a16z Live
a16z Live is a podcast that features recorded live discussions and events hosted or co-hosted by partners of Andreessen Horowitz, a venture capital firm. The episodes include conversations with outside voices on topics related to technology, business, and investing. The content is for informational purposes only and does not constitute legal, business, investment, or tax advice.
Episodes
How Startups are Fixing Healthcare Friction
What if the biggest lever for improving U.S. healthcare isn’t clinical, but operational?In this episode, recorded live at New York Tech Week, a16z General Partner David Haber speaks with Trey Holterman (Tennr) and Christophe Rimann (Camber), two founders tackling the core infrastructure problems slowing healthcare down - from broken referral handoffs to denied insurance claims.They discuss buildin
What Comes After Mobile? Meta’s Andrew Bosworth on AI and Consumer Tech
For the past 20 years, consumer technology has been shaped by the same form factors: apps and touchscreens on smartphones. But advances in AI, wearables, and hardware could introduce an entirely new stack—creating a more agentic, adaptive, and immersive computing experience for users everywhere.Drawing on his early days building Facebook’s News Feed to his work today on smart glasses and AR headse
Who Will Own the Internet? a16z’s Chris Dixon on AI and Crypto
Technology doesn’t grow in isolation—it evolves in waves. Just as mobile, cloud, and social shaped the internet of the past 20 years, so too could crypto, AI, and new hardware usher in an era of the internet that’s pro-innovation, pro-startup, and pro-creator. Speaking with a16z Growth General Partner David George, a16z crypto Founder and Managing Partner Chris Dixon breaks down his vision for a n
How AI Is Changing Warfare, with Anduril CEO Brian Schimpf
Anduril reimagined how startups can build software and hardware for the defense sector. Now, they're using AI to reimagine modern warfare. Speaking with a16z Growth General Partner David George, Anduril cofounder and CEO Brian Schimpf discusses how AI helps humans make better strategic decisions by sorting through the enormous amount of data collected from modern battlefields. Brian also discusses
In The Vault: How AI is Powering Payments with Greg Ulrich
How does a company as massive as Mastercard decide where to deploy AI? Instead of centralizing every AI initiative, Mastercard operates under a “hub and spoke” model — balancing centralized AI leadership with decentralized innovation across business units.In this episode, a16z Partner Marc Andrusko chats with Mastercard’s Chief AI and Data Officer Greg Ulrich about Mastercard’s long history of usi
How Jack Henry is Modernizing Banking Infrastructure
Most financial institutions still bank on software built before the internet, but Jack Henry's CTO, Ben Metz, is leading a quiet revolution to change that. Speaking with a16z General Partner Angela Strange, Metz shares how banks’ historical tech infrastructure and regulatory obstacles have stymied innovation—and how Jack Henry is helping them overcome these challenges. Metz outlines actionable way
Building a $20B+ Open Source Business with MongoDB's Eliot Horowitz
a16z Partner Seema Amble talks with MongoDB and Viam co-founder Eliot Horowitz about building sustainable open source software tools. From challenging Oracle to building the de facto cloud-based database management tool, Horowitz outlines MongoDB’s early go-to-market strategies, approach to community building, and enterprise sales motion. This episode provides detailed tips on creating solutions f
How Zapier Became Profitable in 3 years and Scaled to $5B with Wade Foster
a16z Partner Seema Amble connects with Zapier co-founder Wade Foster about the company’s founding and GTM success utilizing a product-led growth (PLG) strategy. Chock-full of actionable insights, this episode explores Zapier’s product strategy, customer experience, and how the team built a sustainable growth engine that enabled them to reach profitability within three years. Foster also provides v
How Gusto Used Customer Input to Scale Growth with Tomer London
In this episode, a16z Partner Seema Amble chats with Tomer London, co-founder of Gusto, about establishing product-market fit and product discovery. London shares how Gusto, now valued at ~$10 billion with 300,000+ customers, identified early customers who could provide valuable feedback that helped the team optimize the self-service product experience. The conversation explores Gusto's approach t
How to Build a Thriving AI Ecosystem with Lisa Su, CEO of AMD
