ICU Ed and Todd-Cast
Two critical care clinicians break down intensive care trials, both old and new, in a conversational format. They also dive deep into specific topics important to practicing intensive care medicine and feature special guests sharing their expertise. The podcast is educational and clearly states that its content is not medical advice and should not be used to diagnose or treat any condition. The hosts note that opinions expressed are their own and not those of their employers.
Episodes
New/Old: RATE and CESAR
Send us a Text Message (please include your email so we can respond!)Episode 102! In this episode we talk about ECMO anticoagulation strategies with RATE and go back in time to talk about the original landmark trial for ECMO in CESARRATE: https://pubmed.ncbi.nlm.nih.gov/42413523/CESAR: https://pubmed.ncbi.nlm.nih.gov/19762075/If you enjoy the show be sure to like and subscribe, leave that 5 star r
Old/New: TTM2 and ICECAP
Send us a Text Message (please include your email so we can respond!)Episode 101! In this episode we talk about targeted temperature management starting with TTM2 to set the stage and moving towards ICECAP published by Muerer et al in JAMA August 2026!TTM2: https://pubmed.ncbi.nlm.nih.gov/34133859/ICECAP: https://pubmed.ncbi.nlm.nih.gov/42554995/If you enjoy the show be sure to like and subscribe,
New: Olanzapine vs Dex and a look back
Send us a Text Message (please include your email so we can respond!)Episode 100! Can't believe we made it here. 100 episode of trying to fit into Todd's triple booked schedule. This episode we do a little reminiscing about the past 3 years of podcasting but not after talking about a trial published in the form of a research letter about olanzapine versus dexmedetomidine for delirium by
NEXIS and Mailbag
Send us a Text Message (please include your email so we can respond!)Episode 99! In this episode we talk about Nutrition and Exercise in Critical Illness published in AJRCCM June 2026 by Needham et al. A shorter episode today as we're dealing with end-of-summer travel schedules so we add a mailbag segment to this one. NEXIS: https://pubmed.ncbi.nlm.nih.gov/42438140/If you enjoy the show be su
Old/New: EUPHRATES and Tigris
Send us a Text Message (please include your email so we can respond!)Episode 98! We talk about polymyxin B filtration of endotoxin for patients with septic shock in EUPHRATES which sets the stage for Tigris. We also butcher Mesopotamian history (sorry!)EUPHRATES: https://pubmed.ncbi.nlm.nih.gov/30304428/Tigris:https://pubmed.ncbi.nlm.nih.gov/41887242/If you enjoy the show be sure to like and subsc
New/New: MARCH and Tele-Rehab
Send us a Text Message (please include your email so we can respond!)Episode 97! In this episode we talk about mucolytics for patients with difficult to clear secretions on the ventilator and the effects of a tele ICU rehabilitation intervention! We also have some emails following up on scurvy and the taste of chalk.Scurvy History:https://pmc.ncbi.nlm.nih.gov/articles/PMC1276007/Bootcamp: https://
New/New: ARISE-FLUIDS and VICTORY (+mail)
Send us a Text Message (please include your email so we can respond!)Episode 96. In this episode we talk about ARISE FLUIDS (early pressors vs early fluids) and VICTORY (high dose Vitamin C in severe burn) both simultaneously presented and published at the CCR26 conference. Then we start digging out form our ever growing mailbagARISE-FLUIDS: https://pubmed.ncbi.nlm.nih.gov/42274006/VICTORY: https
New/New: BiHCA and SODa-BIC
Send us a Text Message (please include your email so we can respond!)Episode 95! In this episode we talk about "Sodium Bicarbonate for In-Hospital Cardiac Arrest" by Granfeldt et al and "Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock" published by the ANZICS group both presented at the CCR26 conference.BiHCA: https://pubmed.ncbi.nlm.nih.gov/42273
CCR26 and the unpublished results presentations
Send us a Text Message (please include your email so we can respond!)Episode 94! In this episode we give some general reactions to the CCR conference, discuss our impact on the critical care world, and talk briefly about 3 of the presentations from the conference that did NOT have a simultaneous publication (REMAP-CAP oseltamivir, FISSH, and SAVE-ICU)If you enjoy the show be sure to like and subsc
NEW: ATS 2026 and Hantavirus?
