In the Thick of It
In the Thick of It is a bi-monthly podcast from the Hypertrophic Cardiomyopathy Medical Society. Each episode features interviews with experts in the field. The show aims to broaden awareness of new hypertrophic cardiomyopathy studies and advancements. It provides insights into emerging research and clinical developments related to HCM.
Episodes
The Science and Lived Experience of ICDs in HCM
Dr. Rachel J. Lampert, MD, a cardiac electrophysiologist and professor of medicine at Yale School of Medicine, and patient advocate Hannah Keime of HeartCharged join Dr. John Fritzlen to discuss arrhythmias, sudden cardiac death, and life after receiving an implantable cardioverter-defibrillator (ICD) in hypertrophic cardiomyopathy (HCM). The conversation covers how often patients with HC
Long-Term Realities: Managing Disease Progression and ICD Selection in Young HCM Patients
Patient advocates Hannah and Bethany Keime from HeartCharged sit down with Dr. John Fritzlen to discuss the long-term journey of living with hypertrophic cardiomyopathy (HCM). The conversation covers the progressive nature of the condition, including the onset of heart failure symptoms, atrial fibrillation, and myocardial remodeling over decades, as well as how advanced diagnostics like c
Reevaluating Beta Blockers: New Evidence in Non-Obstructive HCM Care
Dr. Florian Rader joins Dr. Louise Bjerregaard to discuss a groundbreaking randomized, double-blind, triple-crossover trial that challenges the long-standing "mantra" of using beta blockers as first-line therapy for non-obstructive hypertrophic cardiomyopathy (HCM). Dr. Bjerregaard explains how the study compared bisoprolol, verapamil, and placebo, revealing that bisoprolol actually resul
The Personalized Heart: Moving Beyond the 15mm Rule in HCM Diagnosis
Dr. John Fritzlen sits down with Dr. Hunain Shiwani to discuss a paradigm shift in diagnosing hypertrophic cardiomyopathy (HCM). For 50 years, the medical community has relied on a static 15mm wall thickness threshold that fails to account for individual body size, age, and biological sex; a bias that often leaves female patients underdiagnosed. Dr. Shiwani details his team’s groundbreaki
The ODYSSEY Continues: Deep Diving into Non-Obstructive HCM Data
Dr. James MacNamara welcomes Dr. Milind Desai from the Cleveland Clinic to dissect the results and implications of the ODYSSEY trial, the largest study ever conducted in hypertrophic cardiomyopathy (HCM). The trial investigated the use of mavacamten in patients with non-obstructive HCM, a population with significant unmet medical needs. While the study did not reach statistical significan
Bionic Tech and Shared Decisions: Exploring the Spectrum of ICD Care in HCM
In this episode of In the Thick of It, Dr. John Fritzlen joins leading electrophysiologist Dr. Mark Link and Hannah and Bethany from Heart Charged to discuss the critical role of implantable cardioverter-defibrillators (ICDs) in managing hypertrophic cardiomyopathy. The group navigates the complex clinical landscape of ICD indications, including the importance of MRI findings and specific
Redefining the Standard: Insights from the MAPLE Trial in Obstructive HCM
In this episode of In the Thick of It, Dr. Floridian Rader and Dr. Ahmad Masri discuss the transformative results of the MAPLE trial, a head-to-head study comparing aficamten—a cardiac myosin inhibitor—to metoprolol in patients with symptomatic obstructive hypertrophic cardiomyopathy1. The trial utilized a rigorous "double-dummy" design to ensure blinding while testing both medications at
Decoding Refractory Symptoms: Advanced Diagnosis and Management in HCM
In this episode of In the Thick of It, Dr. Madeline Smoot talks with Dr. Alex McNamara to discuss the complexities of managing refractory symptoms in patients with hypertrophic cardiomyopathy (HCM). The conversation highlights the distinction between obstructive and non-obstructive symptoms, emphasizing the importance of provocative testing—such as cardiopulmonary exercise testing (CPET)
The "Neglected Middle": Redefining HCM Genetics with Intermediate Effect Variants