High-performance compute is the bedrock of generative AI, and if there’s anyone who knows about high-performance chips, it’s AMD CEO Lisa Su. In this wide-ranging conversation with a16z Operating Partner Bob Swan—himself formerly CEO of Intel—Lisa lays out her vision for the evolution of compute within the AI ecosystem, touching not only on raw power and the continuation of Moore’s Law, but also h
a16z Growth's David George on His Frameworks for Late-Stage Investing
Finding and backing companies that can reach escape velocity is the name of the game over here at a16z Growth—but picking those winners is far from easy. David George, head of the a16z Growth fund, sat down with the I/O podcast to discuss his mental models for growth-stage investing, what it really takes to go public, where AI is today and where it’s headed, and more. [00:03:19] What makes Andrees
Why Human Data is Key to AI: Alexandr Wang from Scale AI
In this conversation with a16z general partner David George, Scale AI founder and CEO Alexandr Wang discusses the three pillars of AI—models, compute, and data—and how creating abundant data is core to the evolution of gen AI. With Scale’s work across enterprise, automotive, and the public sector, Alex is also building the critical infrastructure that will allow any organization to use their propr
In the Vault: Assessing AI Impact vs. Hype with John Stecher of Blackstone
a16z general partner David Haber talks to John Stecher, Chief Technology Officer at Blackstone, where he advances cutting-edge technology, heads up innovation investing, and advises the firm’s investment teams and portfolio companies. The conversation covers how he decides whether to build tech in-house or partner with startups, what qualities he’s looking for in early stage companies, and how he
In the Vault: AI and Banking Innovation with Tim Karpoff of Citi
a16z general partner David Haber and fintech partner Marc Andrusko talk to Tim Karpoff, the Global Head of Strategy at Citi, where he guides the bank’s core focus areas, as well as future investment in emerging tech like AI. The conversation covers the shifting landscape of banking policy and regulation, the increasingly important role startups are playing in partnership with big banks, and where
Building the World’s Most Trusted Driver with Waymo's Dmitri Dolgov
Waymo co-CEO Dmitri Dolgov joined a16z general partner David George to discuss how Waymo is using genAI to help them build safer, sustainable, and more accessible transportation. In the conversation, Dmitri talks about the potential of embodied AI, the value of simulations and building training data, and his approach to leading a company focused on solving the challenges of building AI that can na
Bringing Production-Ready GenAI to the Enterprise
As genAI expands through the enterprise, many leaders are figuring out how to evolve their genAI prototypes into production-ready tools. Pinecone CEO Edo Liberty and LangChain CEO Harrison Chase discuss which parts of the stack to build or buy, how to improve out-of-the-box models by helping customers select and ingest the right data, and picking the right partners to scale genAI applications with
In the Vault: Public Market and Macro Perspectives with Mark Casey of Capital Group
In this episode, which took place at a16z's Connect Fintech event, a16z General Partner David George interviews Capital Group's Mark Casey on his investment philosophy, what sends him into what he calls "barnacle mode," his preference for customer-focused North Star metrics, and more. 0:00-1:42 Intro1:42-5:58 Approach to investing5:58-8:20 What Casey told Jeff Bezos, and what he learned8:20-12:57
In the Vault: New Applications in Fintech with Plaid’s Zach Perret and Marqeta’s Simon Khalaf
In this conversation, which took place at a16z's Connect Fintech event, a16z General Partner Angela Strange, Plaid CEO and cofounder Zach Perret, and Marqeta CEO Simon Khalaf discuss how AI will shape the future of banking, the battle between payment rails in the U. S., and how there's still opportunity to transform the basic credit card into a fully digital product. 0:00-1:42 Intro1:42-1:56 Topic
In the Vault: Placing Multiple Bets on a ‘Mosaic of Solutions’ With Former Global Payments CEO Jeff Sloan
In a new episode of In the Vault, a16z General Partner Angela Strange talks with Jeff Sloan, former CEO of Global Payments, about how he was early to spot significant industry trends, how to make bets that move an organization, and the sea change that AI represents for the financial services industry. 0-1:40 Intro1:40-8:15 Joining Global Payments8:15-19:30 Placing many bets19:30-26:10 Deal integra
In the Vault: Turning Developers Into Clients With Marco Argenti From Goldman Sachs
