Everything Epigenetics
Everything Epigenetics is a podcast that demystifies the science of epigenetics, explaining how your behaviors and environment can influence your genetic expression. Host Hannah Went discusses insights that can help you understand your health and improve your life. The show aims to make epigenetics accessible and practical for everyday listeners.
Episodes
Men vs. Women: Who Really Ages Faster?
Aging is a complex process, but have you ever wondered how it differs between men and women? In this week’s episode of the Everything Epigenetics podcast, Sara Hägg, an Associate Professor at Karolinska Institutet, and I discuss the fascinating differences in biological aging between sexes. We explore how genetics, hormones, and lifestyle choices contribute to aging disparities and what that means
Breaking Down Epigenetics: Sperm, Seminal Plasma, and Generational Impact
Epigenetics offers fascinating insights into how our genes are influenced by lifestyle and environmental factors. In this week’s episode of the Everything Epigenetics podcast, Dr. Raffaele Teperino and I delve into groundbreaking research on epigenetic inheritance and how reproductive fitness impacts long-term health. From the transfer of epigenetic material during conception to the role of patern
Methylation Screening Array: A Revolutionary Tool in Epigenetics
DNA methylation, a cornerstone of epigenetic research, is vital for understanding gene regulation and its implications in health and disease. In this week’s episode of the Everything Epigenetics podcast, I speak with David Goldberg and Nicole Renke about the latest advancements in DNA methylation tools, including Illumina's groundbreaking Methylation Screening Array (MSA).We explore the histo
Heart Health and the Future of Epigenetics with Dr. Meesha Dogan
How can epigenetics revolutionize heart disease prevention? In this week’s episode of the Everything Epigenetics podcast, Dr. Meesha Dogan and I discuss the groundbreaking role of AI-driven epigenetics in cardiovascular medicine. Dr. Dogan shares her journey into the field, the life-changing potential of precision diagnostics, and the critical connection between lifestyle and heart health.You&apos
Unlocking Fertility: How Epigenetics Can Predict and Enhance Reproductive Health with Katherine Zagone, ND
Reproductive longevity and fertility are topics that impact women disproportionately across the globe. In this week’s episode of the Everything Epigenetics podcast, Dr. Katherine Zagone and I discuss how epigenetics can unlock key insights into fertility, biological age, and reproductive health. Dr. Zagone shares her journey into the fertility world, her pioneering work at Clockwize, and how biolo
Unlocking the Secrets of Healthy Aging with Dr. Jamie Justice
What does it take to live not just longer but healthier lives? In this week’s episode of the Everything Epigenetics podcast, Dr. Jamie Justice and I explore the groundbreaking research and initiatives shaping the future of healthy aging. From bridging the gap between lifespan and healthspan to revolutionary breakthroughs like the XPRIZE Healthspan prize, we dive deep into the science and innovatio
Epigenetics and Canine Longevity: Unlocking Healthier, Longer Lives for Dogs
In this week’s episode of the Everything Epigenetics podcast, Dr. Christopher Minteer, Nicholas Minteer, and I dive into the fascinating intersection of canine health, longevity, and epigenetics. We explore how their company, Woofgenix, is revolutionizing the field through cutting-edge research and innovative products that aim to extend the lifespan and healthspan of our beloved pets. From underst
Epigenetic Hacks for Longevity: Strategies to Thrive at 62
In this episode of Everything Epigenetics, host Hannah Went sits down with Dave Pascoe, a retired network security architect who’s redefining the way we think about aging. Despite being 62, Dave has been able to have a lower "biological age" and slow pace of aging, a testament to his dedication to health optimization, epigenetics, and biological tuning. Known for ranking among the top co
From Aging to Cancer Risk in Epigenetics with Dr. Chiara Herzog
In this week's episode of the Everything Epigenetics podcast, Dr. Chiara Herzog and I talk about how epigenetics is making waves in the medical world and how it could change treatment. Translational scientist and research fellow Dr. Herzog provides insights from her role in the Biomarkers of Aging Consortium and her work on the TirolGESUND project, one of the largest multi-omic human lifestyl
Epigenetic Aging in Mood Disorders: Exploring the Role of Lithium and Future Therapies
In this week’s episode of the Everything Epigenetics podcast, Dr. Gabriel Fries and I discuss the fascinating intersections of epigenetics, aging, and psychiatric disorders. Dr. Fries, an Assistant Professor in Psychiatry and Behavioral Sciences at UTHealth, shares his groundbreaking research on the molecular underpinnings of mood disorders such as bipolar disorder and suicide risk. We dive into h
Detecting the Undetectable: Epigenetics in Early Cancer Detection with Dr. Joshua Routh
