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Let's Talk Micro

Let's Talk Micro

Luis Plaza 249 Episodes Jul 2, 2026

Clinical microbiology explained in simple terms, suitable for students and microbiologists alike. We discuss organisms, reactions, infectious diseases, and more. Hosted by Luis Plaza, a Medical Laboratory Scientist and microbiologist, who also shares his experiences in the field.

Episodes

241: What Can Whole Genome Sequencing Realistically Tell Us About Resistance?
241: What Can Whole Genome Sequencing Realistically Tell Us About Resistance? Jul 2, 2026 35:29 Recorded live at ASM Microbe 2026 in Washington, DC, this special episode marks the first live recording of Let's Talk Micro. Joining me are co-host Dr. Andrea Prinzi and guest Dr. Nathan Ledeboer for a discussion on the evolving role of whole genome sequencing (WGS) in clinical microbiology and antimicrobial resistance. Can whole genome sequencing predict antimicrobial susceptibility? What are it
240: CLSI M100 2026: Actualizaciones
240: CLSI M100 2026: Actualizaciones Jun 30, 2026 43:35 En este episodio en español de Let's Talk Micro, Luis conversa nuevamente con el Dr. Germán Esparza sobre los cambios más relevantes incluidos en la edición 2026 del documento CLSI M100. Durante la conversación, revisan nuevas opciones terapéuticas como aztreonam-avibactam, actualizaciones en los puntos de corte para Acinetobacter y Neisseria gonorrhoeae, cambios en aminoglucósidos, consideracione
239: Inside ASM Microbe 2026
239: Inside ASM Microbe 2026 Jun 25, 2026 21:14 ASM Microbe is the largest microbiology meeting in the United States, bringing together thousands of scientists, laboratorians, clinicians, and industry partners to discuss the latest advances in microbiology. In this episode, Luis shares highlights from ASM Microbe 2026, including sessions on diagnostic challenges, antimicrobial resistance, rapid susceptibility testing, emerging therapeutics, lab
238: From the Bench to CPEP: An MLS Journey
238: From the Bench to CPEP: An MLS Journey Jun 18, 2026 50:51 What does it take to go from working at the bench to becoming a future clinical microbiology laboratory director? In this episode, Luis is joined by Dr. Mackenzie Collins, a CPEP fellow at UCLA, to discuss her journey from Medical Laboratory Scientist (MLS) to PhD scientist and CPEP fellow. Mackenzie shares how she discovered laboratory medicine, her experience working as an MLS in molecular micro
237: Micro Minutes: A Case of Mistaken Identity
237: Micro Minutes: A Case of Mistaken Identity Jun 11, 2026 13:14 Have you ever received an identification result that just didn't make sense? In this episode, Luis shares three cases of mistaken identity from the microbiology laboratory: a Gram-positive rod identified as Kocuria, another reported as Sphingomonas, and a yeast that somehow became Brucella. While automated identification systems are powerful tools, they can only work with the information we provid
236:  Let's Talk Andes Virus
236: Let's Talk Andes Virus Jun 4, 2026 31:26 In Part 2 of this hantavirus series, Luis continues the conversation with Dr. Ryan Relich and Dr. Stephanie Seifert by focusing on the recent Andes virus cruise ship outbreak and what makes this hantavirus different from others. The discussion explores the outbreak investigation, the evidence for person-to-person transmission, and why the Andes virus has received so much attention from the public
235: Let's Talk Hantavirus
235: Let's Talk Hantavirus May 28, 2026 43:32 Hantaviruses have recently been in the headlines, but what exactly are they and how do they spread? In Part 1 of this hantavirus series, Luis is joined by Dr. Ryan Relich and Dr. Stephanie Seifert for a deep dive into the world of hantaviruses. The conversation explores the basics of hantaviruses, including their ecology, rodent reservoirs, transmission, and the diseases they cause in humans. The
234: High School, the Laboratory, and Workforce Development
234: High School, the Laboratory, and Workforce Development May 21, 2026 28:50 Workforce shortages continue to impact clinical laboratories across the country, especially in rural healthcare settings. In this episode of Let's Talk Micro, Luis is joined by Kenzi Haigler to discuss an innovative high school laboratory program designed to introduce students to laboratory medicine early and help strengthen the future workforce pipeline. Kenzi shares her journey into the laborato
233: The Background Singers of Gram-Negative Cocci
233: The Background Singers of Gram-Negative Cocci May 14, 2026 22:06 In this episode of Let's Talk Micro, we close out our gram-negative cocci series by talking about the "background singers" of the group—the organisms that quietly show up on respiratory cultures and oral flora plates every day. We explore the world of non-pathogenic Neisseria species, along with rod-shaped and coccobacillary Neisseria and Moraxella that break the classic gram-negative diplococci r
232: What's New at ASM Microbe 2026?
232: What's New at ASM Microbe 2026? May 7, 2026 55:59 This week, Let's Talk Micro is pausing the Gram-negative cocci series to talk about one of the biggest microbiology meetings of the year: ASM Microbe 2026. Luis is joined by Dr. Bobbi Pritt and Dr. Robert Tibbetts to discuss what attendees can expect from this year's meeting in Washington, DC. The conversation covers the new meeting structure, important trends in clinical microbiology, sessions an
231: The Hockey Puck Bug: Moraxella catarrhalis
231: The Hockey Puck Bug: Moraxella catarrhalis Apr 30, 2026 17:30 In this episode of Let's Talk Micro, we continue our gram-negative cocci series with a closer look at Moraxella catarrhalis—better known at the bench as the hockey puck bug. We break down what makes this organism unique, from its classic sliding colony morphology to how it behaves in different patient populations. Is it a colonizer or a pathogen? The answer depends on the clinical context. We walk
230: Same Gram Stain, Different Story: Neisseria meningitidis vs gonorrhoeae
230: Same Gram Stain, Different Story: Neisseria meningitidis vs gonorrhoeae Apr 23, 2026 25:22 In this week's episode, we continue our series on gram-negative cocci and take a closer look at two of the most important organisms: Neisseria meningitidis and Neisseria gonorrhoeae. On the Gram stain, they may look the same—but clinically, they represent very different scenarios. We walk through colonization, transmission, and key virulence factors, and connect them to the infections they cause—f

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