In a new episode of In the Vault, a16z General Partner David Haber talks with Marco Argenti, the chief information officer at Goldman Sachs, about bringing fintech processes into financial services, turning developers into clients, and how AI is a major inflection point in the history of technology.0-1:30 Intro1:30-12:05 From tech to financial services12:05-17:30 Turning developers into clients17:
In the Vault: Finding a Single Source of AI Truth With Marty Chavez From Sixth Street
In a new episode of In the Vault, a16z General Partner David Haber talks with Marty Chavez, a partner and vice chairman of Sixth Street Partners, about the foundational role he’s had in merging technology and finance throughout his career, and the magical promises and regulatory pitfalls of AI. 0-1:30 Intro1:30-12:50 Marty's history and transition to Wall Street12:50-20:50 Financial Crisis and Sec
Harnessing Ecosystem-Led Growth with Crossbeam's Bob Moore
In this SaaS era, partnering with no one means competing with everyone. How the best companies take advantage of ecosystem-led growth—or where they sit in the SaaS ecosystem to improve acquisition, expansion, and access to new markets, as discussed by a16z general partner Sarah Wang and Crossbeam CEO Bob Moore.[00:01:43] The birth of ecosystem-led growth[00:05:12] The data revolution in partnershi
AI Revolution: Bringing AI to the Masses with Quora's Adam D'Angelo
CEO of Quora Adam D’Angelo discusses how building infrastructure for creators can democratize AI, in conversation with a16z’s David George. [01:07] Social networks as compliment to AI[03:59] Poe: bringing AI to the masses[05:51] The future of AI is multi-model and multimodal[08:11] Is the model the product?[11:31] Building AI infrastructure for creators[13:41] Navigating platform shifts[16:02] Sha
Recruiting and Retaining the Right Executive Talent
Hiring the right executives at the right time is the key to scaling your company. But to many founders, the executive search and hiring process can feel like a black box. a16z talent partner Matt Oberhardt dives deep into the executive search process with Kelli Dragovich and Nolan Church on the HR Heretics podcast.[00:01:21] How a16z talent partners assess talent[00:03:42] Balancing internal and e
Building Better Communities with Flock Safety
Respecting privacy and building trust with communities is essential to effectively integrate technology into public safety. a16z general partner David Ulevitch, Flock Safety’s Garrett Langley, and Las Vegas Metropolitan Police Department Sheriff Kevin McMahill discuss how to build and implement products that communities can trust.[00:01:22] Flock Safety's impact on public safety[00:05:50] Building
My First 16: Launching a New Category with Modern Treasury's Dimitri Dadiomov
In this episode, a16z partner Seema Amble talks with Dimitri Dadiomov, the co-founder and CEO of payment operations platform Modern Treasury, about the challenges of creating a new category, hiring for marketing before you hire for sales, and why developing new features is similar to birding.0:00 - 1:20 Intro1:20 - 8:55 The founding of Modern Treasury8:55 - 15:28 First customers15:28 - 20:07 Build
My First 16: Creating a Supportive Builder Community with Plaid's Zach Perret
In this episode, a16z partner Seema Amble talks with Zach Perret, the co-founder and CEO of Plaid, about how Plaid built a community in the early days to acquire customers, how they tracked “free radicals,” and how to orient your first customers around speed. 0 - 1:09 Intro1:09 - 9:57 Plaid history9:57 - 16:39 First customers16:39 - 26:45 Pricing philosophy26:45 - 29:27 Boring as a brand29:27 - 33
My First 16: Welding Yourself to Early Customers with Marqeta's Jason Gardner
In this episode, a16z partner Seema Amble talks with the founder and current executive chairman of Marqeta Jason Gardner about what it means to be welded to your customer and how to expand in multiple verticals.0:00-1:10 Intro1:10-6:01 Marqeta's beginning6:01-9:15 First customers9:15-16:25 "Magic" product market fit16:25-24:58 Building customer relationships/Pricing24:58-32:18 Advice for founders
My First 16: Doubling Down on Founder-Led Sales with Pilot's Waseem Daher
In a new episode of My First 16, a16z partner Seema Amble talks with co-founder and CEO of Pilot Waseem Daher on how he thought about the importance of charging, how secondary signals often matter in an area like accounting, and never stepping away from doing founder-led sales. 0:00 - 1:45 Intro1:45 - 6:36 Pilot's beginning6:36 - 13:25 First customers13:25 - 18:02 Pricing18:02 - 25:29 Building a G
Sales–Product Tension, the Secret to Segment’s Success
Sales wants more features. Product gets bogged down with one-off requests. Progress and growth grinds to a halt. It's a familiar story. How Segment turned the sales-product tension into a successful $3.2B acquisition, as told by the former CRO Joe Morrissey and former chief product development officer Tido Carriero.[00:01:29] Joe's start as CRO[00:03:40] The low point: annual planning[00:07:59] Bu
