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The Feldman Protocol

The Feldman Protocol

Dave Feldman 39 Episodes Oct 9, 2026

Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.

Episodes

Zachary DiMattia and Dave Feldman Debate LDL, Keto-CTA and Lean Mass Hyper-Responders
Zachary DiMattia and Dave Feldman Debate LDL, Keto-CTA and Lean Mass Hyper-Responders Oct 9, 2026 03:01:12 In this episode of The Feldman Protocol, what does emerging research actually reveal about cardiovascular risk in people who develop extreme LDL elevations on ketogenic diets — and how much remains genuinely unresolved? Zachary DiMattia (nutritional scientist, Penn State) joins Dave to discuss his published review on ketogenic diet–induced LDL elevations in normal-weight adults, presents prelimina
Lauren Kennedy West on Schizoaffective Disorder, Ketogenic Therapy, and Psychiatric Identity
Lauren Kennedy West on Schizoaffective Disorder, Ketogenic Therapy, and Psychiatric Identity Oct 3, 2026 02:53:16 In this episode of The Feldman Protocol, can what we eat meaningfully influence the course of serious mental illness? Dave sits down with Lauren Kennedy West (mental health advocate and YouTuber living with schizoaffective disorder) to explore her personal journey from multiple hospitalizations and misdiagnoses to adopting therapeutic ketosis. Lauren makes the case for metabolic psychiatry as a co
Arthur Agatston (Part 3) on Insulin Resistance, LP(a), and Why He Went Militantly Keto
Arthur Agatston (Part 3) on Insulin Resistance, LP(a), and Why He Went Militantly Keto Sep 24, 2026 02:16:48 In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and does the conventional focus on individual biomarkers miss the bigger picture? Dave Feldman sits down with cardiologist Arthur Agatston (MD), creator of the South Beach Diet and the coronary calcium score, to explore blood pressure guideline debates, insulin resistance and preeclampsia, the origins of
Dr. Arthur Agatston (Part 2) - Why Did Most Keto Patients Show Zero Plaque Despite LDL of 250?
Dr. Arthur Agatston (Part 2) - Why Did Most Keto Patients Show Zero Plaque Despite LDL of 250? Sep 21, 2026 02:00:44 In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and what does that mean for interpreting cholesterol markers in lean, low-carb individuals? Arthur Agatston (MD) makes the case for a functional model of atherosclerosis progression, discusses AI-driven advances in cardiac imaging, argues for revisiting how blood pressure is measured and treated, and exp
The Stent Myth: Why Fixing a Blockage Isn’t a Cure - Dr. Arthur Agatston
The Stent Myth: Why Fixing a Blockage Isn’t a Cure - Dr. Arthur Agatston Sep 18, 2026 01:51:31 In this episode of The Feldman Protocol, how well do conventional cardiovascular risk metrics actually identify who is truly at risk for a heart attack decades before it happens? Cardiologist Arthur Agatston (MD) makes the case for coronary calcium scoring as an early detection tool, discusses the natural history of atherosclerotic plaque, revisits key moments in lipid science history, explores wh
Isabella Cooper – Part 2 – Ketogenic Diet and Cancer: What the Science Actually Shows
Isabella Cooper – Part 2 – Ketogenic Diet and Cancer: What the Science Actually Shows Sep 11, 2026 01:56:58 In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progres
Isabella Cooper – Part 1 – The Chemical Removed From Tampons Is Still in Most Diapers
Isabella Cooper – Part 1 – The Chemical Removed From Tampons Is Still in Most Diapers Sep 8, 2026 02:22:20 In this episode of The Feldman Protocol, what does beta-hydroxybutyrate between meals actually reveal about a person's insulin state — and why might that matter for understanding chronic disease risk? Dave sits down with Isabella Cooper (PhD), a biochemistry and pathophysiology scientist whose research spans assay quality control, hyperinsulinemia detection, ketone thresholds, mitochondrial fu
Dr Scott Murray – Is IVUS Plaque ‘Regression’ Just Measurement Noise?
Dr Scott Murray – Is IVUS Plaque ‘Regression’ Just Measurement Noise? Sep 4, 2026 03:28:12 In this episode of The Feldman Protocol, how much does metabolic health shape cardiovascular risk beyond what standard lipid markers can reveal? Dave Feldman sits down with Scott Murray (MD), a UK-based interventional cardiologist, to explore plaque imaging and its limitations, the role of visceral and perivascular fat in heart disease, the lipid energy model and lean mass hyper-responders, cardia
Darius Sharp – Pt 2 – What Happens to Your Lipids After 2,000 Calories of Fat?
Darius Sharp – Pt 2 – What Happens to Your Lipids After 2,000 Calories of Fat? Sep 1, 2026 02:40:47 In this episode of The Feldman Protocol, what actually drives cardiovascular disease in a metabolically healthy, lean individual — and is elevated LDL the most important variable to consider? Darius Sharpe (ER nurse and lean mass hypersponder community member) discusses his unexpected CAC score at age 38, his theory on postprandial glucose and vascular damage, a personal episode of atrial fibrilla
Dr. Malcolm Kendrick – The Country With the Lowest Cholesterol and the Highest Heart Disease Rate
Dr. Malcolm Kendrick – The Country With the Lowest Cholesterol and the Highest Heart Disease Rate Aug 31, 2026 03:35:15 In this episode of The Feldman Protocol, how well does the prevailing understanding of LDL and cardiovascular disease hold up under close scrutiny? Dave sits down with Malcolm Kendrick (MD) — author, researcher, and longtime cardiovascular disease skeptic — who challenges key assumptions across trial methodology, observational data, Mendelian randomization, clinical trial blinding, nitric oxide&#3
Sugar Is Wiring Kids' Brains for Lifelong Addiction – Dr. Jen Unwin
Sugar Is Wiring Kids' Brains for Lifelong Addiction – Dr. Jen Unwin Aug 21, 2026 02:41:55 In this episode of The Feldman Protocol, what does it take to recognize and address a compulsive relationship with food — and why does that recognition matter so much? Jen Unwin (clinical and health psychologist) joins Dave to explore the psychology of hope in medical settings, her personal history with carbohydrate-driven food behaviors, the evidence behind ultra-processed food addiction as a pro
Dr. David Unwin: Low Carb, Diabetes & Food Addiction
Dr. David Unwin: Low Carb, Diabetes & Food Addiction Aug 14, 2026 04:01:08 In this episode of The Feldman Protocol, how does one family doctor's decades-long frustration with a "progressive, incurable" disease lead to a fundamentally different approach to patient care? Dave Feldman and David Unwin (MD) explore the pivotal 2012 patient encounter that reshaped Unwin's practice, the psychology of behavior change and food addiction, real-world data from a 1

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