JACC Specialty Journals
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
Episodes
Computed Tomography–Derived Abrupt Wall-Thickness Transitions as Complementary Markers of Ventricular Tachycardia Substrate in Ischemic Cardiomyopathy
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating whether abrupt wall-thickness transitions on cardiac CT scans can help identify critical ventricular tachycardia (VT) substrate in patients with ischemic cardiomyopathy. The investigators found that these CT-derived structural markers frequently co-localized with VT isthmus bound
Author Interview: INSIGHT Model: Explainable Artificial Intelligence for Real-World EHR-Based Screening of Transthyretin Amyloidosis Cardiomyopathy | JACC: Advances
Dinesh Kalra and Javed Butler discuss the development of an artificial intelligence screening tool to identify high-risk patients who should be considered for diagnostic testing for ATTR-cardiomyopathy (ATTR-CM) from an unselected heart failure (HF) population.
Feasibility and Safety of Strategic Multielectrode Positioning Guided by S3 Protocol for Hemodynamically Unstable Ventricular Tachycardia: The S3-STaMP Project | JACC: Clinical Electrophysiology
Francis E. Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses the S3-STaMP study, which evaluated a novel mapping strategy for patients with hemodynamically unstable ventricular tachycardia (VT). The investigators found that STaMP mapping, guided by the S3 functional mapping protocol, rapidly identified critical VT circuit pathways in nearly three-quarters of patients an
August 2026 Issue Summary | JACC: CardioOncology
Dr. Ky's August 2026 Issue Summary.
Hemoglobin Decline After Oral Anticoagulation Initiation and Subsequent Cancer Detection in Patients with Atrial Fibrillation | JACC: CardioOncology
Commentary by Dr. Duk-Woo Park.
Divergent effects of GnRH agonist and GnRH antagonist treatment on platelet activity and transcriptome | JACC: CardioOncology
Commentary by Dr. Deng Ye on behalf of Leilei Cheng.
A Simple Clinical Risk Score to Improve Prediction of Anthracycline-Induced Cardiotoxicity | JACC: CardioOncology
Commentary by Dr. Joshua Levenson.
Cardiovascular-Kidney-Metabolic Syndrome Staging and Cancer Risk: Insights from Proteomic and Metabolomic Mediators | JACC: CardioOncology
Commentary by Dr. Adithya Yadalam.
Burden and Risk Factors of Cardiovascular Diseases in Asia, 1990–2021: An Analysis for GBD 2021 | JACC: Asia
Commentary by Dr. Kevin Tang.
Chinese Population-Wide Lipid Trajectories From Age 20 to 85: Sex- and Adiposity-Specific Patterns | JACC: Asia
Commentary by Dr. Kevin Tang.
New 10-Year Atherosclerosis Cardiovascular Disease Risk Score for Asian and American Indian Women Service Members | JACC: Asia
Commentary by Dr. Fu-Zong WU.
Association Between Serum Atherogenic Index and Cardiovascular Disease in Early Adulthood: A Cohort Study | JACC: Asia
Commentary by Dr. Xin Zhou.
Burden of Cardiovascular Disease in Asian Countries, 1990-2021 | JACC: Asia
Commentary by Dr. Hyeon Chang Kim.
High Voltage, High Stakes: Assessing Cardiovascular Effects of Electromagnetic Fields From Electric Vehicles | JACC: Asia
Commentary by Dr. Łukasz Kuźma.
Holistic Lifestyle Framework to Longitudinally Evaluate Cardiovascular Disparities and Post-Diagnosis Changes Among Older Thai Adults | JACC: Asia
Commentary by Dr. Ekamol Tantisattamo.
Cardiorespiratory Fitness Reference Standards and Prognostic Stratification in Chinese Patients With Cardiovascular Disease | JACC: Asia
Commentary by Dr. Barry Franklin.
Infective Endocarditis of Transcatheter Aortic Valve Replacement and Transcatheter Edge to Edge Repair Devices | JACC: Advances
Nicole Bhave, Michael Reardon, and Joe Aoun discuss what inspired their paper, the unique microbiology of TAVR endocarditis, and a challenging endocarditis case example.
Tailoring Antiplatelet Therapy Duration After PFO Closure: Insights from the PROLONG Registry | JACC: Advances
Akl Fahed and Carlo Gaspardone discuss the impact of APT duration on long-term outcomes after PFO closure.
Safety and Efficacy of a Novel Rotational Atherectomy System in Coronary Calcifications: The CORECT Trial | JACC: Asia
Commentary by Dr. Kenichi Sakakura.
