Journal of the American Society of Nephrology (JASN)
JASN, the flagship journal of the American Society of Nephrology, publishes basic and clinical science original research articles relevant to the broad discipline of nephrology. The JASN Podcast features discussions with authors of recently published articles, moderated by the JASN Editor-in-Chief and Deputy Editors. Each episode discusses the latest findings featured in the pages of the journal. Additionally, through the Kidney Translation podcast series, Communications Editor Matt Sparks engages with authors on hot topics across the ASN Journal Portfolio. New episodes are available monthly.
Episodes
SHFM3 Is an IS-Dependent IDO1 E3 Ligase
Drs. Chitalia, Almiron, and Sethuraman discuss their study, "Indoxyl Sulfate Promotes Uremic Arterial and Venous Thrombosis by Stabilizing IDO1 via the E3 Ligase SHFM3," with JASN Deputy Editor Alan S.L. Yu and Junior Associate Editor Kyle Jansson.
Barriers to Kidney Transplantation in the United States
Drs. Conor Donnelly, Michal A. Mankowski, and Allan B. Massie discuss the findings of their study, "Evaluating Barriers to Kidney Transplantation in the United States," with JASN Deputy Editor David H. Ellison and Junior Associate Editor Nathan H. Raines.
ASN Kidney Translation Series: ASN Kidney Health Guidance on the Cardiovascular-Kidney-Metabolic Syndrome
This episode of ASN Kidney Translation Podcast explores the ASN Kidney Health Guidance on the Cardiovascular-Kidney-Metabolic (CKM) Syndrome, discussing key recommendations, risk assessment, and strategies to improve kidney, heart, and metabolic outcomes.
APOL1 at the Plasma Membrane and Cytotoxicity
Dr. Oyindamola Christiana Adebayo discusses the results of her study, "Expression of Apolipoprotein L1 Risk Variants at the Plasma Membrane and Haplotype-Dependent Cytotoxicity," on behalf of her coauthors, with JASN Deputy Editor David H. Ellison.
ASN Kidney Translation Series: Cardiovascular-Kidney-Metabolic (CKM) Syndrome Advances
ASN Kidney Translation explores advances in Cardiovascular-Kidney-Metabolic syndrome, including building a cardio-nephrology service (Kidney360), cardiorenal benefits of SGLT2 inhibitors & GLP-1 receptor agonists (JASN), & PREVENT risk prediction (CJASN).
Temporal, Cell-Specific Angiopoietin-2 in CKD
Dr. Fan-Chi Chang discusses findings from her study, "Cell-Specific Roles of Angiopoietin-2 in CKD," with JASN Deputy Editor Alan S.L. Yu.
Cardiovascular Effects of GLP-1 RA in Kidney Failure
Drs. Benjamin Catanese and Daniel Edmonston discuss their study, "Cardiovascular Outcomes among New Users of GLP-1 Receptor Agonists Compared with DPP-4 Inhibitors and Sulfonylureas in Kidney Failure," with JASN Deputy Editor Manjula Kurella Tamura.
ASN Kidney Translation Series: Artificial Intelligence in Nephrology
This ASN Kidney Translation Podcast episode covers advances in artificial intelligence: ASN Workgroup on AI (JASN), AI in nephrology education (CJASN), and ethical issues in AI (K360).
Subclinical Primary Aldosteronism and eGFR Decline
Drs. Gregory Hundemer and Rémi Goupil discuss the results of their study, "Subclinical Primary Aldosteronism and eGFR Decline Over Time," with JASN Deputy Editor David H. Ellison.
ASN Kidney Translation Series: Peritoneal Dialysis
ASN Kidney Translation Podcast episode covers advances in peritoneal dialysis: genetic determinants of ultrafiltration (JASN), fungus-derived ergothioneine depletion in PD (K360), and a survey of PD use in the Veterans Health Administration (CJASN).
