Concentrating on Chromatography
David Oliva 82 episodes Nov 9, 2026
Concentrating on Chromatography is a science podcast hosted by David Oliva that explores the frontiers of chromatography, mass spectrometry and sample preparation. Each episode features conversations with researchers, industry innovators and analytical chemists working on separation science. Topics range from PFAS detection challenges to AI-assisted liquid chromatography, along with practical workflows and sustainability advances. It is aimed at chromatographers, lab professionals and researchers who want to understand the real-world impact of analytical chemistry.
Episodes
Episode 86: Identifying Unknown Compounds: GC-MS, LC-MS, and NMR with James Little
An unfamiliar peak. An inconclusive library search. A molecule that’s visible with one detector but missing from another. How do you figure out what’s actually in your sample?James Little joins David Oliva and Candi Gokey on Concentrating on Chromatography to explore the detective work behind identifying unknown compounds. Drawing on nearly five decades of mass spectrometry experience, including h
Episode 85: Kody Coyne: Building Flash & HPLC Methods for Brand-New Molecules (Undergrad Research)
Undergraduate researcher Kody Coyne is building a safer, hydrazine-free way to make nitrogen–nitrogen, nitrogen–oxygen, and nitrogen–sulfur bonds. Because every product is a brand-new compound, he has to invent the chromatography method to purify it.Kody is a biochemistry major and varsity swimmer at Monmouth College. In this episode he explains how he uses a custom C18 reversed-phase HPLC method
Episode 84: Chris Freye (Los Alamos) — Chromatography, Chemometrics, and the Science of Aging Explosives
Chris Freye, Ph.D., is a staff scientist in the High Explosives Science and Technology group at Los Alamos National Laboratory, where he uses GC×GC, UHPLC, UHPLC-IMS, and high-resolution mass spectrometry to study how high explosives and plastic-bonded explosives (PBXs) change over time.In this episode, Chris discusses his path from rock climbing in the Pacific Northwest to a PhD under GC×GC pione
Episode 83: Beyond DNA: Forensic Lubricant Analysis, DART-MS & Sexual Assault Evidence with Dr. Candice Bridge
When DNA is absent, incomplete, or difficult to interpret, what other evidence can help forensic investigators make meaningful connections?In this episode of Concentrating on Chromatography, David Oliva speaks with Dr. Candice Bridge of the University of Central Florida and the National Center for Forensic Science about the emerging field of forensic lubricant analysis.Dr. Bridge explains how chem
Episode 82: Ultra-Fast GC Meets Mass Spec: Measuring Forest Chemicals That Create Storm Clouds
He built a gas chromatograph and mass spectrometer small enough to fit in a carry-on suitcase, then hauled it up a 43-meter tower in 100-degree Alabama heat to catch invisible forest chemicals in real time.Austin "Augie" Dobrecevich, a PhD researcher at the University of Washington, joins Candi and David to break down how his ultra-fast GC captures a full chromatogram every single second
Episode 81: PFAS, 6PPD-Quinone & the Science of Emerging Contaminants w/ Arielle Cocozza (ALS USA)
Arielle Cocozza, National Technical PFAS Lead at ALS USA Environmental, joins David Oliva and Candi Gokey to break down the current state of PFAS analysis — from her unconventional path out of a physics degree into environmental chemistry, to standardizing PFAS methods across a national lab network.In this episode, Arielle explains what PFAS actually are and why their fluorine-carbon bonds make th
Episode 80: Untargeted Metabolomics & Ocean Chemistry with Mauricio Caraballo
Mauricio Caraballo, PhD, director of the MSCollaboratory at UC San Diego, joins Candi Gokey and host David Oliva to unpack how untargeted LC-MS/MS metabolomics reveals hidden chemistry in coral reefs, fish, and ocean water. They dig into molecular networking, GNPS, and how free mass spec training is helping marine scientists worldwide analyze samples they couldn't otherwise decode.Links: mscol
Episode 79: Mechanical engineer Mason Chilmonczyk on fixing mass spec's bubbles, clogs, and leaks
Mechanical engineer Mason Chilmonczyk, PhD (Andson Biotech) joins host David Oliva to explain why sample prep — not the mass spec itself — is the biggest bottleneck in LC-MS and native MS workflows. Mason breaks down the DynaChip, a microfluidic device that shrinks hours of buffer exchange into seconds, and shares how "democratizing" mass spec is opening the door for cell therapy manufac
