JACC Specialty Journals
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
Episodes
Comparison of Flow Ratio Derived From IVUS With CAG in Complex Lesions: Correlation With FFR | JACC Asia
Commentary by Dr. Jian'an Wang.
Sex Differences in Antiarrhythmic Effects of Empagliflozin: The EMPA-ICD Trial Subanalysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Association Between Cardiac Acceleration Capacity and Susceptibility to Vasovagal Syncope: Autonomic Dysregulation in Vasovagal Syncope | JACC Asia
Commentary by Dr. Jian'an Wang.
Cardio-Kidney-Metabolic Phenotypes and Adverse Clinical Outcomes in Patients With Atrial Fibrillation | JACC Asia
Commentary by Dr. Jian'an Wang.
Postoperative New-Onset Heart Block in Noncardiac Surgery: Model Development, Validation, and Long-Term Prognostic Analysis | JACC Asia
Commentary by Dr. Jian'an Wang.
The Associations Between Heart Rate, Deformational Echocardiographic Parameters, and Outcomes in Patients With Atrial Fibrillation | JACC Asia
Commentary by Dr. Jian'an Wang.
Sex Differences in Antiarrhythmic Effects of Empagliflozin: The EMPA-ICD Trial Subanalysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Development of a Noninvasive Prediction Score for Post-Capillary Pulmonary Hypertension in a Multi-Ethnic Asian Population | JACC Asia
Commentary by Dr. Jian'an Wang.
Ambrisentan for Early-Stage Low-Risk Pulmonary Arterial Hypertension: Design of the Randomized, Double-Blind, Placebo-Controlled ALEPH Trial | JACC Asia
Commentary by Dr. Jian'an Wang.
Persistent Atrial Fibrillation With Conduction System Pacing or Pulmonary Vein Isolation: A Prospective Cohort Study | JACC Asia
Commentary by Dr. Jian'an Wang.
Conceptual Reconsideration of the Classification of Pulmonary Hypertension: From 5 Groups to 2 Groups | JACC Asia
Commentary by Dr. Jian'an Wang.
Prognostic Value of Murray's Law–Based Quantitative Flow Ratio in Multi-Arterial Coronary Artery Bypass Grafting | JACC Asia
Commentary by Dr. Jian'an Wang.
Comparison of Clinical Outcomes Between Incomplete and Complete Revascularization in NSTEMI Patients With Multivessel Disease | JACC Asia
Commentary by Dr. Jian'an Wang.
Comparison of Flow Ratio Derived From IVUS With CAG in Complex Lesions: Correlation With FFR | JACC Asia
Commentary by Dr. Jian'an Wang.
CRP Cutoff Value in East Asians With Coronary Heart Disease: A Systematic Review and Meta-Analysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Validation and Recalibration of PCE, China-PAR and PREVENT Models for Estimating ASCVD Risk in China | JACC Asia
Commentary by Dr. Jian'an Wang.
Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health.
Differential Association Between Surrounding Greenness and Mortality in Individuals With Coronary Heart Disease | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Differential Association Between Surrounding Greenness and Mortality in Individuals With Coronary Heart Disease.
Sex Differences in Cardiac Involvement in Adults With Myotonic Dystrophy Type 1: A Multicenter Study | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Cardiac Involvement in Adults With Myotonic Dystrophy Type 1: A Multicenter Study.
Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock: A Nationwide Analysis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock: A Nationwide Analysis.
Comparison of Microcirculation in Chronic Heart Failure, Cardiogenic Shock, LVAD, and Heart Transplantation | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Comparison of Microcirculation in Chronic Heart Failure, Cardiogenic Shock, LVAD, and Heart Transplantation.
Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening.
Generalizability of Landmark Temporary MCS Device Trials: Insights From the CSWG Registry | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Generalizability of Landmark Temporary MCS Device Trials: Insights From the CSWG Registry.