Recent research from the University of Chicago shows that only 14% of cancers in the U.S. are diagnosed after the patient had a recommended screening test. 57% of diagnosed cancers do not have screening tests and account for 70% of all cancer-related deaths. 86% of cancer cases still go undiagnosed after recommended screenings. 16M+ life years saved in the U.S. from early-detection screenings. I
The Future of Kidney Health: How Dr. Charles Breeze Is Changing the Game with Epigenetics
In this week’s episode of the Everything Epigenetics podcast, I’m joined by Dr. Charles Breeze, an expert in computational epigenetics. We talk about his inspiring journey into the field of epigenetics, his trailblazing research on kidney function across diverse ethnic groups, and the innovative tools he's developed to push the boundaries of epigenetic research.Dr. Breeze shares how his fasci
Alzheimer’s Disease as an Epigenetic Disease with Dr. David Katz
Alzheimer’s disease is a devastating neurodegenerative condition that slowly erodes memory, cognitive function, and the ability to perform even the simplest tasks. It’s heartbreaking not only for those diagnosed but also for their loved ones as they watch a gradual loss of the person they knew. This is exactly how I felt in 2015 when I watched my grandmother be taken by this awful disease.The dise
The Power of Single-Cell Epigenetic Profiling with Alex Trapp
In this week’s episode of the Everything Epigenetics podcast, Hannah Went sits down with Alex Trapp, a computational biologist deeply involved in aging research. The two explore the cutting-edge development of single-cell epigenetic clocks and their potential applications in the field of longevity science. Alex shares his journey from experimental biology to computational approaches and discusses
Development and Application of Epigenetic Predictors with Dr. Varun Dwaraka
The development and application of epigenetic predictors of health is revolutionizing the way we understand and approach personalized medicine. These predictors, derived from analyzing DNA methylation patterns, provide a powerful tool for assessing biological age, disease risk, and overall health.By leveraging advanced machine learning and AI, researchers can identify specific epigenetic markers t
Unraveling the Complexity of Epigenetics in the Brain with Dr. Esther Walton
In Europe, people aged 65 typically spend about half of their remaining years managing disabilities. Much of the existing research on aging has predominantly focused on identifying "cures" rather than exploring strategies for healthy aging. Dr. Esther Walton’s is breaking new frontiers with the unconventional approach that aging begins at birth and should be approached through a comprehe
Epigenetic Regulation of Immunity with Dr. Andrew DiNardo
The immune system adapts to various threats through innate and adaptive responses, utilizing epigenetic mechanisms to regulate gene activity without changing DNA sequences. These mechanisms help maintain long-term immune phenotypes, allowing the immune system to respond to changing environments. In innate immunity, epigenetic changes enable immediate pathogen responses, while in adaptive immunity,
Traumas Epigenetic Impact on Mental Disorders with Dr. Janitza Montalvo-Ortiz
In this week’s episode of Everything Epigenetics, I am joined by Dr. Janitza Montalvo-Ortiz, Assistant Professor of Psychiatry at Yale University, who shares her journey into the world of epigenetics and psychiatry. Dr. Montalvo-Ortiz explains the pivotal role of epigenetics in understanding the genetic and environmental factors contributing to psychiatric disorders and emphasizes the importance o
A therapeutic trip: From experience to epigenome with Dr. Candace Lewis
We are entering a new phase of understanding how our social environments affect our biology, particularly how they influence the genes involved in brain development and function. This knowledge helps us see how experiences like stress, trauma, and isolation can cause changes at the molecular level that may increase the risk of mental disorders. On the other hand, we're also exploring how posi
Personalized Nutrition and Epigenetics with Dr. Lucia Aronica
Personalized nutrition tailors dietary recommendations to an individual's unique biological needs, factoring in genetics, lifestyle, and health conditions to optimize health, prevent disease, and maintain overall well-being. Central to this approach is the role of epigenetics, which studies changes in gene expression that do not involve alterations to the DNA sequence but can be influenced by
Epigenetic Gestational Age Prediction with Kristine Løkås Haftorn
Determining a newborn's due date traditionally relies on maternal reports of the last menstrual period and ultrasound scans. These conventional approaches can lead to uncertainties, especially when it comes to identifying deviations from normal fetal development that could impact research into the effects of preterm or post-term births on newborns.However, researchers, including Kristine Løkå
Causal Epigenetic Age Uncouples Damage and Adaptation with Kejun (Albert) Ying
Machine learning models that use DNA markers can estimate the age of biological samples. However, understanding why these markers change with age is challenging because it's hard to prove that these changes cause aging-related traits. In this week’s Everything Epigenetics podcast, I speak with Kejun Ying who uses large datasets to find specific DNA markers that directly influence aging traits
