Home Podcasts MeSsy with Christina Applegate & Jamie Lynn Sigler
MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production 119 Episodes Aug 20, 2026

Christina Applegate and Jamie Lynn Sigler open up about the unexpected challenges life throws at them, specifically their experiences living with multiple sclerosis. Each week, they engage in raw, often humorous conversations with each other, friends, co-stars, and others who help them navigate the messiness of life.

Episodes

Accept, Adapt, Appreciate with Odette Annable
Accept, Adapt, Appreciate with Odette Annable Aug 20, 2026 00:54:01 This week on Living With It, Jamie sits down with her friend Odette Annable. They discuss parenting a neurodivergent child, trusting your instincts, advocating for your family, and learning to let go of the need to have all the answers. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discov
The Courage to Slow Down
The Courage to Slow Down Aug 18, 2026 00:53:17 This week on MeSsy, Jamie opens up about reaching her limit and learning to make rest part of healing. She also reads listener emails about fighting to be heard by doctors, learning to accept help, and the power of knowing you're not alone.   Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by:  Novartis in ne
Finding Stillness When Life Won’t Slow Down with Bob Roth
Finding Stillness When Life Won’t Slow Down with Bob Roth Aug 13, 2026 01:00:07 This week on Living With It, Jamie sits down with Bob Roth, a leading Transcendental Meditation teacher and CEO of the David Lynch Foundation. They discuss what stress does to the body, how meditation can help calm the nervous system, and how finding stillness can help us navigate uncertainty, illness, and everyday life. Novartis in neuroscience o Our ambition is to create a transformational impac
How Death Informs How We Live with Julie McFadden
How Death Informs How We Live with Julie McFadden Aug 11, 2026 00:58:19 This week, Jamie sits down with hospice nurse Julie McFadden to talk about changing the way we think about death, what she’s learned from those at the end of life, and how accepting our mortality can help us live more fully in the present. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuros
Trusting the Journey with Becca Tobin
Trusting the Journey with Becca Tobin Aug 6, 2026 00:57:11 This week, Jamie sits down with one of her best friends, Becca Tobin, for a conversation about infertility, pregnancy loss, surrogacy, and finding hope after years of uncertainty. They explore grief, resilience, the unexpected paths to parenthood, and what it means to keep moving forward when life doesn't unfold the way you imagined. Novartis in neuroscience o Our ambition is to create a transform
Try to Find the Light with Amanda Kloots
Try to Find the Light with Amanda Kloots Aug 4, 2026 00:59:25 This week, Jamie sits down with Amanda Kloots for an honest conversation about finding joy alongside heartbreak. Amanda opens up about losing her husband, Nick Cordero, how her grief has evolved over the past six years, why she no longer believes we have to "let go" of the people we love, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Jo
Look for the Signs with Kate Doerge
Look for the Signs with Kate Doerge Jul 30, 2026 00:58:17 On this episode of Living With It, Jamie sits down with Kate Doerge to discuss finding hope after profound loss, recognizing signs from loved ones, and the five actions that can transform the way we move through grief. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing
Hope Can Exist Alongside Fear with Myriam Sandler
Hope Can Exist Alongside Fear with Myriam Sandler Jul 28, 2026 01:07:31 This week, Jamie sits down with Mothercould creator Myriam Sandler. They discuss her recent MS diagnosis, trusting your intuition, and finding hope even when life doesn't go as planned. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch   This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformatio
It's Okay Not to Be Okay with Amy Kurtz
It's Okay Not to Be Okay with Amy Kurtz Jul 23, 2026 00:55:27 On the first episode of Living With It, Jamie sits down with Amy Kurtz, a patient advocate and author. They discuss the grief of chronic illness, learning to trust yourself again, and why healing is about so much more than getting better. Novartis in neuroscience o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by disc
All Eyes on Me
All Eyes on Me Jul 21, 2026 00:48:29 This week, Jamie reads listener emails and opens up about the feeling of all eyes on you when you're struggling, the anxiety of the lead up, caregiving, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people livi
Tamsen Fadal
Tamsen Fadal Jul 14, 2026 00:56:14 This week, Jamie sits down with journalist, author, and menopause advocate Tamsen Fadal. They discuss the physical and emotional realities of perimenopause, why so many women feel dismissed by the medical system, and how speaking honestly about aging, identity, and women's health can help us all feel less alone. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Aud
You Do Not Have to Become Someone Else to Heal
You Do Not Have to Become Someone Else to Heal Jul 7, 2026 00:51:03 This week, Jamie reads listener emails and discusses the invisible weight of living with chronic illness, the courage it takes to keep showing up, and the small moments that can bring us back to ourselves. She also shares the reminder she received from a recent on stage performance. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch Thi

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