Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health
This podcast focuses on histamine intolerance, methylation, and holistic health, making complex science accessible to both practitioners and patients. Host Joanne Kennedy, a naturopath and expert in these areas, breaks down advanced topics into practical, evidence-based guidance. She shares insights from her experience as an author and coach, offering clear tips to help listeners understand and take control of their own health.
Episodes
61. SIBO Case Study: Bloating, Constipation, IBS & Histamine
Bloating, constipation, and food reactions after food poisoning—could SIBO be part of the picture?In this episode of The Histamine Well Podcast, Joanne walks through a real patient case of small intestinal bacterial overgrowth (SIBO), exploring persistent digestive symptoms, a methane-positive breath test, and suspected histamine-related reactions.The patient had experienced significant bloating,
Q&A. Why Do I Feel Depressed On Calcium-D-Glucarate?
Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration.In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause.
60. The Gut and Immune System: The Histamine Connection
Could your gut help explain why you’re reacting to foods you once tolerated?In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact.A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histami
Q&A. Why Do I Feel More Bloated on a Low FODMAP Diet?
A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one?In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead
59. Circadian Rhythm: How Your Body Clock Affects Sleep, Hormones, Gut Health & Histamine
In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and immune activity. They also discuss why histamine symptoms may feel worse at certain times of the day or night.Joanne and Melanie talk about the signals that can disrupt your body clock, from spending
Q&A. Why Do I Feel Sick from Taking N-Acetylcysteine?
NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it.In this Q&A episode, Joanne explains how reactions to NAC may be connected to sulfur intolerance, hydrogen sulfide production, gut dysbiosis, biofilm disruption and sensitivity to its mucolytic effects.You’ll also learn w
58. Biofilms: Why SIBO, Candida & Gut Infections Keep Coming Back
Why do SIBO, Candida, and other gut infections sometimes return—even after treatment initially seems successful?In this episode of The Histamine Well Podcast, Joanne explains how biofilms may contribute to persistent bacterial and fungal overgrowths. Biofilms are organised microbial communities surrounded by a protective matrix that can help microorganisms survive antimicrobial treatment and resis
Q&A. Why Do I Feel Sick From Having an Epsom Salt Bath?
Do you feel nauseous, dizzy, exhausted, or brain foggy after an Epsom salt bath? If a bath you hoped would help you relax leaves you feeling worse, you might wonder whether you’re experiencing a “detox reaction,” reacting to the heat or struggling to tolerate the Epsom salts themselves.In this short Q&A episode of The Histamine Well Podcast, Joanne explores possible reasons for feeling sick af
57. Gut Microbiome & Hydrogen Sulfide SIBO | Intestinal Sulfide Overgrowth Explained
Do eggs, garlic, onions or broccoli leave you feeling bloated, fatigued or foggy-headed?In episode 57 of The Histamine Well Podcast, Joanne explores hydrogen sulfide SIBO and intestinal sulfide overproduction (ISO), discussing how sulfur-producing gut bacteria may contribute to these symptoms.Discover:The connection between sulfur intolerance and the gut microbiome.Why hydrogen sulfide production
Q&A. What Should I Do if I'm Constipated on the Low-FODMAP Diet?
