The Curious Clinicians

131 - A President's Polio Sep 18, 2026 23:45 In this episode, Avi walks us through a medical mystery many of us may not be aware of: Did President Franklin Delano Roosevelt truly have polio, or is an alternate diagnosis more likely? Click here for show notes and click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Resident Giancarlo Buonomo and medical student Mi

[Archive] The Smell of the Rain Sep 3, 2026 33:54 In the waning days of summer, we at The Curious Clinicians were in the mood take things back to the rains of spring. This episode is a reboot from our archives of one originally posted on March 27, 2025. Hannah dove into a question inspired by nature: Why do humans have such a keen smell for petrichor, aka the scent of rain?

130 - The Simp with Roshan Sethi Aug 20, 2026 34:51 This week, Dr. Roshan Sethi joined us for a conversation about his new book, The Simp, balancing life as a director, author, and radiation oncologist, and a bit about his upcoming work. Listen for more insights about Hollywood versus medicine and maintaining roles across many areas!

129 - Ironing Out More Platelets Jul 25, 2026 29:34 In this episode, Tony walks us through the surprising physiology behind a phenomenon many of us see every day: Why does iron deficiency cause thrombocytosis? Click here for show notes and click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Resident Giancarlo Buonomo and medical student Millennium Manna are our produce

128 - After Shock with Dr. Rana Awdish Jun 26, 2026 33:17 In this episode, we talk curiosity, healing, and the wonders of the human body with Dr. Rana Awdish, bestselling author of In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope and the new book, After Shock, out now! The book prompts doctors (and everyone else) to feel curious and open to the amazing abilities the human body has to heal. We think that if you enjoy our podcas

127 - ACHOO! (The Sunlit Sneeze) Jun 20, 2026 32:14 In this episode, Avi achoo-ses an seasonal question: Why can sunlight exposure induce sneezing?? Click here for show notes and click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

126 - A Third Circulatory System May 29, 2026 22:05 What are the Hidden Pathways in the Human Body? This week, Avi fills us in on the science behind his New York Times Magazine article (link) describing the interstitium as our third circulatory system. We cover questions that he wasn't able to get to in the article and he fills us in on the story behind this (magazine) story! Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo

125 - Why Comics? May 13, 2026 36:19 This week, we talk with Dr. Grace Farris, who is a hospitalist and the author of See One, Do One, Teach One: The Art of Becoming a Doctor: A Graphic Memoir. We explore how she got into comic-drawing, her advice for people who want to explore storytelling about medicine through comics, and some of the backstory behind the book!

Why Does Umami Taste So Good? Apr 29, 2026 21:13 Today, we are rebooting an absolute classic from way back in our catalog - episode 9. Avi teaches us about the biology behind the taste of umami and why we might have evolved to find it so delicious. Show notes for the episode are a very long scroll down our website, or you can find them here: https://curiousclinicians.com/2020/09/16/episode-9-why-is-umami-so-delicious/ We'll be back in 2 weeks i

124 - One of the Fastest Reactions in the Human Body Apr 9, 2026 24:29 Why don't interstitial lung disease patients typically get increased pCO₂? The answer involves one of the fastest chemical reactions in the human body. Click here for show notes and click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical s

123 - Why-roid Mar 20, 2026 28:31 In this neck(st) episode, Avi asks an isthmus-ing question: Why does an autoimmune antibody stimulate the thyroid in Graves disease? Click here for show notes and click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium

[Archive] Irregularly Irregular Mar 5, 2026 29:35 We apologize for the break in our regularly scheduled programming! This is a reboot of Episode 77, originally posted in September 2023, which asked: why is hyperthyroidism associated with atrial fibrillation? We will return with an adjacent thyroid-related topic in 2 weeks! Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours)

[Archive] More Right Than Left Feb 26, 2026 21:50 This is a reboot of Episode 66, originally posted back in March 2023, where investigated why tricuspid valve endocarditis is more common in persons who inject IV drugs. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com.