Send us a Text Message (please include your email so we can respond!)Episode 93! In this episode we go over TOWAR or "Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage" by Sperry et all published in NEJM and "Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors" published by O'Neill et al in JAMA both in May 2026 and presented at
New: R2D2
Send us a Text Message (please include your email so we can respond!)Episode 92! In this episode we talk about "Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients" published in JAMA by Sonneville et al April 2026!R2D2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/41841304/R2D2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2846726If you enjoy the
New: 4D
Send us a Text Message (please include your email so we can respond!)Episode 91! In this episode we talk about "Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients" published by Godet et al in Intensive Care Medicine October of 2025! We are going to be on a one article per episode kick for a while but hope to get back to normal programming soon!4D: https:/
New: 2026 Sepsis Guidelines
Send us a Text Message (please include your email so we can respond!)Episode 90! In this episode we talk about the 2026 Surviving Sepsis Campaign Guidelines lead by Prescott et all and published in Critical Care Medicine in March of 2026! We review all that's new and all that's changedIf you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on t
New: Hi-PEITHO
Send us a Text Message (please include your email so we can respond!)Episode 89! In this episode we talk about HI-PEITHO or catheter directed thrombolysis versus conventional anticoagulation for intermediate risk pulmonary embolism. This was published in the New England Journal of Medicine by Rosenfield et al.HI-PEITHO: http://nejm.org/doi/full/10.1056/NEJMoa2516567HI-PEITHO (pubmed): https://pubm
New/New: PE and CPR Guidelines
Send us a Text Message (please include your email so we can respond!)Episodes 88! In this episode we talk about guidelines recently released for the management of pulmonary embolism and cardiac arrest! A little hap hazard of an episode as we jump around from topic to topic but good to highlight things that are new and things that are changing!PE: https://pubmed.ncbi.nlm.nih.gov/41712898/CPR: https
Old/New: ALBIOS and ARISS
Send us a Text Message (please include your email so we can respond!)Episode 87! In this episode we talk about Albumin with two related studies, ALBIOS ("Albumin replacement in patients with severe sepsis or septic shock" by Caironi et al) and ARISS ("Albumin Replacement Therapy in Septic Shock" by Sakr et al)ALBIOS: https://pubmed.ncbi.nlm.nih.gov/24635772/ARISS: https://pubme
New: PreVent2
Send us a Text Message (please include your email so we can respond!)Episode 86! In this episode we talk about endotracheal tubes or "Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation" published in Lancet Respiratory Medicine February 2026 by Treggiari et al.Pubmed: https://pubmed.ncbi.nlm.nih.gov/41319
New: LIBERATE-D with Eddie Siew
Send us a Text Message (please include your email so we can respond!)Episode 85! In this episode we go over LIBERATE-D or "A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury" by Liu et al in JAMA 2026. We have the second author, Eddie Siew, on with us to discuss!LIBERATE-D (pubmed): https://pubmed.ncbi.nlm.nih.gov/41201895/LIBERATE-D (
CCR Down Under: ACTiVE and CLIP2
Send us a Text Message (please include your email so we can respond!)Episode 84! In this episode we finish up our discussion of the articles presented with the CCR Down Under Conference with ACTiVE (close loop ventilation) and CLIP2 (cryopreserved platelets for surgical bleeding). Both are neutral trials at best, so we took them both pretty short.ACTiVE: https://pubmed.ncbi.nlm.nih.gov/41361939/AC
CCR Down Under: ImmunoSep
Send us a Text Message (please include your email so we can respond!)Episode 83! Only one article this episode since Todd is feeling a little under the weather, but still a good discussion!ImmunoSep (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842634ImmunoSep (pubmed): https://pubmed.ncbi.nlm.nih.gov/41359996/If you enjoy the show be sure to like and subscribe, leave that 5 star
