JACC Specialty Journals
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
Episodes
Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes.
SGLT2 Inhibitors in Cardio-Oncology: A Systematic Review and Meta-Analysis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on SGLT2 Inhibitors in Cardio-Oncology: A Systematic Review and Meta-Analysis.
Sex Differences in Heart Transplantation Outcomes: A 5-Year Review of the 2018 U.S. Allocation Policy | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Heart Transplantation Outcomes: A 5-Year Review of the 2018 U.S. Allocation Policy.
Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial.
Artificial Intelligence-Enhanced Electrocardiography and Health Records to Predict Cardiac Arrest | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Artificial Intelligence-Enhanced Electrocardiography and Health Records to Predict Cardiac Arrest.
Trends in the Co-Occurrence of Alcohol Use and Cardiovascular Disease Among U.S. Adults, 1999 to 2023 | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Trends in the Co-Occurrence of Alcohol Use and Cardiovascular Disease Among U.S. Adults, 1999 to 2023.
Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants.
Brief Introduction - Procedural Pattern, Clinical Outcomes, and Cost Analysis of Transcatheter Aortic Valve Replacement in Korea | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Single Versus Double Perclose Devices for TF-TAVR Access Closure: A Noninferiority Randomized Controlled Trial | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - SGLT2 Inhibition as a Novel Therapeutic Strategy in Rheumatic Heart Disease | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Updated Wilkins Score Predicting Success of Balloon Mitral Valvuloplasty in Rheumatic Mitral Stenosis | JACC: Asia
Commentary by Dr. Jian'an Wang.
Single Versus Double Perclose Devices for TF-TAVR Access Closure: A Noninferiority Randomized Controlled Trial | JACC: Asia
Commentary by Dr. Jinho Lee.
Updated Wilkins Score Predicting Success of Balloon Mitral Valvuloplasty in Rheumatic Mitral Stenosis | JACC: Asia
Commentary by Dr. Kevin Kam.
Transcatheter Aortic Valve Replacement in Functionally Dependent Patients: Analysis Using a Government-Adjudicated Long-Term Care Certification | JACC: Asia
Commentary by Dr. Mark Tuttle.
Brief Introduction - Transcatheter Aortic Valve Replacement in Functionally Dependent Patients: Analysis Using a Government-Adjudicated Long-Term Care Certification | JACC: Asia
Commentary by Dr. Jian'an Wang.
Novel Allogeneic Mitochondria and Associated Organelle Complex Treatment Prevents Myocardial Ischemia-Reperfusion Injury Through Anti-Apoptotic Effects | JACC: Asia
Commentary by Dr. Chrishan Ramachandra.
Brief Introduction - Novel Allogeneic Mitochondria and Associated Organelle Complex Treatment Prevents Myocardial Ischemia-Reperfusion Injury Through Anti-Apoptotic Effects | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Exercise and Exercise Stress Testing in Brugada Syndrome: Diagnostic, Prognostic, and Safety Implications | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Association Between Cardiovascular-Kidney-Metabolic Syndrome and Myocardial Injury After Noncardiac Surgery: A Retrospective Cohort Study | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Design of IKISS-LM Randomized Controlled Trial: Impact of Kissing Balloon Inflation on Provisional Left-Main Bifurcation PCI | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Myocardial Infarction Without Standard Modifiable Risk Factors From 2025-2040: Forecast Analysis of Multinational, Population-Based Study | JACC: Asia
Commentary by Dr. Jian'an Wang.
August 2026 Full Issue Summary | JACC: CardioOncology
Audio summary of JACC: CardioOncology's June issue.
A Bleeding Risk Score for Cancer-Associated Venous Thromboembolism in Patients Receiving Direct Oral Anticoagulants | JACC: CardioOncology
This podcast by Dr. Larissa Araújo de Lucena discusses the development of the ONCO‑DOAC BLEED score for predicting major bleeding in patients with cancer‑associated venous thromboembolism (VTE) receiving direct oral anticoagulants. The findings support a more personalized, risk‑based approach to anticoagulation in cardio‑oncology, integrating cancer type, comorbidities, and clinical factors while
Differential Transthyretin Stabilization in Patients With Wild-Type and Variant Transthyretin Amyloidosis | JACC: CardioOncology
This podcast by Dr. Ron Witteles reviews new data on transthyretin amyloid cardiomyopathy (ATTR‑CM), highlighting differences in transthyretin stabilization between acoramidis and tafamidis across wild-type and variant disease. The discussion underscores the clinical importance of TTR stabilization, emerging biomarkers such as serum transthyretin, and the expanding therapeutic landscape in cardiac
Immune Profiling Identifies Inflammatory Signatures in Immune Checkpoint Inhibitor– Related Myocarditis | JACC: CardioOncology
This podcast by Dr. Dan Zlotoff reviews new research on immune checkpoint inhibitor–associated myocarditis, a rare but serious complication of cancer immunotherapy, focusing on emerging inflammatory biomarkers such as interleukin‑6 and immune cell signatures. The study highlights potential pathways for risk stratification and targeted therapies, while underscoring the need for larger trials to dev
Upper Extremity Deep Vein Thrombosis in Cancer Patients: Clinical Course by Cancer Site | JACC: CardioOncology
This podcast by Dr. António Araújo highlights new insights from a large international registry study showing that cancer‑associated upper extremity deep vein thrombosis (UEDVT) carries increased risks of recurrent venous thromboembolism and bleeding. The findings emphasize tumor‑specific risk patterns and support more personalized anticoagulation strategies in cardio‑oncology.
Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis | JACC: CardioOncology
This podcast by Dr. Marie Pigeyre explores emerging evidence on clonal hematopoiesis, highlighting its role as a systemic driver of inflammation and its association with increased risk of cardiovascular disease, stroke, and type 2 diabetes. The discussion emphasizes the growing importance of clonal hematopoiesis in cardiometabolic risk, precision prevention, and aging biology, while noting that ro
Comparison of Flow Ratio Derived From IVUS With CAG in Complex Lesions: Correlation With FFR | JACC Asia
Commentary by Dr. Jian'an Wang.
Sex Differences in Antiarrhythmic Effects of Empagliflozin: The EMPA-ICD Trial Subanalysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Association Between Cardiac Acceleration Capacity and Susceptibility to Vasovagal Syncope: Autonomic Dysregulation in Vasovagal Syncope | JACC Asia
Commentary by Dr. Jian'an Wang.
Cardio-Kidney-Metabolic Phenotypes and Adverse Clinical Outcomes in Patients With Atrial Fibrillation | JACC Asia
Commentary by Dr. Jian'an Wang.
Postoperative New-Onset Heart Block in Noncardiac Surgery: Model Development, Validation, and Long-Term Prognostic Analysis | JACC Asia
Commentary by Dr. Jian'an Wang.
The Associations Between Heart Rate, Deformational Echocardiographic Parameters, and Outcomes in Patients With Atrial Fibrillation | JACC Asia
Commentary by Dr. Jian'an Wang.
Sex Differences in Antiarrhythmic Effects of Empagliflozin: The EMPA-ICD Trial Subanalysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Development of a Noninvasive Prediction Score for Post-Capillary Pulmonary Hypertension in a Multi-Ethnic Asian Population | JACC Asia
Commentary by Dr. Jian'an Wang.
Ambrisentan for Early-Stage Low-Risk Pulmonary Arterial Hypertension: Design of the Randomized, Double-Blind, Placebo-Controlled ALEPH Trial | JACC Asia
Commentary by Dr. Jian'an Wang.
Persistent Atrial Fibrillation With Conduction System Pacing or Pulmonary Vein Isolation: A Prospective Cohort Study | JACC Asia
Commentary by Dr. Jian'an Wang.
Conceptual Reconsideration of the Classification of Pulmonary Hypertension: From 5 Groups to 2 Groups | JACC Asia
Commentary by Dr. Jian'an Wang.
Prognostic Value of Murray's Law–Based Quantitative Flow Ratio in Multi-Arterial Coronary Artery Bypass Grafting | JACC Asia
Commentary by Dr. Jian'an Wang.
Comparison of Clinical Outcomes Between Incomplete and Complete Revascularization in NSTEMI Patients With Multivessel Disease | JACC Asia
Commentary by Dr. Jian'an Wang.
Comparison of Flow Ratio Derived From IVUS With CAG in Complex Lesions: Correlation With FFR | JACC Asia
Commentary by Dr. Jian'an Wang.
CRP Cutoff Value in East Asians With Coronary Heart Disease: A Systematic Review and Meta-Analysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Validation and Recalibration of PCE, China-PAR and PREVENT Models for Estimating ASCVD Risk in China | JACC Asia
Commentary by Dr. Jian'an Wang.
Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health.
Differential Association Between Surrounding Greenness and Mortality in Individuals With Coronary Heart Disease | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Differential Association Between Surrounding Greenness and Mortality in Individuals With Coronary Heart Disease.
Sex Differences in Cardiac Involvement in Adults With Myotonic Dystrophy Type 1: A Multicenter Study | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Cardiac Involvement in Adults With Myotonic Dystrophy Type 1: A Multicenter Study.
Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock: A Nationwide Analysis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock: A Nationwide Analysis.
Comparison of Microcirculation in Chronic Heart Failure, Cardiogenic Shock, LVAD, and Heart Transplantation | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Comparison of Microcirculation in Chronic Heart Failure, Cardiogenic Shock, LVAD, and Heart Transplantation.
Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening.
Generalizability of Landmark Temporary MCS Device Trials: Insights From the CSWG Registry | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Generalizability of Landmark Temporary MCS Device Trials: Insights From the CSWG Registry.
Long-Term Outcomes of Targeted Volume Overload Management in Patients With Severe Aortic Stenosis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Long-Term Outcomes of Targeted Volume Overload Management in Patients With Severe Aortic Stenosis.
Should Interventionalists Get an MBA? Wayne Batchelor, MD, MHS, MBA Responds | JACC: Cardiovascular Interventions
Dr. Mohamad Alkhouli speaks with Dr. Wayne Batchelor about what leadership truly means for mid‑career interventional cardiologists and whether pursuing an MBA adds value. Dr. Batchelor highlights trust, communication, and business fluency as essential skills for physician leaders navigating increasingly complex healthcare systems.
Should Interventionalists Get an MBA? Kirk Garratt, MD, MSc Responds | JACC: Cardiovascular Interventions
Dr. Mohamad Alkhouli and Dr. Kirk Garratt discuss leadership in interventional cardiology, highlighting the importance of empathy, communication, and advocacy alongside clinical expertise. Dr. Garratt encourages physicians to intentionally develop leadership skills—through training or experience—as healthcare systems become more complex.
Should Interventionalists Get an MBA? J. Dawn Abbott, MD Responds | JACC: Cardiovascular Interventions
In this conversation, Dr. Mohamad Alkhouli speaks with Dr. Abbott about her leadership journey in interventional cardiology, focusing on how curiosity, mentorship, and skill development organically lead to meaningful leadership roles. Dr. Abbott shares practical insights on motivating teams, navigating complex healthcare systems, and whether formal business training such as an MBA is necessary for
Should Interventionalists Get an MBA? Deepak Bhatt, MD, MPH, MBA Responds | JACC: Cardiovascular Interventions
Dr. Mohamad Alkhouli and Dr. Deepak Bhatt discuss leadership development in interventional cardiology and the value of pursuing an executive MBA mid‑career. Dr. Bhatt shares insights on how business training—from finance to leadership and strategy—can help physicians navigate increasingly complex healthcare systems and become more effective stewards of patient care and resources.
Postoperative New-Onset Heart Block in Noncardiac Surgery: Model Development, Validation, and Long-Term Prognostic Analysis | JACC: Asia
Commentary by Dr. Katsuhiko Imai.
Sex-Based Differences in Clinical Outcomes With Edoxaban Therapy: A Prespecified Analysis of the EPIC-CAD Trial | JACC: Asia
Commentary by Dr. Satoshi Shizuta.
The Associations Between Heart Rate, Deformational Echocardiographic Parameters and Outcomes in Patients With Atrial Fibrillation | JACC: Asia
Commentary by Dr. Deep Chandh Raja.
Cardio-Kidney-Metabolic Phenotypes and Adverse Clinical Outcomes in Patients With Atrial Fibrillation | JACC: Asia
Commentary by Dr. Leandra Serio.
Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model | JACC: Clinical Electrophysiology
Deputy Editor Kenneth Ellenbogen presents an in‑depth discussion of the study "Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model." In this episode, Dr. Ellenbogen walks listeners through how prolonged atrioventricular conduction can drive structural and electrical remodeling in the atria, leading to fibrosis and increased susceptibility to atr
A Pulsed Field Ablation-Based Endocardial Strategy for Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy | JACC: Clinical Electrophysiology
In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel pulsed field ablation–based endocardial strategy for ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy. The paper presents an early consecutive experience demonstrating the feasibility, acute effectiveness, and safety of PFA for VT without the need f
Incidence of Worsening Aortic Regurgitation After Mapping and Ablation in the Aortic Cusps | JACC: Clinical Electrophysiology
In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a large multicenter study evaluating the incidence and clinical significance of aortic regurgitation following mapping and ablation of ventricular arrhythmias in the aortic cusps and commissures. Drawing on contemporary data from four high‑volume centers, the paper provides important reassurance
Associations of Socioeconomic Status With Cardiorenal Metabolic Multimorbidity: Evidence From the UK Biobank Cohort | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Socioeconomic Status With Cardiorenal Metabolic Multimorbidity: Evidence From the UK Biobank Cohort.
