
MeSsy with Christina Applegate & Jamie Lynn Sigler
Christina Applegate and Jamie Lynn Sigler open up about the unexpected challenges life throws at them, specifically their experiences living with multiple sclerosis. Each week, they engage in raw, often humorous conversations with each other, friends, co-stars, and others who help them navigate the messiness of life.
Episodes

Learning to Love Every Version of Yourself with Tiffani Thiessen
This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of yourself. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational im

What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui
This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur

I Don’t Have a Lot of Fight in Me Right Now
This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational impact for people living

How to Live With What You Can’t Control with Ana Rodriguez
In the final episode of Living With It, Jamie sits down with her therapist, Ana Rodriguez, to talk about what it really means to heal when life doesn’t go according to plan. They explore grief, resilience, uncertainty, and the ways we avoid our feelings by trying to fix them or find meaning too quickly.Novartis in neuroscienceo Our ambition is to create a transformational impact for people living

The Hardest Fight Is Learning to Rest with Alberto Crane
This week, Jamie sits down with jiu-jitsu champion and former UFC fighter Alberto Crane to talk about how his MS diagnosis forced him to redefine what it means to be strong. Alberto opens up about learning to slow down, embrace rest, and why sometimes being a fighter means knowing when not to push through.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engine

Stop Apologizing for Wanting More with Heather Dubrow
This week on Living With It, Jamie sits down with Heather Dubrow for an honest conversation about embracing life’s pivots, protecting your peace, and giving yourself permission to want more. Novartis in neuroscienceo Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovativ

There Is Beauty Within All of This Pain with Lindsey Kraft
This week on MeSsy, Jamie sits down with her longtime friend, actress, writer, and musician Lindsey Kraft. They talk about growing up together, navigating rejection and self-doubt, and Lindsey’s unexpected journey from acting to writing her own one-woman musical.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored b

Falling Apart to Come Back Together with Ryan Weiss
This week on Living With It, Jamie sits down with her friend, Ryan Weiss. They talk about letting go of control, sitting with difficult emotions, knowing when it’s time to do things differently, and learning to trust what’s on the other side when life doesn’t look the way you thought it would.Novartis in neuroscienceo Our ambition is to create a transformational impact for people living with sever

Thank God I’m So Neurotic with Cat Cohen
This week on MeSsy, Jamie sits down with comedian, actor, and singer Cat Cohen. Cat opens up about having a stroke at 31, navigating health anxiety in the aftermath, and turning one of the scariest experiences of her life into her most fulfilling creative work yet.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored

We Fight For Joy with Kelsey Chittick
This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a life she never expected. They discuss finding humor in the darkest moments, letting go of the life you thought you’d have, the power of community, and how to choose joy.
Novartis in neuroscience
o Our ambition is to create a transf

There’s No Place Like Home with Annie Meyers-Shyer
This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new passion and career at 45, and why it’s never too late to bet on yourself. Annie also shares how she creates a home that feels like an exhale, the small ways our spaces can support us through difficult seasons, and how her home carried

The Power of Radical Acceptance with Jim Curtis
This week on Living With It, Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you have without giving up hope for the life you want, the stories we build around our suffering, and learning to see your body as an ally instead of the enemy. Plus, Jim shares how releasing old beliefs and changing the way we speak to

Jamie's Son Beau
This week, Jamie sits down with a very special guest: her 13-year-old son, Beau. They have an honest conversation about what it’s been like growing up with a mom who has MS, how Jamie’s strength has shaped him, and what he wants other kids and parents living with chronic illness to know.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch

Accept, Adapt, Appreciate with Odette Annable
This week on Living With It, Jamie sits down with her friend Odette Annable. They discuss parenting a neurodivergent child, trusting your instincts, advocating for your family, and learning to let go of the need to have all the answers.
Novartis in neuroscience
o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discov

The Courage to Slow Down
This week on MeSsy, Jamie opens up about reaching her limit and learning to make rest part of healing. She also reads listener emails about fighting to be heard by doctors, learning to accept help, and the power of knowing you're not alone.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in ne

Finding Stillness When Life Won’t Slow Down with Bob Roth
This week on Living With It, Jamie sits down with Bob Roth, a leading Transcendental Meditation teacher and CEO of the David Lynch Foundation. They discuss what stress does to the body, how meditation can help calm the nervous system, and how finding stillness can help us navigate uncertainty, illness, and everyday life.
Novartis in neuroscience
o Our ambition is to create a transformational impac

How Death Informs How We Live with Julie McFadden
This week, Jamie sits down with hospice nurse Julie McFadden to talk about changing the way we think about death, what she’s learned from those at the end of life, and how accepting our mortality can help us live more fully in the present.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuros

Trusting the Journey with Becca Tobin
This week, Jamie sits down with one of her best friends, Becca Tobin, for a conversation about infertility, pregnancy loss, surrogacy, and finding hope after years of uncertainty. They explore grief, resilience, the unexpected paths to parenthood, and what it means to keep moving forward when life doesn't unfold the way you imagined.
Novartis in neuroscience
o Our ambition is to create a transform

Try to Find the Light with Amanda Kloots
This week, Jamie sits down with Amanda Kloots for an honest conversation about finding joy alongside heartbreak. Amanda opens up about losing her husband, Nick Cordero, how her grief has evolved over the past six years, why she no longer believes we have to "let go" of the people we love, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Jo

Look for the Signs with Kate Doerge
On this episode of Living With It, Jamie sits down with Kate Doerge to discuss finding hope after profound loss, recognizing signs from loved ones, and the five actions that can transform the way we move through grief.
Novartis in neuroscience
o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing

Hope Can Exist Alongside Fear with Myriam Sandler
This week, Jamie sits down with Mothercould creator Myriam Sandler. They discuss her recent MS diagnosis, trusting your intuition, and finding hope even when life doesn't go as planned.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a transformatio

It's Okay Not to Be Okay with Amy Kurtz
On the first episode of Living With It, Jamie sits down with Amy Kurtz, a patient advocate and author. They discuss the grief of chronic illness, learning to trust yourself again, and why healing is about so much more than getting better.
Novartis in neuroscience
o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by disc

All Eyes on Me
This week, Jamie reads listener emails and opens up about the feeling of all eyes on you when you're struggling, the anxiety of the lead up, caregiving, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a transformational impact for people livi

Tamsen Fadal
This week, Jamie sits down with journalist, author, and menopause advocate Tamsen Fadal. They discuss the physical and emotional realities of perimenopause, why so many women feel dismissed by the medical system, and how speaking honestly about aging, identity, and women's health can help us all feel less alone.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Aud

You Do Not Have to Become Someone Else to Heal
This week, Jamie reads listener emails and discusses the invisible weight of living with chronic illness, the courage it takes to keep showing up, and the small moments that can bring us back to ourselves. She also shares the reminder she received from a recent on stage performance.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Thi

Erin Moriarty
This week, Jamie sits down with Erin Moriarty. They discuss Erin's journey with Graves' disease while starring in "The Boys," the invisible toll chronic illnesses can take on your mental health, learning to advocate for yourself, and why vulnerability may be the greatest form of strength.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisc

Mia Calabrese
This week, Jamie is joined by Summer House’s Mia Calabrese. She opens up about her journey with grief and what’s helped her to find joy again. They also discuss the Summer House scandal and Mia shares her thoughts on the reunion and bonus episode.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novarti

Choose Yourself
This week, Jamie reads emails from listeners. She also discusses mom guilt, PMS and MS, letting people know how their actions affect you, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a transformational impact for people living with se

Our Favorite Bravo Men
This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Ou

Aida Turturro
This week, Jamie sits down with the one and only Aida Turturro. They reflect on their years together on The Sopranos, and Aida discusses living with rheumatoid arthritis since childhood, perspective, and finding gratitude during difficult times.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in

What the F*ck Is Normal Anyway?
This week, Jamie reads listener emails and discusses what it means to feel seen, the complicated balance between grief and gratitude, and why you don’t have to be “perpetually positive” to keep moving forward.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to

Lena Hall
This week, Jamie is joined by Tony Award-winning actress and singer Lena Hall. They discuss being present in grief, the power of healing, finding your way back to yourself, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a transformational i

Revisiting Our Convo with Martin Short
In honor of 'Marty, Life is Short,' we are revisiting our conversation with Martin Short. He reminisces, shares funny stories, discusses colonoscopy parties, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurologi

A Conversation with Jamie’s Therapist
This week, Jamie sits down with her therapist, Ana Maria Rodriguez, who is a licensed clinical mental health therapist and the founder and owner of Selva Wellness Collective. They discuss how she helped Jamie through processing what came up while writing her memoir, the way the body stores trauma, ketamine therapy, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and A

The Friendship Episode
This week, Jamie is joined by her two best friends, Becca Tobin and Odette Annable. They discuss navigating friendships in all seasons of life, giving grace to yourself and others, finding your people, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience
Our ambition is to

A Conversation with Jamie's Husband
This week, Jamie is joined by her husband, Cutter Dykstra. They discuss his experience as her partner and caregiver, the role he's played in Jamie's acceptance and outlook, advice for other partners, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to

