Deep Margin
A podcast dedicated to head and neck oncology, featuring conversations about cancer from the collar up. Hosted by Dr Ben O'Leary and Dr Will Ince, it covers topics related to the diagnosis, treatment, and research of head and neck cancers.
Episodes
Episode 27: FLAPS: Foundations, Landmarks and Pioneers in Surgery with Professor Andrew Shache
Andrew Schache joins us - our first New Zealander but out second from the Liverpool head and neck unit. Drawing on his extensive experience, Professor Schache also reflects on the evolution of reconstructive surgery, key developments within the field, and the importance of research, education and innovation in improving patient care. Whether you are a medical student, trainee, surgeon, academic or
Episode 26: Deep Margin goes down under! Lachlan MacDowell talks PROs, survivorship and TROG.
Lockie MacDowell from Princess Alexandra Hospital in Brisbane and the 'Red Journal' talks to us about PROs and his work in helping generate really important evidence around survivorship. We talk sex, side effects, symptoms, communication and mobilising internal resources - something for everyone!
Episode 25: Ymyl Dwfn TNM9 with Professor Mererid Evans
Prof Evans joins us live from sunny Wales to give us the lowdown on TNM 9 and where it sits. This will give Ben and Will something to talk about at parties.
Episode 24: Deep Margin gets skin in the game with Neil Gross
Professor Neil Gross from MD Anderson talks us through his absolutely seminal work in the field of cutaneous SCCs and what this looks like for the head and neck community. Cemiplimab, EMPOWER, C-POST, neaodjuvant strategies - something for all the family.
Episode 23: Terry Jones talks PATHOS trial
Professor Terry Jones, Professor of Head and Neck surgery in Liverpool UK talks us throught the PATHOS trial. Pathos is Greek for "suffering," "experience," or "emotion" and he's shares his work on the trial!
Episode 22: Superstar Nancy Lee talks us through hypoxia, functional imaging and the future of deescalation!
Another rockstar joins us for a great episode talking through some of the advances in head and neck de-escalation
Episode 14 [PART 2]: Chris Holsinger, the robot, E3311; the definitive piece
We're back with Chris Holsinger for part 2 of the TORS adventure
Episode 21: Alan Ho live (post hoc) from the Multidisciplinary Head and Neck Cancers Symposium
Alan Ho, Medical oncologist at MSKCC talks us through his work around Ozuriftamab Vedotin (Oz-V) and other ADC approaches. Ben criticises Will's combination approaches.
Episode 20: PAPER OF THE MONTH Nadeem Riaz talks us through cellular mechanisms of resistance, cluster f**ks and all the ecosystem.
Nadeem Riaz directs the Precision Radiotherapy Initiative and leads a multidisciplinary research lab at the intersection of the DNA damage response and anti-tumor immunity. He talks us through his important paper examining mechanisms of resistance and some of the pitfalls of academia.
Episode 19: NIVOPOSTOP - nivolumab post op - a GORTEC triump with Yungan Tao
Yungan Tao President-Elect GORTEC, and Radiation Oncologist in Head and Neck cancer at Institut Gustave-Roussy talks us through the NICOPOSTOP trial. Will risks diplomatic incidents and out European tour continues.
Episode 18: Our man in Denmark: Jeppe Friborg talks us through DAHANCA/Vores mand i Danmark: Jeppe Friborg taler os gennem DAHANCA
The Danish Head and Neck Cancer (DAHANCA) group was established in 1976 as a working group by the Danish Society for Head and Neck Oncology. Since it has gone from strength to strength and continues to pioneer cooperative group research on a national scale! Current head Jeppe Friborg talks us through their up and coming work. Den danske gruppe for hoved- og halskræft (DAHANCA) blev etableret i 197
Episode 16: PAPER OF THE MONTH ALERT! Immune boost HPV with Mr Meta-Analysis himself Pr Pierre Blanchard
Pierre Blanchard, Professor at Gustave Roussy and Editor of Radiotherapy and Oncology 'the green journal' joins us to discuss his recent trial
Episode 17: Nabil Saba talks us through sinonasal cancer
Professor and Vice-chair of Hematology and Medical Oncology, and Professor of Otolaryngology at the Winship Cancer Institute at the Emory University School of Medicine in Atlanta, Georgia. He talks us through sinonasal histologies . Ben refers Will to social services.
