Home Podcasts Y Combinator Startup Podcast
Y Combinator Startup Podcast

Y Combinator Startup Podcast

Y Combinator 314 episodes Latest May 27, 2026

The Y Combinator Startup Podcast features conversations with Y Combinator partners and founders about building startups. Topics range from the earliest stages of an idea to scaling a company that changes the world. The podcast shares real stories, lessons, and tactics from the frontlines of entrepreneurship.

Episodes

"The CEO Must Be the Chief AI Officer" Jun 10, 2026 00:54:06 Brex co-founder and CEO Pedro Franceschi believes most people still underestimate how much AI will change the way companies are built. AI isn't just another tool, it's a new foundation for building products, teams, and companies.In this episode of Lightcone, Pedro shares why he thinks we're only months into a platform shift as significant as the invention of electricity, how AI has cha
How to Build an AI-Native Services Company Jun 3, 2026 00:11:21 Some of the biggest companies of the next decade won't be software businesses, they'll be services companies like insurance carriers, law firms, and tax practices rebuilt from scratch with AI doing most of the work. In this episode of Startup School, YC Visiting Partner Charlie Warren walks through the playbook for building AI native services companies, covering how to pick a market with t
How To Build Superintelligence Inside Your Company May 27, 2026 00:46:29 Building superintelligence inside a company isn't about adding AI as a feature. It's about making it the operating system the whole organization runs on. In this episode of the Lightcone, we sat down with YC's Pete Koomen to talk for the first time about how he led the effort to build YC's internal agent infrastructure from the ground up. We cover how giving agents unrestricted acc
How The Best Companies Defend Against Mediocrity And Rot May 25, 2026 00:50:04 In this episode of the Main Function Garry sits down with Eric Ries, author of "The Lean Startup", about his new book, "Incorruptible: Why Good Companies Go Bad And How Great Companies Stay Great". Ries breaks down why shareholder primacy often leads to company and product degradation, how founders can lose control of the companies they build, and what legal structures and gove
Paul Graham: Should you move to Silicon Valley? May 13, 2026 00:21:57 Paul Graham is a co-founder of Y Combinator. He's funded and mentored companies like Dropbox, Airbnb, DoorDash, and thousands of others through YC, and is one of the most influential voices in the startup world.In this talk at our YC | Stockholm event last month, Paul walks through why ambitious founders should move to Silicon Valley at least briefly, what makes it uniquely valuable — from serendi
Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers May 8, 2026 00:41:29 We're entering a new era of software where a single person, working with AI agents, can build products that previously required entire teams.In this episode of Lightcone, the hosts break down the rise of AI coding agents, "tokenmaxxing", and the emerging workflows behind tools like Claude Code and OpenClaw. They discuss why AI systems today feel less like productivity tools and more like collabora
Beyond Bigger Models: Recursion As The Next Scaling Law In AI May 1, 2026 00:37:52 A 7-million parameter model outperforming models a thousand times its size on tasks like ARC Prize. That's what recursive reasoning unlocks.In this episode of Decoded, YC's Ankit Gupta and Francois Chaubard break down two recent papers on recursive AI models, HRMs and TRMs, that are achieving state-of-the-art results with a fraction of the parameters of today's largest models.They expl
How to Build the Future: Demis Hassabis Apr 29, 2026 00:40:56 Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads Googl
The $9B Startup That Wants to Create a Billion New Developers Apr 25, 2026 00:39:11 Replit is the leading no-code app builder for consumers and enterprise, letting anyone with an idea build real, deployed software using natural language. The company just raised a $400 million Series D at a $9 billion valuation.In this episode of Founder Firesides, co-founder and CEO Amjad Masad sat down with YC's Andrew Miklas to talk about Replit's 10-year journey from browser IDE to vib
The Playbook For Building An AI Native Company Apr 24, 2026 00:10:27 AI isn't just making teams more productive. It's changing how companies should be built.In this episode of Startup School, YC Partner Diana Hu explains what it means to build an AI-native company, where AI isn't just a tool but the operating system your company runs on.She breaks down how to make your company queryable so agents can improve across every function, why management hierarc
Stripe Head of Design Katie Dill Breaks Down Their New Website Apr 22, 2026 00:43:36 Even the most successful websites eventually need a redesign. Take Stripe for example. After six years with the same homepage, they recently unveiled a brand new site that reflects how the fintech giant has evolved over the past few years. So when is the time right for a new landing page? And what should you prioritize in the redesign? In this episode of Design Review YC’s Aaron Epstein sat down S
The GPT Moment for Robotics Is Here Apr 16, 2026 00:49:26 Physical Intelligence is building a foundation model that can control any robot to do any task — what the team describes as the GPT-1 moment for robotics.The company's cross-embodiment approach trains across many different robot platforms, and recent results show tasks being performed zero-shot that last year required hundreds of hours of data collection.In this episode of The Lightcone, co-fo

Recommended

Playing