Long-Term Impact of Clinical Obesity on Heart Failure Development and Prognosis: New Insights | JACC: Asia
Commentary by Dr. Cheng Liu.
Association Between Complete Right Bundle Branch Block and Vascular Endothelial Function | JACC: Asia
Commentary by Dr. Alena Shantsila.
Blood Pressure Reduction Effects of Salt Substitutes in Different Application Settings: A Meta-Analysis of Randomized Controlled Trials | JACC: Asia
Commentary by Dr. Chi Chiu Wang.
Prognostic Value of Periprocedural Pulmonary Artery Pulsatility Index in Patients After Transcatheter Aortic Valve Replacement | JACC: Asia
Commentary by Dr. Sung-Han Yoon.
Multicenter Experience of Aortic Valve Leaflet Modification in TAVR: From the Asia-Pacific Electrosurgery Working Group | JACC: Asia
Commentary by Dr. Yuxin He.
Understanding Outcomes in Hemodialysis Patients Who Underwent Transcatheter Aortic Valve Replacement With the Latest Devices | JACC: Asia
Commentary by Dr. Raffi Bekeredjian.
Cost-Effectiveness of TAVI VS Minimally Invasive SAVR for Low-Risk Aortic Stenosis in Japan | JACC: Asia
Commentary by Dr. Jae-Sik Jang.
The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications | JACC: Asia
Commentary by Dr. Xinqi Zhong.
Predictive Value of Imaging-Based Classifications for Conservative Management Failure in Isolated Superior Mesenteric Artery Dissection | JACC: Asia
Commentary by Dr. Zhenjie Liu.
Novel Transcatheter Edge-to-Edge Repair System for High-Risk Primary Mitral Regurgitation: 2-Year Pivotal Trial Outcomes | JACC: Asia
Commentary by Dr. Ching-wei Lee.
Atrial Fibrillation and Clinical Outcomes Following Mitral Transcatheter Edge-To-Edge Repair According to Mitral Regurgitation Etiology | JACC: Asia
Commentary by Dr. Panteleimon Papakonstantinou.
Effect of Colchicine on Left Atrial Mechanics in Rheumatic Heart Disease: COL-RHD A Pilot Trial | JACC: Asia
Commentary by Dr. Timothy Ka-chun UN.
Outcomes of left atrial appendage occlusion with a coated device: primary analysis of HEAL-LAA | JACC: Clinical Electrophysiology
In this episode of the JACC: Clinical Electrophysiology podcast, Executive Editor Emile Daoud discusses the primary analysis of the HEAL‑LAA study. The paper by Oluseun Alli, et al, evaluates real‑world outcomes with a next‑generation, fluoropolymer‑coated left atrial appendage occlusion device. In 500 patients across 32 U.S. centers, the study demonstrated excellent early device sealing, no signi
High-Voltage Pulsed Field Ablation: A Novel Strategy for Redo Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy Patients | JACC: Clinical Electrophysiology
In this episode, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel study evaluating high‑voltage pulsed field ablation (hv‑PFA) for redo ventricular tachycardia ablation in patients with nonischemic cardiomyopathy. He highlights why VT ablation remains particularly challenging in this population, the rationale for using high‑voltage PFA to achieve deeper
The Predictive Value of Impedance for Defibrillation Success After Subcutaneous Implantable Cardioverter-Defibrillator Implantation: a Reliable Indicator? " JACC: Clinical Electrophysiology
In this episode, Dr. Kenneth Ellenbogen discusses an important analysis from the PRAETORIAN-DFT trial examining whether shock impedance can reliably predict defibrillation success after subcutaneous ICD implantation. While low impedance values are increasingly used in practice as a surrogate for defibrillation testing, this multicenter study shows that although an impedance
Incidence, Risk Factors, and Outcomes of Atrial Arrhythmias in Patients with Ebstein Anomaly | JACC: Clinical Electrophysiology
In this episode, Jeremy Moore, MD, MS, Associate Editor of JACC: Clinical Electrophysiology, reviews a study showing that adults with Ebstein anomaly face a high lifetime risk of atrial arrhythmias, with more than half developing one by age 60. The most common arrhythmias were intra-atrial re-entrant and focal atrial tachycardias, which were more frequent than atrial fibrillation. Older age, prior
Radiation Safety in Interventional Echocardiography: New Insights From Structural Heart Care | JACC: Advances
In this JACC Advances Author One-on-One podcast, Editor-in-Chief Dr. Dinesh Kalra and Associate Editor Dr. Purvi Parwani speak with Dr. Priscilla Wesley and Dr. Renuka Jain about their prospective study on occupational radiation exposure among interventional echocardiographers during structural heart procedures. The authors discuss findings from 230 TEE-guided interventions, including left atrial
Introducing the New JACC: Advances Podcasts: Exploring the Latest in Cardiovascular Medicine | JACC Advances
The JACC Advances Podcast brings you expert perspectives on the most important developments in cardiovascular medicine. Through author one-on-one interviews, deep-dive discussions with editorial experts, and concise monthly research summaries, each episode highlights impactful science, clinical innovation, and emerging evidence from JACC Advances. Join us every month to stay informed on the latest
Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes.