In this episode of In the Thick of It, genetic counselor Matthew Thomas sits down with Dr. Roddy Walsh and Dr. Juan Pablo Ochoa to discuss their groundbreaking research on the genetic architecture of Hypertrophic Cardiomyopathy (HCM). The conversation centers on "Intermediate Effect Variants" (IEVs)—genetic markers that fall between rare, high-impact Mendelian mutations and common, low-im
The Center of Excellence: Redefining Specialized Care in HCM
In this episode of In the Thick of It, Dr. Betty Raman interviews Dr. Srihari Naidu, Director of the Hypertrophic Cardiomyopathy Medical Center at Westchester Medical Center, to explore what truly defines a "Center of Excellence". Dr. Naidu shares how his philosophy has evolved from a structural focus on advanced imaging and surgical tools to a patient-centered approach that prioritizes i
Metabolic Modulation in Non-Obstructive HCM: Exploring the FORTITUDE Trial
In this episode of In the Thick of It, hosts Dr. Betty Raman and Dr. James MacNamara welcome Professor Martin Maron, Director of the Hypertrophic Cardiomyopathy Center at Lahey Hospital & Medical Center, to discuss the innovative FORTITUDE-HCM study. This Phase 2b trial focuses on the symptomatic non-obstructive HCM population—a group considered to have one of the greatest unmet treat
The SONATA Trial: SGLT2 Inhibition as a New Frontier in HCM Treatment
In this episode of In the Thick of It, Dr. James MacNamara sits down with Dr. Sharlene Day, Director of Translational Research at the University of Pennsylvania, to discuss the groundbreaking SONATA trial. This double-blind, placebo-controlled clinical trial is evaluating the safety and efficacy of sotagliflozin—a dual SGLT1 and SGLT2 inhibitor—in patients with both obstructive and non-ob
Teamwork, Tech, and Tomorrow: Highlights from the 2025 Scientific Sessions
Dr. James MacNamara and Dr. Betty Raman recap the latest annual Hypertrophic Cardiomyopathy Society (HCMS) meeting held in New Orleans. The discussion emphasizes that HCM care is a "team sport," involving a multidisciplinary coalition of physicians, pharmacists, and advanced practice providers. Key highlights include a deep dive into Professor Hugh Watkins' lecture on the future of gene t
Seeing HCM Clearly: Optimizing Echocardiography for Better Diagnosis
How can echocardiographers improve the accuracy and confidence of hypertrophic cardiomyopathy diagnosis? In this episode of In the Thick of It, sonographers Amy Dillenbeck and Brad Mehl explore the essential role of echocardiography in evaluating HCM, sharing best practices for optimizing imaging techniques, Doppler assessment, and contrast use. They discuss the most common challenges in
Understanding NSVT: Risk Assessment and ICD Decisions in HCM
How do we determine which hypertrophic cardiomyopathy patients are at the highest risk for sudden cardiac death? In this episode of In the Thick of It, Dr. Steve Ommen and Dr. Mark Link take a deep dive into the role of non-sustained ventricular tachycardia (NSVT) in risk assessment and ICD decision-making. They discuss how age, VT duration, and other clinical factors influence risk strat
Imaging Matters: How LGE Guides HCM Management
How can late gadolinium enhancement (LGE) on cardiac MRI help predict sudden cardiac death risk in hypertrophic cardiomyopathy? In this episode of In the Thick of It, Dr. Christopher Kramer and Dr. Raymond Chan explore the clinical significance of LGE, from its role in ICD decision-making to the challenges of scar quantification. They discuss how to differentiate true myocardial scar from
Valve Disease and HCM: Predicting and Preventing Complications
How do hypertrophic cardiomyopathy and aortic valve disease intersect, and what makes managing these patients so challenging? In this episode of In the Thick of It, Dr. Srihari Naidu and Dr. Megan Coylewright explore the complexities of aortic valve replacement (TAVR) in patients with HCM. What challenges arise when HCM patients undergo aortic valve replacement, and how can these risks be
Cracking the Code: The Role of Genetics in HCM Diagnosis, Screening, & Treatment
How has genetic testing transformed the understanding and care of hypertrophic cardiomyopathy? In this episode of In the Thick of It, Dr. Victoria Parikh and genetic counselor Tia Moscarello from the Stanford Center for Inherited Cardiovascular Disease explore the powerful role of genetics in HCM diagnosis, family screening, and treatment. They discuss groundbreaking advancements like gen