My First 16: Competing in a Crowd of Incumbents with Mercury's Immad Akhund
In a new episode of My First 16, a16z partner Seema Amble talks with co-founder and CEO of Mercury Immad Akhund about the idea of a “minimum delightful product” in fintech, doing the spreadsheet math on unit economics early on, and how to compete in a category already filled with incumbents. 0:00 - 1:28 Introduction1:28 - 9:14 History of Mercury9:14 - 19:07 Mercury's first customers19:07 - 22:15 S
AI Revolution: Universally Accessible Intelligence with Character.ai's Noam Shazeer
Noam Shazeer, Character.ai CEO and cofounder, talks to a16z's Sarah Wang about the dawn of universally accessible intelligence, the compute it will take to power it, and his pursuit of AGI's first use...[0:59] Real Noam vs. AI Noam[6:14] Next unlocks[8:11] First use case for AGI[11:06] Building a full-stack LLM[13:33] Noam calculates global compute capacity[15:24] Universally accessible intelligen
AI Revolution: Food Fights in the Enterprise with Databricks' Ali Ghodsi
Ali Ghodsi, CEO and cofounder of Databricks, and Ben Horowitz, cofounder of a16z, explain the data wars happening inside and outside enterprises and how they could impact the evolution of LLMs. [0:59] Why is it so hard for enterprises to adopt AI?[3:29] Data wars[4:49] Big vs. small LLMs[8:35] Finetuning[14:14] Open source AI[18:13] Benchmarks[19:51] Why Ali isn't afraid of AIThis conversation is
AI Revolution: Digital Biology with insitro's Daphne Koller
Daphne Koller is the founder and CEO of insitro, a company using AI and machine learning to engineer drug discovery. In this conversation with a16z's Vijay Pande, she discusses how an LLM for cells could revolutionize drug discovery and how to bridge the technological and cultural divide between building with atoms and building with bits.[0:59] Why life sciences?[3:42] AI in the life sciences[7:20
AI Revolution: Democratizing Design with Figma's Dylan Field
Will AI take all the design jobs? Dylan Field, founder and CEO of Figma, looks at the relationship between designers, developers, and AI, in conversation with a16z's David George. [0:58] Will AI replace designers?[4:13] Human vs. AI creativity[8:38] Applying AI to design[11:35] Startups vs. incumbentsThis conversation is part of our AI Revolution series, recorded August 2023 at a live event in San
AI Revolution: Leveling Up with Roblox's David Baszucki
Roblox cofounder and CEO David Baszucki and a16z's Jonathan Lai discuss the ways AI is changing games and virtual worlds, as well as how we create them. [1:00] Generative AI in games[4:56] Fully personalized playthroughs[7:50] Roblox's generative model[11:28] Future of interfaces[13:25] impact on creators[16:36] NPCs as copilots[18:49] VR & spatial computingThis conversation is part of our AI Revo
AI Revolution: Where We Go From Here with OpenAI's Mira Murati
As CTO of OpenAI, Mira Murati oversaw the development and release of GPT-4 and ChatGPT. Here she tells Martin Casado the story behind the release of ChatGPT—and what it tells us about the future of AI and human-machine interactions. [0:59] Mira's background[4:55] Math, physics, and AI[7:31] Natural language interfaces[10:51] OpenAI Roadmap[17:47] Scaling Laws[20:48] One model to rule them all?[23:
AI Revolution: Improving AI with Anthropic's Dario Amodei
Cofounder and CEO of Anthropic Dario Amodei unpacks how far can scaling laws take us and how can AI be used to improve AI, in conversation with a16z's Anjney Midha. [0:59] Dario's background[2:45] GPT-2's emergent capabilities[5:16] Scaling laws[8:55] Why are there so many physicists in AI?[11:58] Constitutional AI[18:29] Anthropic's RoadmapThis conversation is part of our AI Revolution series, re
AI Revolution: Copilots and the Future of Knowledge Work with Microsoft's Kevin Scott
Microsoft CTO Kevin Scott, in conversation with a16z's Bob Swan, explains how AI copilots are keeping developers longer in a flow state and why AI copilots more broadly could be the start of an industrial revolution for knowledge work.[0:59] Microsoft's approach to AI[6:15] The next Industrial Revolution[10:47] Developer productivity & flow state[15:46] Reprogramming the American Dream[20:08] Advi
LATW 2022: Art of the Deal
a16z Cofounder and General Partner Marc Andreessen and Endeavor CEO Ari Emanuel are interviewed by a16z General Partner Sriram Krishnan at the “Time to Build: LA” event during LA Week. The trio chat about the future of content distribution, the bull case for VR over AR, the end of corporate brands, and why there is (or isn’t) ever anything good to watch on TV.
