The Optispan Podcast with Matt Kaeberlein
The Optispan Podcast with Matt Kaeberlein explores the vision of what health should be, focusing on extending the healthy, productive years of life. The show discusses the concept of the "lost decade," where typical individuals lose 10-20 years to disability and disease, and advocates for a shift from disease care to true health care. It aims to help everyone achieve their optimal healthspan through science, lifestyle, and practical insights.
Episodes
Neuroscientist Reveals What's Actually Working for Brain Longevity (with Dr. Tommy Wood)
What if you had more control over your brain's future than you think? Dr. Tommy Wood, neuroscientist, Associate Professor of Pediatrics at the University of Washington, and head of science for motorsport at Hintsa Performance, joins Dr. Matt Kaeberlein to discuss his new book, The Stimulated Mind. From the science of neuroplasticity to the real drivers of dementia prevention, this episode is p
Longevity Doctors Rank the Most Hyped Supplements (AMA with Dr. Kaeberlein and Dr. Byrne)
Dr. Matt Kaeberlein and Clinical Director Dr. Nicki Byrne tackle your most pressing supplement questions in this AMA episode, cutting through the hype to give you science-backed answers you can actually use. From CoQ10 and statins to sulforaphane influencer hype, creatine and kidney disease, and why a popular longevity doctor may be losing Matt's trust, this episode covers a lot of ground. If
New Discovery: This Test Finds Cancer Before It Even Exists (Reaction to Galleri Trial)
The Galleri multi-cancer detection test made headlines when its landmark NHS trial failed to meet its primary endpoint, sending Grail's stock down nearly 50%. But does that mean Galleri is useless? Not exactly. In this episode, Dr. Matt Kaeberlein breaks down what the NHS Galleri trial actually measured, why missing a primary endpoint doesn't tell the whole story, and what the results mean for thr
The Best Women’s Health Tips on the Planet with Dr. Jennifer Pearlman
What if menopause is one of the most important longevity events in human biology, and we've been ignoring it?Dr. Matt Kaeberlein sits down with Dr. Jennifer Pearlman, founder of PearlMD and pioneer in female-centric longevity medicine, to unpack why women's health has been systemically underfunded, undertreated, and misunderstood and what a proactive approach actually looks like.From the f
THIS Helps Detect Heart Disease Before It Happens
Dr. Kim Brockenbrough: https://www.cardiavision.com/https://www.linkedin.com/in/kimberly-brockenbrough-md-1b321a123/https://www.instagram.com/kimbromd?ighsh=YjVpcDcwdHA3ejVvYour calcium score came back zero. You're in the clear, right? Not so fast.In this episode, Optispan Clinical Director Dr. Nicki Byrne sits down with Dr. Kim Brockenbrough, board-certified cardiovascular radiologist, 25-yea
RFK Jr and Joe Rogan's Peptide Claims: Longevity Expert Reacts
Links to All Articles Mentioned:https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-riskshttps://www.fda.gov/media/174456/downloadRFK Jr. just appeared on the Joe Rogan podcast and peptides were front and center. Dr. Matt Kaeberlein breaks down the conversation in real time, fact-checking claims about peptide efficacy, FDA re
Optispan Success Story: What 18 Months of Real Biomarker Data Actually Looks Like (With Carlos Pinto)
What does over 18 months of precision medicine actually look like in practice? In this episode of the Optispan Success Story Series, Dr. Matt Kaeberlein sits down with Carlos Pinto, a tech executive and early Optispan client, to trace his longitudinal health journey from metabolic warning signs to measurable, sustained transformation. Carlos shares how a decade of overlooked biomarkers, a post-pan
Why Some Doctors Are Breaking Rules To Prescribe Peptides
Peptides are everywhere in longevity and functional medicine, but what does the law actually say? In this episode, Dr. Matt Kaeberlein breaks down what a peptide is and the complex regulatory landscape governing peptides in the United States, from FDA approval frameworks to the legal gray zones surrounding compounding pharmacies and unapproved substances.Drawing on the Federal Food, Drug, and Cosm
How Fighting Gives You A Bulletproof Mind with Noah Neiman