SGLT2 Inhibitors in Cardio-Oncology: A Systematic Review and Meta-Analysis | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on SGLT2 Inhibitors in Cardio-Oncology: A Systematic Review and Meta-Analysis.
Sex Differences in Heart Transplantation Outcomes: A 5-Year Review of the 2018 U.S. Allocation Policy | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Heart Transplantation Outcomes: A 5-Year Review of the 2018 U.S. Allocation Policy.
Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial.
Artificial Intelligence-Enhanced Electrocardiography and Health Records to Predict Cardiac Arrest | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Artificial Intelligence-Enhanced Electrocardiography and Health Records to Predict Cardiac Arrest.
Trends in the Co-Occurrence of Alcohol Use and Cardiovascular Disease Among U.S. Adults, 1999 to 2023 | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Trends in the Co-Occurrence of Alcohol Use and Cardiovascular Disease Among U.S. Adults, 1999 to 2023.
Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants.
Brief Introduction - Procedural Pattern, Clinical Outcomes, and Cost Analysis of Transcatheter Aortic Valve Replacement in Korea | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Single Versus Double Perclose Devices for TF-TAVR Access Closure: A Noninferiority Randomized Controlled Trial | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - SGLT2 Inhibition as a Novel Therapeutic Strategy in Rheumatic Heart Disease | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Updated Wilkins Score Predicting Success of Balloon Mitral Valvuloplasty in Rheumatic Mitral Stenosis | JACC: Asia
Commentary by Dr. Jian'an Wang.
Single Versus Double Perclose Devices for TF-TAVR Access Closure: A Noninferiority Randomized Controlled Trial | JACC: Asia
Commentary by Dr. Jinho Lee.
Updated Wilkins Score Predicting Success of Balloon Mitral Valvuloplasty in Rheumatic Mitral Stenosis | JACC: Asia
Commentary by Dr. Kevin Kam.
Transcatheter Aortic Valve Replacement in Functionally Dependent Patients: Analysis Using a Government-Adjudicated Long-Term Care Certification | JACC: Asia
Commentary by Dr. Mark Tuttle.
Brief Introduction - Transcatheter Aortic Valve Replacement in Functionally Dependent Patients: Analysis Using a Government-Adjudicated Long-Term Care Certification | JACC: Asia
Commentary by Dr. Jian'an Wang.
Novel Allogeneic Mitochondria and Associated Organelle Complex Treatment Prevents Myocardial Ischemia-Reperfusion Injury Through Anti-Apoptotic Effects | JACC: Asia
Commentary by Dr. Chrishan Ramachandra.
Brief Introduction - Novel Allogeneic Mitochondria and Associated Organelle Complex Treatment Prevents Myocardial Ischemia-Reperfusion Injury Through Anti-Apoptotic Effects | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Exercise and Exercise Stress Testing in Brugada Syndrome: Diagnostic, Prognostic, and Safety Implications | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Association Between Cardiovascular-Kidney-Metabolic Syndrome and Myocardial Injury After Noncardiac Surgery: A Retrospective Cohort Study | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Design of IKISS-LM Randomized Controlled Trial: Impact of Kissing Balloon Inflation on Provisional Left-Main Bifurcation PCI | JACC: Asia
Commentary by Dr. Jian'an Wang.
Brief Introduction - Myocardial Infarction Without Standard Modifiable Risk Factors From 2025-2040: Forecast Analysis of Multinational, Population-Based Study | JACC: Asia
Commentary by Dr. Jian'an Wang.
August 2026 Full Issue Summary | JACC: CardioOncology
Audio summary of JACC: CardioOncology's June issue.
