Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics
Dr. Kara Fitzgerald hosts a podcast exploring functional medicine, longevity, and epigenetics. She interviews leading experts in the field, discussing cutting-edge research and clinical insights. The show aims to provide thought-provoking ideas and practical information for both practitioners and patients interested in optimizing health and longevity.
Episodes
What the Science Says About Sauna for Longevity: Infrared vs. Traditional
Sauna is everywhere in the longevity conversation, but are all saunas actually doing the same thing? In this episode, Dr. Kara Fitzgerald sits down with Sunlighten co-founder Connie Zack to unpack the science of infrared sauna vs. traditional Finnish sauna, how different wavelengths of infrared and red light interact with the body, and what the research suggests about cardiovascular health, mitoch
What Actually Slows Aging? The Science vs. Hype | Dr. David Barzilai
In this episode of New Frontiers, Dr. Kara Fitzgerald sits down with longevity physician Dr. David Barzilai to separate promising science from hype and explore where the field of longevity medicine is headed.
They discuss the evolution of biological age testing, including DunedinPACE and other aging clocks, and why these tools can provide useful information without telling the whole story. They a
What New Science Reveals About Mitochondria & How We Age
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with neuroscientist and mitochondrial health researcher Dr. Siobhan Mitchell to explore emerging research on mitochondrial dysfunction, aging, and longevity. They discuss how mitochondria change as we age, how mitochondrial dysfunction may contribute to chronic inflammation and age-related disease, and why suppo
The GLP-1 Problem No One Is Talking About: A New Metabolic Approach
GLP-1 receptor agonists have transformed weight loss and metabolic health—but what are we overlooking? In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald is joined by Dr. Sanjay Bhojraj and Dr. Alexis Gonzales to explore the clinical tradeoffs of GLP-1 therapy, including lean muscle preservation, nutrient status, weight regain, and long-term metabolic health.
The convers
The Future of Longevity Medicine Starts Here
Longevity medicine is expanding beyond biological age, biomarkers, and emerging technology. In this special episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald shares four thought-provoking conversations exploring the science, clinical tools, and deeply human questions shaping the future of healthspan.
Dr. Dale Bredesen and Dr. Kat Toups discuss preliminary findings from their si
Why Chronic Disease May Begin Before Birth
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald is joined by Dr. Emily Stone Rydbom, Dr. Leslie Stone, and Dr. Kalea Wattles to explore the science of preconception health, fertility, epigenetics, and chronic disease prevention.
Learn how maternal nutrition, mitochondrial health, methylation, the microbiome, inflammation, and environmental exposures influence fertilit
The Skin Longevity Breakthrough | Carolina Reis Oliveira
Can skincare influence healthy aging beyond reducing fine lines and wrinkles?
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald welcomes Carolina Reis Oliveira, PhD, CEO and co-founder of OneSkin, for a science-based discussion on cellular senescence, skin aging, and the connection between skin health and longevity.
Carolina explains the research behind OneSkin's OS-01
How Medicine Got Menopause Wrong | Dr. Kelly Casperson
Hormones are about far more than hot flashes.
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald is joined by urologist and hormone expert Dr. Kelly Casperson for a conversation that challenges conventional thinking about menopause, hormone replacement therapy (HRT), and healthy aging.
Dr. Casperson explains why menopause may be better understood as a form of hypogonadi
What New Science Says About Building Muscle | Brad Currier, PhD
Resistance training is one of the most powerful interventions for preserving muscle, supporting metabolic health, and promoting healthy aging—but many patients still find it intimidating or confusing. In this episode, Dr. Kara Fitzgerald sits down with exercise physiologist Brad Currier, PhD, to unpack the newly updated ACSM resistance training guidelines and discuss practical approaches for presc
The Infection Driving Chronic Illness | Dr. Richard Horowitz
In this episode of New Frontiers in Functional Medicine, Richard Horowitz joins Kara Fitzgerald to explore the connection between persistent infections, inflammation, and chronic disease.
The discussion highlights emerging research linking Borrelia burgdorferi (Lyme disease) to amyloid production and Alzheimer’s biomarkers, along with the clinical implications of Dr. Horowitz’s MSIDS model. Topic
How He Reversed MS & Beat a Stroke | Montel Williams
Montel Williams joins Dr. Kara Fitzgerald to share his decades-long journey with multiple sclerosis (MS), including early neurological symptoms that preceded his diagnosis by years and his recovery following a hemorrhagic stroke. In this episode, created in partnership with MitoQ, the conversation explores MS through a functional medicine lens, with a focus on neuroinflammation, oxidative stress,
The Estrogen Effect Nobody Talks About | Kiran Krishnan
Cardiovascular health and longevity are deeply influenced by aging, perimenopause, and systemic changes that extend far beyond cholesterol markers alone.