On this episode, Dr. Matt Kaeberlein is joined by Noah Neiman, co-founder of Rumble Boxing and founder of Knuckle Therapy. From panic attacks and rock bottom to building global fitness brands, Noah and Matt explore the profound connection between physical training and mental resilience. Noah shares how structured movement became the foundation for managing ADHD, anxiety, and depression, and why th
Dr. Matt Ranks Longevity Supplements: The Winners and Total Scams
The longevity supplement industry is full of hype, marketing claims, and questionable science. In this episode, Matt breaks down 13 popular supplements through an evidence-based lens.Subscribe for more evidence-based longevity content.Timestamps:0:00 - Introduction: 13 Supplements Ranked, 1:41 - How the Tier List Works (Strong, Good, Promising, Overhyped, Avoid), 2:27 - Fucoidin, 8:04 - Fisetin, 8
Optispan Success Story: How I Got Strong Without Living at the Gym
In this episode, Matt sits down with Shannon Anderson, a 63-year-old executive recruiter who spent decades mistaking good looks for good health. Shannon's 46-year journey from eating disorders to true health is one of the most honest, inspiring conversations we've had on the podcast. Shannon grew up in the era of Jane Fonda and extreme dieting. She struggled with bulimia and anorexia for y
The New Food Pyramid (A Step In The Right Direction)
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/The new Dietary Guidelines for Americans just dropped—and we're breaking down what's actually good, what's questionable, and what the science really says. From the flipped food pyramid to the controversial alcohol recommendations, we cover it all. Plus, a full page-by-page reading of the entire 10-p
What Peter Attia Got Right About Ultimate Health (Rapidfire)
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/This is a reaction video on Peter Attia’s 60-second health take, from carnivore diets and testosterone to seed oils and fasting. Matt provides nuanced medical commentary on where he agrees, disagrees, and adds crucial context that Attia's format couldn't include. Woven throughout is the
Everything I do for Healthspan (and why I skip THESE Supplements)
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/As we close out 2025, I'm sharing a comprehensive and honest review of my personal health optimization protocol. I break down the exact lifestyle habits, supplements, and medications I use daily, and just as importantly, which popular ones I avoid and why.I detail the massiv
This Viral "Whorebath" Test Is Not What You Think It Is
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/They call it the "whorebath" test. 🛁 We call it a massive misunderstanding of science.ing biological age tests.In this episode, Dr. Matt cuts through the noise to explain what ageing clocks actually are, what they measure, and more importantly, what they DON'T. You'll learn why
Preventive Failure: How Modern Healthcare Misses Disease Early
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join Matt and Dr. Nicole (Nicki) Byrne, Clinic Director at Optispan, for a deep dive into preventative Healthspan Medicine. In this episode, they discuss why traditional reactive healthcare is failing us, what true preventative care looks like, and the comprehensive, data-driven approach used at
6 Months on TRT Changed My Body (THIS Is My Takeaway)
This is an AMA episode where Dr Matt answers the pressing questions audience had. In this episode, Matt shares candid updates on his TRT journey and physique, debates rapamycin protocols vs. extreme fasting, and separates the scary headlines from the science on microplastics and "magic" mushrooms. Plus: why he wakes up at 4:30 AM, the truth about HBOT, and a surprising update on his book
The Dangerous Truth About The Peptide Craze (I Tried It)
This podcast episode is part three of a travel series where Matt recounts his recent trips to longevity and healthspan conferences in Geneva, Chicago, and Mauritius. He shares his experiences with jet lag, workouts, and the contrasting cultures of these events, from the more "alternative medicine" feel of the Geneva summit to the more scientifically-grounded Mauritius conference. A major
New Discovery: This Molecule Could Beat Rapamycin in Longevity
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on established pathways like mTOR.In this episode
Matt's Thanksgiving Message
Happy thanksgiving from the Optispan Team!