Struggling with constipation on the low-FODMAP diet? If your bloating has improved but your bowel movements have slowed down, what should you consider next?In this short Q&A episode of The Histamine Well Podcast, naturopath Joanne Kennedy shares how she approaches constipation in patients following a low-FODMAP diet. She discusses fibre intake, hydration, digestive support, and the role of the
56. Can Gut Dysbiosis Cause Anxiety & Depression? What the Science Actually Says
Can an imbalanced gut microbiome contribute to anxiety and depression?We often think of mental health conditions as beginning solely in the brain. However, growing research suggests that the gut microbiome may also influence mood through the gut–brain axis.In this episode of The Histamine Well, Joanne explores what gut dysbiosis is and how the gut communicates with the brain through the vagus nerv
55. Bile & Digestion: Ox Bile, TUDCA, Taurine & Phosphatidylcholine Explained
Could sluggish bile be affecting your digestion, gut health and histamine symptoms?In this episode of The Histamine Well Podcast, Joanne Kennedy explains the essential role bile plays in fat digestion, nutrient absorption, liver detoxification and microbial balance. She also explores how poor bile flow may contribute to SIBO, histamine intolerance and increased oxalate absorption.Joanne breaks dow
54. Stress, Cortisol & Histamine: The Hidden Loop
In this episode of The Histamine Well, Joanne explores the powerful connection between stress, cortisol, mast cell activation, and histamine intolerance. She explains how chronic stress can keep the nervous system trapped in fight-or-flight mode, trigger histamine release, and contribute to symptoms such as itching, flushing, headaches, sinus congestion, digestive issues, and skin reactions.You’ll
Are Oxalates Fueling Your Histamine Intolerance? (with Melanie Peers) [Replay]
Could oxalates be the hidden reason your histamine intolerance symptoms aren’t improving?In this popular podcast replay, Joanne is joined by Melanie Peers to explore the often-overlooked connection between oxalates, histamine intolerance, inflammation, gut health, and nervous system dysregulation.Oxalates are naturally occurring compounds found in many foods—including some commonly considered heal
How Histamine Works (and What Happens When It's Too High) [Replay]
What is histamine, and why does it cause so many frustrating symptoms? In this replay of one of our most popular episodes, Joanne explains the science of histamine intolerance in a simple, practical way. Learn how histamine affects your immune system, gut health, hormones, brain, and skin, why histamine levels become too high, and the common symptoms of histamine intolerance—including migraines, a
Histamine Intolerance: What Actually Causes It [Replay]
One of our most downloaded episodes is back.If you've been diagnosed with histamine intolerance, MCAS, or unexplained food sensitivities, this replay is one you won't want to miss.In this listener-favorite episode, Joanne Kennedy explains why histamine intolerance is not a diagnosis—it's a symptom of deeper underlying health issues. While many people rely on a low histamine diet to
53. Histamine Intolerance vs MCAS: How To Tell The Difference
Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment.In this episo
52. Clinical Experience Of Working With Women On Bioidentical Oestrogen & Progesterone
Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause.In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioident
51. Methylation Optimisation: What The Biohacking Trend Gets Wrong
Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity.But what if more methylation isn't always better?In this episode, Joanne explores the science behind methylation, t
50. Is PMDD a Histamine Problem? H1 and H2 Blockers Explained
Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)?In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing pi
49. Mould & Mitochondria: Why You're Still Exhausted (and What's Really Driving It)
Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve.In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, re
48. How Mould Mycotoxins Cause SIBO
In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction.If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea,
47. The Bile-Histamine Connection: SIBO, Estrogen, Mold & Oxalates Explained
What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation.Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile
46. High Homocysteine: Histamine, Methylation & Why You Might Not Tolerate Methylated B Vitamins
Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients.High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet
Q&A. Should I Take Calcium-D-Glucarate Whilst On HRT Oestrogen?
Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast, Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms.Many women are advised to take supplements that support estrogen detox, but is this always the right approach w
45. Case Study: SIBO, Histamine Intolerance & Hormonal Imbalance
In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms.This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including un
Q&A. How Do Epsom Salt Baths Work & Why Are They Good For Me?
Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation?In this Q&A episode of The Histamine Well Podcast, Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate)—and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities.You’ll lea
44. Sulfur Intolerace Explained: What Is It? Why Does It Happen? How Does It Increase Histamine?
Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better?In this episode of The Histamine Well Podcast, Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction.If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or fa
Q&A. Why Does My Anxiety Get Worse at Night or Wake Me Up at 3am?
