Dr. Robert Tarone, a retired scientist with extensive experience in cancer statistics and experimental design. They discuss the controversial IARC monograph that classified glyphosate as a probable human carcinogen, the flaws in the evaluation process, and the implications of this classification on legal act
Glyphosate: 10 Lessons from 10 Years After IARC - Dr. David Zaruk
In this episode of the Talking Biotech podcast, Kevin Folta and Dr. David Zaruk discuss the complexities surrounding glyphosate, particularly in light of the IARC Monograph 112 published a decade ago. They explore the implications of the reclassification of glyphosate as a probable carcinogen, the ensuing litigation, influence and corruption, and the ethical concerns regarding scientific
Evidence of Pig Domestication - Dr. Jiajing Wang
This conversation explores the domestication of pigs, highlighting their importance in human society, the historical evidence of their domestication, and innovative research methods used to study their relationship with humans. Dr. Jiajing Wang from Dartmouth College discusses the significance of dental calculus in elucidaing pig diets and behaviors, as well as the complex interactions be
The Shingles Vaccines and Dementia - Dr. Pascal Geldsetzer
In this episode of the Talking Biotech podcast, Dr. Kevin Folta speaks with Dr. Pascal Geldsetzer about the relationship between the shingles vaccine and dementia. They discuss the prevalence of shingles, the current vaccination rates, and the potential implications of shingles vaccination on cognitive decline. The data come from a clever analysis of public health data that revealed this
Old Tricks, New Wheat for Celiacs - Maria Rottersman
SummaryIn this episode of the Talking Biotech Podcast, Kevin Folta speaks with Maria Rodtersman, a Ph.D. candidate at UC Davis, about her research on developing wheat to reduce gluten content, specifically targeting immunogenic proteins that trigger celiac disease. They discuss the significance of wheat as a staple crop, the differences between celiac disease and gluten sensitivity, and t
A Tribute to Dr. Franklin Stahl and His Elegant Experiment
The elucidation of DNA's structure led to questions about how it was replicated. Today's Talking Biotech Podcast commemorates the landmark experiments by Dr. Franklin Stahl, who died recently at the age of 95. The experiments have beed described as amont the most elegant in the history of biology, and used a simple test to determine the physical nature of DNA replication. This is a must-k
Social Media, Traditional Media, Ag Misinformation - Connie Diekman and Dr. Cami Ryan
In this episode of the Talking Biotech Podcast, Dr. Kevin Folta discusses the challenges of misinformation in food science with Dr. Cami Ryan and registered dietitian Connie Diekman. They explore the role of social media and traditional media in spreading misinformation, the difficulties scientists face in communicating effectively, and the importance of peer review and other information-
We Are Eating the Earth - Michael Grunwald
In this episode of the Talking Biotech Podcast (464) host Dr. Kevin Folta engages with journalist and author Michael Grunwald about his book 'We Are Eating the Earth.' They discuss the complex relationship between food production, climate change, and biotechnology, emphasizing the need for multifaceted solutions rather than single silver bullet approaches. Grunwald shares insights from hi
New Solutions for Anorexia Nervosa and Obesity - Dr. Roger Cone
In this episode of the Talking Biotech podcast, Dr. Roger Cone discusses the complexities of obesity and eating disorders, emphasizing the role of brain circuits in regulating feeding behaviors. He explains the significance of GLP-1 agonists and melanocortin receptors in developing therapeutic approaches for conditions like obesity, anorexia, and cachexia. The conversation highlights the
Brainstorming to Defeat Antimicrobial Resistance - Dr. Anita Shukla
This episode of the Talking Biotech podcast features Dr. Anita Shukla discussing the critical issue of antibiotic resistance and the innovative engineering solutions being explored to combat it. The conversation covers the evolutionary nature of antimicrobial resistance (AMR), the importance of antibiotics in healthcare, and the collaborative efforts of the Engineering Research Visioning
A Grassroots Run for Ag Commissioner - Dr. Sarah Taber
In this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Dr. Sarah Taber, who shares her journey from agricultural consulting to running for Ag Secretary in North Carolina. It is mostly a story of dedication to changing the norms and changing the rules to benefit more farmers, trying to break deeply entrenched interests to create real change. The conversation explores th
Where Did The Bird Flu Go? - Dr. Kevin Folta
In this episode of the Talking Biotech podcast, Dr. Kevin Folta discusses the current state of avian influenza, particularly the H5N1 strain, its history, zoonotic potential, and the implications for both poultry and human health. Into 2025 it was being detected in wild birds,domestic flocks, cattle and humans. Where did it go? He highlights the importance of surveillance, the impact of