2025 Year in Review
Send us a Text Message (please include your email so we can respond!)Back by popular demand, year in review! Or probably better titled "Our Favorite Articles of the Year" but I kept the title from last year. A smattering of papers and topics in this one ranging from avalanche survival, to intubation, to cardiac resuscitation and more. Happy New Year everyone! We will see you in 2026, tha
New: MODS with Yonathan Freund
Send us a Text Message (please include your email so we can respond!)Episode 81! In this episode we talk to Yonathan Fruend the senior author on the MODS study looking at a single questions approach to ruling out pulmonary embolism in the emergency department. This is not our typical patient population but this is a good episode, don't miss this one!MODS: https://pubmed.ncbi.nlm.nih.gov/41135
CCR Down Under: RSI with Jon Casey
Send us a Text Message (please include your email so we can respond!)We start our Critical Care Reviews Down Under coverage with RSI talking with the first author of the "Ketamine versus Etomidate for Adults Receiving Emergency Endotrachael Intubation", Jonathan Casey! We will pick up the rest of our CCR Down Under Coverage after the holiday break!If you enjoy the show be sure to like an
New/New: EVERDAC and ANDROMEDA SHOCK 2
Send us a Text Message (please include your email so we can respond!)Episode 79! We talk all about perfusion with arterial lines in EVERDAC and personalized resuscitation with ANDROMEDA SHOCK 2! EVERDAC: https://pubmed.ncbi.nlm.nih.gov/41159885/EVERDAC (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2502136ANDROMEDA SHOCK 2: https://pubmed.ncbi.nlm.nih.gov/41159835/ANDROMEDA SHOCK 2(JAMA): https://
New/New: BICAR ICU 2 and SOFA 2
Send us a Text Message (please include your email so we can respond!)Episode 78! We start our discussion of the trials that drop with ESICM with the much anticipated BICAR-ICU 2! Then we talk briefly about some changes to the SOFA score with the new SOFA-2 score. BICAR-ICU2: https://pubmed.ncbi.nlm.nih.gov/41159812/BICAR-ICU 2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840824SOFA-2
New: WFIT with Carla Sevin
Send us a Text Message (please include your email so we can respond!)Episode 77! We will start on ESICM coverage next episode. In this episode we talk about WFIT or "A Randomized Controlled Trial of a Post-ICU Telehealth Care Model" by Bakhru et al published in the blue journal September 2025! A long discussion but a good one!WFIT: https://pubmed.ncbi.nlm.nih.gov/40532205/Editorial: http
LIVE @ CHEST2025: Oscillation, Glucose, and more!
Send us a Text Message (please include your email so we can respond!)We were LIVE from the CHEST Annual Meeting 2025! Thanks to everyone who came out and stuck around to chat afterwards. We cover a lot of ground including some conference and Chicago related banter (~8 minutes if you wanted to skip to the learning!)High frequency oscillation: https://pubmed.ncbi.nlm.nih.gov/40983167/MELLOW: https:/
New: MELLOW, Melatonin, and Mailbag
Send us a Text Message (please include your email so we can respond!)Episode 75! We talk about melatonin! We highlight MELLOW because it has the best acronym (by Burry et al in CHEST 2025). Then we dive into our mailbag!MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/DEMEL: https://pubmed.ncbi.nlm.nih.gov/40608082/Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/40662882/If you enjoy the show be su
Old/New: SBT and SBT Timing
Send us a Text Message (please include your email so we can respond!)Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM.SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/SBT (NEJM): https://www.
LIVE @ CC Bootcamp 2025: PIC
Send us a Text Message (please include your email so we can respond!)We are (were) LIVE at ACNP Critical Care Bootcamp 2025! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the PIC trial or "Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia" by Lemiale e
CCR25: UK-ROX and TARGET-Protein (with Mail bag!)