Do you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts?In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-time anxiety and early morning wake-ups—and why this is often more than just a psychological issue.This episode explains the physiological root causes of anxiety at ni
43. Blood Sugar & Anxiety in Women: The Hidden Cause of Chronic Anxiety
Are you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results?In this episode of The Histamine Well Podcast, Joanne uncovers one of the most overlooked root causes of anxiety in women: blood sugar instability.Learn how blood sugar spikes and crashes can trigger cortisol and adrenaline, creating symptoms that feel exactly like anxiety disorders. Joa
Q&A. Why Do I Still Have Inflammation When My CRP & ESR Are Normal?
If your blood tests are “normal”… why do you still feel inflamed?In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can persist even when CRP and ESR markers come back normal.Many people are told everything is “fine” based on standard blood work—yet continue to experience fatigue, brain fog, s
42. Why Your Hormones Haven't Improved Despite Treatment - The Role of Inflammation, Histamine & Methylation
In this in-depth episode of The Histamine Well Podcast, Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface.Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery.If you’ve tried s
Q&A. Are Bioidentical Hormones Actually Natural?
Are bioidentical hormones truly “natural”—or is that just clever marketing?In this Q&A Clarity Session of The Histamine Well Podcast, Joanne breaks down one of the most common and misunderstood questions in women’s health: what bioidentical hormones actually are, where they come from, and how they differ from both synthetic hormones and herbal remedies.Many women exploring hormone replacement
41. Can’t Tolerate HRT? The Hidden Reason Most Women Miss
Can’t tolerate HRT? This episode explores the connection between histamine intolerance, hormone replacement therapy (HRT), SIBO, gut health, menopause symptoms, and hormone imbalance in women.Joanne Kennedy shares a clinical case study showing how histamine overload and gut dysfunction can worsen HRT side effects like brain fog, fatigue, mood swings, and skin reactions.Learn how the estrogen-hista
Q&A. How Does Sulforaphane Work in the Body? Hint: It Switches On Your Protective Genes
In this Q&A Clarity Session of The Histamine Well Podcast, naturopath Joanne Kennedy explains the science behind sulforaphane and how it activates the NRF2 pathway, often referred to as the body’s “master switch” for protection and repair.Rather than acting as a simple antioxidant, sulforaphane works at a deeper level—helping to switch on a network of protective genes responsible for detoxific
40. The GEMM Protocol: A Deeper Approach To Why Your Gut Isn't Healing - And What To Do About It
In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the gut lining and activating protective genes.Learn how sulforaphane, NRF2 activation, and targeted microbiome support can help improve gut inflammation, hist
Q&A. Should I Take Antibiotics for SIBO?
In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a common and often confusing question: Should I take antibiotics for SIBO?The truth is—it depends.In this episode, Joanne breaks down the two distinct patient scenarios she commonly sees in clinical practice. She explains when antibiotics may be a practical and supportive option, especially for those with lifestyle limit
39. Why Does Your SIBO Keep Coming Back? (And What Most Treatments Miss)
Is SIBO (Small Intestinal Bacterial Overgrowth) really the root cause of your bloating and food intolerances — or is it a downstream effect of deeper dysfunction?In this episode of The Histamine Well Podcast, Joanne explains why SIBO rarely develops in isolation and why antibiotics or herbal antimicrobials alone often fail to prevent relapse.If you’ve been stuck in the cycle of treating SIBO repea
Q&A. How Is Methylation Connected to Mental Health?
In this Q&A episode, we explore how methylation affects mental health, including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance, histamine clearance, and stress resilience — and why low folate, vitamin B12, B6, and B2 can contribute to symptoms such as anxiety, depression, brain fog, fatig
38. Helicobacter pylori, Low Stomach Acid & Histamine: The Gut Cascade Explained
In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disrup
Q&A. What Type of Magnesium Should I Take?
In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Learn when each type may help—and when to avoid certain forms if you’re sensitive. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.