LATW 2022: Building the Future of Games
In this episode of a16z Live, David Banks, a former Riot Games executive who's now the co-founder and CEO of Elodie Games, and Timmu Tõke, the co-founder and CEO of Ready Player Me, a leading platform for cross game avatars, join a16z General Partner and games investor Jon Lai for a conversation about where they think the metaverse is going, and the future of building games
LATW 2022: Building Better Factories
In this episode of a16z Live, Chris Power, the Founder and CEO of the precision parts manufacturing company, Hadrian, talks with a16z American Dynamism Partner Oliver Hsu, about why he decided to build his factories in LA, why software engineers shouldn't be afraid of manufacturing company jobs, and how a single mom and pop machinist shop can affect the national supply chain. What follows is a sli
LATW 2022: Building Better Marketplaces
In this episode of a16z Live, Grant LaFontaine, the co-founder and CEO of the livestream shopping platform Whatnot, talks with a16z General Partner Connie Chan about building the company, his experience as the site's first person to go live, and why he prefers Los Angeles over San Francisco. What follows is a slightly edited version of that conversation.
Investing in Los Angeles
To celebrate the L.A. community and the city's growth, a16z recently hosted, "Time to Build Los Angeles," an event where we invited L.A.-based investors, founders, and operators from across a diverse range of industries to talk about company building in L.A. In the first in our series of interviews, we invited Andrew Chen from a16z, Minnie Ingersoll from TenOneTen, and Turner Novak from Banana Cap
Titan's Clayton Gardner on How the Fintech Market is Changing
In this episode of a16z Live, we are joined by Titan Invest co-founder and co-CEO Clayton Gardner; a16z General Partner Anish Acharya; and a16z growth partner, Alex Immerman. The trio starts their conversation by diving into the difference between active and passive investment management and where Titan fits into that matrix. Building upon that foundation, they discuss how the fintech market is ch
Ben Horowitz on How the Best Leaders Build Culture
Ben Horowitz discusses the leadership styles of Intel’s Andy Grove and Apple’s Bill Campbell, how Okta won its market with culture, and how to look for and hire the talent you don’t have in an interview with David Weiden, founding partner at Khosla Ventures, at the Khosla Ventures CEO Summit. Read a transcript of the conversation here. 0:40: The management legacy of Intel’s Andy Grove4:26: Why eve
The Importance of Partnerships in the Great Unbundling
The API economy and a Cambrian explosion of apps are transforming best-in-class tech from monolithic tools to a stack of 20 applications that work together. Amid this unbundling, partnerships have become a critical part of early go-to-market strategy that can lead to higher quality pipeline and accelerated sales. In this fireside chat, recorded at the 2022 Crossbeam Supernode conference, a16z Gene
Goldman Sachs' Stephanie Cohen on How the Firm's Approach to Technology Has Evolved
a16z General Partner David Haber chats with his former colleague Stephanie Cohen, Goldman Sachs' Global Co-Head of Consumer and Wealth Management, about her journey from being an investment banker to running a global division, how Goldman Sachs stays relevant to different client audiences, and how fintech entrepreneurs can think about partnering with the financial services giant.
CISA Deputy Director Nitin Natarajan on What Cybersecurity Threats Keep Him Up At Night
As the deputy director for the Cybersecurity and Infrastructure Security Agency (CISA), Nitin Natarajan spends most of his days worrying about everything from risk identification and mitigation, to educating young people and small businesses on their potential to be victims. In this fireside chat with Joel de la Garza, a16z operating partner for security, the two men discuss what keeps the CISA of
Building Towards American Dynamism with Chris Power, CEO of Hadrian
Katherine Boyle, General Partner at a16z is joined by Hadrian founder and CEO Chris Power, Packy McCormick, founder of Not Boring, and a16z co-founder Marc Andreessen to discuss the opportunity to automate and upskill in the precision parts industry and shore up U.S. manufacturing with new technology.