122 - When CRP Goes Missing Feb 12, 2026 30:42 This week, Tony shares a morning report physiology pearl: Why do patients with active lupus have a low CRP? Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

Reboot! Bendopnea Jan 23, 2026 23:44 Cold and flu season greetings from the Curious Clinicians! We hope you all are cold-free, but we were unfortunately under the weather this week. In honor of our "heme boards" series from Hannah's PGY-6 year, we decided to reboot this PGY-1 "intern question" that taught us all a new word. We will be back in 2 weeks with our regularly scheduled new episodes! Show notes for this episode are here!

121 - The Forgotten Factor Jan 8, 2026 39:20 This week, Hannah shares the story of an overlooked piece of the coagulation cascade, beginning with a 1950s medical mystery: Why didn't John Hageman bleed? Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna

120 - No Sleep for the Weary Dec 12, 2025 27:47 This week, Avi shares the pathophysiology behind an important question: Why can't people with familial fatal insomnia fall asleep? Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

119 - While My Liver Gently Weeps Nov 27, 2025 26:54 This week, Tony explores a fascinating, hospital rounds-ready question: Why does cirrhosis cause low SAAG ascites? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our

118 - Extremophiles Nov 12, 2025 24:55 This week, Avi follows up Episodes 112 and 114 with the question: How does a bacterial species called Deinococcus radiodurans withstand extreme levels of radiation? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buo

117 - The Body A-Z with Dr. Mike Todorovic Oct 29, 2025 45:33 This week, Dr. Mike Todorovic returns as a special guest to tell us about his book with Dr. Matt Barton, The Body A-Z! Join us as Dr. Mike gives us a sneak preview of the interesting questions and fascinating insights within. You can order the book here, and show notes for this episode are here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), o

116 - Ammonia Rising Oct 8, 2025 29:56 This week, Tony brings us a question straight from the hospital wards: Why does valproic acid cause elevated ammonia? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are o

115 - The Art of the Question with Dr. Mark Shapiro Sep 25, 2025 46:52 This week, Dr. Mark Shapiro joins us for a candid conversation about the art of the question. Join us to think through how we interview, how to make connections, and how curiosity translates in the clinic and beyond. You can read the show notes here! Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

114 - The Mold that Eats Radiation for Breakfast Sep 10, 2025 24:10 This week, Avi follows up Episode 112 with the question: What's with the black mold growing inside Chernobyl? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our produ

Reboot! Hyperkalemia Aug 20, 2025 27:03 This week, we bring back a classic question for new interns and old hats alike: Why do we give calcium in hyperkalemia? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna ar

113 - From Vessel to Bone Aug 6, 2025 25:24 This week, Tony poses a hard question: Why does calcium deposit in blood vessels? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

112 - Wherefore Iodine? Jul 23, 2025 28:46 This week, Avi asks: Why was iodine given to people exposed to radioactivity after Chernobyl? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers. This episo

111 - Null Neutrophils Jul 2, 2025 27:07 This week, Tony asks a physiologic question: Why is Duffy Null status associated with lower neutrophil counts? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our pro

110 - Salt in the Wound Jun 11, 2025 27:21 This week, Avi shares a saline-ent question: Why does rubbing salt in a wound hurt so much? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

109 - The HITs Keep Coming May 28, 2025 28:28 This week, Tony shares another "fresh case" physiology question: Why don't we all get spontaneous HIT? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student (soon to be resident) Giancarlo Buonomo is our producer.

108 - Alpha-gal Again Apr 23, 2025 25:50 This week, Avi shares new insights on the topic of episode 61: alpha-gal! We tackle the question: How could alpha-gal be used to treat cancer? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student (soon to be resident) Gianca

107 - The Smell of the Rain Mar 27, 2025 33:54 This week, Hannah dives into a question inspired by nature: Why do humans have such a keen smell for the scent of the rain? You can read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student (soon to be resident) Giancarlo Buonomo is our

106 - Pulse Check: Methemoglobin Mar 13, 2025 30:46 This week, Tony brings us a fresh case straight from morning report! Join the Curious Clinicians as we learn: Why do patients with methemoglobinemia have an oxygen saturation fixed at 85%? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hou

105 - Grapes of Pseudomonas's Wrath Feb 20, 2025 21:18 We're on a gram negative run! Join the Curious Clinicians as we learn: Why does Pseudomonas smell like grapes? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Bu

104 - A Pseudo-truth? Jan 29, 2025 34:23 Producer Giancarlo Buonomo is back! Join the Curious Clinicians as we learn: Why do we worry about Pseudomonas infection in diabetic patients? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.