37. Candida and Histamine: Why Fungal Overgrowth Keeps Coming Back
In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms.She explains how fungal-driven gut inflammation increases histamine production by activating mast cells, upregulating histidine decarboxylase (HDC), and reducing DAO enzyme activity — making it harder for the body to break
Q&A. Should I Be Taking Antihistamines Long Term?
In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn the difference between symptom suppression and true regulation of the gut, detox pathways, and nervous system. ✨ Want more? Follow on Instagram, Facebook, and YouTu
36. Less Is More: Why Over-Treating Mold & Food Intolerance Makes Things Worse
In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure.After years of misdiagnosis and treatments that failed to address the root cause, Rachel’s health continued to deteriorate — until a simpler, more balanced approach was introduced. Rachel shares
Q&A. If I have MTHFR Does it Mean I Can't Detox?
In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what actually supports healthy histamine balance, gut health, and energy. Perfect for anyone navigating MTHFR, chronic fatigue, or food sensitivities. ✨ Want mo
35. Understanding MARCoNS and Its Impact on Inflammation, Histamine, and Chronic Symptoms
In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms.Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, an
34. Vitamin B12 Explained: Forms, Methylation, Homocysteine & Absorption
In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health.Together, they unpack the complex biochemistry of Vitamin B12, exploring how it supports methylation pathways, homocysteine metabolism, and neurological function. This episode provides clarity on why Vitamin B12 deficiency is of
33. Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation
In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and inflammation.This episode breaks down the biochemistry of methylation in a clear, practical way—exploring how estrogen affects COMT, why some people react bad
32. Hormone Replacement Therapy in Perimenopause: Interview with Rachel Schaefer
Are your hormones out of balance? In this episode of The Histamine Well Podcast, Joanne sits down with Rachel Schaefer, founder of Ginkgo Integrative Medicine, to demystify perimenopause and the role of Hormone Replacement Therapy (HRT) in supporting women’s health.They explore what actually happens during hormone fluctuations in perimenopause, how to recognize estrogen dominance, and the benefits
31. How to Protect Your Home from Mold and EMF Exposure with Building Biologist Jo Lia
Is your home secretly affecting your health? In this episode of The Histamine Well Podcast, Joanne’s colleague Melanie Peers sits down with Building Biologist Jo Lia to uncover the hidden dangers of mold, electromagnetic fields (EMF), and poor indoor air quality.Jo shares her journey into building biology and explains how unseen environmental factors—like hidden mold spores or constant EMF exposur
30. Hydrogen Sulfide SIBO Explained: Symptoms, Testing & Treatments with Rosaria Nithart
In this episode of The Histamine Well Podcast, Joanne sits down with Rosaria Nithart, a French-based naturopath specializing in digestive health, to uncover the complexities of Hydrogen Sulfide SIBO—one of the most misunderstood forms of Small Intestinal Bacterial Overgrowth (SIBO).Together, they break down how Hydrogen Sulfide SIBO differs from hydrogen- and methane-dominant SIBO, exploring the
29. Healing Chronic Illness Through Nervous System Regulation with Jacqui Raadschelders
In this episode of The Histamine Well Podcast, Joanne Kennedy sits down with physiotherapist and neuro-rehabilitation specialist Jacqui Raadschelders to explore the link between nervous system dysregulation and chronic illness.You’ll learn how the limbic system, vagus nerve, neuroplasticity, and brain retraining techniques play a vital role in recovery from conditions influenced by trauma, mold ex
28. Oxalates, Adrenal Fatigue & Blood Sugar Imbalance: Tracy’s Journey to Healing
In this episode of The Histamine Well Podcast, Joanne is joined by colleague Melanie and patient Tracy, who shares her powerful story of navigating the challenges of oxalates, histamine intolerance, adrenal fatigue, and blood sugar imbalances.Tracy’s journey highlights the complex relationship between oxalates, adrenal and blood sugar imbalances, and oxalate dumping symptoms. With support from Mel