Episode 78: SPME, PFAS & Green Chemistry with Dr. Emanuela Gionfriddo
Dr. Emanuela Gionfriddo, Associate Professor of Chemistry at the University at Buffalo, joins host David Oliva to explore solid phase microextraction (SPME), green analytical chemistry, and PFAS analysis. Trained in Professor Janusz Pawliszyn's lab at the University of Waterloo — where SPME was invented — she shares how deep SPME theory reshaped her research and now drives her lab's work o
Episode 77: Hybrid Metabolomics Explained: Bridging Targeted & Untargeted MS with Bruker's Matthew Lewis
On this episode of Concentrating on Chromatography, hosts David Oliva @Organomation and Candice Gokey are joined by Matthew Lewis @Bruker to unpack the new hybrid metabolomics workflow born from Bruker's acquisition of @biocrates .For 20 years, mass spectrometrists have had to choose between targeted quantitation and untargeted discovery. Matthew explains how chemical derivatization, high-re
Episode 76: PFAS Are Everywhere — And 99% Go Undetected | Dr. Viktoria Müller
If you take a handful of dirt from the roadside, it contains PFAS. The challenge isn't finding forever chemicals — it's finding all of them. Standard monitoring methods cover 40 to 50 PFAS species. Thousands more go completely unmeasured. That's the gap Dr. Viktoria Müller has spent her career trying to close.Viktoria is a postdoctoral researcher at the University of Graz specializing
Episode 75: Breathomics, Asthma & GC×GC: PH Stefanuto on Fighting the “Proof‑of‑Concept” Trap
In this episode of Concentrating on Chromatography, David Oliva and co‑host Candi Gokey sit down with Dr. Pierre‑Hugues (PH) Stefanuto to explore how comprehensive GC×GC‑TOFMS breathomics is reshaping asthma research and personalized medicine. PH shares his journey from forensic applications (yes, even the “smell of death”) to non‑invasive exhaled breath analysis for chronic lung inflammation, and
Episode 74: Decoding the Glycocode: AI-Powered Glycoproteomics & Cancer Research | Jacob Russell (Riley Lab, UW)
In this episode of Concentrating on Chromatography, host David Oliva is joined for the first time by co-host Candice (Candi) Gokey — PhD candidate at UC San Diego / San Diego State University and expert in LC-MS/MS method development for untargeted metabolomics to interview Jacob Russell, a third-year PhD student in the Riley Research Group at the University of Washington (Seattle).Jacob's res
Episode 73: How Chromatography Helps Build Better Catalysts | Dr. Madalyn Radlauer (San José State University)
Chemistry doesn't end when the reaction is finished. In many research labs, chromatography is what allows scientists to understand whether their chemistry actually worked.In this episode of Concentrating on Chromatography, we sit down with Dr. Madalyn Radlauer, Associate Professor of Chemistry at San José State University, to discuss how her research group combines polymer chemistry, catalysis
Episode 72: PFAS in Water, Food & Packaging: Michelle Taylor on the "Forever Chemicals" Documentary Series
In this episode of @ChromatographyTalk , @Organomation General Manager David Oliva sits down with Michelle Taylor, Editor-in-Chief of LabCompare, to go behind the scenes of their groundbreaking two-part documentary series on PFAS (per- and polyfluoroalkyl substances). The conversation kicks off with a startling revelation: many of the world’s leading PFAS experts have completely stopped eating
Episode 71: In Silico Modeling, 2D-LC & Green Chromatography: Imad Ahmad on the Future of Method Development
In this episode of @ChromatographyTalk , @Organomation General Manager David Oliva sits down with Imad Haidar Ahmad, Scientific Research Director at Amgen leading separations for Discovery Chemistry and Externalization. Imad's career spans Novartis, Merck, and now Amgen, and his research on computer-assisted method development has landed multiple front covers in Analytical Chemistry.We d
Episode 70: AIMS vs. LC-MS for Cancer Diagnostics: ccRCC Metabolomics with Rachel Wood | Queen's University
What if you could assess a tumor's metastatic potential — without extensive sample prep — directly from tissue? Rachel Wood is working on exactly that.Rachel Wood is a PhD candidate at Queen's University (Kingston, Ontario), working jointly in the labs of Dr. Richard Oleschuk (Chemistry) and Dr. Chris Nicoll (Pathology & Molecular Medicine). Her research applies Ambient Ionization Mass
Episode 69: Droplet Cyclic Ion Mobility Mass Spec: Compressing Months of Enzyme Screening Into Just 14 Hours!