103 - Oral Argument Jan 8, 2025 26:40 Welcome back to the Curious Clinicians! In today's episode, Tony asks an important question: "Why don't we administer insulin orally?" Read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

102 - Long Lives the Lobster Dec 25, 2024 30:03 Happy Holidays from the Curious Clinicians! In today's episode, Avi shells us about a fascinating question: "Why do lobsters live so long?" Read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

101 - Automatic ABO Dec 11, 2024 29:29 In today's episode, Hannah asks the question: "Why do we 'automatically' form antibodies to ABO blood type antigens that are not our own?" Read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

[Archive] Thanksgiving & The Food Coma Nov 27, 2024 15:58 Join us as we revisit our annual Thanksgiving episode, in which we answered the question: "Does tryptophan in turkey really cause a food coma?" Read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

100! - Our Favorite Questions Nov 13, 2024 23:56 For our 100th episode this week, the Curious Clinicians take a look back at some of our favorite old episodes. Take a trip down memory lane with us and get some spaced repetition of our favorite learning points along the way. Thank you so much for listening to our show! Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credit

99 - Living on a Lung Oct 30, 2024 33:44 This week, the Curious Clinicians come to you LIVE from the CHEST 2024 conference explore a breathtaking topic: How could you live with only one lung? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

[Archive] Tusks and Tumor Suppressors Oct 16, 2024 31:29 Before our 100th episode, we are rebooting some favorite early episodes! In episode 89, we asked the question: Why don't elephants get cancer? Read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

98 - How Do You Feel? Oct 6, 2024 33:08 This week, the Curious Clinicians meet Dr. Jessi Gold to talk about an important, and often undiscussed question in medicine: "How Do You Feel?" Dr. Gold's new book, out 10/8, covers the mental and physical costs of caring for others as a medical professional. More information about her book can be found here. Regular episodes will return with our final pre-100th episode reboot on 10/16 and a sp

97 - Cascading Prescriptions Oct 2, 2024 22:11 This week, the Curious Clinicians explore the mechanism behind-- and against-- a common prescribing cascade: Why does gabapentin cause edema? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

[Archive] - Why is fever beneficial? Sep 18, 2024 26:02 Before our 100th episode, we are rebooting some favorite early episodes! In episode 24, we asked the question: Why is fever beneficial? Read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

[Archive] The Fast and the Furosemide Sep 4, 2024 20:28 Before our 100th episode, we are rebooting some favorite early episodes! In episode 25, we asked the question: Why can furosemide improve pulmonary edema from heart failure almost immediately? Read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

96 - Dr. Mike Todorovic and the Wonders of the Na+/K+ATPase Pump Aug 21, 2024 40:50 Dr. Mike Todorovic, medical educator and science communicator extraordinaire, joins The Curious Clinicians to discuss the Na+/K+ ATPase pump ("the most important enzyme in the human body") and his approach to digital medical education. Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Atte

95 - Beethoven Redux Aug 7, 2024 23:33 This week, the Curious Clinicians return to the topic of episode 72, "Bringing up Beethoven" with a surprising news update and new perspectives on a 200 year old tale! Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

94 - Flash in the PA Jul 24, 2024 34:00 This week, the Curious Clinicians give a 'hot take' on a common symptoms: why do hot flashes occur? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

93 - Pumping Protons, Pumping Blood Jul 10, 2024 37:15 Producer Giancarlo Buonomo joins the Curious Clinicians this week to answer a morning report musing: why do we use IV PPIs to treat upper GI bleeding? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of N

92 - When the Cause is the Remedy Jun 26, 2024 21:48 Instead of "Why do we...?" this week the Curious Clinicians answer a "Why don't we?" question: why don't we use steroids in acute pancreatitis? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly

91 - Ancient Antibiotics Jun 12, 2024 24:28 The Curious Clinicians answer a fascinating historical perspective: what was the role of antibiotics in ancient society? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student G