The Importance of the Imprintome with Dr. Randy Jirtle
The idea of the impintome is still foreign to many people. So, let’s start with a simple explanation.For the majority of genes, we inherit two functional copies—one from our mother and one from our father. However, imprinted genes follow a different pattern, as we inherit only one functional copy. Depending on the specific gene, either the copy from our mother or our father undergoes epigenetic si
Integrating Epigenetics into the Social Models of Heath Disparities with Dr. Lauren Schmitz
Did you know that the Great Depression—the worst economic downturn in US history—impacted how fast individuals aged biologically decades later according to their epigenetic aging profiles?!Yep… you read that right. Results show that faster epigenetic aging later in life is associated with worse economic conditions, specifically, during the prenatal period, suggesting it may be a sensitive window f
Prioritizing Your Health Investment with Dr. Jeoff Drobot
I always have a great time chatting with Dr. Jeoff Drobot, and in this podcast he doesn’t disappoint. He is an expert in “age accounting” and often speaks about biological age in terms of environmental debits and credits..What does this look like? Well, retirement should not be the first time you start thinking about longevity. Just like a small amount of money invested well can grow to become sig
Unlocking the Epigenome from a Single Drop of Blood with Dr. Toinét Cronjé
In this week’s Everything Epigenetics episode, I speak with Dr. Toinét Cronjé about what epigenetics can do for the field of epidemiology. Epidemiology is the study of the distribution and determinants of health-related states or events in populations and the application of this study to control health problems. By studying epigenetics and epidemiology in tandem, Dr. Cronjé seeks to understand pat
Tracking and Measuring Biomarkers to Maximize Longevity with Dr. Michael Lustgarten
In this week's Everything Epigenetics episode, I speak with Michael Lustgarten on tracking and measuring biomarkers to maximize longevity. His long-standing goal is to live longer than everyone that has ever lived. To do that, he plans on using the best available science to “biohack” his way to super-longevity. Contrary to the prevailing belief that aging is an inescapable and uncontrollable
Methylation Risk Scores with Dr. Mike Thompson
You may be familiar with polygenic risk scores (PRS), but have you ever heard of methylation risk scores (MRS)? MRS are crucial to understand, as they’re a tool that quantifies DNA methylation levels at specific genomic regions linked to particular conditions, shedding light on the potential impact of epigenetic modifications on disease susceptibility.In contrast, PRS calculates an individual&apos
The Role of Epigenetics in Functional Medicine with Dr. Jeffrey Bland
In this Everything Epigenetics episode, Dr. Jeffrey Bland and I discuss his significant contributions to functional medicines and how he has shaped this field. We also define functional medicine as a multidisciplinary approach that draws on the expertise of various healthcare professionals, including doctors, nutritionists, and researchers, to address complex health issues from a holistic perspect
Assessing the Reproducibility and Integrity of DNA Methylation with Dr. Karen Sugden
The reliability of testing epigenetic DNA methylation using Illumina beadchips is of paramount importance due to the specific intricacies of this technology. Illumina beadchips are widely used platforms for high-throughput epigenetic analysis, employing thousands of probes to measure DNA methylation levels at specific genomic loci. In this week’s Everything Epigenetics podcast, Dr. Karen Sugden an
MOSAIC: Multi-Organ Scores of Aging across Integrated Components with Raghav Sehgal
Various aging clocks have been developed to quantify the aging process and predict age-related diseases. These biological age clocks are powered by different types of omics data and clinical biomarkers, and they’re especially useful for observational studies, clinical trials, and basic science aimed at combating biological aging. Nonetheless, current research indicates that there is significant va
Personalized Biomarkers to Predict Surgery Outcomes with Dr. Christopher Ames
Risk stratification in surgery is a crucial aspect of modern medical practice that involves assessing the potential risks and benefits associated with a surgical procedure for an individual patient. The goal is to optimize patient outcomes and improve decision-making by identifying those who may be at higher risk for complications.While vital for guiding clinical decision-making, current risk stra
Reduce Your Biological Age in Just 8-Weeks with Dr. Kara Fitzgerald
Dr. Kara Fitzgerald's work in epigenetics revolves around the concept of "nutrigenomics" and "nutrigenetics," which are areas that investigate how nutrients and dietary factors can influence gene expression and how an individual's genetic makeup may affect their response to different nutrients.She has been at the forefront of applying epigenetic principles in the cont
A Deeper Dive into DunedinPACE with Dr. Daniel Belsky