The Origin of Critical Maize Traits - Regina Fairbanks and Dr. Jeffrey Ross-Ibarra
This episode of the Talking Biotech podcast delves into the evolutionary significance and domestication history of corn (maize). Dr. Kevin Folta hosts a discussion with Regina Fairbanks and Dr. Jeffrey Ross-Ibarra from UC Davis, exploring the traits that enabled maize's domestication, the role of the TGA gene, and the implications for modern breeding. The conversation highlights the impor
The GE Corn Ban in Mexico - Luis Ventura
In this episode of the Talking Biotech podcast, Kevin Folta and Luis Ventura discuss the recent constitutional ban on genetically engineered corn in Mexico. They explore the implications of this regulation, the disinformation surrounding it, and the challenges faced by Mexican farmers. The conversation also touches on the broader impact of this ban on biotechnology in Latin America and th
The Mexico GMO Corn Controversy - Luis Ventura
This conversation explores the complex relationship between corn and Mexico, focusing on its cultural, economic, and agricultural significance. The discussion highlights the moratorium on genetically engineered (GM; GMO) corn, the public perception of biotechnology, and the impact of environmental NGOs on policy decisions. The conversation also delves into the perspectives of farmers rega
Synthetic Biology and Natural Products - Dr. Philipp Zerbe
This conversation explores the intersection of natural products and synthetic biology, emphasizing the importance of science communication and outreach. Julia Ball shares her passion for connecting the public with plant science, while Dr. Philip Zerbe discusses the potential of synthetic biology in producing valuable natural products, particularly terpenoids. The discussion highlights the
Designing New Proteins with A.I. - Stefan Van Grieken
In this episode of the Talking Biotech podcast, Dr. Kevin Folta speaks with Steph van Grieken, CEO of Cradle, about the revolutionary intersection of AI and protein engineering. They discuss the central role of proteins in biological systems, the innovative software Cradle is developing to enhance protein design, and the implications of these advancements for therapeutics and industrial a
Garden Biotech- The Purple Tomato, Dr. Nathan Pumplin
In this episode of the Talking Biotech podcast, Dr. Kevin Folta discusses the introduction of the Purple Tomato by Norfolk Healthy Produce. Dr. Nathan Pumplin, CEO of Norfolk Healthy Produce, shares insights on the development, consumer reception, and regulatory landscape surrounding this innovative product. The conversation highlights the importance of consumer education and the potentia
Disinformation Warfare Against Food, Farming and Medicine - Dr. Kevin Folta
Social media teems with false information about food and farming. Influencers cover Instagram and Facebook with claims that food is poison and farmers are "dousing" crops in dangerous chemicals. It is a disinformation campaign that is founded on the fact that Americans make poor food and lifestyle choices, but instead of blaming our behaviors, they blame food and medicine, pushing bogus
Mpox- The Virus, Transmission and Treatment - John Rizk
In this episode of the Talking Biotech podcast, Kevin Folta interviews John Rizk, a pharmacist and epidemiologist, about M-Pox (formerly known as monkeypox). They discuss the emergence of M-Pox, its characteristics, transmission, symptoms, and recovery. The conversation also covers risk factors, diagnosis, vaccination strategies, treatment options, and the importance of health equity in a
Anticipating Future Limiters of Biotech Applications - Joe Damond
n this episode, Dr. Kevin Folta speaks with Joe Damond about the rapidly evolving landscape of life sciences, particularly focusing on gene and cell therapies. They discuss the exciting advancements in medical technology, the economic challenges associated with developing new therapies, and the implications for healthcare systems and patient access. The conversation also touches on the ro
Apeel: A Solution to Food Waste - Jenny Du
In this episode of the Talking Biotech podcast, Kevin Folta interviews Jenny Du, co-founder and senior vice president of operations at Apeel, a company focused on reducing food waste through innovative post-harvest technology. They discuss the significant issue of food waste, particularly in fresh produce, and how Apeel's products work to extend the shelf life of fruits and vegetables by
Trees that Survive Citrus Greening - Gary England
Citrus greening disease or HLB has severely impacted Florida citrus production. And while many solutions have been proposed, there is interest in a number of trees that have shown to not show symptoms of the disease. This week's episode discusses the disease with retired extension specialist Gary England as he evaluates "survivor" trees. These trees continue to produce even when infected
The New Face of Anti-Ag Pseudoscience - Vance Crowe
In this conversation, Dr. Kevin Folta and Vance Crowe discuss the evolving landscape of agriculture communication, the rise of pseudoscience, and the cultural shifts affecting public trust in science. Vance shares his journey from working at Monsanto to founding Legacy Interviews, emphasizing the importance of capturing personal stories. They explore the challenges posed by influencers sp
