KDIGO Conversations in Nephrology
KDIGO Conversations in Nephrology is a podcast presented by KDIGO Communications, the outreach arm of the global organization Kidney Disease: Improving Global Outcomes. Each episode brings in international experts to discuss a broad range of topics relevant to clinicians who treat patients with kidney disease. The conversations translate current evidence and clinical guidelines into practical insights for nephrology practice. It serves as an educational resource for healthcare professionals looking to stay updated on advances in kidney care.
Episodes
Episode 33: Treating FSGS: From Steroids to Dual Endothelin Angiotensin Receptor Antagonists and What Comes Next
In the third episode of the KDIGO Conversations in Nephrology FSGS series, host Dr. Kirk Campbell (University of Pennsylvania) sits down with world-renowned glomerular disease expert Dr. Jai Radhakrishnan (Columbia University) to navigate the shifting landscape of Focal Segmental Glomerulosclerosis (FSGS) management.The conversation dives deep into the diagnostic complexities of FSGS, moving beyon
Episode 32: Proteinuria First: Managing What Matters in FSGS
In this second episode of the three-part KDIGO Conversations in Nephrology series, Dr. Kirk Campbell speaks with Dr. Laura Mariani about the central role of proteinuria reduction in the management of focal segmental glomerulosclerosis (FSGS). The discussion explores the biologic link between podocyte injury and proteinuria, the goals and findings of the PARASOL initiative, and how proteinuria may
Episode 31: The Podocyte Problem: Understanding FSGS
Join Dr. Kirk Campbell (University of Pennsylvania) and Dr. Alessia Fornoni (University of Miami) for an in-depth conversation on the evolving landscape of Focal Segmental Glomerulosclerosis (FSGS). The first episode of this three-part FSGS series explores the transition from traditional histological classifications to a more precise clinical and molecular understanding of the disease. Dr. Campbel
Episode 30: Challenges of Implementing Evidence-Based Guidance for IgA Nephropathy
This final episode in KDIGO’s four-part IgAN series focuses on the challenges and opportunities of implementing the updated KDIGO IgAN Guideline in clinical practice. The conversation examines a shifting treatment paradigm that emphasizes earlier intervention and simultaneous, multi-targeted therapy, while addressing persistent barriers to guideline adoption, including gaps in disease awareness, d
Episode 29: How I Treat IgAN: Lessons from the Case Files
This third episode in KDIGO’s four-part IgAN series explores how to apply KDIGO guidance in real-world IgAN care through two illustrative patient cases. Building on earlier episodes in the series, the discussion highlights dynamic risk assessment, treatment selection, and monitoring strategies, along with practical decisions about RAS inhibitors versus DEARAs, TRF-budesonide versus systemic glucoc
Episode 28: APOL1 Screening and Early Detection - Patient and Clinician Perspectives
In the final episode of KDIGO’s three-part Conversations in Nephrology series on APOL1 kidney disease, host Kirk Campbell, MD (University of Pennsylvania, United States), speaks with Titilayo Ilori, MD (Boston University, United States), and kidney health advocate Joshua Albright (United States) about how APOL1 genetic testing can shape the future of kidney care. Their conversation brings together
Episode 27: Management of Patients with APOL1 Kidney Disease
In this second installment of KDIGO’s three-part podcast series on APOL1 kidney disease, host Kirk Campbell, MD (University of Pennsylvania, United States), welcomes Barry Freedman, MD (Wake Forest University School of Medicine, United States) for a practical discussion on patient management. They examine how APOL1 risk variants influence progression, review current therapeutic approaches, and exp
Episode 26: Burden and Pathophysiology of APOL1 Kidney Disease
This is the first episode of a three-part KDIGO Conversations in Nephrology series on APOL1 kidney disease. Host Kirk Campbell, MD (University of Pennsylvania, United States), speaks with Bessie Young, MD (University of Washington, United States) about the discovery, burden, and biology of APOL1 kidney disease. Their discussion explores how APOL1 variants contribute to increased kidney disease ris
Episode 25: Treatment Revolution in IgA Nephropathy
This second episode in KDIGO’s four-part IgAN series addresses the treatment revolution in IgAN. Join Dana Rizk, MD (University of Alabama at Birmingham, US), and Shikha Wadhwani, MD (University of Texas Medical Branch, US) in understanding how disease pathophysiology is fueling a wave of new therapies that go beyond traditional supportive care. Key topics include what's changed since the KDIG
Episode 24: Overview of the Latest Guidance in IgA Nephropathy Management
This is the first episode in KDIGO's four-part series on the KDIGO 2025 IgAN/IgAV Guideline. Join Dana Rizk, MD (University of Alabama at Birmingham, United States), and Brad Rovin, MD (Ohio State University, United States), Co-Chair of the 2025 KDIGO IgAN Guideline, for a deep dive into the latest updates in patient care. Their conversation explores the key takeaways from the new guideline, t