Send us a Text Message (please include your email so we can respond!)Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in
CCR24/Old: FLUID and BICAR-ICU
Send us a Text Message (please include your email so we can respond!)Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metab
New: A2B with Wes Ely
Send us a Text Message (please include your email so we can respond!)Episode 70! In this episode we have a special guest, Wes Ely, join us to talk about A2B or "Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients" by Walsh et al published in JAMA May of 2025. A long discussion but a good one, don't miss this one!Pubmed: https://pubmed.ncbi.
CCR25: RESCUE-3 and PROMIZING
Send us a Text Message (please include your email so we can respond!)Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilat
New: MODE with Kevin Seitz
Send us a Text Message (please include your email so we can respond!)Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial".Disclaimer, this is stated in the episode but Todd and I are author
CCR25 Recap
Send us a Text Message (please include your email so we can respond!)Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference!If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format!
New: TASC with Benjamin Tillman
Send us a Text Message (please include your email so we can respond!)Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap e
New/Old: Risk factors for Stress Ulcers and Transfusions in GIB
Send us a Text Message (please include your email so we can respond!)Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding!Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/Tran
New: REMAP-CAP Steroids
Send us a Text Message (please include your email so we can respond!)Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025.Pubmed: https://pubmed.ncbi.n
New/Old: PEERLESS and PEITHO
Send us a Text Message (please include your email so we can respond!)Episode 63! We talk about intermediate risk PE in "Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism" by Jaber et al published in Circulation in February 2025. Then we talk about "Fibrinolysis for patients with intermediate-risk pulmon
ISICEM Review and SESAR
Send us a Text Message (please include your email so we can respond!)Episode 62! We talk briefly about two of the analyses that dropped with the ISICEM conference and then talk in depth about SESAR or "Inhaled Sedation in Acute Respiratory Distress Syndrome" by Jabudon et al in JAMA 2025. Then was answer a question on sleep in the ICU. Eddie did misspeak when he said one of the dexmedeto
New/Review: Extubating to HFNC
Send us a Text Message (please include your email so we can respond!)Episode 61! We talk about HFNC including extubation to HFNC in "Early weaning from invasive mechanical ventilation via high-flow nasal oxygen versus conventional weaning in patients with hypoxemic respiratory failure" by Ayyawar et al published in Critical Care Science. Then we talk about weaning HFNC from the "How
SCCM: PROACTIVE and ASA in sepsis
Send us a Text Message (please include your email so we can respond!)Episode 60! We jump to SCCM where we talk about 2 late breakers - PROACTIVE or "Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation" by Downar et al and "Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock" by Almeida et al
TRAUMOX2, SAHARA, and mailbag
Send us a Text Message (please include your email so we can respond!)Episode 59! We finish our CCR down under coverage with TRAUMOX2 or "Early Restrictive vs Liberal Oxygen for Trauma Patients" published in JAMA by Arleth et al and then switch to SAHARA or "Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage" by English et al published in NEJM. We
Old/New: FLORALI and RENOVATE
Send us a Text Message (please include your email so we can respond!)Episode 58! We talk about non-invasive oxygen support and RENOVATE or "High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure" published in JAMA December 2024 and presented at the CCR Down Under Conference. We supplement this by first talking about FLORALI or "High-flow oxygen
CCR Down Under: SCREEN with Adam Wright
Send us a Text Message (please include your email so we can respond!)Episode 57! We were excited to have on this episode Dr. Adam Wright who is a PhD in Bioinformatics to discuss SCREEN or "Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial" published by Arabi et al in JAMA 2024 and presented at the CCR Down Under Conference. A
CCR Down Under: ADAPT-Sepsis
Send us a Text Message (please include your email so we can respond!)Episode 56! In this episode we spend a few minutes talking about making decisions on ECMO initiation but spend most of the episode talking about ADAPT-Sepsis or "Biomarker-Guided Antibiotic Duration for Hospitalized PatientsWith Suspected Sepsis" published by Dark et al in JAMA 2024 and presented at the CCR Down Under C
2024 Year in Review and CCR Down Under
Send us a Text Message (please include your email so we can respond!)Episode 55 and Happy New Year! In this episode we talk broad strokes about the CCR Down Under Conference and the trials that were presented, then Todd and Eddie go over a bunch of articles from the year 2024 that they didn't have time to go over or want to re-emphasize for whatever reason. Big show and we hope you enjoy!TIGH
New/Old: BALANCE and iDIAPASON
Send us a Text Message (please include your email so we can respond!)Episode 54! In this episode we talk about antibiotic duration in bacteremia (BALANCE) and also antibiotic duration in Pseudomonas Ventilator associated pneumonia (iDIAPASON). BALANCE (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2404991BALANCE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39565030/iDIAPASON (ICM): https://link.