From Imaging to Intervention: Navigating Apical Aneurysms in HCM
What are left ventricular apical aneurysms, and why do they pose such a high risk in hypertrophic cardiomyopathy patients? In this episode of In the Thick of It, Dr. Ethan Rowin and Dr. Jeffrey Geske delve into this rare but critical HCM phenotype. They discuss how to accurately define and detect apical aneurysms, the importance of advanced imaging techniques like contrast echocardiograph
Managing HCM in Pediatric Patients: Why Early Detection Matters
Why is early detection of hypertrophic cardiomyopathy in children so critical for effective treatment? In this episode of In the Thick of It, Dr. Matthew Martinez sits down with pediatric cardiologist Dr. Tess Saarel to explore the unique challenges of managing HCM in young patients. They discuss the importance of personalized risk assessments, the role of genetics in tailoring care, and
Complex Layers: Screening for and Managing Comorbidities in HCM
What makes managing common conditions like hypertension and sleep apnea uniquely challenging in hypertrophic cardiomyopathy patients? In this episode of In the Thick of It, Dr. Michael Ayers and Dr. Robyn Bryde tackle the complexities of treating comorbidities such as obesity and type 2 diabetes within the context of HCM. They delve into how obstructive physiology impacts treatment choice
Understanding the Impact of Atrial Fibrillation in HCM Patients
What does it take for healthcare providers to meet the unique needs of HCM patients experiencing AFib? In this episode, Dr. Ethan Rowin and Dr. Jose Joglar delve into the critical topic of atrial fibrillation (AFib) in patients with hypertrophic cardiomyopathy (HCM). They discuss the heightened risk of stroke associated with AFib, the necessity for prompt anticoagulation, and the complexi
Educating Patients and Families About Genetic Implications of HCM
In today’s episode of In the Thick Of It, Dr. Anna Woo is joined by Dr. Sharon Cresci for a conversation on hypertrophic cardiomyopathy and its genetic implications. What role does genetic testing play in identifying familial variants and whether inheriting a pathogenic variant will lead to disease? Learn about the importance of genetic testing, lifelong serial screening, collaborative tr
Septal Myectomy and Mitral Valve Repair: Personalized Approaches in Treating HCM
On today's episode of 'In The Thick of It', Dr. Benjamin Van Boxtel welcomes Dr. Daniel Swistel and Dr. Joseph Dearani to discuss Septal Myectomy and mitral valve repair. Why is personalized patient care crucial when managing hypertrophic cardiomyopathy? Tune in as these specialists explore the importance of customized procedures, teamwork across disciplines, ongoing education, and stayin
Optimizing Treatment: The New Hypertrophic Cardiomyopathy Guidelines Explained
On this episode of 'In The Thick of It', Dr. Steve Ommen joins Dr. Matthew Martinez to explain the latest changes and updates to the HCM guidelines. What is the importance of personalized patient care, shared decision-making, and lifestyle adjustments for HCM patients? Find out as Dr. Martinez and Dr. Ommen discuss risk assessment methodologies, effective management strategies for atrial
Navigating Cardiac Myosin Therapy: Insights for NYHA Class II HCM Patients
When should we make the critical decision to start Cardiac Myosin therapy in NYHA Class II HCM patients? Today, Dr. Patrycja Galazka is joined by Dr. Sara Saberi, Assistant Associate Professor in Cardiovascular Medicine and co-director of the Inherited Cardiomyopathy Program at the Frankel Cardiovascular Center. Together, we dive into the intricate world of Cardiac Myosin Inhibitors, addr
Gene Therapy and the Future of Heart Health: A Conversation with Dr. Sharlene Day and Dr. Carolyn Ho
How do you envision the role of gene therapy in shaping the future of cardiac care? In today’s episode, your host, Dr. Sharlene Day, engages in an enlightening conversation with Dr. Carolyn Ho, delving into the transformative world of gene therapy. Together, they navigate the complexities of gene therapy's fundamental concepts and potential applications in treating genetic cardiomyopathie
Advancements in Nonobstructive HCM: A Discussion with Dr. Michelle Kittleson