90 - Less Sugar, More Blood May 29, 2024 23:10 The Curious Clinicians answer a sweet question about a new medication: Why do SGLT2 inhibitors cause erythrocytosis? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Gianc

89 - Tusks & Tumor Suppressors May 15, 2024 29:45 The Curious Clinicians answer a gigantic oncologic and evolutionary question: Why don't elephants get (as much) cancer? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Gi

88 - Shunting a Mismatch May 1, 2024 23:02 Hold your breath for this one! The Curious Clinicians answer a puzzling pulmonary physiology question: Why can systemic pulmonary vasodilators worsen hypoxemia in COPD-associated pulmonary hypertension? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Pa

87 - Aquagenic Wrinkling Apr 17, 2024 22:05 The Curious Clinicians answer an early curiosity question: Why do my fingers wrinkle when I take a bath? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo

[Archive] UMAMI Apr 4, 2024 19:17 In this episode from our archives, originally posted on September 16, 2020, The Curious Clinicians examined why the savory flavor umami is SO DELICIOUS. Dig in! Show notes: https://curiousclinicians.com/2020/09/16/episode-9-why-is-umami-so-delicious/ CME: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians Audio edited by Clair Morgan of Nodderly

86 - Enlarging Alcohol Mar 21, 2024 22:33 The Curious Clinicians are on tap to ask, why does chronic alcohol use cause macrocytosis? Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer.

85 - NephMadness 2024 Mar 5, 2024 28:59 Welcome to NephMadness 2024! In collaboration with Things We Do For No Reason (TWDFNR), we are excited to promote the start of this amazing medical education opportunity. Inspired by the "March Madness" college basketball tournament, NephMadness is a "a free online, CME-granting, evidenced-based, noncommercial learning initiative that leverages the tools of social media to teach about the latest

84 - History & Hemochromatosis: The Ins and Outs of Iron Feb 21, 2024 32:01 The Curious Clinicians examine why the genetic mutations leading to hereditary hemochromatosis might have offered an evolutionarily advantage to our Neolithic ancestors. The answer relates to an old breakfast stalwart- cereal and milk! Read the show notes here. Audio edited by Clair Morgan of Nodderly.com. This episode is sponsored by Audible! New members can try Audible free for 30 days using ou

[Archive] - (Trans)locating the Bacteria Feb 7, 2024 21:25 On this episode from our archive, originally posted on March 15, 2022, The Curious Clinicians examine why cirrhosis predisposes to SBP, and why bacterial translocation across the bowel wall into ascites doesn't actually occur! Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited b

83 - Thalidomide Embryopathy Jan 31, 2024 26:50 The Curious Clinicians investigate the history and mechanisms of how thalidomide caused embryopathy in the late 1950s and early 1960s in over 10,000 babies across the world. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Gian

[Archive] In Vivo Veritas Jan 26, 2024 27:29 On this episode from our archive, originally posted on February 16, 2022, The Curious Clinicians investigate why antiphospholipid antibodies can be falsely positive during acute illness or thrombosis. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderl

When Normal Labs Aren't Necessary Jan 17, 2024 34:18 In this episode, we investigate the reasons why we don't (and don't need to) transfuse to normal hemoglobin levels. Read the show notes on our website here. And subscribe to our new Substack! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Our producer is medical studen

[Archive] Of Ticks, Alpha-gal, and Red Meat Allergies Dec 20, 2023 21:22 The Curious Clinicians are currently on a holiday break, but we'll be back with new content in 2024! In the meantime, we hope you enjoy this episode from our archive, originally posted December 10, 2022. We told the story of a tiny carbohydrate called alpha-gal, delving into unsettling meat allergies after tick bites, ancient viruses, allergic reactions to an anti-cancer antibody, and xenotranspla

81 - Avoiding Malaria Dec 6, 2023 24:04 In this episode, we examine how sickle cell trait protects against malaria, in multiple ways. Read the show notes on our website here. And subscribe to our new Substack! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Our producer is medical student Giancarlo Buonomo.

