Bryan Johnson Podcast
The Bryan Johnson Podcast explores a new era of being human, focusing on longevity and health optimization. Hosted by Bryan Johnson, joined by longevity physician Dr. Mike Mallin and co-founder Kate Tolo, the podcast discusses science-based protocols to help listeners become their best selves. Johnson shares his personal journey from living in extreme poverty to selling his company for $800 million and building the world's best health protocol, Blueprint. The podcast also delves into the implications of AI and the need for a new globally adopted ideology.
Episodes
Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)
Should I try shrooms for science? In part two of three of our series investigating drugs for longevity, I’m putting psilocybin, LSD and DMT under the microscope - and revealing some pretty exciting research that connects psychedelics to longer lifespans. We’ll also talk about weed, and what the data says about marijuana for longevity.
Study Links:
Psilocybin for Cancer Patients
LSD: Longevi
Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)
Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.
Study Links:
Ketamine’s Effects on Epigenetic Age
Extending Ketamine’s Therapeutic Window
Ibogaine Therapy for PTSD
Jesse James West on AI, Fitness & Self-Worth
Fitness creator Jesse James West is a natural bodybuilder who makes some of the coolest videos on YouTube for over 7 million subscribers. We’re talking about his motto of “stay relentless,” and how he balances work, health and life now that he’s newly married. Plus, he shares about the time that he also had a breakdown in Target - and how it may have saved his life.
Connect with Bryan:
X: https
Don’t ‘Dye’ - Empowering Kids to Understand Health
Between synthetic dyes, air pollution, and environmental toxins, kids have a lot of obstacles in the way of their health. I’m reviewing some top offenders (like synthetic dyes and added sugars) and discussing how to empower our kids to make informed choices.
Study Links:
Synthetic Dyes in Food & Beverages
HEPA Filters in LA Schools
US Kids Face Deadlier Odds
Peanut Allergies & Air Pollution
Nobody Taught You THIS About Sex
My team and I looked into the biological effects of eating a*s and choking during sex - here’s what we found. I’m also sharing why I monitor my erections - and why this metric is critical for good health and longevity.
Study Links:
Choking During Sex
Overnight Erections
Female Erection Cycles
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead
What Stress, Burnout, and Hustle Culture Do To Your Body
Had I protected my body and brain, I’d be wealthier and more successful today. Culture is lying to you — you do not need to martyr yourself to be successful. Here’s how you can avoid making the same mistake I did.
Study Links:
Burnout + Heart Attack Risk
Hours Worked + Heart Disease
Sleep Deprivation in CEOs
Sleep Deprivation in Judges
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: B
These Toxins Are Silently Ruining Your Health
Society is bathing us in chemicals. From wildfires to 4th of July fireworks, toxins feel inescapable. Here’s what I’m doing to limit exposure and reduce my levels.
Show Links:
Blueprint Food Guide: https://blueprint.bryanjohnson.com/pages/blueprint-protocol#food-guide
Further Listening:
“How Sauna Detoxified My Body” - Bryan Johnson Podcast
“We Need to Talk About Microplastics” - Bryan Jo
How to Travel Without Wrecking Your Sleep and Brain
International travel is brutal on your mind, body, and sleep. We discuss the recent data and I share my current jet lag protocol (still evolving) to help minimize the damage after long flights.
Study Links:
Olympic Athletes + Jet Lag: https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.998484/full
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtub
We Need to Talk About Microplastics
Microplastics are everywhere — even in glass bottles. Should you be worried? Kate, Mike, and I interpret the data to understand the risk. I’ll share how I reduced my own levels by 93% so you can too.
Study Links:
Glass Bottle Study: https://www.sciencedirect.com/science/article/pii/S0889157525005344
Impact on Children: https://www.nejm.org/doi/abs/10.1056/NEJMms2409092
Connect:
X: https:/
Advanced Guide to Better Sleep
Quality sleep is the highest-return investment I’ve ever made. In this episode we walk you through my exact protocol, so you can cherry-pick what works, experiment, and track gains for yourself.
Study Links:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3902870/
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjoh
How Sauna Detoxified My Body
At last, we tested sauna for longevity. I’m dropping my sauna protocol and explaining why they are definitely worth the hype. Plus, hear about my first time ever stepping into one, and why it was one of the most difficult — but rewarding — protocols I’ve ever done.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/br
The Dark Side of Fame, Money & High Performance With Dr. Mike Israetel
Dr. Mike Israetel is back. We’re talking about deep work, sharing a brain with AI, strategies for creativity, and how money and fame changed our lives, for better and worse.
About Dr. Mike:
Dr. Mike Israetel is an expert in the field of fitness and performance. He’s served as a professor at Lehman College, Temple University, and the University of Central Missouri, teaching exercise science cour
How I Became The World's Healthiest Human
I’ve become the worlds healthiest human. Today I’m sharing more on my longevity protocols and biomarker testing and why that’s an essential piece of the Don’t Die movement. We’re also getting into sperm health and why it’s important to keep your testicles cool.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjo
‘Dad Bod’ Science, Bone Density & Protein Myths
If you’re worried about “dad bod,” listen up. We’re discussing a new study among mice. We review the new data behind dad bod and how you can prevent it. We also dive into bone health and why you should care, and the healthiest way to get your protein.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
Evening Exercise, Poor Sleep, and Resting Heart Rate
Is it better to work out at night or in the morning? A new WHOOP study covers new data on evening exercise. Kate, Mike and I also share why lowering your resting heart rate (RHR) may be one of the most powerful strategies for longevity and overall health.
WHOOP Study: https://www.nature.com/articles/s41467-025-58271-x
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@
India's Air Pollution and Hyperbaric Oxygen Therapy
There’s a new treatment for longevity — one you probably haven’t heard of before. I review my experiments with hyperbaric oxygen therapy (HBOT) and how it dramatically transformed my biomarkers. We’ll also cover the ways air pollution shows up in your body, something I experienced firsthand while traveling in India.
Links and Studies
Analyzing India’s Air Quality: https://x.com/bryan_johnson/
Creatine, Sleep Trackers, and AI Doctors
What’s the truth when it comes to creatine? And which sleep tracker gets you the best results? Blueprint co-founder Kate Tolo and Blueprint Chief Medical Officer Dr. Mike Mallin join me to discuss the science behind some of the hottest wellness topics to find out which ones are actually worth your time.
UNSW Creatine study: https://www.unsw.edu.au/newsroom/news/2025/03/sports-supplement-creatin
The Future of Fitness: Dr. Mike Israetel on AI, Steroids & Online Criticism
Fitness expert Dr. Mike Israetel shares his take on artificial intelligence, what to consider before trying steroids, and his experience dealing with haters. Dr. Mike Israetel is an expert in the field of fitness and performance. He’s served as a professor at Lehman College, Temple University, and the University of Central Missouri, teaching exercise science courses focusing on nutrition, strength
This is the Bryan Johnson Podcast
The Bryan Johnson Podcast is ushering in a new era of being human. In this podcast I am joined by longevity physician Dr. Mike Mallin, my co-founder Kate Tolo, and the occasional guest. We discuss the science-based protocol to help you become your best self. Join us on this journey. New episodes releasing weekly.
Fixing Trevor Wallace's Burnout Lifestyle
Just how bad is Trevor Wallace’s comedy career for his body? Comedian and host of the podcast “Stiff Socks” talks about his life on the road. I offer Trevor some practical tips to help him look and feel his best.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_brya
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