Episode 15: Don't mention the 'P' word; long term functional outcomes with Professor Kate Hutcheson
Superstar Kate Hutcheson, Professor in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center. and Director of Speech Pathology and Audiology talks to us about long term outcomes and examines Will's literacy.
Episode 14 [PART 1] : ding ding round 2 in the red corner it's Chris Holsinger live with the E3311 trial and TORS adventures
Chris Holsinger from Stanford gets grilled by Ben and Will on TORS history in this part 1/2 episode.
Episode 13: Ding Ding: TORS round 1 - the blue corner we have Professor David Palma talking about RT
We talk ORATOR, ORATOR 2 and the genesis of evidence in TORS!
Episode 12: The Nasopharyngeal Gardener talks ctDNA with Dr Melvin Chua
Melvin Chua joins the deeply marginal crowd to talk EBV ctDNA, its clinical use, science, gardening and islands.
Episode 11: Radiotherapy Revolutions with Professor Chris Nutting
Chris Nutting, Professor of Radiotherapy and leader on many pivotal trials at the ICR joins us to talk through the past 25 years of radiotherapy advances and the data underpinning these. We talk about the future and Will has some technical difficulties so there is less nonsense than usual!
Episode 10: The Rockstar talks ctDNA with Dr Glenn Hanna
Dr Glenn Hanna, Director of the Center for Cancer Therapeutic Innovation (CCTI) at Dana Faber Cancer Insitute joins us for our 10th episode and it's a cracker; Glenn talks us through the finer points of ctDNA, MRD and what the future holds for this exciting space.
Episode 9: Salvage surgery and red lines with Vin Paleri
Professor Vin Paleri, Consultant Head and Neck Surgeon at The Royal Marsden Hospitals and Professor of Head and Neck Surgery at the Institute of Cancer Research talks us through salvage surgery data, patient selection and how to tame feral oncologists.
Episode 8: Paul Swiecicki, bispecifics and other unpronouncables!
Paul Swieciki, Associate Professor from Michigan joins us for a deep dive into bispecifics. We talk future targets, current excitiement and Ben gets excited about merchandise and a potential grudge match with friend of the show hardman Ari Rosenberg. It's a belter!
Episode 7: Immuno-radiotherapy with Swashbuckling David Sher, the node whisperer
David Sher, Medical Director of Radiation Oncology, Chief of Head and Neck Radiation Oncology Service at UT Southwestern joins us for a comprehensive discussion about radiotherapy and its interaction with the immune system. We cover SABR, perioperative trials and elective node irradiation; it's quite a journey!
Episode 6: Schilling's Sentinels; Sentinel lymph node biopsy in HNSCC and management of the clinically N0 neck with Clare Schilling
Clare Schilling, Consultant oral and maxillofacial surgeon and honorary associate professor at the University College London Head and Neck Academic Centre (HNAC) joins us live from Birmingham, where Ben likes to holiday. We talk Weiss, D'Cruz, risk and the future. Clare invites Will and Ben to 'have a go at it' too -it's a real blast!
Episode 5: Xevinapant, X-rays and Xmas is coming with Jonathan Schoenfeld
Jonathan Shoenfeld Director of Head and Neck and Melanoma Radiation Oncology at Dana-Farber Brigham Cancer Center, and MGB Endowed Chair in Radiation Oncology joins us for some apoptotic inhibitory catharsis and takes us down his Cambridge memory lane!
Episode 4: Perioperative promises (KEYNOTE 689 and NIVOPOSTOP) with Ravi Uppaluri
Ravi Uppalauri, Director of Head and Neck Surgical Oncology at the Brigham and Women’s Hospital and Dana-Farber Cancer Institute, talks us through his views on 2025's important perioperative trials. Ben leaps like a salmon.
Episode 3: ESMO 2025 The doyen's verdict with Kevin Harrington
Head and neck oncology rockstar Professor Kevin Harrington joins us to talk about his ESMO highlights and Will's criminal tendencies.
Episode 2: ESMO 2025 COMPARE with Hisham Mehanna
Professor Hisham Mehanna comperes and compares arms of COMPARE....
Episode 1: ESMO 2025 Ari's ADCs with Ari Rosenberg
Ari Rosenberg, Assistant Professor at the University of Chicago and medical oncologist gives us his take on ADCs in head and neck cancer some of the latest data , Ben talks military strategy and Will gives fashion tips live from ESMO 2025 inBerlin!
Deep Margin has arrived!
Introductory episode explaining what to expect from the world's newest head and neck oncology podcast.
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