[Archive] Thanksgiving & The Food Coma Nov 22, 2023 15:58 Today we reach back into The Curious Clinicians archives, just in time for Thanksgiving. In this episode, originally posted in November 2021, Hannah, Avi, and Tony examine whether tryptophan from turkey actually causes the infamous Thanksgiving food coma. The answer might surprise you... Check out the episode's show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Phys

80 - A Scleroderma Crisis Nov 8, 2023 18:10 In this episode, we explore why ACE inhibitors treat scleroderma renal crisis so effectively (and why bilateral nephrectomy used to be the treatment of choice…). Read the show notes on our website here. And subscribe to our new Substack! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan o

79 - Kurious Keto Oct 19, 2023 20:42 In this episode, The Curious Clinicians ask why a ketogenic diet can help control seizures in refractory epilepsy? Read the show notes on our website here. And subscribe to our new Substack! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com.

78 - Valve Privilege Oct 4, 2023 27:35 For this episode, The Curious Clinicians ask why patients with bioprosthetic heart valves don't require immunosuppression? Read the show notes on our website here. And subscribe to our new Substack! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com.

77 - Irregularly Irregular Sep 21, 2023 28:20 On this episode, The Curious Clinicians learn about why hyperthyroidism is associated with atrial fibrillation. Read the show notes on our website here. And subscribe to our new Substack! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com.

76 - Radical Regeneration Sep 6, 2023 26:21 On this episode, The Curious Clinicians explore the liver's incredible ability to regenerate after injury or resection. Read the show notes on our website here. And subscribe to our new Substack! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. This episode was sponsor

[Archive] The Last Breath Aug 24, 2023 35:09 This week, The Curious Clinicians are bringing back an episode from the archive that was originally posted in December, 2021. Tony joined Dr. Adam Rodman as a guest on the Bedside Rounds podcast. We were thrilled to share that episode here. How can we medically tell whether or not someone is alive or dead? The answer is more complicated than you'd think. This episode was a live podcast Adam and T

75 - Feeling the Burn Aug 9, 2023 25:02 On this episode, The Curious Clinicians investigate why alcohol both causes a burning sensation when you first swallow it (hint: the mechanism has something to do with chili peppers) and why you get a general sense of total body warmth within the next few minutes. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM

74 - DIFFerent Babies Jul 26, 2023 21:57 On this episode, The Curious Clinicians examine an intriguing question - why are babies protected from infection and colitis by C. Diff? We'll touch on factors relating to immunology, microbiology and human development. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair

73 - Random Acts of Medicine with Dr. Christopher Worsham Jul 13, 2023 38:03 On this episode, The Curious Clinicians are joined by Dr Christopher Worsham, co-author of a fascinating and insightful new book, Random Acts of Medicine, which explores the use of natural experiments to better understand healthcare and is now out in hardcover! Audio edited by Clair Morgan of Nodderly.com.

[Archive] 16 - The Eyes Have It (Part I) Jun 29, 2023 18:50 This week, we reach back into the archive for an episode from 2021 (the first in a two-part series related to the eyes) where Tony, Hannah, and Avi explored why Wilson disease can present with Kayser-Fleischer corneal rings. Remember to pick up CME/MOC credit just for listening to the episode! Check out the show notes for this episode and read Avi's tweetorial on this topic. Audio edited by Cla

72 - Bringing Up Beethoven Jun 13, 2023 24:07 On this episode, The Curious Clinicians dive into musical history, examining what might have caused German composer Ludwig van Beethoven's infamous deafness. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com.

71 - Slow to Resolve Jun 1, 2023 20:17 In this episode, The Curious Clinicians learn about why pneumonia takes weeks to resolve on chest x-ray, whereas symptoms generally resolve much sooner. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com.

[Archive] - Bendopnea May 18, 2023 21:49 This episode originally aired April, 2021, where The Curious Clinicians examined why some patients feel short of breath specifically when bending over, aka "bendopnea". You can read the show notes for this episode on our website. Don't forget to pick up CME/MOC credits, courtesy of VCU Health. Audio edited by Clair Morgan of Nodderly.

70 - Blood Meal May 4, 2023 22:44 In this episode, The Curious Clinicians examine why upper gastrointestinal bleeding raises BUN. The answer involves experiments where participants were asked to drink blood (!) and the 700 sextillion (7 x 1023) amino acids that comprise the hemoglobin content in a liter of blood. Read the show notes here. Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.

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