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Kiran Krishnan to explore the biology of vascular aging, endothelial dysfunction, and metabolic changes that emerge in midlife and beyond. As estrogen de
Seed Oils vs Science: What the Data Shows | Dr. Bill Harris
Fatty acids remain one of the most debated areas in clinical nutrition, yet many widely held beliefs may not align with current evidence. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Bill Harris, PhD, Founder of OmegaQuant Analytics and co-inventor of the Omega-3 Index, to examine the role of omega-3 and omega-6 fatty acids in cardiovascular risk and
When High Protein Backfires in the Gut Dr. Tom Fabian
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald speaks with Tom Fabian, PhD, Senior Educator and Research Specialist at Diagnostic Solutions Laboratory, about why higher protein intake doesn’t always lead to better muscle outcomes. Emerging research shows that digestion, microbiome balance, and immune signaling all influence how effectively the body utilizes dietary pr
The Tough Gut Playbook: Rebuilding Gut Resilience in IBS-Prone Patients
As more patients present with digestive sensitivity and increasingly restricted diets, restoring gut resilience has become a central clinical challenge. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald speaks with Colleen Cutcliffe, PhD, CEO and co-founder of Pendulum Therapeutics, about emerging microbiome science and practical strategies for supporting microbial balan
New Food Guidelines: Progress or Missed Opportunity? | Dr. Robert Lustig
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald speaks with Dr. Robert Lustig about the new USDA dietary guidelines and the broader forces shaping nutrition and metabolic health. Dr. Lustig brings a characteristically direct and nuanced perspective on sugar, ultra-processed foods, and food policy—raising important questions about what drives real change. It’s a thought
Why Bone Loss Accelerates With Aging: The Gut–Bone Connectio
Bone loss doesn’t start when fractures happen — it begins years earlier.
In this episode, we explore how bone aging accelerates during menopause and the emerging role of the gut microbiome as a driver of skeletal decline. Dr. Kara Fitzgerald speaks with research scientists from Sōlaria biō, the company behind Bōndia, about their work studying plant-derived microbes, microbial synergies, and the c
Epstein Files: A Functional Medicine Response
The continued release of the Epstein files has sparked difficult but necessary conversations across the medical, longevity, and wellness communities.
In this candid and deeply reflective episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Dr. Sara Szal and Dr. Brad Jacobs to explore what this moment calls forward from clinicians — ethically, professionally, and per
Why Aging Is Not a Fat Problem — A Muscle-Centric Approach to Longevity
What if obesity and metabolic dysfunction start in the muscle, not the fat tissue we usually measure? In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald and Dr. Gabrielle Lyon unpack this emerging science, from intramuscular adipose tissue to protein needs, anabolic resistance, fatty liver disease, and the role of muscle in healthy aging. A compelling episode with immedia
Platelet-Derived Exosomes in Aesthetics: Data, Safety, and Real-World Use Cases
Exosomes are becoming one of the most talked-about tools in regenerative medicine, but not all exosomes are created equal. In this episode of New Frontiers, Dr. Kara Fitzgerald talks with Alisa Lask, CEO of Plated Skin, about the science behind platelet-derived exosomes and why their signaling pathways matter for repair, renewal, and changes in skin appearance.
We explore how discoveries in cardi
The Oral Microbiome: The Hidden Biomarker Driving Aging, Fertility & Systemic Inflammation
Functional dentistry is emerging as a powerful missing link in systems-based care. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Staci Whitman, DMD, IFMCP, a leading voice in functional pediatric dentistry and co-founder of the upcoming Institute for Functional Dentistry. Together, they explore how the oral microbiome, airway health, saliva, hormones,
The Hidden Immune Signal Accelerating Aging & the Beta-Glucan That Fixes It
Beta-glucans might be one of the most overlooked levers in immune resilience, and that has major implications for longevity. Talking with my long-time friends and colleagues Drs. Bob Rountree and Chris D’Adamo reminded me just how powerful this molecule truly is. The clinical reach here is stunning, from immune aging and cancer support to vaccine response, gut–brain effects, and overall resilience
From Hot Flashes to Healthspan: The FxMed Guide to Hormones & Longevity
In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with hormone and women’s health expert Dr. Carrie Jones to explore the powerful connection between mitochondrial health and women’s hormones. Together, they unpack how mitochondrial function influences hormone balance, metabolism, energy, mood, and resilience, especially during perimenopause and menopause. Dr. J
Guide to Building a Sustainable Concierge Longevity Practice
Dr. Kara Fitzgerald sits down with Dr. Brooke Stubbs, an internal and lifestyle medicine physician who transitioned from hospital medicine to a concierge model focused on prevention and personalization. Together, they discuss how to design a practice that supports both patients and practitioners, from efficient systems and appropriate pricing to functional lab integration.