Episode 23: A Patient and Caregiver Perspective
What does life with a rare kidney disease really look like?Marianne Silkjaer Nielsen (Founder of CompCure, Denmark) offers a powerful voice for patients and caregivers. She reflects on the long diagnostic journey, the challenges of managing rare kidney disease, and the need for better awareness, advocacy, and international registries to improve outcomes.This episode is part of a four-part KDIGO Co
Episode 22: Advancing Research and Novel Therapies for C3G
What does the future of treatment for C3 Glomerulopathy (C3G) look like? Dr. Nicole van de Kar (Radboud University Medical Center, The Netherlands) unpacks the pathophysiology of C3G, from genetic and autoantibody factors to the central role of the alternative pathway. She explores the limits of current C5 therapies and the potential of new strategies targeting C3 activation that could reshape pat
Episode 21: Diagnosis and Management of C3G
How do patients with C3 Glomerulopathy (C3G) present, and why is confirming the diagnosis so complex? Dr. David Kavanagh (National Renal Complement Therapeutics Centre, United Kingdom) walks through the diagnostic process, the shortcomings of traditional immunosuppression, and the promise of emerging therapies like alternative pathway inhibitors. He also tackles one of the toughest challenges: man
Episode 20: The Role of Complement in Kidney Diseases
Why does it matter if a kidney disease is complement-driven or complement-associated? Dr. Matthew Pickering (Imperial College London, United Kingdom) explains this critical distinction and why it changes how clinicians approach diagnosis and treatment. The discussion explores promising new therapies such as C3 and C5 inhibitors and how biomarkers are paving the way for precision medicine in nephro
Episode 19: Extracorporeal Blood Purification in the Context of Multiorgan Support: Current Role and Best Practices
Episode 19 is the third episode in KDIGO's three-episode series on acute kidney injury (AKI), hosted by Dr. Kathleen Liu (University of California at San Francisco, United States).
In this episode, Dr. Liu and Dr. Claudio Ronco (International Renal Research Institute of San Bortolo Hospital, Italy) discuss recent advancements and best practices surrounding Extracorporeal Blood Purification wi
Episode 18: Personalized Care for AKI – The Role of Digital Decision Support Tools and Augmented Human Intelligence to Improve Outcomes in AKI
Episode 18 is the second episode in KDIGO's three-episode series on acute kidney injury (AKI), hosted by Dr. Kathleen Liu (University of California at San Francisco, United States). In this episode, Dr. Liu is joined by Dr. Kianoush Kashani (Mayo Clinic, United States) to discuss the rising importance of personalized care in AKI treatment. They delve into the world of digital health, exploring
Episode 17: Stratifying the Risk of Persistent AKI and Clinical Practice
This is the first episode in KDIGO's new 3-episode series on acute kidney injury (AKI), hosted by Dr. Kathleen Liu (University of California at San Francisco, United States). In this episode, Dr. Liu is joined by Dr. Jay Koyner (University of Chicago, United States) to discuss the emerging field of persistent acute kidney injury (AKI).
They delve into the question: what exactly is persistent
Episode 16: Appropriate CKD Referral to Specialists
In this episode, Dr. Peter Lin (Canadian Heart Research Centre, Canada) and Ikechi Okpechi (University of Alberta, Canada) discuss the right time to refer patients with CKD to a nephrologist. This episode also addresses rapid CKD progression and the utility of risk prediction equations.
This episode is supported by an independent educational grant from AstraZeneca.
Episode 15: Applying CKD Interventions
Join host Dr. Peter Lin (Canadian Heart Research Centre, Canada) in conversation with Dr. Joel Topf (Oakland University, William Beaumont School of Medicine, USA) as they discuss how to combat CKD progression and the role of non-pharmacological vs pharmacological interventions. This episode will explore whether foundational therapies are underused and how to tailor the right treatment for the righ
Episode 14: CKD Evaluation & Measurement
In this episode, Dr. Peter Lin (Canadian Heart Research Centre, Canada) and Dr. Magdalena Madero (National Heart Institute Mexico City, Mexico) discuss best practices for CKD evaluation and measurement. This episode focuses on the importance of assessing GFR and albuminuria, identifying the causes of CKD, CKD progression, and when more accurate GFR measures (such as cystatin) should be conducted.
Episode 13: Early Detection of CKD
Join host, Dr. Peter Lin (Canadian Heart Research Centre, Canada) and Dr. Lekha Tummalapalli (Weill Cornell Medicine, United States) as they discuss the importance of early CKD detection. This episode explores risk factors, screening for CKD, and country specific factors to take into account when screening for CKD.
This episode is supported by an independent educational grant from AstraZeneca.
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Episode 12: Is There Still Any Role for Plasma Exchange in AAV?