Long-Term Outcomes of Targeted Volume Overload Management in Patients With Severe Aortic Stenosis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Long-Term Outcomes of Targeted Volume Overload Management in Patients With Severe Aortic Stenosis.
Should Interventionalists Get an MBA? Wayne Batchelor, MD, MHS, MBA Responds | JACC: Cardiovascular Interventions
Dr. Mohamad Alkhouli speaks with Dr. Wayne Batchelor about what leadership truly means for mid‑career interventional cardiologists and whether pursuing an MBA adds value. Dr. Batchelor highlights trust, communication, and business fluency as essential skills for physician leaders navigating increasingly complex healthcare systems.
Should Interventionalists Get an MBA? Kirk Garratt, MD, MSc Responds | JACC: Cardiovascular Interventions
Dr. Mohamad Alkhouli and Dr. Kirk Garratt discuss leadership in interventional cardiology, highlighting the importance of empathy, communication, and advocacy alongside clinical expertise. Dr. Garratt encourages physicians to intentionally develop leadership skills—through training or experience—as healthcare systems become more complex.
Should Interventionalists Get an MBA? J. Dawn Abbott, MD Responds | JACC: Cardiovascular Interventions
In this conversation, Dr. Mohamad Alkhouli speaks with Dr. Abbott about her leadership journey in interventional cardiology, focusing on how curiosity, mentorship, and skill development organically lead to meaningful leadership roles. Dr. Abbott shares practical insights on motivating teams, navigating complex healthcare systems, and whether formal business training such as an MBA is necessary for
Should Interventionalists Get an MBA? Deepak Bhatt, MD, MPH, MBA Responds | JACC: Cardiovascular Interventions
Dr. Mohamad Alkhouli and Dr. Deepak Bhatt discuss leadership development in interventional cardiology and the value of pursuing an executive MBA mid‑career. Dr. Bhatt shares insights on how business training—from finance to leadership and strategy—can help physicians navigate increasingly complex healthcare systems and become more effective stewards of patient care and resources.
Postoperative New-Onset Heart Block in Noncardiac Surgery: Model Development, Validation, and Long-Term Prognostic Analysis | JACC: Asia
Commentary by Dr. Katsuhiko Imai.
Sex-Based Differences in Clinical Outcomes With Edoxaban Therapy: A Prespecified Analysis of the EPIC-CAD Trial | JACC: Asia
Commentary by Dr. Satoshi Shizuta.
The Associations Between Heart Rate, Deformational Echocardiographic Parameters and Outcomes in Patients With Atrial Fibrillation | JACC: Asia
Commentary by Dr. Deep Chandh Raja.
Cardio-Kidney-Metabolic Phenotypes and Adverse Clinical Outcomes in Patients With Atrial Fibrillation | JACC: Asia
Commentary by Dr. Leandra Serio.
Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model | JACC: Clinical Electrophysiology
Deputy Editor Kenneth Ellenbogen presents an in‑depth discussion of the study "Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model." In this episode, Dr. Ellenbogen walks listeners through how prolonged atrioventricular conduction can drive structural and electrical remodeling in the atria, leading to fibrosis and increased susceptibility to atr
A Pulsed Field Ablation-Based Endocardial Strategy for Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy | JACC: Clinical Electrophysiology
In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel pulsed field ablation–based endocardial strategy for ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy. The paper presents an early consecutive experience demonstrating the feasibility, acute effectiveness, and safety of PFA for VT without the need f
Incidence of Worsening Aortic Regurgitation After Mapping and Ablation in the Aortic Cusps | JACC: Clinical Electrophysiology
In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a large multicenter study evaluating the incidence and clinical significance of aortic regurgitation following mapping and ablation of ventricular arrhythmias in the aortic cusps and commissures. Drawing on contemporary data from four high‑volume centers, the paper provides important reassurance
Associations of Socioeconomic Status With Cardiorenal Metabolic Multimorbidity: Evidence From the UK Biobank Cohort | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Socioeconomic Status With Cardiorenal Metabolic Multimorbidity: Evidence From the UK Biobank Cohort.