Longevity Problem: 70% Of All Deaths Are Caused By Aging - Dr. Andrew Steele
Longevity scientist Dr. Andrew Steele sits down with Dr. Matt Kaeberlein to make the provocative case that aging should be treated as humanity's greatest challenge, even bigger than climate change. In this deep conversation, they explore why two-thirds of all deaths are caused by aging, the cutting-edge science that's already extending healthy lifespan in animals, and what it would really
Scientist Reacts: Why Megadosing Creatine Is A Waste Of Time
Creatine is being called a "cognitive super-drug" that feels like "speed without the speed." Influencers are telling you to mega-dose 20 grams a day for brain power, bone health, and more. But what does the science actually say?In this episode, we go beyond the hype and fact-check the wildest creatine claims taking over the internet. I break down the real evidence on mega-dosin
We'll Pay $101 Million If You Prove You Can Reverse Aging
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join me for a fascinating conversation with Dr. Jamie Justice, Executive Director of the $101 Million XPRIZE Healthspan. In this podcast, we discuss the world of longevity science, from the ambitious goals of this global competition to the lessons learned from the stalled TAME trial.Dr. Justice
Dr. Stanfield Mortgaged His House For $150k To Prove Longevity Drug Works
In this in-depth conversation, Dr. Brad Stanfield sits down with Dr Matt Kaeberlein to discuss his journey from a primary care physician in New Zealand to a leading voice in the evidence-based longevity space. We cover the launch and philosophy behind his YouTube channel, the challenges and exciting results of his self-funded rapamycin clinical trial, and his critical perspective on supplements, m
Don't Fall For This Scam: Matt's Deepfake PSA
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and mate
You Might Have The Heart Attack Gene. Here Are The Signs
Joel Jamison is back for another deep dive, and this episode is packed with actionable insights, personal health revelations, and answers to your burning questions. We cover everything from the legitimacy of new health tech to Joel's ongoing journey with a shocking calcium score and what he's doing about it.If you have a family history of heart disease, use wearable tech, or are just focus
The $40 Cure They Don't Want You to Know About
In this podcast, I sit down with Dr. Jon Berner to explore two of the most promising yet misunderstood therapeutic agents: Lithium and Rapamycin.We begin with a groundbreaking discussion on Lithium, moving far beyond its traditional use in psychiatry. We break down the recent landmark study in Nature that positions lithium as a potential powerhouse for combating Alzheimer's disease, delve into
Longevity Lie: Doctor Reveals Why Anti-Aging Supplements Don’t Work
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join me for an in-depth conversation with Dr. Alex and Dr. Jan from the YEARS Healthspan Clinic in Berlin. They pull back the curtain on what a truly evidence-based, scientific approach to longevity medicine looks like, moving beyond the hype and "snake oil" to focus on rigorous diagno
Blood Cleaning: Cuts Age Biomarkers 2.6 Years in 90 Days!
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Ever heard of a medical procedure that’s been called an “oil change for your blood”?In this episode, I sit down with Dr. Brad Younggren to explore Therapeutic Plasma Exchange (TPE), a cutting-edge intervention that just might help extend healthspan, reduce biological age, and even clear hidden t
Doctor Reveals: The Dark Side of the Longevity Industry
Just back from the tour of the longevity world! In this episode, we discuss my recent travels to two major conferences: the high-end Longevity Investors Conference in Gstaad, Switzerland, and the academic GJAM Conference in Jena, Germany.We unpack the stark contrasts between these two worlds, from the venues and treatment of attendees to the fundamental divides in how people perceive and practice
Why 400+ Alzheimer's Drugs Failed (Here's What Works)
Alzheimer’s is often talked about but rarely understood in full. For decades, most research has focused on amyloid plaques, but what if that’s only part of the story? In this deep-dive, Dr. Cory, from the Institute for Systems Biology explains a new way of looking at Alzheimer’s: It is not simply a plaque problem, but as a breakdown in the brain’s “debris management” system, especially how it hand
Female Biohacker: Why Women Need Different Longevity Protocols (Simple Steps)
Ever wondered how simple, consistent practices can transform your health? In this episode, Kayla Barnes shares her personal journey from growing up on a standard diet to discovering the science-backed habits that help manage toxin exposure, support heart and brain health, and reduce stress.She talks about:• How her environment affected her toxin levels and what helped bring them down• The surprisi
AI Medicine: ChatGPT Reads Blood Tests Faster Than Your Doctor
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Most people take supplements without ever checking if their body actually needs them. Is that smart… or just expensive guesswork?In this podcast, Dr. Matt Kaeberlein sits down with Ryan Ware to unpack the truth about supplements, the rise of AI in medicine, and how people are co
Is Creatine Harming Your Kidneys? The Blood Test Myth Explained.