Biotech Enhancement of Protein in World Staple Crops - Dr. Ling Li
Protein is essential for normal human development and physiology, yet is a significant global deficiency. World food staple crops like rice, wheat, cassava, and potato have relatively protein levels, yet constitute a significant portion of calories consumed. Dr. Ling Li of Mississippi State University has identified that overexpression of a gene called NF-YC4 can lead to higher protein ac
The GMO Tree You Never Heard About - Dr. Chris Dardick, USDA/ARS
We regularly discuss a small suite of commercial crops that have been genetically enhanced with transgenes. However, one additional genotype was transformed long ago, and approved for use in the USA, Canada and EU-- but nobody talks about it much. It is the plum resistant to plum pox virus (PPV), a devastating virus of stonefruits. While rare in the USA, it is endemic throughout the re
Anti-GMO Hawaii Memories; A Career in Ag Science - Dr. Steve Savage
In 2013 a number of county ordinances sought to end the use of biotech crops on various Hawaiian islands. Hawaii's warm year-'round climate permits several corn seasons a year, so seed corn for the mainland is produced in these locations. However, these technologies are not appreciated by a subset of the population, who see these companies as poisoning paradise. Drs. Steve Savage and Kevi
Enabling Local Production of Protein Therapeutics - Dr. Kerry Love, Sunflower Therapeutics
Great products and ideas are everywhere, yet limited by the ability to actually produce them in needed quantitites. The technologies from Sunflower Therapeutics enable bioprocess applications throughout the globe in a deployable unit with a small footprint. Dr. Kerry Love describes the technology and it's applications, along with the philosophy of a public benefit corporation that seeks t
Measuring the Health of T-Cells - Dr. Nigel McCracken, Virax Biolabs
T-cells are a critical part of the adaptive immune system, actively targeting problematic invaders. From pathogens to cancers, T-cells seek and destroy potentially dangerous cells, and maintain a memory of their presence. In today's episode Dr. Nigel McCracken describes this part of the adaptive immune system and how Virax Biolabs is using specialized tests to ascertain the presence and
Resistance to Correction, Breaking Trust in Science - Drs. Andrea Love and Nicole Keller
Disinformation clouds the public understanding of science, especially technology in agriculture and medicine. So when a leading journal publishes false information, academic experts have an obligation to help correct the process. This may be done via a variety of methods, but cordial and collegial discussion is the first step. When that fails, notes to editors and authors are in order. Wh
Your Role in Editing Wikipedia - Susan Gerbic
Wikipedia is the go-to source for many people when starting to research a subject. But is the information correct, or does the information even exist in Wikipedia at all? Susan Gerbic has been training people to edit Wikipedia pages through the Gorilla Skeptics of Wikipedia project. They have edited tens of thousands of pages with over 16 million views. Susan describes the process as wel
Gene Editing in Specialty Crops - Dr. Tom Adams, CEO Pairwise
Crop genetic engineering has focused primarily on large-acreage crops like corn. But what about the universe of specialty crops that tantalize consumers, things like blackberries or salad greens? Pairwise has used precision twists on gene editing to change specific traits in fruit and vegetable crops. Pairwise founder and CEO, Dr. Tom Adams, discusses the current progress, general philo
Special Panel - From Pre-Clinical to Clinical Trials
Advancement of a new drug from pre-clinical trials to clinical trials is a pivotal time in validation of its therapeutic effects and safety. A panel of experts discusses the process.
Talking Biotech Begins Year 10! with Dr. Liza Dunn
Today's episode marks the beginning of the 10th year of the Talking Biotech Podcast. To celebrate, Drs. Liza Dunn and Kevin Folta discuss the last decade of biotech breakthroughs and communications efforts, the fight against technology and the amazing progress in gene editing and human genetic therapies. Plus, what you can do to help the effort going forward.
Targeting Chronic Inflammation Via the Inflamasome - Dr. David Bearss
Chronic inflammation goes hand-in-hand with many diseases, complicating symptoms and affecting routes of treatment. What is the molecular basis of inflammation, and can it be targeted by new drugs? Scientists have studied the molecular basis of the inflammatory response and have identified specific proteins that complex to initiate the response. New drugs are showing promise in breaking t
Development of Biotech Partnerships
Strategic partnerships are becoming more important in development and deployment of biotechnology solutions. Today's panel discusses the way partnerships are formed, some of the important considerations with IP and licensing, and how relationships are managed.
