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The Proof with Simon Hill

The Proof with Simon Hill

Live better for longer 416 episodes Latest Jun 1, 2026

The Proof Podcast is a space for science-based conversation. Host Simon Hill, a qualified physiotherapist and nutritionist, explores health and longevity benefits from mastering exercise, nutrition, mindfulness, recovery, sleep, and alignment. The show provides facts, nuance, and trustworthy recommendations without hyperbole.

Episodes

Nutrition for satiety and weight loss | Dr Federica Amati Jun 9, 2026 5613 GLP-1 medications are now part of the mainstream conversation, but the biology of appetite and satiety, the system these drugs operate within, gets far less attention than the drugs themselves. In this episode, I sit down with Dr Federica Amati, Head Nutritionist at ZOE and author of the new book The Appetite Reset, to explore what's actually happening in the gut and brain when appetite signals do
The Surgeon Defending Statins, GLP-1s, and Ancel Keys | Dr Terry Simpson Jun 1, 2026 6151 In this episode, I sit down with bariatric surgeon and science communicator Dr Terry Simpson for a wide-ranging conversation about health misinformation, GLP-1 medications, statins, ApoB, the Mediterranean diet, and the loud contrarians who dominate social media. Terry has familial hypercholesterolemia, a family history of premature cardiovascular disease, and lost 50 pounds on tirzepatide, all of
Has Optimisation Culture Gone Too Far? | Sarah Ann Macklin May 28, 2026 4248 In this episode, I’m joined by Sarah Ann Macklin to explore the hidden psychological costs of modern wellness culture and why pursuing health can sometimes leave us feeling more anxious, overwhelmed, and disconnected. Sarah shares insights from her new book, Healthy Shouldn’t Be This Hard, as we unpack self-compassion, perfectionism, body image, mindset, and the pressure to constantly optimise ev
What the Headlines Get Wrong About the Future of Meat | Bruce Friedrich May 26, 2026 6460 Six years on from our first conversation, global meat consumption is at a record high, and the harms of industrial animal agriculture have only deepened. Bruce Friedrich, founder of the Good Food Institute, is back on the podcast to argue that the answer is not asking people to eat less, but rebuilding meat itself from the ground up. Bruce is the author of the new book Meat: How the Next Agricult
Improving cholesterol and blood pressure with diet | A Masterclass May 18, 2026 7036 Cardiovascular disease is the world's leading killer, and yet the prevention conversation has become noisier and more confused than ever. In this Masterclass I bring together the evidence-first material I think is most useful for understanding cholesterol, blood pressure, and long-term heart health. You will hear from Dr Walter Willett at Harvard, cardiology dietitian Michelle Routhenstein, and n
The Peptides Quietly Accelerating Aging | Dr Valter Longo May 11, 2026 6456 The peptide and GLP-1 conversation has reached a fever pitch. Growth-hormone-releasing peptides are being marketed as longevity tools, GLP-1s are being treated as a default rather than a last resort, and a wellness aesthetic of higher IGF-1, more muscle, and less fat is being sold as the route to a longer life. In this episode, I sit down with Dr Valter Longo, Professor of Gerontology at USC and D
The Diet That Lowers Cholesterol Like a Statin | Dr Andrea Glenn May 4, 2026 5709 Plant-based nutrition has rarely been more contested. Seed oils are vilified, butter is celebrated, protein is treated as a pure quantity question, and nutrition epidemiology is routinely dismissed by people who have never read one of its papers. In this episode, I sit down with Dr Andrea Glenn, an Assistant Professor at NYU and Visiting Scientist at the Harvard T.H. Chan School of Public Health,
Food Labels, Fibre, and Ultra-Processed Foods: What Really Matters | Rhiannon Lambert Apr 28, 2026 3512 Ultra-processed foods are now the central nutrition conversation of the decade, but the gap between the marketing and the evidence has never been wider. In this episode, I sit down with registered nutritionist and Sunday Times bestselling author Rhiannon Lambert to bring some practical clarity to what the science actually says. We get into how the NOVA system can be too blunt to be useful, why ca
The Peptide Lie: What a Drug Developer Reveals About the Compounds Everyone Is Injecting | Dr Leigh Baxt Apr 21, 2026 2742 Peptides are being marketed as solutions for everything from injury recovery to longevity, but what does the science actually say? In this episode, Dr Leigh Baxt joins me to break down what peptides are, how drug development really works, and why so many of the claims circulating online are running far ahead of the evidence. We explore the difference between approved peptide medicines and unregul
Preventing and reversing osteoporosis | Dr Belinda Beck Apr 13, 2026 5058 In this episode, I’m joined by Dr Belinda Beck to challenge long-held beliefs about osteoporosis and bone health. We break down what actually works, what doesn’t, and why many people are being given outdated advice. We explore the science of bone adaptation, the importance of heavy resistance training, and how to think about prevention and treatment across the lifespan. What We Cover Why wal
New microbiome science | Dr Tim Spector Apr 6, 2026 5147 In this episode, I return to a conversation I promised to continue - sitting back down with Prof Tim Spector, MD, to explore everything that has changed in microbiome science since Episode 224. Tim and the ZOE team have now published a landmark Nature paper with 34,000 microbiome samples, run a clinical trial comparing personalized nutrition against government guidelines, and Tim has published a b
Food and weight loss | Dr Kevin Hall Mar 30, 2026 6981 In this episode, I’m joined by Dr Kevin Hall from the NIH to unpack the science behind ultra-processed foods, energy balance, and the new U.S. Dietary Guidelines. We explore what controlled feeding studies reveal about why people tend to eat more calories on ultra-processed diets, and whether it’s the foods themselves or the broader environment driving these effects. What We Cover Key takeaw

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