What if you could compress 179 days of grueling laboratory workflow into just 14 hours?In this episode of @ChromatographyTalk , @Organomation General Manager David Oliva sits down with analytical chemist Laura Penabad to discuss her groundbreaking new research in biocatalysis and high-throughput screening. Evolving engineered enzymes typically requires checking thousands of variants—a massive
Episode 68: Peak Fitting, Deconvolution & AI in Chromatography
Chromatography software hasn't fundamentally changed in decades — but the peaks it's trying to measure have gotten a lot harder to solve. In this episode of @ChromatographyTalk I sit down with Ron Brown, creator of PeakFit and PeakLab, and returning guest Dr. M. Farooq Wahab, analytical chemist and research engineering scientist at the University of Texas at Arlington, to dig into the re
Episode 67: Is Your Lab Sitting on a Data Goldmine? AI, Deep Learning, & Mass Spectrometry with mzio
Welcome back to another episode of Concentrating on Chromatography! In this episode of @ChromatographyTalk host David Oliva sits down with Dr. Ansgar Korf, CEO and Co-Founder of mzio GmbH, to explore how their vendor-agnostic platform is fundamentally changing how researchers and industrial users extract value from complex mass spectrometry data.Historically rooted in the open-source academic co
Episode 66: Why Sustainable Labs Save Money: James Connelly, CEO of My Green Lab
Can sustainability actually make laboratories more efficient—and more profitable?In this episode of Concentrating on Chromatography, @Organomation General Manager David Oliva sits down with James Connelly, CEO of My Green Lab, to discuss how a grassroots movement founded by scientists evolved into the leading global organization for laboratory sustainability.James explains why sustainability is
Episode 65: Why Scientists Need to Tell Their Story | Funding, Visibility & Industry Impact
Why should analytical chemists, chromatographers, and researchers care about science communication? Is publishing papers enough? How can scientists increase their visibility without spending hours on social media?In this episode of @ChromatographyTalk , David is joined by Lisa Jones and Johnnie Aycock, co-hosts of @TheNoonShow100.1 and creators of the upcoming BrightPath program on Alabama Pub
Episode 64: The Chemistry of Human Decomposition: GC×GC, Body Farms, and Forensic Science
In this episode of @ChromatographyTalk David sits down with Dr. Darshil Patel, Assistant Professor of Forensic Science at the University of North Dakota, to discuss his remarkable journey from dentistry in India to becoming a leading researcher in forensic chemistry across Australia, Canada, and the United States.Dr. Patel shares how his work at human taphonomic facilities—commonly known as &quo
Episode 63: LC-MS Metabolomics and Next-Generation Ionization Technologies #chromatography #massspectrometry
In this episode of @ChromatographyTalk , David speaks with Joseph Corstvet from the Fernandez Lab at Georgia Tech about the future of mass spectrometry, LC-MS metabolomics, and the development of low-cost ionization technologies.Joe discusses his work using LC-MS lipidomics to monitor mesenchymal stromal cell (MSC) senescence and explains how metabolomics could eventually become a real-world qual
Episode 62: When One Atom Changes Everything | JC Poutsma on Mass Spectrometry, Proteomics & Gas-Phase Chemistry
What happens when you replace just one atom in an amino acid?In this episode of @ChromatographyTalk David sits down with JC Poutsma, Professor of Chemistry at William & Mary, to explore the fascinating world of gas-phase ion chemistry, peptide fragmentation, and the hidden molecular behavior revealed by mass spectrometry.Professor Poutsma explains how subtle structural changes in biomolecule
Episode 61: Why Biologics QC Is So Much Harder Than Small Molecule Pharma | Colette Quinn of Waters
In this episode of @ChromatographyTalk David speaks with Colette Quinn, Senior Director within the Biologics Business at Waters Corporation, about the rapidly evolving world of pharmaceutical and biopharma QA/QC.As biologics become more complex, QA/QC labs are being pushed beyond traditional pass/fail testing toward deeper molecular characterization, advanced analytics, and data-driven decision
Episode 60: Why Capillary LC Is the Future of LC-MS Sensitivity #chromatography #massspectrometry