Dietary Sodium Intake and Risk of Incident Heart Failure in the Southern Community Cohort Study | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Dietary Sodium Intake and Risk of Incident Heart Failure in the Southern Community Cohort Study.
Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease.
Remote Management of Patients With Heart Failure in Medically Underserved Areas | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Remote Management of Patients With Heart Failure in Medically Underserved Areas.
Development of a Predictive Tool in Patients With High Pretest Probability for Transthyretin Amyloid Cardiomyopathy | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Development of a Predictive Tool in Patients With High Pretest Probability for Transthyretin Amyloid Cardiomyopathy.
Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study.
Cardiovascular-Kidney-Metabolic Syndrome and Life Expectancy in U.S. Adults | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Cardiovascular-Kidney-Metabolic Syndrome and Life Expectancy in U.S. Adults.
10-Year Excess Mortality After First-Time Non–ST-Segment Elevation Myocardial Infarction: The Western Denmark Heart Registry | JACC: Advances | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on 10-Year Excess Mortality After First-Time Non–ST-Segment Elevation Myocardial Infarction: The Western Denmark Heart Registry.
Cardiac Biomarker Complete Response in AL Amyloidosis | JACC: CardioOncology
Dr. Michel G. Khouri reviews a landmark study examining patients with AL amyloidosis who achieved a complete cardiac biomarker response, highlighting profound improvements in cardiac structure, function, and long-term survival that rival the general population. The discussion underscores the transformative impact of early diagnosis and modern plasma cell–directed therapies, while reminding clinici
Cardiovascular Adverse Events Associated with Bispecific T-cell Engager Therapy | JACC: CardioOncology
Dr. Qun Shao discusses two multicenter studies evaluating cardiovascular adverse events associated with bispecific T‑cell engager therapies. Drawing on data from over 700 patients, the episode highlights the incidence, predictors, and clinical impact of cardiovascular complications, emphasizing the importance of baseline risk assessment, targeted monitoring, and multidisciplinary management as use
Myocardial Expression of PD-L1 as a Marker of Poor Prognosis in Immune Checkpoint Inhibitor–Associated Myocarditis | JACC: CardioOncology
Research fellow, Adrian Chen, discusses a multicenter study evaluating myocardial PD‑L1 expression as a prognostic biomarker in immune checkpoint inhibitor–associated myocarditis. The conversation highlights how elevated myocardial PD‑L1 identifies patients at markedly higher risk for early adverse cardiac events and explores its potential role in improving risk stratification and guiding earlier,
June 2026 Issue Summary | JACC: CardioOncology
Dr. Ky's full issue summary.
Stepwise Assessment of Computational Coronary Physiology and Plaque Vulnerability: Impact on Coronary Revascularization Decision Making | JACC: Asia
Commentary by Dr. Elvin Kedhi.
The Future of Cardio-Oncology: Progress and Priorities | ACC.26 | JACC: CardioOncology
At ACC.26, Dr. Tharshini Ramalingam speaks with JACC: CardioOncology Editor-in-Chief Dr. Bonnie Ky about the rapid evolution of cardio-oncology, the field's most urgent priorities, and the need for stronger evidence, risk prediction, cardioprotective strategies, and global implementation. Dr. Ky also shares practical advice for early-career investigators on mentorship, resilience, and what makes a
Cardiogenic Shock From ICI Myocarditis With Predominant RV Failure | ACC.26 | JACC: CardioOncology
In this ACC.26 interview, Dr. Tharshini Ramalingam speaks with Dr. Eric Yang of UCLA about a rare and sobering case presented at ACC.26 of immune checkpoint inhibitor myocarditis with predominant right ventricular failure and cardiogenic shock. Their discussion highlights the diagnostic complexity of atypical myocarditis, the importance of recognizing unusual presentations, and the need for better
Risk Scores for Transcatheter Tricuspid Interventions | JACC: Cardiovascular Interventions
Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Dr. Charles Davidson, discuss a recently published original research paper studying the transcatheter tricuspid valve intervention risk scores.