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Many people taking creatine get alarming results on standard kidney function tests, suggesting their kidneys are failing. This video explains why the popular supplement can create a false positive, debunks the myth of kidney damage, and reveals a more accurate blood marker you s
Elite Performance: How Pro Athletes Use HRV to Train Smarter (Not Harder)
In this episode, Dr. Matt Kaeberlein sits down with Joel Jamieson to explore the science of heart rate variability and how it connects to longevity, recovery, and performance. Joel shares his journey from training elite fighters to becoming a global authority on HRV training, emphasizing that healthspan is built on consistency, balance, and resilience rather than endless high-intensity workouts. T
Magic Mushrooms: The Next Anti-Aging Drug?
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/A new scientific paper reports that psilocybin, the compound in magic mushrooms, can extend lifespan in mice. A longevity scientist breaks down the data, exploring the study's strengths and weaknesses and discussing the potential biological mechanisms that could connect psyc
A Scientific-Backed Discussion On Fighting Cognitive Decline
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Today Dr. Kevin White and Erik Nelson join us for a deep-dive conversation as they unveil a new, multi-faceted program designed to halt and even reverse cognitive decline. They break down the key diagnostics, lifestyle pillars, and advanced therapies that form the foundation of thei
Debunking 10 Longevity Myths You Still Believe | 126
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements, this episode separates scientific fact from
Inside the Offshore Clinics Developing Gene Therapy to Fight Aging | 125
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Meet the founders (Ivan Morgunov, Anna Vakhrusheva) of Unlimited Bio, a biotech company developing gene therapies in special economic zones, operating outside of traditional FDA regulation. This episode explores their model, the science behind their therapies targeting the extracell
Testosterone, Rapamycin & Diet Myths: A Scientist's AMA | 124
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/In this Ask Me Anything episode, longevity scientist Dr. Matt Kaeberlein tackles viewer questions on controversial topics like testosterone therapy and the longevity drug rapamycin. He also offers his science-based perspective on diet strategies, supplements, and body composition, s
A Geroscience Roundtable: de Grey, Kennedy & Kaeberlein on the Path to Longevity Escape Velocity | 123
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Join longevity pioneers Dr. Aubrey de Grey, Dr. Brian Kennedy, and Dr. Matt Kaeberlein for a rare, unfiltered discussion on the future of aging. They debate the timeline for longevity escape velocity, the promise of new damage-repair therapies, and offer their candid thoughts on
Longevity Conference Attendees Hospitalized After Using Peptides? | 122
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Following a breaking news story about hospitalizations at a longevity conference, scientist Dr. Matt Kaeberlein shares his firsthand experience from the event. He reveals the dangerous mix of legitimate science, unregulated therapies, and outright pseudoscience, offering critical ad
I'm Taking TESTOSTERONE: My Story, Mistakes & Insights From a Longevity Perspective | 120
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein shares his personal and candid journey with testosterone therapy, from initial symptoms and hesitation to the mistakes he made starting out. This conversation breaks down the real-world benefits, side effects, and essential lab work, offering
A Physicist's Radical Theory of Why We Age
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Physicist Jan Gruber presents a radical theory of aging, describing it as a gradual loss of resilience against random, stochastic events. This new model challenges how we think about biological clocks and could revolutionize the way we measure health and develop future longevity
Doctors Reveal Their Blueprint for Lifelong Health (4 Pillars & Key Blood Tests) | 118
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt sits down with Dr. Nicki Byrne and Dr. Kevin White to break down the four essential pillars for a long and healthy life: eat, move, sleep, and connect. They also reveal the specific blood tests that go beyond a standard checkup to help you build a personalized health st
Rapamycin Improves Autophagy? | Analyzing Longevity News | 117
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity expert Dr. Matt Kaeberlein breaks down three new scientific studies on the popular anti-aging drug rapamycin and the supplement taurine. Discover which research shows real promise for conditions like chronic fatigue and which studies are being overhyped in the longevit