27. Why Blood Tests & Functional Medicine Tests Aren’t the Full Story: Gut, Histamines, Genes, Hormones & More!
In this episode of The Histamine Well Podcast, host Joanne Kennedy and guest Mariella Gebhardt unpack the nuances of medical testing in functional medicine—and why lab results alone don’t always tell the full story.From histamine intolerance and methylation issues to gut health, Candida, mold exposure, and hormone imbalances, Joanne and Mariela explore the limitations and benefits of testing while
26. Mold & Chronic Illness: Symptoms, Testing, and Detox Strategies with Melanie Peers
Could mold be the missing link in your chronic health puzzle?In this episode of The Histamine Well Podcast, Joanne speaks with Melanie Peers about the hidden impact of mold illness and how it can silently drive histamine intolerance, food sensitivities, and long-term inflammation.You’ll discover how mold exposure can:Raise histamine levels and trigger mast cell activationDisrupt methylation and de
25. Energy Healing Essentials for Perimenopause: A Discussion with Claire Tait
Perimenopause isn’t just a physical transition — it’s an emotional, spiritual, and energetic shift. In this empowering episode of The Histamine Well Podcast, Joanne speaks with Claire Tait, a holistic kinesiologist and intuitive energy healer, about how to navigate perimenopause with greater balance, calm, and self-awareness.Claire shares her expertise on how kinesiology, reiki, acupressure, yoga,
24. Histamine & Anxiety – How High Histamine Triggers Fight-or-Flight Symptoms
Can histamine be the hidden reason behind your anxiety?In this episode, I break down how histamine acts as a neurotransmitter in the brain — and why an overload can leave you wired, anxious, and unable to relax. We dive into how methylation, estrogen, mold, and gut inflammation (including SIBO and oxalates) all feed into the histamine-anxiety loop.Whether you're a practitioner treating patien
23. Could Your Histamine Intolerance Actually Be Sulfur Intolerance?
We break down how disrupted sulfur metabolism can mimic histamine symptoms—severe bloating, crushing fatigue, joint pain, brain fog, skin flushing—and why reactions to garlic, onions, eggs, brassicas, NAC, and glutathione are key clues.You’ll learn the roles of sulfite/sulfide vs. sulfate, SUOX + molybdenum, B12, mitochondria, hydrogen sulfide overgrowth, and environmental drivers like mold and ox
22. PMDD, Histamine Intolerance & Methylation: Anastasia’s Journey from Breakdown to Breakthrough
In this deeply personal and powerful episode, Joanne sits down with patient Anastasia Lamont to explore her journey through PMDD (Premenstrual Dysphoric Disorder), histamine intolerance, and overmethylation. Anastasia opens up about the debilitating symptoms she endured — from suicidal ideation and extreme fatigue to chronic pain and severe skin conditions — and how her life transformed through ta
21. How to Treat SIBO Naturally: Diet, Herbs, Testing & the Clinical Approach That Works
Struggling with persistent SIBO symptoms or unsure where to start with natural treatment? In this episode, I break down exactly how I treat SIBO in clinic — from diet and herbs to overlooked factors like biofilm, enzymes, histamine, and oxalates.Whether you're a health practitioner, student, or someone personally dealing with SIBO, you'll walk away with a deep understanding of the step-b
20. Acid Load, Mineral Depletion & the Hidden Link to Histamine Intolerance & Oxalates
In this episode of The Histamine Well, we're diving into one of the most overlooked root causes behind symptoms like fatigue, histamine intolerance, hormonal imbalance, oxalate sensitivity, mood swings, and chronic inflammation: acid load and mineral depletion.You'll learn:Where acidity in the body comes from — from diet and inflammation to mitochondrial dysfunction and gut dysbiosisHow
19. Clinical Insights into PMDD, Severe PMS & the Role of Methylation
In this episode of The Histamine Well, Joanne dives deep into Premenstrual Dysphoric Disorder (PMDD) and severe PMS — the kind that can leave you feeling anxious, depressed, exhausted, and unlike yourself for half the month.Joanne shares insights from her clinical practice to explore what’s really going on beneath the surface, including:Hormone imbalances like estrogen dominance and low progestero