According to Dr. Daniel Belsky at Columbia University, there are three limitations of epigenetic biological age clocks:1. Mortality selection Essentially, biological age measures may underestimate true aging because older participants represent slower agers. 2. Cohort EffectsBiological age measures may overestimate true aging because older participants carry an excess burden of early-life exposure
How Fit Are You According to Your DNA? With Kristen McGreevy
As we age, physical fitness tends to decline. This decline can be attributed to various factors such as changes in body composition, reduced muscle mass and strength, decreased flexibility, and diminished cardiovascular endurance. Additionally, the body's ability to recover from physical exertion also tends to slow down with age.It has been well validated that the rate at which this decline o
Predicting Mental Illnesses Using Epigenetics with Dr. Zachary Kaminsky
According to the National Institute of Mental Health, approximately 20% of adults (around 51.5 million people) experience a mental illness each year. I believe that is 51.5 million people too many!There is a HUGE need for the ability to predict mental illness, as the current diagnostic process has many limitations and challenges. By analyzing epigenetic markers associated with mental disorders, we
Epigenetic Coaching with Lindsey Lekhraj
Epigenetic coaching is a revolutionary approach to health and wellness that leverages the latest research on epigenetics to optimize gene expression. As you all know, epigenetics refers to changes in gene activity that are not caused by changes in the underlying DNA sequence, but rather by environmental factors such as diet, stress, and exercise. With the help of an epigenetic coach, like Lindsey
Epigenetic Transgenerational Inheritance with Dr. Michael Skinner
I hate to break it to you, but yes - what your grandmother did directly influences how your DNA is regulated today. This is called epigenetic transgenerational inheritance. Epigenetic transgenerational inheritance refers to the transmission of epigenetic marks from one generation to the next. This phenomenon can occur through the germline and affect the development and health of future generations
Epigenetic Clocks in Patients with Cancer with Dr. Christin Burd
Cancer acts as an accelerator of aging. Furthermore, we know that cancer and cancer therapies can elicit aging-associated cognitive phenotypes and reveal or exacerbate underlying cognitive deficits, increase the risk of physical impairment, heart disease, diabetes and other chronic health conditions, and accelerate the hallmarks of aging. Dr. Christin Burd and her team, from The Ohio State Univers
Human Skeletal Muscle Epigenetic Clock Explained with Dr. Sarah Voisin
Maintaining muscle mass is crucial for healthy aging, as it is closely linked to overall physical function and quality of life. As we age, our bodies naturally experience a decline in muscle mass and strength, known as sarcopenia. This loss of muscle mass can lead to a range of negative health outcomes, including decreased mobility, increased risk of falls and fractures, and decreased metabolic ra
A Clinician's Insight into Epigenetic Informed Medicine with Dr. Mahsin Habib
It’s always a pleasure speaking with Dr. Habib, and in this podcast he doesn’t disappoint. His mantra of “The right treatment, for the right patient, at the right time” has revolutionized the way healthcare providers should approach clinical care. He takes an integrated approach to healthcare, and notes that Next Health is not “married” to a single treatment method or restricted by conventional me
Epigenetic Scores for the Proteome with Danni Gadd
The proteome is the collection of proteins that are present within a specific cell, tissue, or system within the body. Our circulating proteome refers to the proteins circulating in our bloodstream and is made up of proteins that are either produced in the circulatory system, or proteins that enter the bloodstream from other organs and tissues in the body.Why do we care about this? As we know, pro
Biological Age & Stress with Dr. Jesse Poganik
If you’re human, I’m sure you’ve been stressed out at some point in time. Unfortunately, it is an inevitable occurrence during any stage of life. Not only does stress make you feel older, in a very real sense, it can speed up aging. But, what if you could reverse your increased aging following recovery from that stress? In this week’s Everything Epigenetics podcast, Dr. Jesse Pognaik speaks with m
How fast are you aging, really? With Dr. Terrie Moffitt
Measuring your Biological Age has been extremely popularized because of how highly correlated it is to almost every chronic disease and death. However, the Biological Age of a person is limited in the sense that it is a “historical-based” age, meaning it only captures how quickly you’ve been aging since your inception up until the present moment.Have you ever wondered how quickly you’re aging at t
Recommended
10-41: A UCSO Podcast
108.3 WGKSRADIO DEEP HOUSE PARTY
10 at a Time
10Fold Founders
10% Happier with Dan Harris
10-Minute Contrarian
10 Minutes Korean - Learn Korean & English Naturally
10 Minutes with Jesus
10 Minute Teacher Podcast with Cool Cat Teacher
10 minutos con Jesús
10th Floor Podcasts
10 to Life