Are the symptoms of nonobstructive hypertrophic cardiomyopathy (nHCM) holding patients back from living their fullest lives? Join Dr. Melissa Lyle and Dr. Michelle Kittleson as they unravel the mysteries of nHCM symptoms like congestion, angina, and exercise intolerance. How can we better manage these symptoms and pave the way for improved quality of life? Tune in as they explore innovati
Imaging in HCM with Dr. Caroline Coats & James Moon
In today’s episode, Cardiologist Dr. Caroline Coats is talking with with Dr. James Moon, the CEO of Mycardium AI Ltd, and a distinguished Professor of Cardiology at University College London. Dr. Moon’s groundbreaking work in cardiac MRI, especially in hypertrophic cardiomyopathy, has changed the way professionals understand and diagnose heart conditions. Today, we’re delving into his we
Unlocking Heart Health: Dr. Ayers & Dr. Owens on Myosin Inhibitors
Our topic of discussion today is a critical one that impacts the world of cardiology and beyond cardiac myosin inhibitors. This cutting-edge area of research has the potential to revolutionize the way we approach cardiac diseases, and our experts are here to shed light on the latest developments, breakthroughs, and implications for patients and athletes alike.So, whether you're a medical
2023 HCMS Sessions Oral Abstract Presentations
You’re listening to In the Thick of It, a podcast from the HCM Society, where we interview experts in the Hypertrophic Cardiomyopathy field, to broaden the awareness of new HCM studies & advancements! In this episode, Dr. Robyn Bryde and Dr. Bradley Lander will interview each presenting author of the selected abstracts to tell us more about their HCM research. The guests are Dr. Said
HCM Exercise Prescription with Dr. Michael Emery
Welcome to "In the Thick of It," a podcast by the HCM Society, dedicated to shedding light on the latest developments in Hypertrophic Cardiomyopathy. In this episode, Cardiologist Dr. Robyn Bryde engages in an insightful conversation with Dr. Michael Emery. They delve into the crucial topic of exercise restrictions in HCM, exploring the art of crafting exercise prescriptions, counseling a
What's Next for Non-obstructive Hypertrophic Cardiomyopathy
Today, host Dr. Eli Friedman chats with Dr. Ahmad Masri, of Oregan Health Sciences University Hypertrophic Cardiomyopathy Center. Dr. Friedman and Dr. Masri are good friends and former coworkers, and today they’re talking about finding treatment for patients with non-obstructive Hypertrophic Cardiomyopathy, specifically focusing on drugs on clinical trials and Cardio Mitotrope Ninerafaxst
4. HCM Care Evolution: Building Patient-Centric Excellence, with Lisa Salberg
Today, host Dr. Bradley Lander chats with Lisa Salberg, the founder of the HCMA, the Hypertrophic Cardiomyopathy Association. Since 1996, Lisa has been on a journey to educate, advocate, and support other patients based on her experience with HCM - including medical errors that nearly cost her life, and the death of her sister.With a heartfelt story and personal experiences of HCM, Lisa s
3. Athletes with HCM: Breakthrough Study for Vigorous Exercise
Today, cardiologist Dr. Robyn Bryde interviews Dr. Matthew Martinez, the Director of Sports Cardiology and Hypertrophic Cardiomyopathy at Morristown Medical Center in New Jersey. Recorded from the Care of the Athletic Heart Conference, they discuss the effects of vigorous exercise on patients with hypertrophic cardiomyopathy (HCM). Historically, patients with HCM were advised to restrict
2. Obstructive Hypertrophic Cardiomyopathy: Survival in Patients 65 and Older
On today's episode, professor of medicine and director of the HCM Center at Westchester Medical Center in New York, Dr. Srihari Naidu, speaks with Haslam Family Endowed Chair in Cardiovascular Medicine, Dr. Milind Desai. Dr. Desai has come today to discuss an article he wrote for the Journal of the American College of Cardiology, which looks at the long-term outcomes of septal reduction t
1. Could vigorous exercise be safe for persons with HCM?
Learn more here in the first episode of In the Thick of It by HCMS. Special thanks to Dr. Rachel Lampert and the LIVE-HCM investigators for this important study!View Episode 1 slidesIn the Thick of It is brought to you by the HCM Society, and is produced by Earfluence.
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