Dr. Stubbs explains how
Reversing Aging: Screening, Wearables & What To Do Now
Dr. Kara Fitzgerald talks with Sergey Young, founder of the Longevity Vision Fund and XPRIZE board member, about the future of aging medicine. Hear how AI, wearables, new diagnostics, and early screening are making longevity solutions more practical, affordable, and clinically relevant for functional medicine practitioners.
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcas
Aging & Hair Loss Explained: OS-01’s Science-Backed Approach
Hair loss is more than cosmetic. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald explores new research on the OS-01 peptide and its role in targeting senescent cells. Learn how peptide therapy compares to minoxidil, and how hormones, thyroid health, stress, UV exposure, and the scalp microbiome all play a role in thinning hair. Carolina Reis Oliveira, PhD, co-founder o
The Bile Acid Imbalance Accelerating Aging: How to Detect & Fix It
Have you ever struggled to understand why some patients just don’t respond as expected, even when you’re following all the usual gut protocols? In this episode, I sat down with Dr. Tom Fabian, who breaks down the latest insights from StoolOMX and GI-MAP testing and shows us how to put them into practice for our most complex cases.
We dive into how identifying specific types of inflammation, bile
Why Functional Medicine Is the Future of Longevity
Can functional medicine unlock the secrets to healthy aging? In this special preview of the Functional Medicine is Longevity Medicine™ Masterclass happening on September 17- September 19, 2025, Dr. Kara Fitzgerald sits down with three leading voices in medicine and research:
- Dr. Bob Rountree: functional medicine pioneer in integrative approaches to health
- Dr. Dale Bredesen: internationally r
Why Centenarians Are Defying Science: Secrets to Living 100+
It was a pleasure to sit down with Dr. Nir Barzilai for a conversation that turned out to be both lively and thought-provoking. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases.
We get into the science behind why some people live 20–30
The Science-Backed Bitter Compound That Mimics GLP-1 (No Injections Needed!)
I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plate
10 Year Anniversary: What I Learned After 200+ Conversations with the Best Minds in FxMed
In this very special episode, I have the privilege of turning the tables on Dr. Kara Fitzgerald as we celebrate 10 years of the New Frontiers podcast. I’ve been honored to walk alongside Kara on much of this journey—as a colleague, a collaborator, a mentee, and a friend—and it’s been incredible to witness the evolution of both her work and the field itself.