A MeSsy Update!
We’re taking a short break for the next few weeks while Jamie and Christina focus on their book launches. We’ll be back soon with brand new episodes! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Olivia Munn
This week, Christina and Jamie are joined by Olivia Munn. They discuss Olivia’s breast cancer diagnosis, how she was finally able to shed her armor, why you shouldn’t tell someone going through something to look on the bright side, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Veracity - He

Carl Radke
This week, Christina and Jamie are joined by Carl Radke, Summer House cast member and host of "More Life with Carl Radke.” They discuss his journey to sobriety, holding in shame, forgiveness, behind-the-scenes of the show, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Wildgrain - Wildgrain

How to Heal Your Relationship With Life
This week, Christina and Jamie are joined by Jamie’s friend Ryan Weiss. They discuss how he helped her through a difficult time, the power of dance, emotional avoidance, why it’s so hard to look inward, and more.
Check out Ryan's course "How to Be Okay When Things Are Not Okay" and use code MESSY at checkout for 10% off
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bre

We Don’t Want to Be Defined by This
This week, Christina and Jamie read listener emails and discuss the fragility of life, fighting against your body, and more,
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/MESSY #honeylovepod Hosted by Simplecast, an AdsWizz company.

Kelly Ripa
This week, Christina and Jamie are joined by their friend Kelly Ripa. They discuss Kelly's career and how it began at a toy fair, the processing she had to do while writing her own book, the challenges of playing yourself on television, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fat

Stop Talking About It for a Minute
This week, Christina and Jamie read listener emails and discuss skincare products from childhood, crazy animal stories, not thinking too far into the future, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free

How You Feel on the Inside Can Be Up to You
This week, Christina and Jamie read listener emails and discuss the Married... with Children reunion, catch up on their TV shows, Jamie opens up about a recent experience, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Veracity - For up to 45% off your order, head to https://VeracityHealth.c

I Can't Worry About Tomorrow
This week, Christina and Jamie read listener emails and discuss MS fatigue, finding little moments of self care, how to better communicate with friends, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod
Jone

Bobbi Brown
This week, Christina and Jamie are joined by Bobbi Brown. They discuss overcoming obstacles, how to elevate your mood, taking baby steps, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 40% off your entire order at https://Lolablankets.com by using code MESSY at checkout. Exp

I’m a F**king Warrior
This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to Wildgr

The Impact of Inflammation with Dr. Will Cole
This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
MudWtr - Start your new morning ritual & get up t

This Is Not Your Fault
This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod
Jones Road Beauty - Use c

There’s a Lot of Unknown in Life
This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show – get 40% off a Calm Premium Subscription at https://calm.com

Are You Mad At Me? with Meg Josephson
This week, Christina and Jamie are joined by Meg Josephson, author of “Are You Mad at Me?: How to Stop Focusing on What Others Think and Start Living for You.” They discuss the fawn response, how to start healing, the importance of taking a pause, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored b

Montel Williams
This week Christina and Jamie are joined by Montel Williams. They discuss his experience living with MS, bedside manner, why being ill doesn’t make you weak, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your lon

We're All Crushing It
This week, Christina and Jamie read listener emails and discuss perspective, not stuffing your feelings down, journaling, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Nobl - Don’t miss NOBL’s biggest Sale of the Year! Head to NOBLTravel.com for up to 62% off your entire order! #NOBL #a

How to Feel Safe in Your Body with Deb Dana (Re-Release)
This week, Christina and Jamie are revisiting their conversation with Deb Dana, LCSW, a clinician and speaker specializing in complex trauma. They discuss how to understand our nervous systems, polyvagal theory, how to feel safe in a body that may feel unsafe, and more.
Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This show is spo

You Don’t Deserve to Feel Guilt
This week, Christina and Jamie read listener emails and discuss big feelings, reality dating shows, guilt, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today.
MudW

Best of MeSsy: Edie Falco, Jean Smart, and Katey Sagal
This week, we revisit conversations with three incredible guests: Edie Falco, Jean Smart, and Katey Sagal.
Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit.Hollow Socks - For a limited time Hollow Socks is having

Robert Iler
This week, Christina and Jamie are joined by Robert Iler, who starred on "The Sopranos" with Jamie. They discuss memories from their time on the show, his path to becoming sober, his friendship with Jamie, and much more.
Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Ridge - Upgrade your wallet today!