New/New-ish: IVIO and PARAMEDIC-3
Send us a Text Message (please include your email so we can respond!)Episode 53! In this episode we talk about access in patients with out of hospital cardiac arrest. Both articles are similar so we talk in depth about IVIO and then bringing PARAMEDIC-3 to round out our discussion. A good acronym discussion too, don't miss it!IVIO (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2407616IVIO (pu
New/New: INTREPID and PROLABI
Send us a Text Message (please include your email so we can respond!)Episode 52! In this episode we talk about fevers in acute neurologic injury and double that up with talking about low tidal volume ventilation in patients with neurologic injuryINTREPID (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2824088INTREPID (pubmed): https://pubmed.ncbi.nlm.nih.gov/39320879/PROLABI (Blue): http
LIVE @ CC Bootcamp 2024: NONSEDA
Send us a Text Message (please include your email so we can respond!)We are (were) LIVE at ACNP Critical Care Bootcamp 2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the NONSEDA trial or "Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients" by Olsen et al publ
FAST and IV Fluid Shortage
Send us a Text Message (please include your email so we can respond!)Episode 50! In this episode we talk about SBT frequency and "Frequency of Screening and Spontaneous Breathing Trial Techniques" by Burns et al from JAMA 2024 that was released with the ESICM conference. In our second segment, instead of another trial we talk a little bit about the IV fluid shortage happening in the Unit
LIVE @ CHEST2024: Minocycline for delirium and Amio vs lido for cardiac arrest
Send us a Text Message (please include your email so we can respond!)We are LIVE at CHEST2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about a few articles that were recently published in CHEST - "Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial" p
New: Long Term Outcomes of ICU Visitation Policies
Send us a Text Message (please include your email so we can respond!)Episode 48! In this episode we talk about the long term effects of ICU visitation policies on families. Long Term Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/39172240/Long Term Outcomes of Visitation (ICM): https://link.springer.com/article/10.1007/s00134-024-07577-3Outcomes of Visitation (pubmed): https://pu
New/Guidelines: Cognitive Dissociation and Death by Neurologic Criteria
Send us a Text Message (please include your email so we can respond!)Episode 47! In this episode we talk about a prospective observational study examining cognitive motor dissociation by Bodien et al published in the New England Journal of Medicine and then we pair that talking about the guidelines for death by neurologic criteria published in SCCM! An episode of somber but important topics!Cognit
New/Old: TIMELESS and ANDROMEDA-Shock
Send us a Text Message (please include your email so we can respond!)Episode 46! In this episode we talk about thrombolytic windows in acute ischemic stroke from TIMELESS published by Albers et al published in the New England Journal of Medicine and then we talk about ANDROMEDA shock and serial lactates published by Hernandez et al!TIMELESS (pubmed): https://pubmed.ncbi.nlm.nih.gov/38329148/TIMELE
New/Guidelines: 1-BED and SUP Guidelines
Send us a Text Message (please include your email so we can respond!)Episode 45! In this episode we talk about sepsis bundles and the 1-BED trial by Fruend et al and discuss the stress ulcer prophylaxis guidelines just published in SCCM!1-BED (pubmed): https://pubmed.ncbi.nlm.nih.gov/38913098/SUP Guidelines: https://www.sccm.org/Clinical-Resources/Guidelines/Guidelines/SCCM-ASHP-Guideline-Preventi
CCR24: BLING3 with Joanna Stollings
Send us a Text Message (please include your email so we can respond!)We were honored to be joined by Joanna Stollings (and honestly we needed someone to keep us grounded) to talk about BLING3 or "Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis" published in JAMA by Dulhunty et al and also released with the CCR24 conference.pubmed: https://p
CCR24: HEMOTION and DEFENDER