Together, we reflect on the stories, sc
Dead Mitochondria Might Be Fueling Cardiovascular Aging — Here’s The Fix
This is a really exciting conversation with Dr. Davide D’Amico from Timeline, where we’re taking a closer look at Urolithin A and heart health. It should come as no surprise that this mitochondrial wonderkin of a nutrient is showing promise here—especially when you consider that 40% of the heart’s weight is mitochondria. That’s an extraordinary factoid, and one that really shifts how we think abou
Why Human-Centered AI Is the Future of Medicine & Mental Wellness
This episode is a little different from what we usually cover on New Frontiers, but it’s one I couldn’t wait to bring to you. I’ve been thinking a lot about how we—as clinicians—are supposed to keep up in this era of high-throughput technology. We’re swimming in data: labs, multi-omics, diet logs… and an ever-growing stream from wearables. There’s just so much coming at us, and too often, we’re aw
Legal Pitfalls That Could Destroy Your Practice & How to Avoid Them
In many ways, the legal side of functional medicine can feel like the Wild West—uncertain, unregulated, and full of risks. The reality is, we all want to have our practices legally buttoned up, but navigating the legal landscape can feel overwhelming—and expensive. What Scott Rattigan, creator of Functional Lawyer, shares in this episode is a real game-changer. He not only breaks down the complexi
Why You’re Aging Faster Than You Think & How to Slow It
I’ve been looking forward to sharing this conversation with you because it’s one I’m truly passionate about. Today, we’re diving into the DunedinPACE epigenetic clock with one of its creators, the brilliant Dan Belsky. It’s a tool I use regularly with my patients, and one that’s transforming how we approach aging and interventions. While this show is a bit more technical than usual, the science is
What New Research Says About Cartilage Regeneration and Joint Longevity
What if a human trial of over 1200 patients showed improved mobility and reduced pain in osteoarthritis (OA) patients using a natural combination of boswellia and celery seed extract? What if a second follow-up randomized, placebo-controlled human trial found that within 90 days, this same combination increased OA patients' ability to perform a walk test by over 50%, reduced markers of cartilage d
The Truth About Chronic Illness: How to Reset Your Nervous System & Slow Aging
We’ve all had patients struggling with chronic conditions like long COVID, fibromyalgia, Lyme disease, and chronic fatigue. Despite all the tools in our functional medicine toolkit, there’s still something missing. How can we truly help them? I’m excited to have Ashok Gupta back on the New Frontiers podcast to offer a new take on healing from chronic illness. He explains that many chronic disease
Hidden Mitochondria Problems Are Accelerating Your Age & Draining Your Health
What if the key to reversing chronic disease, slowing cognitive decline, and boosting energy lies in the tiny powerhouses inside your cells—and we’ve finally found a way to protect them?
We know mitochondria power our cells, but did you know they also create oxidative stress as they generate energy? Protecting mitochondrial health is critical—but most antioxidants can't reach inside the mitochond
p-Tau 217: The Breakthrough Biomarker Revolutionizing Early Alzheimer’s Detection
Join me for a fascinating conversation around an exciting breakthrough in dementia detection that’s offering real hope for early intervention. Dr. Hans Frykman, Chief Scientific Officer at Neurocode Laboratories, is here to share groundbreaking insights into cutting-edge biomarkers that can identify pathology associated with Alzheimer's disease before symptoms even appear. What’s even more fascina
Cutting-Edge Metabolomic Testing for IBS, Longevity, and Metabolic Health
We’re witnessing an exciting shift in how we understand gut health and disease—and it’s all thanks to the powerful metabolites produced by the microbiome, like short-chain fatty acids (SCFAs) and secondary bile acids. In today’s episode, Dr. Tom Fabian shares groundbreaking insights into how these postbiotics influence intestinal barrier integrity, immune balance, and even muscle regeneration. The
A Fresh Take on Exposomics: Resiliency Factors That Offset Environmental Risks
It’s very difficult (often impossible) to completely avoid many of the environmental toxins that can cause harm - like air pollution and forever chemicals that contaminate our water and food supply. But Drs. Bob and Rosalind Wright at Mount Sinai have a hopeful solution to this dilemma. They are pioneering the study of “resiliency factors,” not just “risk factors,” that can offset the risks of ha
This GLP-1-Supporting Probiotic Is A Constant In Our Longevity Stack
Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the f
Healing Depression Project: Providing Hope For Treatment-Resistant Patients
For many struggling with depression, the message they often hear from traditional care is "just live with it" or "there’s nothing more we can do." In today’s episode, we’re challenging that narrative. I’m joined by Dr. Achina Stein and Silvia Covelli from the Healing Depression Project - a groundbreaking residential treatment and research program. Dr. Stein, a functional psychiatrist, and Silvia,
NAD+ in the Spotlight: New Insights on Boosting Cellular Resilience
We’re doing a deep dive into NAD, a molecule that has received a lot of attention but still confuses many of us, clinicians included. My guest today is able to unpack the complexities of NAD in a way you’ll find extremely illuminating and useful. I’m excited to have Dr. Greg Kelly Senior Director of Product Development at Qualia, back with us, explaining how NAD is foundational for energy, longevi
The Podcast After the Podcast: More on Age Reversal with Dr. Greg Fahy
After my conversation with Dr. Greg Fahy in August, I realized that I had additional questions that we didn't have time to address the first time around. Importantly, since here I am studying the effects of dietary and lifestyle interventions on aging, I wanted to know his thoughts on the dietary components of the TRIMM study and beyond. Dr. Fahy shares his thoughts on my question and some others
Innovative Approaches to Restoring Brain Function After Concussion and TBI
The brain’s ability to recover after trauma is astonishing—and often overlooked in conventional care. In this episode of New Frontiers in Functional Medicine, I sit down with Dr. David Musnick, a long-time friend and brilliant clinician, to explore how we can unlock the brain’s full potential for healing. Dr. Musnick challenges the standard of care for traumatic brain injuries and post-concussion
An HRT Revolution is Underway. Ready to Individualize Recommendations for Hormone Health?
