The Knowable Magazine podcast examines the limits of what science can know and how our understanding of major scientific and technological questions evolves over time. Hosted by science journalists Adam Levy and Charlotte Stoddart, each episode tackles a different puzzle, ranging from the existence of black holes to the challenge of building an artificial heart. The show pairs these deep questions with surprising discoveries and fresh perspectives along the way. It is produced as an extension of Knowable Magazine's science journalism.
Episodes

Speech interjections aren't throwaway lines
Bonus episode: Knowable Magazine Podcast co-host Adam Levy talks with linguists Mark Dingemanse and Martina Wiltschko about the importance of the little "throwaway" utterances we use during conversations — such as Mmhmm, Huh? and more. Long ignored by scholarship, these interjections, as they're termed, are key to keeping conversations flowing. But that realization was recent, because much of earl

Quantum entanglement's long journey from 'spooky' to law of nature
Quantum mechanics has always included mind-bending ideas. But the concept of quantum entanglement, famously termed "spooky at a distance" by Albert Einstein in a 1947 letter, seemed to challenge the limits of belief. It remained well on the edges of modern physics until John Stewart Bell's 1964 paper suggesting a way to actually test the baffling idea that two particles can somehow share a measure

How the placebo effect went mainstream
Sloppy by modern standards — and maybe even those back then — a 1955 article on the placebo effect by Harvard anesthesiologist Henry K. Beecher was nonetheless remarkable and influential. It paved the way for sounder drug trials and pushed scientists to better understand how we process pain. To explore its significance, Host Charlotte Stoddart enlisted the help of Ted Kaptchuk, director of the Pro

The fossil that launched a dinosaur revolution
The fossil Archaeopteryx forever changed our understanding of dinosaurs and the origin of birds, but it took a century after its discovery and a one-page paper to shift scientific consensus. Here's the story of that landmark 1973 article by American paleontologist John Ostrom, and published in the journal Nature, describing the bird-like features of Archaeopteryx and convincingly arguing tha

Scientists warned about climate change in 1965. Nothing was done.
A key report to President Lyndon B. Johnson in 1965 warned that humankind was "unwittingly conducting a vast geophysical experiment" through the burning of fossil fuels and a consequent buildup of "the invisible pollutant" — carbon dioxide — in the atmosphere. Here's the story of what happened next to that report — and what didn't, and why. Host Adam Levy speaks with Harvard science historian Naom

How antidepressants changed ideas about depression
Serendipitous discoveries led to drugs like Prozac and to new insights into the physical basis of this debilitating disorder. But scientists continue to search for deeper understandings and therapies that will bring relief to those who still struggle.

How particle accelerators came to be
PODCAST: They started out so small, one could fit on the palm of your hand, but to make groundbreaking discoveries, physicists had to think really big — as in, vast machines with the power and capacity to reveal the tiniest building blocks of our universe.

The history of climate change offers clues to Earth's future
Digging — quite literally — into our planet's past to study its paleoclimate has shed light on bygone ice ages and hints at trouble ahead for our now-warming planet.

Structural biology: How proteins got their close-up
The journey to understanding these critically important molecules, in their thousands of different flavors, began with a chance discovery. Today, after decades of painstaking lab work and dizzying technological leaps, the field of protein science is exploding.

The search for exoplanets
Not that long ago, scientists found evidence that our Sun wasn't unique — other stars have their own orbiting bodies. It was a discovery centuries in the making. What does this mean for Earth today and our place in the universe? (Season 2/Episode. 2) Hyperlinks to scientists and papers in mainbar

The science of dreams
Freud thought that dreams were the gateway to our unconscious mind. Today, many scientists think the opposite: that the dreaming brain is quite similar to our awake, conscious state. But dreaming is a very personal experience and one that we can't share — making the phenomenon very difficult to study. We still don't know for sure why we dream, but in this episode, we'll hear how psychologists, neu

Season two trailer
What are the limits to what's knowable — and how has our thinking about big questions in science and technology has evolved over time? Knowable Magazine's science history podcast returns on February 1, with brand new episodes exploring the science of dreams, the search for extrasolar planets, the quest to treat depression and so much more. Subscribe today to stay in the know. The Knowable Magaz

Memory, the mystery
Memory, the mystery: Just in the past half-century, our understanding of how exactly our brains remember has taken huge leaps. Amazingly, this is just the beginning. The Knowable Magazine podcast from Annual Reviews explores the limits to what's knowable — and how thinking about big questions in science and technology evolve over time.

The dazzling history of solar power
The dazzling history of solar power: Once fringe and futuristic, this renewable energy shines brightly today as a cheap and efficient source of energy. Still, it remains controversial — for much different reasons. The Knowable Magazine podcast from Annual Reviews explores the limits to what's knowable — and how thinking about big questions in science and technology evolve over time.

The heart of invention
Replacing or assisting the human heart with a machine would save countless lives. But the quest to build an artificial heart has had many gruesome missteps and caused researchers to reimagine how to keep our blood flowing. The Knowable Magazine podcast from Annual Reviews explores the limits to what's knowable — and how thinking about big questions in science and technology evolve over time.

How black holes morphed from theory to reality
Black holes, from theory to reality: Physicists were mostly skeptical when the idea of black holes emerged a century ago from Einstein's work. This podcast episode tells the story of how the evidence evolved from circumstantial to conclusive. The Knowable Magazine podcast from Annual Reviews explores the limits to what's knowable — and how thinking about big questions in science and technology evo
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