18. Balancing Methylation: A Game-Changer for Mental Health, Perimenopause & Menopause
In this episode of The Histamine Well, host Joanne speaks with Amanda Bradshaw, co-founder of Mood Sense, to explore the critical role methylation plays in mood, mental health, and hormonal transitions like perimenopause. Joanne shares her clinical insights and surprising test results showing that some patients assumed to be under-methylators were actually over-methylating—changing the course of t
17. How Gluten Causes Immune Dysfunction, Chronic Inflammation and High Histamine
In this episode, Joanne Kennedy discusses a comprehensive case study of a patient with various symptoms like abdominal pain, migraines, and joint pain who was incorrectly suspected of having mold and oxalate problems. The root cause turned out to be gluten intolerance. Joanne explains the impact of gluten on the immune system, highlighting how it can cause significant inflammation and histamine is
16. Emotional Eating, Gut Health & Histamine: A Conversation with Amber Romaniuk
In this episode of the Histamine Well Podcast, Joanne is joined by Amber Romanic, an expert in emotional eating, digestion, and hormonal health.Amber shares her personal journey overcoming emotional eating and discusses how it impacts gut health and increases histamine levels.They explore common emotional eating triggers, the role of high cortisol, and the pitfalls of extreme diets like intermitte
15. The Connection Between High Histamine Levels and Hypoglycemia
In this episode of the Histamine Well Podcast, Joanne explores the surprising link between high histamine levels and hypoglycemia. She details how elevated histamine can disrupt blood sugar regulation through various mechanisms, including overstimulation of insulin production, suppression of glucagon, and cortisol dysregulation. Joanne also offers practical advice on managing high histamine and bl
14. Understanding SIBO and Histamine: An In-Depth Discussion with Joanne Kennedy & Melanie Peers
In this episode of the Histamine Well Podcast, Joanne is joined by her colleague Melanie Peers to discuss the relationship between small intestinal bacterial overgrowth (SIBO) and histamine intolerance. They explore the complexities of SIBO, its causes, symptoms, and its impact on histamine levels in the body. Joanne and Melanie also delve into related issues such as the role of the migrating moto
13. The Role of Digestive Enzymes in Gut Health and Histamine Balance
In this episode of the Histamine Well Podcast, host Joanne Kennedy delves into the significance of digestive enzyme deficiencies in managing histamine intolerance and chronic gut issues like SIBO. Joanne explains the critical roles of hydrochloric acid, pancreatic enzymes, and bile acids in maintaining a healthy digestive system, and how their insufficiencies can lead to increased histamine levels
12. The Connection between Methylation, Gallbladder Health & Histamine with Nutritionist Olivia Hass
In this episode of the Histamine Well podcast, Joanne dives into the connection between methylation, detoxification, and gallbladder health. Joined by nutritionist Olivia Haas, they discuss how impaired methylation affects bile flow, leading to gallbladder dysfunction and increased histamines. Olivia explains the essential role of the gallbladder in digestion, detoxification, and overall health. T
11. Practical Tips for Lowering Histamine Levels Quickly
In this episode of the Histamine Well Podcast, Joanne does something a little different. She shares her step-by-step approach for rapidly lowering your histamine bucket while working toward identifying and treating the root cause. This episode is packed with clinical gems and practical strategies—perfect for both patients and practitioners.In this episode, you’ll learn:Why a low histamine diet is
10. Practitioner's Perspective - Managing Complex Cases of SIBO, Histamine, Oxalates & Mould
In this episode of the Histamine Well Podcast, Joanne is joined by Naturopath Mariela Gebhardt from Austria to discuss a fascinating and complex case. Initially thought to be related to SIBO, Mariela shares how, despite seeing early improvement in her patient's gut health, she remained in a heightened anxious state and developed an unusual symptom: toe pain.Mariela identified this as an oxala