Ken Griffin on Unfettered Conversations with A and Z
An excerpt from a Clubhouse conversation, where Marc interviews Ken Griffin, CEO and founder of Citadel, on GameStop one year later and why the stock price hasn't crashed, as well as about his winning bid for the Constitution in the auction against ConstitutionDAO.
a16z Bio + Health #20: How useful is real world data in medicine?
What are you doing with real world data? [1:39]How valuable is real world data? [7:24]How and where do we need shared data infrastructure? [16:37]Can real world data be used for clinical decision support? [20:40]Are diagnostic companies becoming the data aggregator layer? [26:52]What will define the core competency of academic medical centers (AMCs)? [30:35] How could drug manufacturers use real w
a16z Bio + Health #19: Going B2C2B in Digital Health
Who is your "B" and who is your "C"? [2:02]Why did they choose B2C2B? [6:36]How did they craft their enterprise story? [11:42]Does going B2C2B increase CAC (customer acquisition costs)? [16:56]Three things to build an enterprise story around [22:26]How did their choice of B2C2B impact investor conversations? [34:23]What mix of consumer vs. healthcare talent did they need? [40:42] For more on the n
One on One with A and Z #12: What is the most misunderstood area of markets?
This is an excerpt from the a16z Clubhouse show One on One with A and Z, where a16z cofounders Marc Andreessen and Ben Horowitz answer questions on tech trends, company building, and more. To catch full live episodes of the show, follow the a16z Club on Clubhouse.
Good Time Show: Performance with Purpose with Indra Nooyi
Indra didn't plan her career -- and that was a good thing [2:15]The personal tradeoffs of professional success [4:24]Deciding between a job at GE and PepsiCo [7:27]Rising up the ranks of PepsiCo [12:13]Transitioning PepsiCo to healthier foods... and doing well by doing good [16:34]Management hack: writing letters to parents [19:04] "Performance with Purpose" -- what is it and why does it matter? [
One on One with A and Z #11: How much rare knowledge is there?
This is an excerpt from the a16z Clubhouse show One on One with A and Z, where a16z cofounders Marc Andreessen and Ben Horowitz answer questions on tech trends, company building, and more. To catch full live episodes of the show, follow the a16z Club on Clubhouse.
Good Time Show: What It Takes to Survive with Lyft Founder John Zimmer
The early days of Zimrides [2:08]Driving early virality [7:56]Competing with Uber [15:47]Why they took political stances [27:03]Managing through the pandemic [38:09]The future focus for Lyft -- autonomous vehicles and the end of car ownership [42:50]Follow the a16z Club to join conversations with tech founders, builders, and leaders live and in-full.
a16z Bio + Health #18: What will it take to cure diabetes?
An overview of diabetes Type 1 and Type 2 [2:58]Thinking beyond Type 1 and Type 2 [6:58]New treatment options: stem cells, continuous glucose monitoring [14:19]What's the timeline on stem cell therapies? [17:15]Therapies for controlling, rather than curing, diabetes [23:52]The current technology challenges to treating diabetes [29:52]The challenges in education and access [35:41]This is an excerpt
a16z Bio + Health #17: Proteomics and Product around a Technological Breakthrough
Founding story of Nautilus [1:43]Why was the Nautilus approach to proteomics a breakthrough? [6:12]Why a startup instead of academic research? [9:57]How to pick a good cofounder (it's not that different from choosing a spouse) [15:32]Advice for academic founders: how to work with VCs [21:14]The tipping points of scale & the challenges of finding good talent [25:17]Is proteomics really a gamechan
One on One with A and Z #10: The Impact of System Design on Culture
This is an excerpt from the a16z Clubhouse show One on One with A and Z, where a16z cofounders Marc Andreessen and Ben Horowitz answer questions on tech trends, company building, and more live . To catch full episodes of the show, follow the a16z Club on Clubhouse.
Capital Markets #1 with MSCI CEO Henry Fernandez: What goes into an index?