Ask a Longevity Scientist: Testosterone, "Miracle" Supplements & Falling for the Hype | 116
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein tackles your burning questions on testosterone therapy, trending supplements like astaxanthin and C15, hyperbaric oxygen, and more. Get science-backed insights and learn what truly matters for starting your health and longevity journey.0:00 - Intro: Ask Matt
Scientist Fact-Checks Controversial Medical Takes: Dr. Mike React
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein reacts to controversial takes on supplements, MRIs, protein, and rapamycin from Dr. Eric Topol. This video breaks down the evidence behind popular health trends, helping you separate science from hype.0:00 - Setting the Stage: Expert Reaction1:03 - Experts Se
Gut Microbiome Expert: The HIDDEN Side Of Health You're MISSING | Dr. Sean Gibbons | 114
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Sean Gibbons, a leading microbiome expert, sits down with me to decode the complex world of your gut bacteria. Learn about good vs. bad bacteria, the impact of antibiotics and aging, and how diet and probiotics can influence your journey to better health.0:00 - Intro: What I
LiveLong Conference: Takeaways on Longevity Science & Hype | 113
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein & Dr. Kevin White share takeaways from the LiveLong Experience conference, covering Therapeutic Plasma Exchange (TPE) insights, Hormone Replacement Therapy (HRT) debates, longevity science, and navigating misinformation vs. fact.0:00 Intro: LiveLong Conferenc
This Simple Test Can Reveal Your Risk Of Heart Disease | 112
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein reviews his personal Cleerly CCTA scan results with Prime Health Associates founder Dr. Kevin White, analyzing soft vs. calcified heart plaque, assessing cardiovascular risk, and discussing the value of early detection for longevity.0:00 Intro: What is a Cleerly
The Hidden Health Toll Of Grief (and the 4 Tasks that Actually Work). | Emma Payne | 111
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Help Texts CEO Emma Payne discusses the profound impact of grief on health (physical/mental), effective coping strategies (Warden's Tasks), and how text-based support can help navigate loss and foster post-traumatic growth.0:00 Intro: Grief's Impact on Health & Biolo
Rapamycin: The Worst Longevity Idea Ever Conceived? | 110
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/Dr. Matt Kaeberlein fact-checks Dr. Chris Masterjohn's essay calling rapamycin the "Worst Longevity Idea Ever," correcting misinformation about side effects (cataracts, glucose, heart) and benefits using scientific data from mouse and human studies.0:00 Intro: Tackling the "Worst Longevity Idea
Siim Land: Biohacking Longevity, Health Span Truths & Cutting Through the Hype | 109
Subscribe to our channel: https://www.youtube.com/@optispanBiohacking expert Siim Land joins Matt Kaeberlein to discuss optimizing health span with science-based lifestyle tips (diet, exercise, sleep), key biomarkers, and navigating longevity misinformation & biological age clock hype.0:00 Introduction: Meet Siim Land2:41 Defining Longevity: Health Span vs Lifespan4:31 The Longevity Escape Vel
The Science of Aging Well: "A Practical Approach to HealthSpan Medicine" | 108
Subscribe to our channel: https://www.youtube.com/@optispanSign up for the Optispan Newsletter: https://www.optispan.life/Read or get your copy of Matt's Scientific American Article: https://www.scientificamerican.com/custom-media/healthspan/In this episode, Dr. Matt Kaeberlein reads and discusses his insightful article, "A Practical Approach to HealthSpan Medicine," featured in the Scientific Ame
Longevity Experts Discuss Their Health Advice & Approach | Dr. Marcus Ranney & Dr. Brian Kennedy | 107
Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein is joined by Dr. Marcus Ranney and Dr. Brian Kennedy, leading experts in longevity science. Recorded at the Rise for Aging Conference in Bangalore, India, they discuss India’s growing role in longevity research, the impact of AI in aging and healthcare, and unique health challenges in India, such as diet, diabetes, and
Brain Aging & Alzheimer’s Prevention: The Future of Cognitive Health Testing | Dr. Christin Glorioso | 106
Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Christin Glorioso, founder of NeuroAge Therapeutics, explore groundbreaking advancements in brain aging and Alzheimer's prevention. Learn how cutting-edge brain age testing—combining MRI, cognitive assessments, blood biomarkers, and genetics—can predict Alzheimer’s risk decades in advance. Discover the imp