9. Health Implications of Low Homocysteine – A Clinical Perspective
In this episode of the Histamine Well Podcast, host Joanne delves into the often-overlooked topic of low homocysteine levels. Joanne explains that while high homocysteine is commonly flagged for its cardiovascular risks, low homocysteine is seldom discussed despite its significant implications for health. She explores how low homocysteine can indicate sulfur depletion, often linked to issues such
8. Insights Into Over & Under Methylation with Scientist James Bradshaw
In this episode of the Histamine Well, Joanne is joined by scientist James Bradshaw to discuss the complexities of methylation and its critical role in genetics, mood, and overall health. James shares his extensive background in biochemistry and cellular biology and introduces Mood Sense, the first saliva test for assessing methylation-related mood disruptions. They explore the essentials of methy
7. MTHFR, Methylation, Folic Acid & Folate Testing - A Clinical Perspective
In this episode of The Histamine Well Podcast, Joanne dives deep into the topic of MTHFR, an enzyme crucial for the process of methylation. Joanne explains the significance of methylation in various biochemical and genetic processes such as detoxification, neurotransmitter regulation, and genetic expression. The episode also addresses why methylfolate is essential, discusses common causes of methy
6. Understanding Multiple Food Intolerances: Histamine, Oxalates, Sulfur and More!
In this episode of The Histamine Well, Joanne breaks down the complexities of multiple food intolerances.She explains how SIBO and oxalates can drive up histamine, leading to oxalate, histamine, and FODMAP intolerances.Oxalates also deplete sulfur. This can cause an overgrowth of sulfur-producing bacteria in the gut, triggering sulfur intolerance. A lack of sulfur can also contribute to salicylate
5. Practitioner's Perspective- Managing SIBO and Hormonal Imbalances Without Testing: A Practical Approach
In this episode of the Histamine Well Podcast, Joanne is joined by naturopath Bridget Greenall to discuss Small Intestinal Bacterial Overgrowth (SIBO), particularly focusing on how to diagnose and treat it without testing. They explore the intertwined issues of SIBO, inflammation, and blood sugar dysregulation and their impact on hormonal health, including PMS and hot flushes. The conversation pro
4. Balancing Oestrogen & Histamine: What Every Woman Should Know
In this episode of the Histamine Well podcast, Joanne delves into the intricate relationship between histamine and oestrogen. She explores how histamine can stimulate excess oestrogen production and vice versa, leading to a range of symptoms such as migraines, dizziness, anxiety, and digestive issues. Joanne discusses the impact of factors like methylation, gut health, and enzyme functionality on
3. Are Oxalates Causing Your Histamine Intolerance and Lowering Homocysteine? | Featuring Melanie Peers
In this episode of the Histamine Well podcast, Joanne is joined by her colleague, Melanie Peers, an expert in oxalate issues. Together they explore the complex world of oxalates, their profound impact on histamine intolerance, methylation pathways, and overall health. They discuss how oxalates drive chronic inflammation, deplete sulfur levels, and disrupt both the methylation and transsulfuration
2. Main Causes of Histamine Intolerance: What's Behind The Symptoms
High histamine levels are often a signal of deeper imbalances, and in this episode of The Histamine Well, we’re uncovering the hidden root causes that could be driving your symptoms. From SIBO and gluten intolerance to leaky gut and methylation issues, we’ll explore why histamine intolerance is rarely just about food and how addressing the underlying factors can lead to real, lasting solutions. Wh
1. Understanding Histamine: How it Works and What Happens When it's Too High
In the inaugural episode of the Histamine Well Podcast, Joanne, introduces the nuanced topic of histamine intolerance. Designed for both health practitioners and patients, the episode breaks down the science behind histamine, its role in the body, the widespread issue of chronic inflammation driving up histamine levels, and the symptoms it causes such as skin issues, gastrointestinal problems, anx
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