Home Podcasts MeSsy with Christina Applegate & Jamie Lynn Sigler
MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production 119 Episodes Oct 13, 2026

Christina Applegate and Jamie Lynn Sigler open up about the unexpected challenges life throws at them, specifically their experiences living with multiple sclerosis. Each week, they engage in raw, often humorous conversations with each other, friends, co-stars, and others who help them navigate the messiness of life.

Episodes

Learning to Love Every Version of Yourself with Tiffani Thiessen
Learning to Love Every Version of Yourself with Tiffani Thiessen Oct 13, 2026 00:54:10 This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of yourself. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational im
What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui
What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui Oct 6, 2026 00:57:32 This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur
I Don’t Have a Lot of Fight in Me Right Now
I Don’t Have a Lot of Fight in Me Right Now Sep 29, 2026 00:31:25 This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational impact for people living
How to Live With What You Can’t Control with Ana Rodriguez
How to Live With What You Can’t Control with Ana Rodriguez Sep 24, 2026 00:59:08 In the final episode of Living With It, Jamie sits down with her therapist, Ana Rodriguez, to talk about what it really means to heal when life doesn’t go according to plan. They explore grief, resilience, uncertainty, and the ways we avoid our feelings by trying to fix them or find meaning too quickly.Novartis in neuroscienceo Our ambition is to create a transformational impact for people living
The Hardest Fight Is Learning to Rest with Alberto Crane
The Hardest Fight Is Learning to Rest with Alberto Crane Sep 22, 2026 00:41:23 This week, Jamie sits down with jiu-jitsu champion and former UFC fighter Alberto Crane to talk about how his MS diagnosis forced him to redefine what it means to be strong. Alberto opens up about learning to slow down, embrace rest, and why sometimes being a fighter means knowing when not to push through.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engine
Stop Apologizing for Wanting More with Heather Dubrow
Stop Apologizing for Wanting More with Heather Dubrow Sep 17, 2026 00:54:49 This week on Living With It, Jamie sits down with Heather Dubrow for an honest conversation about embracing life’s pivots, protecting your peace, and giving yourself permission to want more. Novartis in neuroscienceo Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovativ
There Is Beauty Within All of This Pain with Lindsey Kraft
There Is Beauty Within All of This Pain with Lindsey Kraft Sep 15, 2026 00:54:02 This week on MeSsy, Jamie sits down with her longtime friend, actress, writer, and musician Lindsey Kraft. They talk about growing up together, navigating rejection and self-doubt, and Lindsey’s unexpected journey from acting to writing her own one-woman musical.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored b
Falling Apart to Come Back Together with Ryan Weiss
Falling Apart to Come Back Together with Ryan Weiss Sep 10, 2026 00:47:20 This week on Living With It, Jamie sits down with her friend, Ryan Weiss. They talk about letting go of control, sitting with difficult emotions, knowing when it’s time to do things differently, and learning to trust what’s on the other side when life doesn’t look the way you thought it would.Novartis in neuroscienceo Our ambition is to create a transformational impact for people living with sever
Thank God I’m So Neurotic with Cat Cohen
Thank God I’m So Neurotic with Cat Cohen Sep 8, 2026 00:47:55 This week on MeSsy, Jamie sits down with comedian, actor, and singer Cat Cohen. Cat opens up about having a stroke at 31, navigating health anxiety in the aftermath, and turning one of the scariest experiences of her life into her most fulfilling creative work yet.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored
We Fight For Joy with Kelsey Chittick
We Fight For Joy with Kelsey Chittick Sep 3, 2026 00:53:37 This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a life she never expected. They discuss finding humor in the darkest moments, letting go of the life you thought you’d have, the power of community, and how to choose joy. Novartis in neuroscience o Our ambition is to create a transf
There’s No Place Like Home with Annie Meyers-Shyer
There’s No Place Like Home with Annie Meyers-Shyer Sep 1, 2026 00:53:29 This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new passion and career at 45, and why it’s never too late to bet on yourself. Annie also shares how she creates a home that feels like an exhale, the small ways our spaces can support us through difficult seasons, and how her home carried
The Power of Radical Acceptance with Jim Curtis
The Power of Radical Acceptance with Jim Curtis Aug 27, 2026 00:53:50 This week on Living With It, Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you have without giving up hope for the life you want, the stories we build around our suffering, and learning to see your body as an ally instead of the enemy. Plus, Jim shares how releasing old beliefs and changing the way we speak to

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