Gut Health: Science-Backed Tips For Leaky Gut, IBS, & Your Microbiome | Dr. Mary Pardee | 105
Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Mary Pardee sit down to discuss insights on gut health, digestion, and common GI issues like IBS and constipation. This video covers practical approaches to improving gut function, debunking myths, and identifying effective solutions for long-term wellness, all while attempting to separate fact from fiction in
The Truth About Biological Age Tests | 104
Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein dives into the controversial world of biological age tests. Many direct-to-consumer tests claim to measure your biological age, but are they accurate or useful? Based on extensive research and clinical experience, we uncover why these tests are statistically meaningless, lack regulatory validation, and fail to provide actio
Dr. Kevin White: Concierge Medicine & Its Impacts On Living Longer & Healthier Lives | 103
Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We discuss the costs, the role of insurance, advanced di
Thomas Delauer: NEW Nutrition, Exercise, and Mindset Shifts In 2025 | 102
Subscribe to our channel: https://www.youtube.com/@optispanThomas DeLauer & I (Dr. Matt Kaeberlein) discusses his evolving perspectives on nutrition, exercise, and health optimization. Thomas shares how his views on insulin, low-carb diets, and fructose have shifted, his approach to training for strength and longevity, and the importance of sleep, emotional well-being, and recovery. Delauer al
My Biggest Health & Longevity Breakthroughs at 54 | 101
Subscribe to our channel: https://www.youtube.com/@optispanI share the top health and longevity strategies that have transformed my energy, fitness, and well-being at 54 - From hormone optimization (TRT) and resistance training to diet improvements, alcohol reduction, and preventative diagnostics.0:00 - Reflections on Turning 54 & Longevity Mindset1:42 - Hormone Optimization: The Biggest Game-
Dr. Greg Fahy: Thymus Regeneration & Boosting The Immune System For Longevity | 100
Subscribe to our channel: https://www.youtube.com/@optispanDr. Greg Fahy discusses his groundbreaking research on thymus regeneration, immune system rejuvenation, and the role of growth hormone, DHEA, and metformin in reversing aging-related immune decline. He explains the TRIM protocol, the impact of thymic involution on longevity, and the potential for improving vaccine response and overall heal
The Benefits Of Testosterone Replacement Therapy (TRT) For Men - Dr. Kevin White | 99
Subscribe to our channel: https://www.youtube.com/@optispanIs testosterone therapy right for you? In this episode, Matt Kaeberlein & Kevin White explore the benefits, risks, and misconceptions of testosterone replacement therapy (TRT). Learn about low testosterone symptoms, when to get tested, and the differences between primary and secondary hypogonadism. We also cover treatment options like
The Effects of Rapamycin on APOE4 Carriers & Brain Function | 98
Subscribe to our channel: https://www.youtube.com/@optispanIn this video we discuss current studies relating to Rapamycin use and it's effects on brain function, specifically for APOE4 carriers. This data may (or may not) provide evidence to support the claim that Rapamycin can be beneficial for those with the APOE4 variant.0:00 - Introduction1:58 - Should APOE4 Carriers Take Rapamycin? 3:30 -
Crypto-Powered Science: How Blockchain & DAOs Are Reimagining Longevity Research | 97
Subscribe to our channel: https://www.youtube.com/@optispan
In this video I sit down with the COO of Molecule AG, Benji Leibowitz, to discuss how blockchain and cryptocurrency can be applied to intellectual property (IP) in biotech research, particularly in funding longevity studies. The discussion covers concepts like DAOs (Decentralized Autonomous Organizations), tokenized intellectual property
Peter Attia: Training, Eating & Optimizing To Live Longer & Healthier In 2025 | 96
Subscribe to our channel: https://www.youtube.com/@optispan
In this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the benefits of purposeful exercise, and prioritizing d
These Supplements Help Dogs Live Longer? | 95
Subscribe to our channel: https://www.youtube.com/@optispanIn this video of Longevity this Week, Matt, Nick, and Mitchell sit down to discuss longevity supplements for pets, scientific evidence backing them, supplement industry ethics, and broader implications in the longevity field.0:00 - Introduction to Longevity Supplements for Pets0:16 - Supplement Ingredients1:30 - Evaluating Scientific Evide
Aging "Hotspot" Found in Brain? Hypochondriacs Don't Live as Long? | 94