Journal Club - Were "High Levels" of Glyphosate Found in Sperm? - Dr. Andrea Love
The news reports say that scientists have found "high levels" of herbicide in human sperm, and suggest it is a cause of infertility. But what do the data really say? Dr. Andrea Love and I discuss the paper. A report by Vasseur et al., in the June 2024 Ecotoxicology and Environmental Safety entitled Glyphosate presence in human sperm: First report and positive correlation with oxidative st
Standardizing Therapeutic Protein Production in Plants - Jim Wilson
Where many therapeutic compounds are raised in bacteria or fungi, plants sometimes offer many advantages as bioreactors. Capital and production costs are lower, and products may be edible instead of injectable. The problem tends to be standardization, and conditions that ensure that the desired proteins are produced This episode features Jim Wilson from Zea Biologics, where cleanrooms, pr
Canadian Rules for Gene Editing - Jennifer Hubert
Canada has a unique approach to plant genetic improvement that follows the product, not the process. In other words, if there is potential risk from any genetic manipulation technique, from polyploidization to transgenic to gene edits, Canadian regulators assess the relative risk in the final product. But what does the regulatory climate look like going forward as gene editing becomes mor
Overcoming CAR-T Cell Bottlenecks - Dr. Andy Scharenberg
Immunotherapy is weaponizing the body's immune system against cancer or other disease. One of the most promising approaches is CAR-T cell therapy, yet as this technology has been implemented, it's limitations have been identified. Dr. Andy Scharenberg described the current drawbacks of CAR-T cells and how his company, Umoja, is re-engineering CAR-T cells in vivo to create more effective t
The FDA Regulatory Ecosystem- Expert Panel Discusses the Process
How do new drug applications move forward to approval? Four experts discuss the partnership between the FDA, the drug developer, and the data needed to move a product forward. It is a surprising discussion that reveals the depth of the FDA process. Joined by Dr. Debra Webster, Dr. Julia Marre, Dr. Michael Matthews and Dr. Jonathan Helfgott.
The Psychology of Risk - Dr. Felicia Wu
We live in amazing times of technological advance, but how are the real benefits of new tech lost to an inflated sense of risk? Dr. Felicia Wu from Michigan State University shares her expertise in describing the psychological basis of risk and applying it to questions like glyphosate and aspartame.
Restoring the Forest with GE American Chestnut - Dr. Andy Newhouse and Erik Carlson
This is an update on the American Chestnut Restoration Project, as discussed previously on the podcast. The American Chestnut dominated the forests of Appalachia until an imported fungus destroyed the entire range. Efforts to restore the chestnut and its ecology have employed a biotechnology approach, integrating a gene from wheat that limits the mechanism the fungus uses to attack the tr
Addressing Disparities in Women's Healthcare - Sabrina Johnson, CEO Daré Bioscience
Despite being over half of the population women's health care lags behind other areas of drug development. The problem is caused by many facets, but is augmented by the fact that many of the conditions are not life threatening or are functions of aging. Sabrina Johnson, CEO of Daré Bioscience, discusses how the disparity exists, the pipeline of drugs that seek to mitigate female-specific
Return of Talking Biotech; Stories in the News
After a three month hiatus the Talking Biotech Podcast is back. Today's episode is a visit with Colarbra CEO Aoi Senju about his view for the podcast, followed by synopsis of three major news stories that broke since the last Talking Biotech Podcast. The new format includes a video component, and I'll be speaking with panels and also discussing recent news stories. It is an exciting oppor
Temporary Hiatus, Changes Coming!
After 8.5 years of weekly podcasts I'm going to take a 5 week break and plan new episodes for 2024. I'm going through a medical glitch that has me unable to do my normal work. On top of this we're going to switch to an audio plus video format to find a wider audience. So check back in 2024 for the next episode. Have a great rest of 2023, thank you for listening, and looking forward to be
A Novel RNAi Approach to Crop Protection - Todd Hauser
Even under the best conditions, crops need our assistance to survive the numerous threats that limit production. Classically, synthetic and natural compounds have been used to control insects, fungi and weeds, sometimes with negative collateral effects or fostering resistance of genetically tolerant genotypes. Todd Hauser from Trillium Ag describes his company's novel RNAi approach. RNAi
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