For anyone who has been paying attention, you may already know that the takeaways related to hormone replacement therapy (HRT) from the original Women’s Health Initiative (WHI) study have been completely overhauled. It’s about time! As a result, it’s not an understatement to say that we are in the midst of a total transformation in hormone replacement therapy (HRT) and it’s essential that as provi
Beyond Retinol: The Role of Urolithin A in Aging and Skin Health
Talking with Dr. Julie Faitg was a powerful reminder of just how much we’re discovering about mitochondria and aging. When you pair an elite mitochondrial scientist with a breakthrough nutrient like Urolithin A, the insights go beyond what you’d expect. Julie gives us this incredible look into how we can actually change the course of aging at the cellular level. This conversation made me rethink w
Are You a Fast Metabolizer of Omega Fatty Acids? Lessons from a Legend
It’s not overstating it to say that I have cited Dr. Artemis Simopoulos’ work in virtually every lecture I have ever given that included the topic of omega-3 fatty acids. She is an incredible human being, indomitable NIH researcher, and absolute legend in her field. In our conversation on New Frontiers, Dr. Simopoulos reviews those essential truths about the evolution of our dietary intake of omeg
A 360-Degree View of the Microbiome: Practical Strategies for Clinicians
The centrality of gut health in total body health and aging means it’s a key topic for us to keep revisiting and updating our knowledge on. For instance, how confident do you feel about interpreting analytical indices such as phyla distribution, dysbiosis index, diversity score, as well as the myriad bacterial populations that can be resident in the GI tract? Join me and Dr. Julia Malkowski as we
Promise and Controversies: State of the State of Longevity Science with Matt Kaeberlein, PhD
It's important to me to include a variety of voices in the sphere of aging and longevity, and Matt Kaeberlein PhD is certainly one that I appreciate for his tempered and rational arguments. I value his insights and his work with other scientists who are tussling with the challenging questions and research interpretations in this field. We are at this extraordinary inflexion point where scientists
Addressing the Gut-Skin Axis: A Root Cause Approach to Chronic Skin Conditions
In this episode of New Frontiers, Dr. Kara Fitzgerald sits down with Dr. Valerie Gershenhorn, a leading expert in functional dermatology and a Clinical Team Member for Diagnostic Solutions Laboratory, to explore the profound impact of the gut-skin axis and autonomic nervous system on chronic skin conditions like acne, eczema, and more. Dr. Gershenhorn shares her comprehensive approach, including t
You Are Only As Young As Your Immune System with Dr. Greg Fahy
Your thymus isn't talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential "education" of the immune cells that protect your body from invaders. Through this action it also affects levels of inflammation (an immune-mediated process). It's also interesting to note that most of us end up dying of an immune-relat
Innovative Approaches to Cardiovascular Care: A Deep Dive with Dr. Mark Houston
Cardiovascular disease might be the leading cause of death, but after my conversation with Dr. Mark Houston, I'm more convinced than ever that we have the power to change that narrative. We delved into the power of diet and lifestyle changes, the essential role of nitric oxide and the impressive results of innovative supplements like Vascanox HP by Calroy Health Sciences in managing blood pressure
Latest Research Data on Diet & Other Interventions for Multiple Sclerosis with Dr. Terry Wahls
What a tour de force conversation with Dr. Terry Wahls, who is, with her groundbreaking research, changing both conventional and functional medicine's approach to multiple sclerosis and ultimately patient care. I'm very excited to see the findings of her ongoing clinical trials, which evaluate the use of several popular dietary patterns, using MRIs to measure brain volume loss, microbiome data, me
Targeting Cellular Senescence for Healthier, More Youthful Skin With Dr. Alessandra Zonari
*Save the date! Join me and Dr. Alessandra Zonari for a free webinar on July 25th 2024 and get your questions answered on all things OS-01 peptide and biological aging. Register at https://www.drkarafitzgerald.com/webinars/
I'm thrilled to be joined by Dr. Alessandra Zonari to take a deep dive into a breakthrough in skincare science that has caught my attention—OneSkin's OS-01 peptide. This epi
Resolving Chronic Inflammation using SPMs: A Two-Phase Approach with Ashley Koff RD
Practitioners, if specialized pro-resolving lipid mediators (SPMs) aren't already on your radar, you'll be a convert by the end of this New Frontiers episode.