PD Use in Health Service Areas, 2009–2020
Dr. Christopher Knapp discusses the findings of his study, "Peritoneal Dialysis Initiation Patterns by Health Service Area during an Era of Expansion," with JASN Deputy Editor Manjula Kurella Tamura.
ASN Kidney Translation Series: ASN Kidney Health Guidance on Conservative Management in People with Kidney Failure
The authors of the ASN Kidney Health Guidance on Conservative Management in People with Kidney Failure discuss optimal approaches to addressing and providing a care path for patients who choose not to pursue dialysis to support personalized patient care.
LCN2-Induced CLUH Inhibition Disrupts Mitochondria in Kidney
Drs. Morgan Gallazzini and Eloïse Marques discuss the results of their study, "Clustered Mitochondrial Homolog Inhibition by Lipocalin-2 Orchestrates Mitochondrial Disruption and Contributes to Kidney Disease," with JASN Deputy Editor Alan S.L. Yu.
ASN Kidney Translation Series: Kidney Transplant Advances
ASN Kidney Translation Podcast episode covers advances in kidney transplantation: an SGLT2i trial in kidney transplant recipients (CJASN), delivery outcomes after kidney transplantation (JASN), and strategies and policies for living donation (Kidney360).
Automatic Organ and Cyst Volumes in ADPKD
Dr. Martin R. Prince discusses the findings of his study, "Automatically Measuring Kidney, Liver, and Cyst Volumes in Autosomal Dominant Polycystic Kidney Disease," with JASN Deputy Editor David H. Ellison.
Coronary Disease Screening Prior to Kidney Transplant
Dr. Avantika Israni discusses the results of her study, "Class 1 Indications for Coronary Revascularization Identified in Prekidney Transplant Screening" with JASN Deputy Editor Manjula Kurella Tamura and Junior Associate Editor Benjamin Lazarus.
ASN Kidney Translation Series: Advances in Glomerular Filtration Rate
This episode of the ASN Kidney Translation Podcast, hosted by Dr. Matthew Sparks, covers CT-based body composition and GFR estimates in cancer (CJASN), transdermal GFR measurement (JASN), and novel hemodynamic markers in acute heart failure (K360).
Bone Marrow Inflammation Drives Glomerular Damage
Drs. Eunsil Hahm and Ryan Spear discuss the results of their study, "Dysregulated Bone Marrow Contributes to Glomerular Injury through Soluble Factors," with JASN Deputy Editor Alan S.L. Yu and Junior Associate Editor Anna Julie Peired.
ICD Code Accuracy for CVD in CKD
Drs. Anna Zemke and Nisha Bansal discuss the findings of their study, "Accuracy of Identification of Cardiovascular Events with International Classification of Diseases Diagnosis Codes versus Physician Adjudication in CKD and Kidney Failure."
Dapagliflozin and HRQoL in Patients with CKD
Dr. Priya Vart discusses the results of his study, "Effects of Dapagliflozin on Health-Related Quality of Life in Patients with CKD," with JASN Deputy Editor Manjula Kurella Tamura.
ASN Kidney Translation Series: Glomerulonephritis
In this ASN Kidney Translation podcast episode, we cover a JASN study on podocyte STAT3 deletion in KLF4 podocytopathy, a CJASN report on early C3G recurrence after transplant, and a Kidney360 study linking foot process effacement to disease progression.
ASN Kidney Translation Series: ASN Kidney Health Guidance on Potassium and Phosphorus Food Additives
The authors of the ASN Kidney Health Guidance on Potassium and Phosphorus Food additives discuss clinical approaches to managing hyperkalemia and CKD-mineral and bone disorder risks associated with food additives for people with kidney disease.
RNA Sequencing of IgA Nephropathy Kidneys
Drs. Anna Levin and Annika Wernerson discuss the findings from their study, "Transcriptomic Patterns in Adult and Pediatric Patients with IgA Nephropathy or IgA Vasculitis with Nephropathy," with JASN Deputy Editor David H. Ellison.