Frequency and Outcomes of Acute Hemodynamic Instability Following TTVR | JACC: Cardiovascular Interventions
Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Dr. Volter Rudolph, discuss a recently published original research paper examining the frequency and outcomes of acute hemodynamic instability following tricuspid interventions.
His-Pacing versus Biventricular Pacing for Cardiac Resynchronization Therapy: Long-term follow-up from the His-alternative I Trial | JACC: Clinical Electrophysiology
In this episode of JACC: Clinical Electrophysiology, Deputy Editor Dr. Kenneth Ellenbogen discusses His-Pacing versus Biventricular Pacing for Cardiac Resynchronization Therapy: Long-term follow-up from the His-alternative I Trial.
Return-to-Play for Athletes with Desmosomal Arrhythmogenic Cardiomyopathy: A Single Center Experience | JACC: Clinical Electrophysiology
Deputy Editor Kenneth Ellenbogen hosts a focused discussion on the study "Return‑to‑Play for Athletes with Desmosomal Arrhythmogenic Cardiomyopathy: A Single Center Experience." In this episode, Dr. Ellenbogen examines how desmosomal arrhythmogenic cardiomyopathy impacts athletic participation and highlights real‑world insights from a single‑center cohort. He walks listeners through the clinical c
Functional Conduction Block During Extra-Stimulus Mapping Masks Deceleration Zones and Reveals Additional VT Substrate | JACC: Clinical Electrophysiology
Deputy Editor Francis Marchlinski hosts a deep‑dive discussion on the study "Functional Conduction Block During Extra‑Stimulus Mapping Masks Deceleration Zones and Reveals Additional VT Substrate." In this episode, Dr. Marchlinski explores how extra‑stimulus pacing can alter the visualization of critical conduction deceleration zones and uncover previously hidden components of the ventricular tach
LONG-TERM OUTCOMES AND SAFETY OF HIS-PURKINJE CONDUCTION SYSTEM PACING: A MULTICENTER OBSERVATIONAL STUDY IN CHINA (The ChiCSP Study)
Dr. Kenneth Ellebogen, Deputy Editor of JACC: Clinical Electrophysiology, discusses the long-term outcomes and safety of His-Purkinje conduction system pacing: a multicenter observational study in China.
His Pacing vs Biventricular Pacing for Cardiac Resynchronization Therapy | JACC: Clinical Electrophysiology
In this episode, Dr. Kenneth Ellenbogen, Deputy Editor of JACC: Clinical Electrophysiology, discusses new long-term findings from the His-Alternative I trial, the first European randomized study comparing His-bundle pacing with conventional biventricular pacing for cardiac resynchronization therapy (CRT). He highlights five-year outcomes demonstrating that when His-bundle pacing is achieved with l
April 2026 Issue Summary | JACC: Asia
Audio Summary of the April 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
Profiles of Comprehensive Morphological Phenotypes and Outcomes in Functional Mitral Regurgitation | JACC: Asia
Commentary by Dr. Jian'an Wang.
The Effect of High-Density Lipoprotein on the Rheumatic Mitral Valve Calcification and Surgical Prognosis | JACC: Asia
Commentary by Dr. Jian'an Wang.
Biological Age Acceleration and All-Cause Mortality in Moderate to Severe Aortic Valve Stenosis: A Prospective Cohort Study | JACC: Asia
Commentary by Dr. Jian'an Wang.
Early Safety and Feasibility Study of a Novel Transcatheter Aortic Valve With Polymeric Leaflets | JACC: Asia
Commentary by Dr. Shinichi Shirai.
Early Safety and Feasibility Study of a Novel Transcatheter Aortic Valve With Polymeric Leaflets | JACC: Asia
Commentary by Dr. Jian'an Wang.