Subscribe to our channel: https://www.youtube.com/@optispanWe explore the psychological and health implications of hypochondriasis, especially in the context of biological age testing and wearables. We then delve into how anxiety and fixation on health metrics can influence behavior and potentially exacerbate health risks. This discussion transitions to a groundbreaking study on brain aging from t
Correcting the Record on Past Videos: Biological Age Tests, Full Body MRI's & More | 93
Subscribe to our channel: https://www.youtube.com/@optispanMatt & Nick cover past episode fixes, address audience comments, and share updates about the channel and what you can expect to see from the channel moving forward into the New Year. 00:00 Intro & Setting New Years Goals 07:34 Full body MRI's11:55 DrugAge Database1:17:22 Biological Age Tests1:29:38 Matt Talking Too Much?1:32:17 Pod
LIVE AMA: Longevity Scientists Answer Your Health & Longevity Questions LIVE | 92
Subscribe to our channel: https://www.youtube.com/@optispan
In this episode, Matt and Brian Kennedy delve into the potential benefits and side effects of interventions like Rapamycin, the role of biomarkers, and optimal approaches to enhancing healthspan and cognitive function. Together they highlight the challenges of supplement use, aging research methodologies, and regulatory hurdles like the
My Review of Peter Attia’s AMA: What I Agree & Disagree With | 91
Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt shares his thoughts on Peter Attia's AMA , exploring areas of agreement and differing perspectives on health and longevity. Topics include the significance of grip strength, biomarkers for health assessment, exercise strategies while traveling, and advancements in longevity research like Klotho and GLP-1 agonists. Mat
Longevity Scientists Answer 30 MORE of Your Health & Longevity Questions | 90 PART 2
Subscribe to our channel: https://www.youtube.com/@optispanIn this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The
MEGA Q&A: We Answer 30 of Your Health & Longevity Questions | 90 PART 1
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In this Part 1 episode, Matt and Brian Kennedy cover various aspects of aging research, including the connection between the immune system and aging, the role of inflammation, the potential of supplements and wearables in healthspan, and insights on longevity interventions. They also discuss the challenges in the field regarding clinical
I Got a Full Body MRI: IS IT WORTH IT? I Share My Results | 89
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In this episode of the Optispan Podcast, Matt Kaeberlein shares his experience of undergoing a whole body MRI, discussing its potential as a screening and preventative tool for health optimization. He covers the benefits and drawbacks of whole body MRIs, shares specific details about his experience with the provider Ezra, and reflects on
Understanding Women's Hormonal Health, Hormonal Changes & How Hormone Replacement Therapy Can Help | 88
In the final installment of this three-part series, Matt and Kim Celmer explore the essential topic of hormonal health for women, highlighting its impact on both overt and silent symptoms of hormonal changes. Celmer offers practical advice for initiating meaningful conversations with healthcare providers about hormone levels with both diving into the intricacies of hormone replacement therapy (HRT
Longevity Scientist On Ethan Klein's "Revolutionary New Drug For Dogs" Discussion (H3 Podcast) | 87
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Matt Kaeberlein & Nick Arapis discuss the potential of new drugs aimed at extending the lifespan of dogs and cats. The conversation highlights recent advancements, including Loyal’s injection-based treatment targeting the IGF-1 hormone, which may add years to a dog’s life. They also address misconceptions regarding claims about cat
Epigenetic & Glycan Age Tests Results: Are Biological Age Tests Accurate? | 86
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In this episode of the Optisan Podcast, Dr. George Sutphin discusses biological age tests, focusing on epigenetic and glycan age assessments. The conversation explores the accuracy, relevance, and implications of these tests for understanding biological versus chronological age. Key topics include the limitations of current biomarkers,
Cold Plunge & Brown Fat, Different Types of Stress, and The Power of The Mind | 85
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In this episode with our guest Dr. Thomas Seager, we delve into the transformative power of cold plunge therapy and its profound effects on resilience and longevity. We explore real-life case studies, including lessons learned from infrastructure failures like Hurricane Katrina and the Oroville Dam crisis. Discover how psychological res
Bryan Johnson Stopped Taking THIS & It DOESN'T Make Sense... | 84
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