Alternative Splicing and Polyadenylation in Glomerular Disease
Drs. Shipra Agrawal and Monoj K. Das discuss the results of their study, "RNA Alternative Splicing and Polyadenylation and Regulation of the Glomerular Filtration Barrier," with JASN Deputy Editor Alan S.L. Yu and Junior Associate Editor Jason O. Wu.
ASN Kidney Translation Series: Cardiovascular-Kidney Connection
Kidney Translation Podcast discusses cardiovascular and kidney disease studies: CKM syndrome stages and mortality prediction, cardiac risk prediction in patients with kidney failure undergoing noncardiac surgery, and SGLT2 inhibition in type 1 diabetes.
The PEER-HD Randomized Controlled Trial
Dr. Ladan Golestaneh discusses the findings of her study, "Effect of Peer Mentorship on Hospitalizations among Patients Receiving Maintenance Hemodialysis: A Pragmatic Randomized Controlled Trial," with JASN Deputy Editor Manjula Kurella Tamura.
Disaster Management in Kidney Care
Dr. Shaifali Sandal and Saly El Wazze discuss the results of their study, "A Roadmap for Disaster Risk Reduction and Management in Kidney Care: A Scoping Review and Content Analysis," with JASN Deputy Editor Manjula Kurella Tamura.
Regulation of Renal Glucose Handling by mTORC2
Drs. David Pearce and John Demko discuss the results of their study, "Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium," with JASN Deputy Editor David H. Ellison.
Drug Screening in Drosophila Nephrocytes
Dr. Tobias Hermle and Dominik Spitz discuss the findings of their study, "A Drug-Screening Platform for Podocytopathies in Drosophila Nephrocytes," with JASN Deputy Editor Alan S.L. Yu.
ASN Kidney Translation Series: ADPKD Advances
On this ASN Kidney Translation Podcast, Dr. Matthew Sparks discusses key ADPKD studies: circadian clock disruption and cyst growth (JASN), depressive symptoms in adults with ADPKD (Kidney360), and biomarker-based kidney outcome prediction (CJASN).
Anticoagulation in Dialysis Recipients with Atrial Fibrillation
Dr. Ziv Harel discusses findings from his study, "Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis: A Pilot Randomized Controlled Trial," with JASN Deputy Editor Manjula Kurella Tamura.
CASR Determines Renal Response to Hypercalcemia
Drs. Henrik Dimke and Nina Himmerkus discuss the results of their study, "Calcium-Sensing Receptor in the Thick Ascending Limb and the Renal Response to Hypercalcemia," with JASN Deputy Editor David H. Ellison.
ASN Kidney Translation Series: ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury
The ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury provides strategies to optimize recovery, implement individualized care, and coordinate best practices in AKI-D management.
ASN Kidney Translation Series: Kidney Stones
In this episode of the ASN Kidney Translation Podcast series, Dr. Matthew Sparks dives into groundbreaking kidney stone research from JASN, CJASN, and Kidney360, exploring CKD risk, asymptomatic stone passage, and how pharmacotherapy affects recurrence.
Molecular Signature of NPCs in the Catshark
Drs. Agnès Boutet and Yasmine Lund-Ricard discuss the findings from their study, "Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula," with JASN Deputy Editor David H. Ellison.
Acetazolamide and the Kidney in T1D
Dr. Charles Ginsberg discusses the results of his study, "Acetazolamide Therapy and Kidney Function in Persons with Nonalbuminuric Diabetes Mellitus Type 1," with JASN Deputy Editor Manjula Kurella Tamura.
Kidney Protection by Acetylcholine
Drs. Luan D. Truong, Richard J. Johnson, and Gabriela Espinosa Garcia discuss the findings from their study, "Production of Acetylcholine by Podocytes and its Protection from Kidney Injury in Glomerulonephritis," with JASN Deputy Editor Alessia Fornoni.