Effect of Device Size on Outcomes Following Left Atrial Appendage Closure in Borderline-Sized Anatomy | JACC: Asia
Commentary by Dr. Jian'an Wang.
Prognostic Value of Left Ventricular Kinetic Energy for Predicting Major Adverse Events in Hypertrophic Cardiomyopathy | JACC: Asia
Commentary by Dr. Shujuan Yang.
Prognostic Value of Left Ventricular Kinetic Energy for Predicting Major Adverse Events in Hypertrophic Cardiomyopathy | JACC: Asia
Commentary by Dr. Jian'an Wang.
Cardiometabolic Risk Among Internal Medicine Specialists in Indonesia (CARMEINA): A Nationwide Study | JACC: Asia
Commentary by Dr. Jian'an Wang.
Left Atrial Strain Outperforms Ventricular Strains in Cardiovascular Outcome Association Across Echocardiography and Magnetic Resonance | JACC: Asia
Commentary by Dr. Jian'an Wang.
Temporal Trends in Age Profile and Safety of Balloon Pulmonary Angioplasty for CTEPH | JACC: Asia
Commentary by Dr. Jian'an Wang.
Importance and Management of Non-High-Density Lipoprotein Cholesterol in Dyslipidemia Treatment | JACC: Asia
Commentary by Dr. Jian'an Wang.
Use of Electrocardiograms to Identify Coronary Artery Disease: Cross-Validation of an Artificial Intelligence Model | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Use of Electrocardiograms to Identify Coronary Artery Disease: Cross-Validation of an Artificial Intelligence Model.
VExUS Point-of-Care Ultrasound Tool to Detect Changes in Volume Status: A Prospective Observational Study | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on VExUS Point-of-Care Ultrasound Tool to Detect Changes in Volume Status: A Prospective Observational Study.
Comparative Strategies to Overcome Diuretic Resistance in Heart Failure: A Network Meta-Analysis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Comparative Strategies to Overcome Diuretic Resistance in Heart Failure: A Network Meta-Analysis.
Prehabilitation in Patients Undergoing Cardiac Procedures: A Systematic Review and Meta-Analysis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Prehabilitation in Patients Undergoing Cardiac Procedures: A Systematic Review and Meta-Analysis.
Pregnancy in Women With Impaired Left Ventricular Function: Data From ROPAC | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Pregnancy in Women With Impaired Left Ventricular Function: Data From ROPAC.
Cardiac Rehabilitation Utilization Among Veterans: A Sex-Based Analysis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Cardiac Rehabilitation Utilization Among Veterans: A Sex-Based Analysis.
Frailty Status Predicts Adverse Outcomes in Ambulatory Heart Failure With Preserved Ejection Fraction | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Frailty Status Predicts Adverse Outcomes in Ambulatory Heart Failure With Preserved Ejection Fraction.
Intracoronary Vasoactive Therapy for No-Reflow During Primary PCI: A Network Meta-Analysis of Randomized Trials | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Intracoronary Vasoactive Therapy for No-Reflow During Primary PCI: A Network Meta-Analysis of Randomized Trials.
Mechanical Debulking in Calcified Arteries: ROLLING STONE Study | JACC: Cardiovascular Interventions
Dr Aaysha Cader, Social media editor for JACC Interventions discusses the paper, Intravascular Lithotripsy or Mechanical Debulking in Complex Calcified Coronary Arteries: Multicenter, Prospective ROLLING STONE Study, with its first author, Dr Enrico Cerrato.
TRANScatheter edge-to-edge rePAir for SAM related mitral REgurgitation in patieNTs with HCM. The TRANSPARENT registry | JACC: Cardiovascular Interventions
Dr Aaysha Cader, Social media editor for JACC Interventions discusses the paper, Transcatheter Edge-to-Edge Repair for SAM-Related Mitral Regurgitation in Patients With HCM: The TRANSPARENT Registry, with Professor Luca Testa.