In functional medicine, we excel at addressing inflammation through nutrition and lifestyle. However, brilliant researchers like Dr. Charles Serhan from Harvard have shown us that resolving inflammation requires a two-phase approach. We nee
Towards Predicting Autism in Utero with Dr. Janine LaSalle
What if we could actually identify and even correct significant autism risk factors in utero, before a baby is born?
This is the promise of the game-changing research of Dr. Janine LaSalle, epigeneticist extraordinaire from UC Davis. With autism rates continuing to increase at alarming rates (the latest data from the CDC, released in 2023, is 1 in 36 children in the US, an increase from the prio
Challenging Food Reactions? Addressing the Gut Microbiome and More with Dr. Thomas Fabian
Addressing adverse food reactions goes way beyond simply cutting out the culprits, so I’m thrilled to have Dr. Tom Fabian join us again on New Frontiers to highlight the interventions that will move the needle for our patients. We explore the mechanisms through which specific strains can either exacerbate or alleviate both immune-mediated and non-immune-mediated food reactions, and discuss the fas
Smart, Actionable Strategies for Childhood Resilience, with Dr. Elisa Song
Dr. Elisa Song is one of those clinicians that I could just keep talking to! She's a respected colleague and pioneer in pediatric functional medicine with so many practical tips for navigating childhood illness and health. Need to get your kiddo/patient through a blood draw they don't want to do? Or get your picky eater to take their supplement? Dr. Song has the answers. I appreciate her candor as
Mitigating Muscle Loss from GLP-1 Agonists, with Dr. Anurag Singh
Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a con
Tackling Alzheimer's Disease Head On - the Inspiring Work of Dr. Heather Sandison
Dr. Sandison confesses that when she first heard Dr. Dale Bredesen talk about his work reversing cognitive decline and Alzheimer's disease she was skeptical. But when she started to apply the Bredesen principles in her clinical work and saw just how meaningful the improvements were to patients' symptoms and quality of life, as she puts it: "...how do I do anything else with my life, but basically
Targeting Senescent Cells? Dose and Timing Matters - with Dr. Greg Kelly
Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds,
Barry Sears (of Zone Diet Fame) on Lifetime Metabolic Health and Sourcing Omega-3s
I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the un
Unraveling PCOS and Fertility: Debunking Common Misconceptions with Dr. Tara Harding
Gear up for an enlightening dive with Dr. Tara Harding, a vanguard in the realm of women’s health and fertility. Renowned for her exceptional work as a family nurse practitioner and fertility coach, Dr. Harding brings a wealth of knowledge from her battle against infertility and medical gaslighting, all while breaking barriers and fostering a supportive community for those navigating the complex j
AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price
Fellow clinicians, get ready for a mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. And being able to test th
Decoding Aging: The Science Of Cellular Rejuventation With Dr. Vittorio Sebastiano
It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano, a reproductive biologist by training, realized that because we are able to create life, that same body of information could be harnessed to create youth - that is, radically reverse our biological aging process to a younger time point without losing cellular identity.
In 2014, he and his lab began unpacking
Advanced Metabolomics: Identifying the Metabolic Signature for Aging with Betsy Redmond
Aging itself stands as the paramount driver of disease. As functional practitioners, the question arises: How can we assess biological age to make precise corrections that foster both healthspan and lifespan? Enter the era of omics, where metabolomics emerges as an exceptional tool with transformative potential. I'm thrilled to welcome back Dr. Betsy Redmond, longtime friend and the senior educati
Burnout in Healthcare: Causes, Consequences, and Solutions with Dr. Jonathan Prousky
Working in healthcare brings a unique set of challenges and stressors. But the truth is that any of us can get to burnout through challenging circumstances of work or study. And the consequences can range from severe to devastating. Burnout still hasn't been fully understood or recognized by the medical profession and other industries - there is still no official diagnosis classification. Along wi
Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging?