ASN Kidney Translation Series: Genetic Testing in Nephrology
On this ASN Kidney Translation episode, Dr. Matthew Sparks hosts discussions on nephrology research in genetics. Topics include genetic testing in CKD, ADTKD screening, and digenic Alport syndrome insights.
JASN Welcomes Basic Science Research
JASN encourages investigators to submit their basic science original research to the journal. Editor-in-Chief Rajnish Mehrotra and Deputy Editors Alessia Fornoni and David H. Ellison discuss the types of basic research that JASN publishes.
ASN Kidney Translation Series: Novel Therapies for IgA Nephropathy
Novel therapies for IgA nephropathy are discussed in this ASN Kidney Translation podcast episode, including efficacy and safety of ravulizumab, selective endothelin receptor antagonist SC0062, and long-term results from a study of atacicept as treatment.
Polycystin-2 Regulates Natriuretic Peptide Production
Drs. Ivana Kuo and Karla M. Márquez-Nogueras discuss the results of their study, "Cardiac Localized Polycystin-2 in the Natriuretic Peptide Signaling Pathway and Hypertension," with JASN Deputy Editor David H. Ellison.
ASN Kidney Translation Series: ASN Kidney Health Guidance on the Management of Obesity in Persons Living with Kidney Diseases
The inaugural ASN Kidney Health Guidance on the Management of Obesity in Persons Living with Kidney Diseases examines psychosocial considerations, lifestyle modifications, pharmacologic options, and metabolic/bariatric surgery.
KLF15 Agonist in Kidney Disease
Drs. Sandeep K. Mallipattu and Bhaskar Das discuss the findings from their study, "A Small Molecule Agonist of Krüppel-Like Factor 15 in Proteinuric Kidney Disease," with JASN Deputy Editor Alessia Fornoni.
Stem Cells in Renovascular Disease
Dr. Lilach O. Lerman discusses the results from her study, "Renovascular Disease and Mitochondrial Dysfunction in Human Mesenchymal Stem Cells," with JASN Deputy Editor Alessia Fornoni.
ASN Kidney Translation Series: Gender Equity in Nephrology
Issues of gender equity in nephrology are covered in an episode of ASN Kidney Translation: An ASN Journals' Podcast, including equal access to mentorship and research opportunities, fellowship programs' parental leave policies, and representation in RCTs.
Complications of Uninephrectomy
Drs. Alicia A. McDonough and Aurelie Edwards discuss the findings from their study, "Potassium-Alkali–Enriched Diet, Hypertension, and Proteinuria following Uninephrectomy," with JASN Deputy Editor David H. Ellison.
JASN Welcomes Late-Breaking Clinical Trial Manuscript Submissions
JASN encourages investigators to submit their late-breaking clinical trial manuscripts for rapid consideration and peer review and, if accepted, online publication in JASN concurrent with Kidney Week.
sGC Activator Avenciguat for CKD
Dr. Hiddo J.L. Heerspink discusses the findings from his study, "Effect of Avenciguat on Albuminuria in Patients with CKD: Two Randomized Placebo-Controlled Trials" with JASN Editor-in-Chief Rajnish Mehrotra.
Absolute CKD Progression Risk
Drs. Maria Clarissa Tio and Tariq Shafi discuss the findings from their study, "Individualized Risk of CKD Progression among US Adults" with JASN Deputy Editor Manjula Kurella Tamura.
ASN Kidney Translation Series: PPI, Antivirals, and Cough Syrups: Nephrotoxins and Kidney Injury
The effect of pantoprazole on eGFR slope, antiviral medications for Herpes Zoster, & link between pediatric AKI in Uzbekistan and cough syrups are covered in this episode of ASN Kidney Translation: An ASN Journals' Podcast.
Tubular Effect of Proteinuria
Andrew Hall discusses results of his study, "Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria," with JASN Deputy Editor David H. Ellison.