The MSCI origin story [1:07]How does an index get constructed? [6:51]How do you keep an index accurate? [11:42]MSCI business model... how do they get paid? [16:27]MSCI, competition, and why not an open source index? [23:14]ESG and investment objectives [27:00]ESG disclosure frameworks and the role of government in ESG [32:50]Defining ESG [34:44]MSCI, crypto, and other asset classes [42:55]Why an i
Good Time Show: Metaverse + Crypto
SPEAKERS:Aarthi Ramamurthy, international, ClubhouseDonnie Dinch, founder and CEO, BitskiGabby Dizon, cofounder, Yield Guild GamesJarrod Dicker, operating partner, TCGJesse Walden, founder, Variant FundJon Lai, principal, a16zPacky McCormick, founder, Not BoringSriram Krishnan, general partner, a16zTwobadour, founder, MetapurseJustin “3LAU” Blau, producer and musicianoriginally aired on Clubhouse
a16z Infra #6: The Cost of Cloud vs. Repatriation
This conversation centers on the arguments and findings of the a16z piece The Cost of Cloud, a Trillion Dollar Paradox. The Core Findings of The Cost of Cloud piece [5:22]Cloud is a significant part of COGS for public SaaS companies [8:38]Should you allocate engineers to reduce cloud cost or just focus on growth? [12:06]How much of a problem is not knowing cloud spend? [15:56]The tradeoff between
Good Time Show: a16z's Journey with Crypto and Crypto Investing
This podcast is an excerpt. Follow the a16z Club to join conversations with tech founders, builders, and leaders live and in-full.Early days of a16z crypto [2:38]New crypto governance capabilities [16:34]How is the VC model different when investing in crypto? [22:24]Crypto regulation and the recent attempt at holiday rulemaking [29:49]Is anyone effectively regulating crypto? [34:15]How do you star
a16z Infra #5: Category Creation with Armon Dadger (HashiCorp) and Stephen Mullaney (Aviatrix)
What makes a category? [0:37]The leading indicator? Everyone thinks you're crazy. [5:36]Can you create a category whole cloth? [7:02]How to create a category [12:05]The best category creation CEOs are product marketers [15:55]Category creation tactics: certification programs [18:54]Category creation tactics: persona-based storytelling [22:17]Is there a repeatable way to make a category? [25:35]The
People Behind the Product #3: What's Next in Retail?
SPEAKERS (in order they are heard in the episode):Shannon Kelly, a16zConnie Chan, a16zBrandon Chu, VP Product and GM of Platform, ShopifyD'Arcy Coolican, a16zNait Jones, a16zJess Lee, Cofounder and CEO, Modern CitizenImran Khan, Co-founder and CEO, VerishopThis is an excerpt from the a16z Clubhouse show People Behind the Product. To catch full episodes of the show, follow the a16z Club on Clubhou
4B with Margit #9: What Exactly Is Growth Hacking?
The origins of growth hacking [1:20]Brand building vs. growth hacking? [13:58]Where does growth fit into the organization? [31:06]The cold start problem: growth hacking from 0 to 1 [36:47]What can't be measured? [47:53]How do you test and validate new channels? [51:38] Do growth hacks always work, or at some point does it come down to product? [54:55]How do you allocate budget? [1:00:27]For the l
Future.com: The Why, The What, and The Who
Why Future with Marc Andreessen, Margit Wennmachers, and Sonal Chokshi [2:20]The New Creator Economy with Joost van Dreunen, Wes Kao, Cuy Sheffield, Chris Lyons, Lauren Murrow, and Zoran Basich [17:58]Bubbles, Speculation, and Innovation with Byrne Hobart, Jamie Catherwood, and Zoran Basich [35:38]Work Models & Measures for the Information Age with Rajiv Ayyangar, Nicole Forsgren, and Das Rush [
One on One with A and Z #9: The Big Questions around Remote Work
What was the biggest surprise from the past 15 months of remote work? [5:24]How do you handle conflict and build trust? [10:09]What's the role of offsites? [15:45]Should you adjust compensation for different geographies? [24:02]How do you measure productivity? [34:10]What is the impact of remote work on retention and turnover? [49:17]How do startups built on decentralized platforms (e.g., Ethereu
Good Time Show with Plaid CEO Zach Perret
This podcast is an excerpt. Follow the a16z Club to join conversations with tech founders, builders, and leaders live and in-full.In this episode: The abandoned M&A with Visa [3:47]Communicating to employees around the M&A [8:29]Plaid's near death experiences in the early days [12:41]The fintech trends that made Plaid possible [17:29]What is a bank now? [26:54]Fintech and new revenue models [29:20
a16z Bio + Health #16: Digital Health for Complex Care
In what ways is digital health for complex care under or overrated? [4:04]Are digital health solutions better suited to tackling clinical or non-clinical needs for complex care? [17:32]The challenge of the physician's inbox [27:55]Have we meaningfully moved the needle on complex digital care? If so, where? [32:08]Should we focus on applying basic tech to easy optimization and automation problems o
Good Time Show: DAO Primer
Decentralized autonomous organizations, or DAOs, are one of the hottest topics in crypto and tech right now. But what exactly are they? Why do they matter? And what new modes of governance, ownership, and creation do they make possible?