Dietary Sodium Intake and Risk of Incident Heart Failure in the Southern Community Cohort Study | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Dietary Sodium Intake and Risk of Incident Heart Failure in the Southern Community Cohort Study.
Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease.
Remote Management of Patients With Heart Failure in Medically Underserved Areas | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Remote Management of Patients With Heart Failure in Medically Underserved Areas.
Development of a Predictive Tool in Patients With High Pretest Probability for Transthyretin Amyloid Cardiomyopathy | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Development of a Predictive Tool in Patients With High Pretest Probability for Transthyretin Amyloid Cardiomyopathy.
Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study.
Cardiovascular-Kidney-Metabolic Syndrome and Life Expectancy in U.S. Adults | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Cardiovascular-Kidney-Metabolic Syndrome and Life Expectancy in U.S. Adults.
10-Year Excess Mortality After First-Time Non–ST-Segment Elevation Myocardial Infarction: The Western Denmark Heart Registry | JACC: Advances | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on 10-Year Excess Mortality After First-Time Non–ST-Segment Elevation Myocardial Infarction: The Western Denmark Heart Registry.
Cardiac Biomarker Complete Response in AL Amyloidosis | JACC: CardioOncology
Dr. Michel G. Khouri reviews a landmark study examining patients with AL amyloidosis who achieved a complete cardiac biomarker response, highlighting profound improvements in cardiac structure, function, and long-term survival that rival the general population. The discussion underscores the transformative impact of early diagnosis and modern plasma cell–directed therapies, while reminding clinici
Cardiovascular Adverse Events Associated with Bispecific T-cell Engager Therapy | JACC: CardioOncology
Dr. Qun Shao discusses two multicenter studies evaluating cardiovascular adverse events associated with bispecific T‑cell engager therapies. Drawing on data from over 700 patients, the episode highlights the incidence, predictors, and clinical impact of cardiovascular complications, emphasizing the importance of baseline risk assessment, targeted monitoring, and multidisciplinary management as use
Myocardial Expression of PD-L1 as a Marker of Poor Prognosis in Immune Checkpoint Inhibitor–Associated Myocarditis | JACC: CardioOncology
Research fellow, Adrian Chen, discusses a multicenter study evaluating myocardial PD‑L1 expression as a prognostic biomarker in immune checkpoint inhibitor–associated myocarditis. The conversation highlights how elevated myocardial PD‑L1 identifies patients at markedly higher risk for early adverse cardiac events and explores its potential role in improving risk stratification and guiding earlier,
June 2026 Issue Summary | JACC: CardioOncology
Dr. Ky's full issue summary.
Stepwise Assessment of Computational Coronary Physiology and Plaque Vulnerability: Impact on Coronary Revascularization Decision Making | JACC: Asia
Commentary by Dr. Elvin Kedhi.
The Future of Cardio-Oncology: Progress and Priorities | ACC.26 | JACC: CardioOncology
At ACC.26, Dr. Tharshini Ramalingam speaks with JACC: CardioOncology Editor-in-Chief Dr. Bonnie Ky about the rapid evolution of cardio-oncology, the field's most urgent priorities, and the need for stronger evidence, risk prediction, cardioprotective strategies, and global implementation. Dr. Ky also shares practical advice for early-career investigators on mentorship, resilience, and what makes a
Cardiogenic Shock From ICI Myocarditis With Predominant RV Failure | ACC.26 | JACC: CardioOncology
In this ACC.26 interview, Dr. Tharshini Ramalingam speaks with Dr. Eric Yang of UCLA about a rare and sobering case presented at ACC.26 of immune checkpoint inhibitor myocarditis with predominant right ventricular failure and cardiogenic shock. Their discussion highlights the diagnostic complexity of atypical myocarditis, the importance of recognizing unusual presentations, and the need for better
Risk Scores for Transcatheter Tricuspid Interventions | JACC: Cardiovascular Interventions
Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Dr. Charles Davidson, discuss a recently published original research paper studying the transcatheter tricuspid valve intervention risk scores.
Frequency and Outcomes of Acute Hemodynamic Instability Following TTVR | JACC: Cardiovascular Interventions
Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Dr. Volter Rudolph, discuss a recently published original research paper examining the frequency and outcomes of acute hemodynamic instability following tricuspid interventions.
His-Pacing versus Biventricular Pacing for Cardiac Resynchronization Therapy: Long-term follow-up from the His-alternative I Trial | JACC: Clinical Electrophysiology
In this episode of JACC: Clinical Electrophysiology, Deputy Editor Dr. Kenneth Ellenbogen discusses His-Pacing versus Biventricular Pacing for Cardiac Resynchronization Therapy: Long-term follow-up from the His-alternative I Trial.
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