Set7 Regulates Glomerular Injury
Assam El-Osta discusses the findings from his study, "Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells," with JASN Deputy Editor David H. Ellison.
Daprodustat and Heart Failure in CKD
Jonathan W. Cunningham and Ajay K. Singh discuss the results of their study, "Daprodustat and Heart Failure in CKD," with JASN Deputy Editor David H. Ellison.
Changes in ESKD Incidence
Susan R. Mendley and Chyng-Wen Fwu discuss the findings of their study, "Age- and Race-Specific Changes in ESKD Incidence over Four Decades," with JASN Editor-in-Chief Rajnish Mehrotra.
Dr. Briggs and Dr. Mehrotra discuss the next chapter for JASN
In this podcast, outgoing Editor-in-Chief Josie Briggs talks with incoming Editor-in-Chief Raj Mehrotra about his vision for the next chapter of JASN.
SGLT2 Inhibitors and Continuation of Renin Angiotensin Blockade
Dr. Briggs and Brendon Neuen discuss his paper in the December issue of JASN. This article on the CREDENCE and EMPA-CKD clinical trials shows that SGLT2 inhibitors allow more consistent use of RAS blockade in patients with declining renal function.
Kidney Transplant Registry Data: Advice for Users
In this podcast, EIC Josie Briggs talks with Associate Editor John Gill about the valuable data resources for research on kidney transplantation. Drs. Gill and Briggs provide some advice for users of these important resources.
Next Steps in Development of Mesenchymal Stem Cells as Possible Therapeutic for Kidney Disease
In this podcast, EIC Josie Briggs talks with Giuseppe Remuzzi about the NEPHSTROM Trial & the next steps in translational work to test the possibility that mesenchymal stem cells can be used as a therapeutic agent to promote repair of kidney damage.
Historical Redlining and the Incidence of Kidney Failure in US Cities
In the podcast, EIC Josie Briggs discusses a paper entitled "Structural Racism, Historical Redlining, and Incidence of Kidney Failure in US Cities" with co-authors Kevin Nguyen and Deidre Crews.
Antibiotic Use & Kidney Stones and Sodium Bicarbonate & the Vascular Dysfunction of CKD
In the episode, EIC Josie Briggs discusses a randomized control trial addressing the impact of sodium bicarbonate on the vascular dysfunction in CKD and an observational case control study of the impact of antibiotic use on kidney stone formation.
How Many Nephrons in a Human Kidney? A New Number and a Discussion of Why it Matters
In this podcast, Dr. Josie Briggs discusses with Dr. Andrew Rule his latest study showing the need to revise our estimate of the number of nephrons in the human kidney.
The Angiopoietin-Tie 2 Pathway is Ischemic Kidney Injury
In this episode, JASN Associate Editor Katalin Susztak talks with Dr. Susan Quaggin about work from her laboratory on ischemic injury and translational targets in the Angiopoietin-Tie 2 pathway.
Urea and Uremia
JASN EIC Josie Briggs talks with Deputy Editor Tom Hostetter about the unsolved problem of the chemical causes of the uremic syndrome. A new study reports a correlation of outcomes in CKD with protein carbamylation, a breakdown product of urea.
Genomic Diagnostic Methods for CKD
This podcast covers two papers, one describes a clinical workflow for incorporating whole exome sequencing and the other provides evidence genomic disorders contribute to monogenic CKD in adults and children.
Intensive BP Control and CKD Progression and Prognosis in Anti-GBM Disease
In the March podcast, Dr. Briggs discusses a study that addresses prognostic measures in Anti-GBM Disease and a meta-analysis of studies testing whether intensive blood pressure controls slows progression of CKD.
Pregnancy Risk for Kidney Patients; Cost Effectiveness Research in Dialysis
In this Podcast, Dr. Briggs summarizes the goals of the new JASN Special Series, Health Policy Catalyst, and summarizes papers focusing on cost effectiveness research in nephrology and on the special risk of unwanted pregnancies for kidney patients.