In this episode, host Dr. Vladimir Tesar (General University Hospital, Prague) and Dr. Micheal Walsh (McMaster University, Canada) explore the benefits of plasma exchange for patients with ANCA-associated vasculitis. This episode discusses how to identify patients who may benefit from plasma exchange and the role of plasma exchange in patients with double-positive ANCA and anti-GBM. The utility of
Episode 11: Recent Progress in the Treatment of AAV and its Impact on the Outcome of the Patients
In this episode, host Dr. Vladimir Tesar (General University Hospital, Prague) and Dr. David Jayne (Addenbrooke's Hospital, United Kingdom) discuss the roles of various agents in the induction and maintenance treatment of ANCA- associated vasculitis. They will explore the use of rituximab and complement inhibition in treating ANCA-associated vasculitis. This episode will address the gaps in knowle
Episode 10: Challenges in the Early Diagnosis of AAV
Join host, Dr. Vladimir Tesar (General University Hospital, Prague), in conversation with Dr. Duvuru Geetha (Johns Hopkins University School of Medicine, United States) as they discuss the main causes of delays in diagnosis of ANCA-associated vasculitis and the different ways to increase awareness of the disease. This episode will also discuss the role of kidney biopsy in the optimal management an
Episode 9: Best Practices in Nutrition, Drug Management, and Multi-Organ Support in Patients with AKI
Join host, Dr. Marlies Ostermann (Guy's and St Thomas' Hospital, United Kingdom), in conversation with Dr. Sandra Kane-Gill (University of Pittsburgh School of Pharmacy, United States) as they discuss the importance of drug stewardship when treating critically ill patients. This episode will examine various terms such as drug-induced acute kidney injury, drug-associated acute kidney injury, and ne
Episode 8: The Role of Hemodynamics for AKI and Maintaining Hemodynamic Stability in KRT Patients
In this episode, KDIGO Conversations in Nephrology host, Dr. Marlies Ostermann (Guy's and St Thomas' Hospital, United Kingdom), and Dr. Rinaldo Bellomo (University of Melbourne, Australia) will discuss the importance of hemodynamic stabilization in protecting kidney function for patients on kidney replacement therapy. This episode will also discuss the different strategies and therapies available
Episode 7: Best Practices in Fluid Management During CKRT
Join host, Dr. Marlies Ostermann (Guy's and St Thomas' Hospital, United Kingdom), in conversation with Dr. Javier Neyra (University of Alabama in Birmingham, United States) as they explore the role of kidney replacement therapy in managing fluid overload. They will discuss optimal monitoring and how best to remove fluid safely and effectively, including the evaluation of patients’ response to flui
Episode 6: Management of Dyskalemias
Join KDIGO Conversations in Nephrology host, Dr. Roberto Pecoits-Filho, in conversation with Dr. Chuck Herzog as they explore the challenges that occur when managing dyskalemia. They address the consequences of hyperkalemia and hypokalemia. They also discuss how both hospitalized patients and outpatients are affected by hyperkalemia.
Dr. Roberto Pecoits-Filho is Senior Research Scientist at Arbor
Episode 5: Approaches to RASi Optimization
Join KDIGO Conversations in Nephrology host, Dr. Roberto Pecoits-Filho, in conversation with Dr. Patrick Rossignol as they discuss approaches to RASi optimization. Additional topics include:
Monitoring of creatinine and potassium
What happens after? Is the GP responsible for follow-up?
When to discontinue, when to return?
Lack of communication between specialties
How different specialties r
Episode 4: Benefits of RASi Utilization
Join host, Dr. Roberto Pecoits-Filho, and Dr. Catherine Clase as they discuss the benefits of RASi utilization. Additional topics include:
The role of RASi in the management of CKD progression
Outcomes
ACE / ARBs
Is RASi underutilized? Is it worth not to discontinue?
The impact of the KDIGO Blood Pressure Management in CKD Guideline and Diabetes Management in CKD Guidel
Episode 3: How to Develop an Acute Dialysis Care Quality Program - Quality Metrics and Continuous Improvement
Dr. Ravi Mehta and Theresa Mottes discuss which key components are needed when starting a quality improvement program (QI) for acute dialysis and why those components are needed. They also discuss how to get leverage to implement a QI program and the keys to a successful CRRT quality program.
This episode was supported by Baxter.
Episode 2: Maximizing Filter Life During CRRT – Best Practices on Anticoagulation and Citrate Use
Dr. Ravi Mehta and Dr. Ashita Tolwani discuss best practices on anticoagulation and citrate use, why circuit patency and integrity are important for CRRT, and how and when to use anticoagulation. They also discuss preferred methods for anticoagulation and the parameters that should be monitored for circuit integrity.
This episode was supported by Baxter.
Episode 1: Deciding When and Who Should Start Acute Dialysis - From Evidence to Bedside Practice
In this episode, Dr. Ravi Mehta and Dr. Marlies Ostermann discuss the controversy around defining the optimal timing for starting dialysis in critically ill patients. Dr. Osterman highlights the most relevant parameters that influence when to offer, start, and stop dialysis and gives a comprehensive review of the recent trials on the timing of dialysis. And finally, both presenters address the cha
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