What makes capillary LC so powerful—and why are more scientists paying attention to it?In this episode of @ChromatographyTalk , David sits down with Samuel Foster of Axcend to discuss how capillary liquid chromatography is changing the conversation around LC-MS sensitivity, solvent consumption, instrument footprint, and chromatographic efficiency.Sam explains how lower flow rates can dramatically
Episode 59: The Future of Ion Chromatography | PFAS Testing, EPA 1621 & AOF Explained #analyticalchemistry
How are PFAS regulations changing, and what role will ion chromatography play in the future of environmental testing?In this episode of @ChromatographyTalk , David interviews Jay Gandhi, PhD, Vertical Markets Manager at Metrohm USA, for an in-depth discussion on PFAS analysis, the rise of AOF (Adsorbable Organic Fluorine) testing, and the development of EPA 1621 and ISO 18127 standards.With more
Episode 58: How Separation Science Is Taught vs. How It’s Actually Used #nmrspectroscopy #massspectrometry
What do students really learn before they ever touch an analytical instrument? And is chemistry education keeping up with the pace of modern chromatography, mass spectrometry, and sample preparation?In this episode of Concentrating on Chromatography, David speaks with instructor Natasha Le about the realities of teaching chemistry and separation science to today’s students—many of whom are pursuin
Episode 57: Frugal Science Meets Sample Prep: A Field-Ready Lyophilizer for Biofluids
What if you could dry biofluid samples in the field—without a vacuum system, freeze dryer, or full lab setup?In this episode of Concentrating on Chromatography, I sit down with Rajas Poorna and Charles Anderson to explore their work on a frugal, field-deployable alternative to traditional lyophilization through the Evapinator project.Originally inspired by the principles of frugal science, their a
Episode 56: Fighting Antibiotic Resistance with LC-MS: Targeting Bacterial Cell Walls #chromatography #massspec
In this episode of Concentrating on Chromatography, host Dave Oliva sits down with Chris Reid to explore how chemical biology and LC-MS are being used to tackle one of the most urgent global challenges: antimicrobial resistance.As antibiotic resistance continues to rise—and new drug development struggles to keep pace—researchers are looking beyond traditional approaches. Instead of targeting how b
Episode 55: PFAS in Water: Why We’re Missing 96% of the Problem | Dr. Leigh Terry #analyticalchemistry
What if most PFAS contamination isn’t even being measured?In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.While most regulatory methods focus on a small number of compounds like PFOA and PFOS, ther
Episode 54: AQbD Explained: How Design of Experiments is Transforming Chromatography (LC-MS, Pharma & Biopharma)
In this episode of Concentrating on Chromatography, David Oliva sits down with Amanda Guiraldelli Mahr to break down one of the most important (and often misunderstood) concepts in analytical chemistry: Analytical Quality by Design (AQbD).If you’ve ever relied on trial-and-error for method development—or wondered how top labs are using Design of Experiments (DOE), modeling, and AI to work smarter—
Episode 53: How GLP-1 Drugs Are Analyzed: Chromatography & Mass Spectrometry Explained #analyticalchemistry
In this episode of Concentrating on Chromatography, we sit down with Kelly Broster McMahon to explore the analytical science behind one of the most important pharmaceutical trends today: GLP-1 therapeutics.Drugs like Semaglutide have transformed the treatment of diabetes and obesity—but ensuring their safety, efficacy, and quality requires cutting-edge analytical workflows.In this conversation, we
Episode 52: Mass Spec Without Chromatography? How DART is Changing Clinical & Forensic Testing
Can mass spectrometry work without chromatography?In this episode of Concentrating on Chromatography, host David Oliva speaks with Jeff Zonderman of Bruker about how Direct Analysis in Real Time (DART) mass spectrometry is enabling rapid sample analysis with little or no chromatography.Traditional LC-MS workflows rely on chromatography, solvent-intensive sample preparation, and complex instrumenta
Episode 51: Did Mars Destroy Its Own Biosignatures? | GC-MS, Sterols & the Search for Life
What if Mars already had biosignatures… and destroyed them?In this episode of Concentrating on Chromatography, host David Oliva sits down with Megan Farrah from Tufts University to explore how GC-MS is being used to reconstruct potential biosignatures under simulated Martian conditions.Inside a Mars Simulation Chamber, Megan irradiates sterols and hopanes — two of NASA’s priority targets for life
Episode 50: LC-MS Is Throwing Away 99% of Your Signal — Can Ion Mobility Fix It?