When it comes to mitochondrial health, few nutrients have burst onto the bioenergetics stage with quite the impressive force as the postbiotic rock star Urolithin A (UA). On this New Frontiers episode Dr. Chris Rinsch, co-founder of Amazentis / Timeline, shares the incredible scientific journey of UA's discovery and subsequent unfolding of its many benefits, as confirmed by multiple clinical studi
Resolving Osteoporosis and Optimizing Bone Health - A Tour de Force Update
Did you know that "bone-eating" osteoclast cells are derived from immune cell precursors and are stimulated by inflammation, just like other immune cells? Or that bone has its own glycocalyx whose health is essential to realize the benefits of exercise for bone? Folks, Dr. Keith McCormick is back on New Frontiers with ever-more juicy pearls like these, and with important updates on bone care for f
Breast Health and Beyond: A Practitioner's Guide to Functional Testing
Over 270,000 new cases of breast cancer are diagnosed each year in the US. And while BRCA mutations often get the most press, there are other, potentially more critical factors we can address. Today, Dr. Ruth Hobson joins us to delve into the realm of breast health, shedding light on both modifiable and non-modifiable risk factors, and sharing real-life strategies for supporting our patients.
We
Have You Met Your Imprintome Yet? Here’s Why You Should
The epigenetic pioneer, Dr. Randy Jirtle, returns to New Frontiers to share his latest groundbreaking work. And I really do mean groundbreaking. Dr. Jirtle's work in mapping our "imprintome" is literally creating a brand new branch of scientific study that is expected to provide valuable insights and opportunities for epigenetially-targeted therapies, including nutrition and lifestyle. What I so a
From Complex to Accessible: Streamlining Functional Medicine Labs
If you're a clinician and finding yourself pressed for time in your practice, you're certainly not alone. A recent survey of over 9,000 US physicians revealed that more than half are experiencing burnout. Fortunately, the field of functional medicine is rapidly evolving, bringing tools that promise to streamline and improve accessibility in our practices. Rupa Health is one such tool.
In this epi
The Role of Adrenal Function in Thyroid Health and Longevity with Dr. Izabella Wentz
Get ready for an enlightening conversation as I welcome Dr. Izabella Wentz, renowned Thyroid Pharmacist and an accomplished author, to New Frontiers. We’ll talk about her new book and dive into the often underappreciated and enigmatic connection between adrenal dysfunction and hypothyroidism, and how extreme stress can accelerate aging and impact immunity.
Dr. Wentz provides invaluable insights i
Mark Newman: Maximizing Hormone Health With The DUTCH Test
In this episode, I have the pleasure of interviewing Mark Newman, the president and founder of Precision Analytical, the company behind the revolutionary DUTCH test.
Mark is a true pioneer in the field of hormone testing, and in our conversation, we delve into the latest developments in this rapidly evolving field. We discuss how the DUTCH test has expanded to include additional markers, providin
Specialized Pro-Resolving Mediators: As Close to a Panpharmacon as We Can Get?
Harvard's award-winning Dr. Charles Serhan isn't just an expert on specialized pro-resolving lipid mediators (SPMs), he is the scientist who actually discovered them. His breakthroughs opened up a brand new field of research and clinical application with immense potential. After all, chronic, unresolved inflammation is a contributor or cause of so many conditions.
The growing body of research on
Mastering Cardiovascular Longevity: Glycocalyx & Biohacking for Optimal Heart Health
Vascular health is fundamentally essential to longevity and health span, and that’s why I’m thrilled to be welcoming Dr. Michael Twyman to New Frontiers. Trained as an invasive cardiologist, Dr. Twyman has made the shift to a more preventative approach, moving beyond traditional cath lab results to focus on the health of the 60,000 miles of blood vessels that carry vital blood, oxygen and nutrient
Evidence-Based Diet for Health and Stress Resiliency through the Microbiome with Dr. Vincent Pedre
I’m so happy to be here with Dr. Vincent Pedre to dig into emerging science on the microbiome. Dr. Pedre shares extensive clinical pearls from his vast experience in functional gut health in an approachable and fun way as he drills down on possible causes of the challenging gut epidemic we clinicians see in the increasing numbers of IBS patients walking through our doors.
Dr. Pedre and I discuss
Measuring Metabolites of Dysbiosis and Gut Function to Create Targeted Interventions
As we gain insight into microbiome impact on our health, we need accurate tests that tell us not only what and how much is there, but also which metabolites, or post-biotics created that can have downstream effects. So today I’m thrilled to welcome the brilliant Dr. Erika Ebbel Angle, PhD, biochemist, CEO, and co-founder of Ixcela, to discuss their fingerstick gut microbiome test. We’ll discuss th
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