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The Root Cause Medicine Podcast

The Root Cause Medicine Podcast

Rupa Health 339 Episodes Oct 9, 2026

The Root Cause Medicine Podcast, hosted by Rupa Health, explores the underlying causes of various medical conditions. Each episode features interviews with renowned medical experts, specialists, and pioneers who have shaped the understanding and treatment of specific diseases. The podcast aims to provide listeners with insights into root causes, symptoms, and available treatments.

Episodes

The Gut Ecosystem: An Update on How Keystone Species Shape the Microbiome
The Gut Ecosystem: An Update on How Keystone Species Shape the Microbiome Oct 9, 2026 1:05:15 Dr. Oscar Coetzee joins Dr Lara Zakaria on the Root Cause Medicine Podcast to discuss emerging research on keystone commensal organisms and how microbial communities interact within the gut ecosystem.The conversation focuses on organisms including Akkermansia muciniphila, Faecalibacterium prausnitzii, Roseburia, Bifidobacterium longum, and Bifidobacterium adolescentis. Rather than viewing individu
Menopause Botanicals: Identity, Standardization & Patience
Menopause Botanicals: Identity, Standardization & Patience Oct 1, 2026 26:18 Dr. Eric Viegas joins the Root Cause Medicine Podcast to discuss an often-overlooked part of evaluating botanical supplements for menopause: whether the product being used actually matches the ingredient that was studied.The conversation focuses on five botanicals and botanical categories—black cohosh, Vitex (chasteberry), rhapontic rhubarb, maca, and soy isoflavones. Rather than framing individua
Meet the New Voices of  the Root Cause Medicine Podcast
Meet the New Voices of the Root Cause Medicine Podcast Sep 24, 2026 55:55 You've been hearing new voices in the host chair lately — so this week we're pulling back the curtain to introduce them properly. Dr. Kate Kresge sits down with Dr. Holly Lucille, Dr. Lara Zakaria, and Dr. Jessica Christie for a roundtable on the winding, deeply personal paths that led each of them into root-cause medicine.A pharmacist nearly buried under her own stack of nutrition books who came
C15:0, ferroptosis, and metabolic health: What practitioners should know
C15:0, ferroptosis, and metabolic health: What practitioners should know Sep 17, 2026 54:01 Dr. Lara Zakaria is joined by Stephanie Venn-Watson, DVM, MPH, to explore emerging research on pentadecanoic acid (C15:0), an odd-chain saturated fatty acid initially studied through research involving bottlenose dolphins.The conversation connects C15:0 with cell-membrane composition, lipid peroxidation, ferroptosis, iron metabolism, metabolic health, and steatotic liver disease. It also examines
Medicine for All People: Food, Nature, Community, and Joy as Part of Whole-Person Care
Medicine for All People: Food, Nature, Community, and Joy as Part of Whole-Person Care Sep 10, 2026 1:06:46 Dr. Geeta Maker-Clark joins the Root Cause Medicine Podcast to discuss ideas from her book, Medicine for All People: Science and Ancient Wisdom for Revolutionary Healing. Drawing from family medicine, integrative medicine, culinary medicine, community health and her own upbringing, she explores a broader view of medicine that includes food, plants, nature, community, service, trust, dance, gratitu
Beyond the Label: What Matters in Curcumin and Boswellia Quality
Beyond the Label: What Matters in Curcumin and Boswellia Quality Aug 27, 2026 24:46 Dr. Holly Lucille, ND, is joined by Ellie Abraham, PhD, to explain why two curcumin or Boswellia supplements may not be equivalent, even when the front of the label looks similar. The conversation covers boswellic acid standardization, AKBA, curcumin delivery systems, piperine, botanical sourcing, finished-product testing, certificates of analysis, and supply-chain controls. Research supports mean
Immunometabolism: What Your Immune System Can Teach You About Metabolic Health
Immunometabolism: What Your Immune System Can Teach You About Metabolic Health Aug 22, 2026 59:33 What if metabolism and immune function aren’t separate systems, but part of one continuous conversation?In this episode of the Root Cause Medicine Podcast, Dr. Jeffrey Bland joins Kate Kresge to explore immunometabolism, the study of how immune activity and cellular metabolism influence one another. They discuss how inflammation can affect energy use across tissues, why metabolic health is about
One Hidden Immune Trigger Everyone Misses: A Complex Autoimmune Case Study
One Hidden Immune Trigger Everyone Misses: A Complex Autoimmune Case Study Aug 17, 2026 12:27 What happens when a patient with multiple autoimmune conditions has already addressed the obvious contributors—but continues to experience flares?In this Root Cause Medicine Podcast case study, Dr. Kate Kreske sits down with clinical nutritionist and IFM-certified practitioner Robyn Puglia to explore a complex case involving polyautoimmunity and persistent immune dysregulation. The patient had alr
TG6, Lymphocyte Patterns and Early Autoimmunity
TG6, Lymphocyte Patterns and Early Autoimmunity Aug 13, 2026 1:07:12 What if some of the immune activity we’re looking for isn’t showing up where we expect to find it?In this episode, I sit down with Robyn Puglia of Cyrex Laboratories to explore TG6, lymphocyte patterns, and early autoimmunity—and specialized testing many practitioners may not realize is available through Cyrex Wheat Burden panel, the Lymphocyte Map, and Array 5.We look at neurological manifestatio
The Missing Piece in Youth Sports: Building Healthy, High-Performing Teen Athletes
The Missing Piece in Youth Sports: Building Healthy, High-Performing Teen Athletes Aug 6, 2026 55:09 What does it take to help young athletes perform at their best—not just today, but for decades to come?In this episode of Root Cause Medicine, Dr. Kate Kresge sits down with emergency medicine physician and functional medicine practitioner Dr. Erik Peterson to discuss a whole-person approach to adolescent athletic performance. Drawing from more than 20 years in emergency medicine, his background a
How to Build a Thriving Practice Without Burning Out
How to Build a Thriving Practice Without Burning Out Jul 30, 2026 47:07 How to Build a Thriving Practice Without Burning OutOne of my favorite parts of hosting the Root Cause Medicine Podcast is introducing you to practitioners who are making a real difference—not only in the lives of their patients, but in the lives of other clinicians.Today's guest is Lesli Bitel, a registered dietitian whose career has taken a path that many practitioners may recognize pieces of. S
Root, Leaf, Extract: What Matters in Ashwagandha
Root, Leaf, Extract: What Matters in Ashwagandha Jul 17, 2026 18:49 Dr. Holly Lucille is joined by Ellie Abraham, PhD, to explain why two ashwagandha supplements may not be the same, even when they list the same ingredient. (Thalhamer 2024) This conversation covers differences between root and leaf extracts, withanolide standardization, botanical identity testing, certificates of analysis, and manufacturing quality. It also emphasizes that a well-made product may

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