Liquid chromatography–mass spectrometry (LC-MS) has been the backbone of modern analytical workflows for decades — but what if one of its most trusted components is also its biggest bottleneck?In Episode 50 of Concentrating on Chromatography, host Dave Oliva sits down with Daniel DeBord, Chief Technology Officer at MOBILion Systems, to explore how high-resolution ion mobility may be changing the w
Episode 49: UV–Vis vs LC–MS: Studying Light-Induced Degradation in Phthalocyanines
Light can heal. Light can power devices. But light can also destroy molecules.In this episode of Concentrating on Chromatography, we sit down with Kshmeya Chopra to explore how phthalocyanines — highly conjugated macrocycles used in photodynamic therapy, sensing, and organic electronics — respond to prolonged light exposure.Using UV–Vis spectroscopy, Kshmeya and her research team systematically in
Episode 48: Using LC-MS & GC-MS to Decode Photoredox Catalyst Stability
In this episode of Concentrating on Chromatography, we sit down with Lindsay Repka to discuss how LC-MS and GC-MS transformed her lab’s approach to photoredox chemistry.What began as a project to develop a visible-light photocrosslinking handle unexpectedly led to a major discovery: the solvent (DMF) was reacting with the photocatalyst itself. Using high-resolution LC-MS, Lindsay’s team observed m
Episode 47: Tracking Toxic PCBs in River Water using Gas Chromatography–Electron Capture Detection
In this episode of Concentrating on Chromatography, David speaks with Francis Femi Oloy about using chromatography to uncover hidden pollutants in real-world water systems.Femi’s team analyzed polychlorinated biphenyls (PCBs) in six major rivers in southwestern Nigeria — compounds that were banned decades ago but still persist in the environment. Using a workflow that many analytical labs will rec
Episode 46: How LA-ICP-MS Imaging Reveals Disease in Tissue | Metrology, Multiplexing & Analytical Chemistry
How do you see proteins, metals, and disease processes inside real tissue — and still trust the numbers?In this episode of Concentrating on Chromatography, David sits down with Monique Mello, analytical chemist, educator, and LA-ICP-MS imaging specialist, to explore how laser ablation ICP-MS (LA-ICP-MS) and immuno-mass spectrometry imaging (iMSI) are transforming pathology, environmental science,
Episode 45: How Chemists Design Cancer-Targeting Radiopharmaceuticals | Chelators Explained
How do chemists design molecules that safely carry radioactive metals through the body to target cancer cells?In this episode of Concentrating on Chromatography, David sits down with Simona Mastroianni and Marianna Tosato to explore the chemistry behind radiopharmaceuticals — drugs that combine radioactive isotopes with specially designed chelators to diagnose and treat cancer.Their latest researc
Episode 44: Drug Discovery Where the Market Doesn’t Go: Targeting Neglected & Opportunistic Pathogens
Neglected and opportunistic infectious diseases affect some of the world’s most vulnerable populations—but often receive the least attention from traditional drug discovery pipelines.In this episode of Concentrating on Chromatography, host David Oliva sits down with Brad Haubrich to explore how early-stage drug discovery is being applied to fungal and parasitic pathogens, including those responsib
Episode 43: Detecting Haloacetic Acids in Water with GC-MS | Method Development, Pools, & Real-World Challenges
Haloacetic acids (HAAs) are disinfection byproducts formed when chlorine or bromine reacts with organic matter in water—and some are linked to serious health concerns. In this episode of Concentrating on Chromatography, we sit down with Jessica Whitehouse, MSc student at the University of Calgary, to discuss how she developed a GC-MS method to detect and quantify HAAs in real-world water samples.D
Episode 42: Selective Separations: What Membrane Science Can Teach Chromatographers
In this episode of Concentrating on Chromatography, host David Oliva sits down with Dr. Steven Weinman, Associate Professor of Chemical and Biological Engineering at the University of Alabama, to explore how membrane science and chromatography intersect in modern separation challenges.Steven shares his journey from chemical engineering student to membrane researcher, and explains how membranes are
Episode 41: N‑Glycans, Whey Protein, and the Gut Microbiome: Mass Spec Insights with Matthew Bolino
How do the hidden carbohydrate structures on your favorite protein powders shape the gut microbiome? In this episode of Concentrating on Chromatography, Matthew Bolino, M.S., from the University of Nevada, Reno, breaks down his latest research on N‑glycans from common dietary proteins (whey, egg white, soy, and pea) and how their structural diversity influences microbial fermentation and short‑cha
Episode 40: Mass Spectrometry, Surface Sampling and Dried Matrix Spots - Greener Chemistry and 3D Printing
In this episode, we interview Daniel Reddy, 2025 CAS Future Leader and PhD candidate at Queen's University, about his groundbreaking research on automated mass spectrometry and dried matrix spots (DMS).Dan's work combines computer vision, 3D printer automation, and laser micromachining to revolutionize sample preparation—reducing CO₂ emissions by 28-fold and organic solvent use by 21-fold
Episode 39: The Evolving Chromatographer: How Agilent is Designing for Today's Lab Users (Separation Science Collaboration)