Send us a Text Message (please include your email so we can respond!)Episode 43! In this episode come close to finishing our dedicated discussion of the CCR24 trials talking about transfusion targets in TBI (HEMOTION) and dapagliflozin in critical illness (DEFENDER)!HEMOTION: https://www.nejm.org/doi/full/10.1056/NEJMoa2404360HEMOTION (pubmed): https://pubmed.ncbi.nlm.nih.gov/38869931/DEFENDER: ht
CCR24: PROTECTION and CYCLE
Send us a Text Message (please include your email so we can respond!)Episode 42! In this episode we foray into weight lifting and body building as we talked about amino acids for kidney protection after cardiac surgery (PROTECTION) and cycling in addition to PT in mechanically ventilated adults (CYCLE). We also feature our first real ad for the Critical Care ACNP/PA Bootcamp! Details below! Baggin
CCR24: Brief Overview and REVISE
Send us a Text Message (please include your email so we can respond!)Episode 41! We continue our CCR24 recap with a brief overview and thoughts on the conference as a whole and then dive into REVISE or "Stress Ulcer Prophylaxis duringInvasive Mechanical Ventilation" published by Cook et al in NEJM June 2024. Not the sexiest of all the topics but important nonetheless (and we will get to
CCR24: PREOXI with Kevin Gibbs
Send us a Text Message (please include your email so we can respond!)Episode 40! In this special episode releasing at the conclusion of the PREOXI presentation at the Critical Care Reviews 2024 conference in Belfast, Ireland - we discuss the recently published PREOXI trial evaluating NIV vs facemask as pre-oxygenation for emergent endotracheal intubation. Kevin Gibbs, the first author and presente
New/Mailbag: APROCCHSS-CAP, Intubation Timing, and Driving Pressure
Send us a Text Message (please include your email so we can respond!)Episode 39! In this episode we talk about steroids in septic shock from community acquired pneumonia - a secondary from the APROCCHSS trial. We then dive into our mailbag to talk about a couple of topics we've been asked questions about and address them in a more broad sense. A pseudo-mailbag but with real answersAPROCCHSS-C
ATS 2024: Review of NEJM/JAMA/ATS Session
Send us a Text Message (please include your email so we can respond!)We're live from ATS! We decide to format our episode after the NEJM/JAMA/ATS combined session and talk about the articles presented there. Some of them we've talked about before but provide new insights from listeners and questions from the audience. Some of them are new and we provide our thoughts from the presentation
Old/New: NICE SUGAR and TGC-Fast
Send us a Text Message (please include your email so we can respond!)Episode 37! In this episode we talk about glycemic control in the ICU. We liked the flipped script and so we're again going old article first. NICE-SUGAR or "Intensive versus conventional glucose control in critically ill patients" was published in NEJM 2009 and then we talk about TGC-Fast or "Tight Blood-Gluc
Old/New: HALT-IT and TXA in GI Bleed with cirrhosis
Send us a Text Message (please include your email so we can respond!)Episode 36! In this episode we talk about tranexamic acid in GI bleeds. We flip the script a little bit and talk about our OLD article first, HALT-IT or "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis: A randomized controlled trial" published in Lancet in 2020. This sets the stage for our new
New/Obs: SPEED UP and Extubation on Pressors
Send us a Text Message (please include your email so we can respond!)Episode 35! In this episode we talk about extubation practices with "Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial" published in Intensive Care Medicine by Hernandez et al. We then talk about an observati
New/New: Oxygen Targets from ISICEM
Send us a Text Message (please include your email so we can respond!)Episode 34! In this episode we talk about oxygen targets! Specifically we go over the two oxygen target analyses that were published simultaneously with ISICEM. We spend most of our time with HOT-COVID published by Nielson et al and then dip a little into individualized treatment effects of oxygen targets published by Buell et al
New: VENT-AVOID with Eddy Fan and Whitney Gannon
Send us a Text Message (please include your email so we can respond!)Episode 33! In this episode we are excited to be joined by Eddy Fan and Whitney Gannon, two extraordinary ECMO researchers to talk about VENT-AVOID or " Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease" published March 2024 by Duggal et al