Use of Kidney Organoids to Study Steroid-Resistant Nephrotic Syndrome
In this podcast, Dr. Briggs discusses organoid studies with author Dr. Melissa Little. The work explores the varied molecular mechanisms of specific mutations that cause SRNS and suggests promise for eventual design of mutation-specific treatments.
Highlights in Renal Transplantation
In this podcast, EIC Dr Briggs discusses two studies on kidney transplantation with Dr. John Gill. Topics discussed include novel molecular markers and the role of HLA-DQ mismatches, work suggesting new approaches to reduce chronic graft loss.
Comparing Costs of Hemodialysis and Peritoneal Dialysis
In this podcast, EIC Josie Briggs talks with Lekha Tummalapalli about a study addressing costs of hemodialysis and peritoneal dialysis. An editorial on this issue is published in the November (33.11) issue of JASN.
Gender Differences in Care of CKD Patients
In this podcast, JASN EIC, Josie Briggs talks with Juan-Jesus Carrero, Professor of Kidney Disease Epidemiology at Karolinska Institute. His study, published in the October issue of JASN, documents striking differences in care of men and women with CKD.
Climate Change: Implications for Nephrology
In this episode we cover two papers that examine the impact of climate change on nephrology practice. Specifically, the effect of extreme weather events on hemodialysis patient mortality and greenhouse gas emissions associated with dialysis treatment.
August 2022 JASN Highlights: Addressing CKD Progression and Hazards of Intradialytic Hypotension
Two highlighted clinical studies: the first addresses the effect of combining a SGLT2 inhibitor and a MRA on proteinuria; the second considers vascular reactivity as a risk factor for cerebral hypoxia when blood pressure falls during dialysis treatments.
Addressing Racial and Ethnic Disparities in Kidney Disease
In this podcast, Dr. Briggs and JASN Deputy Editor, Dr. Donald Wesson discuss the special series highlighted in the July Issue. The series focuses on kidney health disparities with an emphasis on strategies for their elimination.
Discontinuing Immunosuppressant Use after Allograft Failure: Do We Have the Answers?
Dr. Briggs summarizes findings in a study published in the June issue of JASN. The study examines the impact of continued immunosuppression in patients with failed allografts; the effects are surprising and suggest current guidelines may not be optimum.
A New Approach to Advance Care Planning for Dialysis Decisions: Deciding not to Decide
In this podcast Dr. Briggs talks with Dr. Kate Butler about advance care planning for patients with chronic kidney disease.
JASN May 2022 Highlights: Inflammation as a Driver of CKD Progression
In the May 2022 JASN highlights, Dr. Briggs summarizes two important studies on the role of inflammation as a driving factor in the progression of CKD.
Roxadustat and the Interpretation of Non-Inferiority
In this Podcast, JASN EIC, Josie Briggs, discusses a clinical trial from the April issue on roxadustat in dialysis patients with Magdalene Assimon. Dr. Assimon explains the interpretation of the finding that roxadustat is non-inferior to epoetin alpha.
The Renal Framingham - CVD Prediction
Kidney patients are at high risk for cardiovascular disease. In this Podcast, Dr. Briggs talks and Dr. David Charytan discuss recent work to improve the prediction of CVD in kidney patients. New work from CRIC aims to update the Framingham equation.
Lowering GFR to Protect GFR!
In this episode, Dr. Josie Briggs and Dr. Brendon Neuen discuss the GFR paradox: SGLT inhibitors and other kidney-protective drugs initially cause a drop in GFR.
Insights into Collapsing Glomerulopathy
Josie Briggs talks with Nicholas Steers about his work using inbred mice strains to understand the genetic factors that result in collapsing focal segmental glomerulosclerosis in HIV nephropathy, insights also relevant to a rare complication of COVID-19
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