Join us as we sit down with Jim Gearing, Associate Vice President of Marketing for Agilent's Gas Phase Division, to explore how the world of chromatography is changing and how intelligent instrument design is meeting users where they are.This interview was conducted in collaboration with Separation Science, the premier online learning platform for analytical scientists, providing expert conten
Episode 38: How Mass Spectrometry Actually Works: The Quadrupole Explained
In this episode of Concentrating on Chromatography, we sit down with Dr. Lee Polite from Axion Training Institute to break down one of analytical chemistry's most powerful yet misunderstood techniques: gas chromatography-mass spectrometry (GC/MS).What You'll Learn:- Why GC and MS are the "perfect pair" – and what happens when you try to use MS alone- The electron gun: how molecul
Episode 37: Why Fake Banana Flavor Doesn't Taste Like Real Bananas | HS-GC-MS
Connor Johnson, a researcher from the University of Alberta, discusses his award-winning honours project analyzing the volatile organic compounds (VOCs) in two banana species using headspace gas chromatography-mass spectrometry (HS-GC-MS). He completed this specific project as an undergraduate at Thompson Rivers University (TRU).For over 60 years, commercial banana flavoring has remained unchanged
Episode 36: PFAS, Mycotoxins & Food Safety Testing with SCIEX's Holly Lee (Separation Science Collaboration)
Join us for an in-depth conversation with Holly Lee, Global Technical Marketing Specialist at SCIEX, as we explore the cutting edge of food and environmental safety testing. Holly shares her expertise on analyzing ultra-short chain PFAS like TFA, masked mycotoxins, pesticide residues, and the latest LC-MS/MS workflows transforming laboratory efficiency.In this episode of Concentrating on Chromatog
Episode 35: Regulated Drinking Water Testing: PFAS Detection, Sample Prep & Real Lab Insights
In this episode of Concentrating on Chromatography, we sit down with Alex Brody, an organic chemist at Aqua America, to discuss the rigorous analytical methods required for regulated drinking water testing.Alex walks us through the multi-step PFAS detection process using EPA Method 537.1, including extraction, nitrogen blowdown concentration, and LC-MS analysis. He explains why sample preparation
Episode 34: Mapping Cancer's Blueprint: How Spatial Proteomics is Revolutionizing Detection
In this episode of Concentrating on Chromatography, we sit down with Andreas Metousis, a PhD researcher at the Max Planck Institute of Biochemistry, to explore cutting-edge spatial proteomics and its role in understanding ovarian cancer development.Andreas discusses how Deep Visual Proteomics (DVP)—a method combining artificial intelligence, laser micro-dissection, and advanced mass spectrometry—i
Episode 33: Teaching Separation Science in High School | Chemistry Teacher Dr. Vanderveen
In this episode of Concentrating on Chromatography, David interviews his former high school chemistry teacher, Dr. Kristen Vanderveen from The Bromfield School, about teaching separation science at the high school level.Dr. Vanderveen shares her approach to introducing chromatography, filtration, and gravimetric analysis to both first-year chemistry students and AP Chemistry students. She discusse
Episode 32: GLP-1 Peptide Analysis: Chromatography Challenges & Solutions with Phenomenex's Sean Orlowicz (Separation Science Collaboration)
Join host David Oliva from Organomation for an in-depth conversation with Sean Orlowicz, Principal Marketing Development Manager at Phenomenex, about the analytical challenges and innovative solutions for GLP-1 peptide therapeutics like semaglutide and tirzepatide.In this episode, presented in collaboration with Separation Science (https://www.sepscience.com/)—a premier learning platform for analy
Episode 31: Fecal Microbiota Transplantation (FMT) Explained | Multidimensional Chromatography & Gut Health
Join us for an insightful conversation with Dr. Ryland Giebelhaus a chromatographer and metabolomics researcher from the University of Victoria, as he breaks down fecal microbiota transplantation (FMT)—a revolutionary treatment changing lives by restoring healthy gut bacteria. In this episode, you’ll learn:- What FMT is and why it’s a game-changer for treating recurrent Clostridioides difficile in
Episode 30: Unraveling Neuroendocrine Cancer Research with Mass Spectrometry | Dr. Rachael Guenter
Join us in this fascinating episode of Concentrating on Chromatography as Dr. Rachael Guenter, PhD, shares her eight-year journey researching neuroendocrine tumors. Discover how her background in plant pathology and engineering shaped her translational medicine approach, and learn about the crucial role of mass spectrometry in uncovering protein-level insights in these rare cancers. Dr. Guenter al
Episode 29: HPLC Peak Shapes Explained: Why Your Chromatography Peaks Are Not Perfect & How to Fix Them
Join analytical chemist Dr. M. Farooq Wahab from the University of Texas at Arlington as he breaks down the science behind chromatographic peak shapes in this episode of the Concentrating on Chromatography podcast. Perfect for undergraduate chemists and researchers alike, this conversation covers:- What makes an ideal chromatographic peak shape and why it matters - Common reasons your HPLC peaks m