How Vulnerable Can I Be? with Craig Thomas
This week Christina and Jamie are joined by Craig Thomas, an author and Co-Creator, Executive Producer and Writer of How I Met Your Mother. He shares his experience raising a son with Jacobsen Syndrome, discusses the power of storytelling to make people feel less alone, and talks about his new novel, “That’s Not How It Happened.”
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and

We Don’t Move Past It, We Move With It
This week, Christina and Jamie read listener emails and discuss aging, being able to express emotions authentically, where to turn when you’re feeling stuck, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout

Everybody’s Got Something
This week, Christina and Jamie read listener emails and discuss dynamic disability, not being alone in your struggles, the meaning we attach to things, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit.
Mu

It’s Okay to Be Yourself with Baylen Dupree
This week Christina and Jamie are joined by Baylen Dupree. She opens up about having Tourette syndrome, the importance of being yourself, why it's crucial to remember that everyone is struggling, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Baylen's Beautifully Complex: https://beautifullycomplexbybaylen.com/
This epis

Megan Mullally
This week Christina and Jamie are joined by Megan Mullally. They discuss how her role as Karen on Will & Grace came to be, understanding family trauma, the comfort of TV, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show– get 40%

Do What You Can When You Can
This week Christina and Jamie are joined by Christina’s friend, Cindy Locke. They share how they first connected online and discuss the impact of trauma, advice to people who are newly diagnosed, the importance of support, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
CBDistillery - If you’r

Fraser Olender
This week, Christina and Jamie are joined by Fraser Olender from “Below Deck.” They discuss what his job as chief stew actually entails, his journey to find his true self, the escape of being busy, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
MudWtr -Start your new morning ritual & get

We Are Not the Things That Happen to Us
This week, Christina and Jamie read listener emails and discuss conditional friends, not identifying as the things that happen to us, staying honest, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term heal

Change Your Brain, Change Your Pain with Dr. Daniel Amen
This week, Christina and Jamie are joined by Dr. Daniel Amen, a physician, double board-certified psychiatrist, and award-winning researcher. They discuss why pain can also live in your brain, the doom loop and how to get out of it, the cost of repressed emotions, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episod

We Have to Pivot
This week, Christina and Jamie read listener emails and discuss their kids starting the new school year, the power of manifestation, accepting reality, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Pre

I Just Wanna Be Stoned
This week, Christina and Jamie read listener emails and discuss hormones, housewives, acknowledging the struggle, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Sleep Number - It’s the Sleep Number's Biggest Sale of the Year. 25% Off the i8 Bed plus free home delivery. Limited time. Exclus

Ed Helms
This week, Christina and Jamie are joined by Ed Helms. They discuss working together on "Vacation," his love of comedy, the importance of curiosity, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout. Ex

Live From the Hospital
This week, Christina joins Jamie live from the hospital in LA. They discuss what Christina’s going through, her recent trip abroad, their upcoming memoirs, the way the universe works, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
IRestore - Unlock your best hair & skin with @iRestorelas

Jenny Mollen
This week, Christina and Jamie are joined by Jenny Mollen, a New York Times bestselling author and actor. They discuss the feeling of not being in control, the trials of parenting, and more.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Honeylove - Save 20% Off Honeylove by going to honeylove.com/messy #hon

Easy on My Nervous System
This week, Christina and Jamie read listener emails and discuss wins and losses, shows that are easy on the nervous system, why people don't understand invisible diseases, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
O-Positiv - Take proactive care of your health and head to OPositiv.co

Any Movement Counts with Doctor Gretchen
This week, Christina and Jamie are joined by Dr. Gretchen Hawley, an MS-certified specialist and physical therapist. They discuss what to do if you're feeling overwhelmed, the importance of staying consistent, why mindset is just as important as movement, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Get the latest rese

Life Is Like an Episode of Chopped
This week, Christina and Jamie read listener emails and discuss body work, Christina’s new obsession, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off

Clea Shearer
This week, Christina and Jamie are joined by Clea Shearer. They discuss how The Home Edit came to be, Clea’s breast cancer diagnosis, and the importance of fighting for your health and trusting your gut.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Function - Function currently has a waitlist, but th

There Are All Kinds of Heartbreak
This week, Christina and Jamie read listener emails and discuss how connected our bodies are with our emotions, friendship heartbreaks, starting a family, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Beam - Right now, Beam is offering UP TO 40% off their best-selling Dream Powder for our li

Judd Apatow
This week, Christina and Jamie are joined by Judd Apatow. They discuss working on "Anchorman," parenting advice, spirituality, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top

How Could You Not Like Pizza?
This week, Christina and Jamie read listener emails and discuss New York pizza, the trick to finding lost jewelry, how brain inflammation affects us, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term hea

Kaitlyn Bristowe
This week, Christina and Jamie are joined by Kaitlyn Bristowe. They discuss starting over, the impact of therapy, their love of dance, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
BetterHelp - This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at bett

F Our Lives... Let’s Read Some Emails
This week, Christina and Jamie read listener emails and discuss being the “everything” friend, feeling validated in what you’re going through, finding support, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Shop MeSsy merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/home
This episode is sponsored
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