Old/Old/Old: VASST, VANISH, ATHOS-3
Send us a Text Message (please include your email so we can respond!)Episode 32! We got a lot of feedback on our last episode so we decided to address it in a full episode! A lot of listeners asked us about vasopressors specifically vasopressin and angiotensin-2 so we talk about VASST, VANISH, and ATHOS-3. It is a full episode but a good one!VASST: https://pubmed.ncbi.nlm.nih.gov/18305265/VANISH:
Obs/Old: Invasive vs Non-invasive Blood Pressure and 65 Trial
Send us a Text Message (please include your email so we can respond!)Episode 31! This episode we talk first about invasive vs non-invasive blood pressures from an observational paper titled "Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults" published in journal of Intensive Care Medicine by Haber et al and then for our old trial we further the discussion of bloo
SCCM: PROPHY-VAP and Mailbag
Send us a Text Message (please include your email so we can respond!)Episode 30! This episode is a little different. We recap the SCCM conference first. THEN we go into PROPHY-VAP or "Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury" published January 2024 by Professor Dahyot-Fizelier in Lancet Respiratory Medicine. Then we dive into our lo
ATS vs ESICM ARDS Guidelines
Send us a Text Message (please include your email so we can respond!)Episode 29! We stray a little bit from our new and old article structure to talk about two recently published but slightly different ARDS recommendations from ATS and ESCIM. We compare and contrast them and give our takes on the data and evidence.Thanks to everyone who emails in and gives feedback, we will do our mail bag next ep
New/Old: PRONECMO and EOLIA
Send us a Text Message (please include your email so we can respond!)Episode 28! In this episodes we talk about ECMO! PRONECMO evaluated the effect of prone positioning on patients already on ECMO by Schmidt et al in JAMA December 2023 and then EOLIA by Combes et al in NEJM 2018 which is our old article which randomized patients to ECMO or not. Great discussion here!PRONECMO: https://pubmed.ncbi.n
New/Old: NICO and Intubation timing
Send us a Text Message (please include your email so we can respond!)Episode 27! In this episodes we sit down to talk all about the "when" to intubate a patient centered around acute poisoning in the NICO trial or "Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial" published by Freud et al in JAMA November 2023. We en
New: ACORN with PulmPEEPs
Send us a Text Message (please include your email so we can respond!)This was easily our most requested article to discuss and for good reason - Eddie and Todd recently published the ACORN trial or "Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection" in JAMA October 2023. We recognize our bias as the first and last authors on the paper so we wanted to get som
New/Obs: MINT and ICH related to transfusions
Send us a Text Message (please include your email so we can respond!)Episode 25! In this episode we talk about the MINT trial or "Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia" published in NEJM November 2023 by Carson et al. We supplement this with a recent observational cohort study that gives Todd anxiety titled "Intracerebral Hemorrhage Among Bl
New/New/New: COVID Trials (ESICM Part 2)
Send us a Text Message (please include your email so we can respond!)Episode 24! Three trials about COVID were published with ESICM which we talk about all three here. COVID has been decreasing in prevalence in our ICU at least so we anchor our discussion around what we can learn from these trials about ARDS in general or what we can carry forward to future pandemics compared to our typical "
New/New: AMIKINHAL and STRESS-L (ESICM Part 1)
Send us a Text Message (please include your email so we can respond!)Episode 23! We spend a little bit of time talking about our recent conference related travel and food experience but dive into our coverage of the trials that released with ESICM including "Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia" by Ehrmann et al published in NEJM and "Landiolol and Organ Failu