Episode 28: Building a Global Culture of Lab Sustainability: My Green Lab’s Mission & Impact with Pernilla Sörme
Join us for an insightful conversation with Pernilla Sörme, Technical Program Director at My Green Lab, as we explore how one organization is transforming laboratories worldwide into leaders in environmental sustainability. Discover the driving mission behind My Green Lab, the measurable impact on research and industry, and real-world tips for saving energy and reducing plastic waste in scientific
Episode 27: Unlocking Hemoglobin Variant Detection: LC-HR-MS Breakthrough with Ainslie Chen
In this episode of the Concentrating on Chromatography podcast, host David Oliva interviews Ainslie Chen about her cutting-edge research on hemoglobin variant testing using liquid chromatography-high resolution mass spectrometry (LC-HR-MS). Ainslie discusses her novel method for separating and identifying hemoglobin subunits with mass shifts less than 1 Da, overcoming critical limitations in conve
Episode 26: Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria
Join us for a fascinating conversation with Dr. Subhoja Chakraborty from the University of Central Florida, whose cutting-edge research targets the global challenge of malaria drug resistance. Dr. Chakraborty shares her journey from structure-based drug design during her PhD to her recent collaborative work repurposing human kinase inhibitors as rapid, selective antimalarials against drug-resistan
Episode 25: Host David Oliva Interviewed on Learning, Leadership, and Organomation (Lab Matters Podcast Replay)
In this special episode of Concentrating on Chromatography, host David Oliva steps into the guest role to share his journey as featured on the Lab Matters podcast. David discusses his transition from a passion for business and economics to leading Organomation, a renowned manufacturer of laboratory instrumentation and sample preparation tools. Organomation's flagship products—like the N-EVAP,
Episode 24: Illuminating the Dark Kinome: Mass Spectrometry, Proximity Labeling, and the Future of Kinase Discovery – Isaac Plutzer Interview
Join us for an exciting deep dive with Isaac Plutzer, a graduate researcher at Washington University in St. Louis, as he explores the mysterious "dark kinome"—the hundreds of under-studied protein kinases with high potential for therapeutic discovery. In this interview, Isaac explains what kinases are and why a substantial fraction remain enigmatic, despite being critical regulators of c
Episode 23: The Research Funding Crisis: Dr. Guy Caldwell on NIH Cuts, Lab Survival, and the Fight for Medical Breakthroughs
Join Dr. Guy Caldwell, Distinguished Research Professor at the University of Alabama, for a riveting and urgent conversation that goes beyond the lab bench to the heart of America’s biomedical research crisis. In this episode, Dr. Caldwell—an internationally recognized leader in neurodegenerative disease research—shares the real-world impact of NIH funding freezes, budget cuts, and policy gridlock
Episode 22: How Do We Find Life on Other Planets? The Analytical Chemistry Behind Biosignature Detection
Join us for a fascinating conversation with Dr. Chad Pozarycki, PhD in analytical chemistry and astrobiology, as we dive into the cutting-edge science behind searching for life beyond Earth. In this episode, we explore groundbreaking research on how biosignature molecules—such as amino acids and ATP—can accumulate and persist in extreme, hypersaline brine environments analogous to those found on M
Episode 21: The AI Revolution in Chromatography: Building Massive Retention Databases | Prof. Dwight Stoll
🧪 Transform Your Understanding of Modern Chromatography & AI!Join us for an eye-opening conversation with Professor Dwight Stoll from Gustavus Adolphus College as he reveals how his team is revolutionizing liquid chromatography through high-throughput data collection and machine learning. With over 43,000 retention measurements and groundbreaking research spanning three major publications, Pro
Episode 20: Uncovering PFAS Challenges: Forever Chemicals in Labs with Edward Faden of MAC-MOD
Join David Oliva on the Concentrating on Chromatography podcast as he interviews Edward Faden, Vice President and co-owner of MAC-MOD Analytical, a leading provider of chromatography solutions since 1986. In this insightful discussion, Edward shares the history and expertise of MAC-MOD, based in Chadds Ford, Pennsylvania, and dives deep into the critical challenges of analyzing PFAS (per- and poly
Episode 19: Building DIY Lab Equipment for Water Research: Homemade Nitrogen Evaporators & PFAS Analysis
Join us for an in-depth conversation with Dr. Eamonn Clark, postdoctoral researcher at the University of Hawaii, Mānoa and the Water Resources Research Center, as he shares his journey in water research and laboratory innovation.In this episode:- Dr. Clark introduces his work on water treatment and disinfection byproducts, including research following the Red Hill fuel spill in Oahu.- A behind-th
Episode 18: From Forensic Science to Energy Industry: PhD Chemist's Journey with Advanced Chromatography
Dr. Haleigh Boswell, Research Chemist at Chevron, joins the Concentrating on Chromatography podcast to discuss her fascinating career journey and cutting-edge analytical work in the energy industry. In this in-depth interview, Dr. Boswell shares:🔬 Technical Insights:- How two-dimensional gas chromatography (GCxGC) differs from traditional GC and why it's revolutionary for complex sample analys