a16z Bio + Health #15: The mRNA Revolution with Moderna CEO Stephane Bancel
mRNA research before COVID and how "mRNA is code" [3:21]The early days of COVID: designing a vaccine in 48 hours [5:44]The software behind the vaccine: getting mRNA researchers out of Excel and into a drug design studio [9:11]The first draft of the vaccine was the final draft [11:10]How the government sped up vaccine development for COVID [12:18]What other new vaccines will come from mRNA? [15:34
Boss Talk #15: Copycats, Inventors vs. Operators. Hiring SDRs, and more
Fab 5 Freddy on New York in the 70s, Warhol, Blondie, Basquiat, and Yo! MTV Raps [1:40]Contrarian strategy and challenging assumptions [5:12]Boring AI and solving meaningful problems [8:42]Drop-in audio copycats [14:39]How is copying software different from remixing hip hop? [21:07]Do you want a CEO as an inventor or an operator? [24:12]Recruiting sales development reps [30:34]Being a boss and hav
GTM #2: Product-led Marketing
The six functions in an enterprise marketing org [2:54]Why product marketing is the killer function [6:52]How do you hire a world class product marketer? [11:16]Is community or developer evangelists its own function or part of product marketing? [17:46]How does community tie into the marketing funnel? [22:56]Is community top of funnel, an accelerant for the whole funnel, or something else entirely
Boss Talk #14: New Media Models with Substack
What did Substack think about the NYTimes article "Why We’re Freaking Out About Substack" [1:01]What is Substack? [4:40]The issues with social media content models and how Substack is different [5:54]What about the echo chamber? [8:54]Turning cultural principles (e.g., freedom of the press) into actual culture [12:00]Will Substack replace traditional media? [14:01]Would Donald Trump be welcome on
People Behind the Product #2: Collectibles Comeback
eBay to today, a brief history of collectibles and tech [1:03]Are collectibles about sentiment or investment? [5:13]How do you bring the excitement of a collection to digital goods? [13:34]Is the future of all collectibles digital? [20:20]The role of blockchain and NFTs [26:39]Are collectible marketplaces different from other marketplaces? [32:19]Importance of live video [38:28]Celebrity interest
NFT Virtual Summit (full audio)
For videos of the NFT Virtual Summit, visit a16z.com. Session 1: The Future of the Digital Ownership Economy with Dan Boneh (Stanford University) and Chris Dixon (a16z)What is an NFT? [3:01]Why are NFTs so big right now? [7:04]The most exciting programmable ownership structures [11:36]NFTs and composability: what can you do with NFTs? [15:16]How would quantum impact the immutability of the bloc
a16z Bio + Health #14: How do we safely deliver more gene therapies?
What inspired Eric and Sam to start Dyno [4:09]How does the use of ML impact Dyno's GTM [10:40]The current challenges of gene therapy [21:43]Why Dyno wants to be a horizontal platform for gene therapy [30:56]How does Dyno think about competition [44:23]After party and audience Q&A [52:01]It's Time to Heal, Mondays at 5pm PT on Clubhouse. Join the a16z bio team — Jorge Conde, Vineeta Argawala, Juli
Boss Talk #13: Book Club for Bosses
Note: the recording of this episode starts a minute or two into the show.Ali recommends: The Hard Thing about Hard Things by Ben Horowitz [0:18]Ben recommends: High Output Management by Andy Grove [4:36]Marc recommends: Who Really Matters: The Core Group Theory of Power, Privilege, and Success by Art Kleiner [10:48]Best read for enterprise sales: Power Base Selling by Jim Holden, et al [13:06]Mic
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