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Health Optimization Medicine Podcast

Health Optimization Medicine Podcast

Health Optimization Medicine and Practice 180 Episodes Oct 14, 2026

The Health Optimization Medicine Podcast explores health optimization, decision-making, consciousness, performance, and human potential through conversations with leading researchers and clinicians. Produced by Health Optimization Medicine & Practice and Smarter Not Harder, Inc., it bridges rigorous science with real-world clinical application. Hosted by Dr. Ted Achacoso, Dr. Scott Sherr, Boomer Anderson, and Jodi Duval, the show features guests like Karl Friston and Donald Hoffman. New episodes are released every Wednesday.

Episodes

Safety Is A Biological State | HOMe Podcast #030
Safety Is A Biological State | HOMe Podcast #030 Oct 14, 2026 42:57 In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz and Jodi Duval explore safety as a biological state and examine what happens when a threat has ended but the body's response has not yet fully resolved. The conversation looks at safety from two interconnected perspectives: the cell and the nervous system. Jodi explains how cells respond to threats through the Cell Dang
Hidden Toxicities In Your Cells Are Making You Sick | HOMe Podcast Special Episode
Hidden Toxicities In Your Cells Are Making You Sick | HOMe Podcast Special Episode Oct 7, 2026 14:06 In this special episode of the Health Optimization Medicine Podcast, Dr. Jup Kuipers, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Scott Sherr discuss how toxicities can build up over time, affect cellular energy production, and eventually show up as problems across different organ systems. The team looks at two clinical cases involving mercury and arsenic exposure, and how symptoms were initially
Eye Health & Vision Optimization w/ Dr. Bryce Appelbaum | HOMe Podcast #029
Eye Health & Vision Optimization w/ Dr. Bryce Appelbaum | HOMe Podcast #029 Sep 30, 2026 47:27 In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Bryce Appelbaum to discuss the connection between vision, screen time, brain function, and nervous system regulation. Most people think of vision as eyesight, or how clearly they can see an eye chart. Dr. Appelbaum explains why vision is much broader. It involves how the brain receives information throu
Unlock Your Brain with Better Glymphatic Clearance | HOMe Podcast #028
Unlock Your Brain with Better Glymphatic Clearance | HOMe Podcast #028 Sep 23, 2026 16:18 In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval explore the glymphatic system and the role sleep plays in clearing metabolic waste from the brain. Getting eight hours of sleep does not necessarily mean getting eight hours of effective brain clearance. The team looks at how the autonomic nervous system, norepinephrine, cerebrospinal fl
The Cellular Mechanisms of Stress | HOMe Podcast #027
The Cellular Mechanisms of Stress | HOMe Podcast #027 Sep 16, 2026 14:15 In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Jodi Duval, and Dr. Allen Bookatz explore what happens inside the cell when the body perceives stress or danger. The discussion focuses on Dr. Robert Naviaux's Cell Danger Response and how mitochondria can alter energy production and signaling in response to perceived threats. The team examines why fatigue, brain fog, in
Read Your Genes! APOE4, Brain Health, and Longevity | HOMe Podcast #026
Read Your Genes! APOE4, Brain Health, and Longevity | HOMe Podcast #026 Sep 9, 2026 10:34 In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Jup Kuipers, Boomer Anderson, Dr. Allen Bookatz, and Dr. Scott Sherr explore a difficult question: can we influence the biology of an aging brain carrying APOE4 risk? APOE4 is not simply a diagnosis, and a genetic result does not tell us what is happening in someone's brain today. The team looks at how APOE4 may aff
Why You're Frozen in Survival Mode: Understanding CDR | HOMe Podcast #025
Why You're Frozen in Survival Mode: Understanding CDR | HOMe Podcast #025 Sep 2, 2026 14:14 In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval sit down to discuss what happens when the body's cellular defense systems remain activated after the original threat has passed. Fatigue and brain fog are often treated as problems that require more stimulation, more exercise, or more supplements. But what if low energy
The Real Cause of Endotoxemia: Leaky Gut Explained | HOMe #023
The Real Cause of Endotoxemia: Leaky Gut Explained | HOMe #023 Aug 26, 2026 15:08 In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers explore a misunderstood cause of chronic fatigue and leaky gut: the bioenergetic failure of your colonocytes. While many practitioners throw random probiotic strains and anti-inflammatory herbs at gut issues, metabolomic research shows this approach fails to addres
Can Creatine Protect the Brain from Sleep Deprivation? | HOMe Podcast #024
Can Creatine Protect the Brain from Sleep Deprivation? | HOMe Podcast #024 Aug 26, 2026 15:16 In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Jup Kuipers explore how acute sleep deprivation affects brain energy metabolism and whether creatine monohydrate can help preserve cognitive function when sleep loss is unavoidable. Rather than relying on stimulants like caffeine or modafinil to push through fatigue, the team
Is Your Cellular Membrane Leaking the Fuel That Keeps You Going? (Why NAD+ Isn't Enough) | HOMe #022
Is Your Cellular Membrane Leaking the Fuel That Keeps You Going? (Why NAD+ Isn't Enough) | HOMe #022 Aug 12, 2026 23:39 In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval explore one of the most overlooked causes of declining cellular energy: the structural breakdown of the mitochondrial membrane. While many people invest in premium longevity supplements like NAD+, NMN, and CoQ10 to improve energy production, emerging research suggests t
Dr. Dominic D'Agostino Explains What Ketones Actually Do to Your Body | HOMe Podcast #021
Dr. Dominic D'Agostino Explains What Ketones Actually Do to Your Body | HOMe Podcast #021 Aug 5, 2026 52:39 In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Dominic D'Agostino, the premier researcher in ketogenic metabolic therapies. Moving past the mainstream fads of keto ice cream and internet trends, they break down how exogenous ketones actually impact cellular energy, cardiovascular health, and environmental stress. From the liver toxicity associated w
Metformin is Poisoning Your Cells | HOMe Podcast #020
Metformin is Poisoning Your Cells | HOMe Podcast #020 Aug 3, 2026 18:47 In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Jodi Duval, and Dr. Jup Kuipers take a deep dive into the shocking new 21-year pre-diabetes follow-up study (DPPOS) published in the Journal of the American Medical Association on June 15, 2026. Moving past the mainstream longevity hype surrounding Metformin as an anti-aging cure-all,

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