Episode 17: From Lab Building to Fingerprint Aging: Dr. Petr Vozka on Advanced Chromatography
In this episode of Concentrating on Chromatography, host David Oliva interviews Dr. Petr Vozka, Assistant Professor at California State University, Los Angeles, about his journey establishing the Complex Chemical Composition Analysis Lab (C³AL).Dr. Vozka shares how he built his research facility during the pandemic, focusing on creating opportunities for first-generation and underrepresented under
Episode 16: Innovative Pyrolysis GC-MS Techniques with Eugene Oga
Eugene Oga, a PhD student in Analytical Chemistry at the University of North Dakota, joins David Oliva to discuss his innovative research on silicone sealant degradation using evolved gas analysis and thermal desorption-pyrolysis gas chromatography. With his background in materials chemistry and current focus on analytical techniques, Eugene shares insights into how these advanced methods can char
Episode 15: Optimizing Lab Sourcing Insights from Academia and Industry
In this enlightening episode of Concentrating on Chromatography, host David Oliva engages in a comprehensive discussion with Lisa Jones, Director of Higher Education Relations at I.W. Tremont Co. and active NAOSMM volunteer, alongside Jim Averso, Co-President at I.W. Tremont and producer of the LabExact brand of laboratory consumables.The conversation explores critical aspects of laboratory supply
Episode 14: Mastering Filtration in Chromatography: Expert Tips on Syringe Filters
In this episode of Concentrating on Chromatography, host David Oliva interviews Jim Averso, Co-President of I.W. Tremont and manufacturer of the LabExact brand, celebrating their 45th year in business. Jim shares expert insights on the critical role of filtration in chromatography sample preparation.Discover:- Why proper filtration is essential for protecting your expensive HPLC columns- How to se
Episode 13: Unlocking Comprehensive Two-Dimensional Gas Chromatography: Simplifying Method Development for Users
Join us on the Concentrating on Chromatography podcast as David Oliva interviews Katelynn Perrault Uptmor, PhD about her recent article, "Detangling the Complex Web of GC x GC Method Development to Support New Users." In this insightful conversation, Katelynn explains the basics of comprehensive two-dimensional gas chromatography (GC x GC), its advantages over traditional one-dimensional
Episode 12: High-Resolution Mass Spectrometry (HRMS) in Palladium-Catalyzed Reactions
Dive into the world of cutting-edge catalysis research with Dr. Roberto Silva Villatoro in this captivating episode of Concentrating on Chromatography. Hosted by David Oliva, General Manager of Organomation, this interview explores how high-resolution mass spectrometry (HRMS) is revolutionizing our understanding of palladium-catalyzed reactions.
Key highlights:
- Discover how HRMS detects elusiv
Episode 11: Sustainable Chemistry & Innovative Chromatography
Join us for an insightful interview with Dr. Isaiah Speight, Assistant Professor at William and Mary, as he discusses his groundbreaking work in sustainable chemistry and innovative chromatography techniques. In this engaging conversation, Prof. Speight shares:
- His research focus on sustainable chemistry from synthesis, financial, and educational perspectives
- The importance of NOBCChE (Natio
Episode 10: Analyzing PFAS and Androgens through HPLC and Radiochromatography
Dive into the world of environmental toxicology with Andrea Andress Huacachino, a PhD student at the University of Pennsylvania. In this fascinating interview, Andrea discusses her groundbreaking research on PFAS (per- and polyfluoroalkyl substances) and their impact on androgen regulation. Learn about:
- The novel finding of PFOA's effect on pre-receptor androgen regulation
- Innovative use
Episode 9: Unraveling Coffee's Potato Taste Defect Insights from 2D Gas Chromatography
Dr. Caitlin Cain discusses her groundbreaking research on potato taste defect (PTD) in coffee using comprehensive two-dimensional gas chromatography (GC×GC). Learn how this advanced technique revealed 359 class-distinguishing analytes related to PTD, providing unprecedented insights into this complex flavor issue.
Key points covered:
- Advantages of GC×GC over traditional one-dimensional GC for
Episode 8: Natural Product Discovery through Liquid Extraction Based Ambient Ionization Mass Spectrometry
Dive into the cutting-edge world of natural product discovery with Jess Deng, a fourth-year PhD candidate at Queen's University. In this engaging interview, Jess discusses her groundbreaking research using ambient ionization mass spectrometry to streamline the discovery of novel fungal metabolites.
Key highlights:
- Learn about the liquid microjunction surface sampling probe (LMJ SSP) and its adv
Episode 7: Antibiotic Drug Discovery UPLC Analysis and Challenges in Medicinal Chemistry
In this insightful interview, Medicinal Chemist Schyler Odum discusses his work in antibiotic drug discovery and the critical role of Ultra-High Performance Liquid Chromatography (UPLC) in his research. Schyler, a fifth-year graduate student at UTHSC, shares his expertise on:
The importance of antibiotic drug discovery in academic institutions
How UPLC differs from HPLC and its benefits in chemica
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