A Bleeding Risk Score for Cancer-Associated Venous Thromboembolism in Patients Receiving Direct Oral Anticoagulants | JACC: CardioOncology
This podcast by Dr. Larissa Araújo de Lucena discusses the development of the ONCO‑DOAC BLEED score for predicting major bleeding in patients with cancer‑associated venous thromboembolism (VTE) receiving direct oral anticoagulants. The findings support a more personalized, risk‑based approach to anticoagulation in cardio‑oncology, integrating cancer type, comorbidities, and clinical factors while
Differential Transthyretin Stabilization in Patients With Wild-Type and Variant Transthyretin Amyloidosis | JACC: CardioOncology
This podcast by Dr. Ron Witteles reviews new data on transthyretin amyloid cardiomyopathy (ATTR‑CM), highlighting differences in transthyretin stabilization between acoramidis and tafamidis across wild-type and variant disease. The discussion underscores the clinical importance of TTR stabilization, emerging biomarkers such as serum transthyretin, and the expanding therapeutic landscape in cardiac
Immune Profiling Identifies Inflammatory Signatures in Immune Checkpoint Inhibitor– Related Myocarditis | JACC: CardioOncology
This podcast by Dr. Dan Zlotoff reviews new research on immune checkpoint inhibitor–associated myocarditis, a rare but serious complication of cancer immunotherapy, focusing on emerging inflammatory biomarkers such as interleukin‑6 and immune cell signatures. The study highlights potential pathways for risk stratification and targeted therapies, while underscoring the need for larger trials to dev
Upper Extremity Deep Vein Thrombosis in Cancer Patients: Clinical Course by Cancer Site | JACC: CardioOncology
This podcast by Dr. António Araújo highlights new insights from a large international registry study showing that cancer‑associated upper extremity deep vein thrombosis (UEDVT) carries increased risks of recurrent venous thromboembolism and bleeding. The findings emphasize tumor‑specific risk patterns and support more personalized anticoagulation strategies in cardio‑oncology.
Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis | JACC: CardioOncology
This podcast by Dr. Marie Pigeyre explores emerging evidence on clonal hematopoiesis, highlighting its role as a systemic driver of inflammation and its association with increased risk of cardiovascular disease, stroke, and type 2 diabetes. The discussion emphasizes the growing importance of clonal hematopoiesis in cardiometabolic risk, precision prevention, and aging biology, while noting that ro
Comparison of Flow Ratio Derived From IVUS With CAG in Complex Lesions: Correlation With FFR | JACC Asia
Commentary by Dr. Jian'an Wang.
Sex Differences in Antiarrhythmic Effects of Empagliflozin: The EMPA-ICD Trial Subanalysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Association Between Cardiac Acceleration Capacity and Susceptibility to Vasovagal Syncope: Autonomic Dysregulation in Vasovagal Syncope | JACC Asia
Commentary by Dr. Jian'an Wang.
Cardio-Kidney-Metabolic Phenotypes and Adverse Clinical Outcomes in Patients With Atrial Fibrillation | JACC Asia
Commentary by Dr. Jian'an Wang.
Postoperative New-Onset Heart Block in Noncardiac Surgery: Model Development, Validation, and Long-Term Prognostic Analysis | JACC Asia
Commentary by Dr. Jian'an Wang.
The Associations Between Heart Rate, Deformational Echocardiographic Parameters, and Outcomes in Patients With Atrial Fibrillation | JACC Asia
Commentary by Dr. Jian'an Wang.
Sex Differences in Antiarrhythmic Effects of Empagliflozin: The EMPA-ICD Trial Subanalysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Development of a Noninvasive Prediction Score for Post-Capillary Pulmonary Hypertension in a Multi-Ethnic Asian Population | JACC Asia
Commentary by Dr. Jian'an Wang.
Ambrisentan for Early-Stage Low-Risk Pulmonary Arterial Hypertension: Design of the Randomized, Double-Blind, Placebo-Controlled ALEPH Trial | JACC Asia
Commentary by Dr. Jian'an Wang.
Persistent Atrial Fibrillation With Conduction System Pacing or Pulmonary Vein Isolation: A Prospective Cohort Study | JACC Asia
Commentary by Dr. Jian'an Wang.
Conceptual Reconsideration of the Classification of Pulmonary Hypertension: From 5 Groups to 2 Groups | JACC Asia
Commentary by Dr. Jian'an Wang.
Prognostic Value of Murray's Law–Based Quantitative Flow Ratio in Multi-Arterial Coronary Artery Bypass Grafting | JACC Asia
Commentary by Dr. Jian'an Wang.
Comparison of Clinical Outcomes Between Incomplete and Complete Revascularization in NSTEMI Patients With Multivessel Disease | JACC Asia
Commentary by Dr. Jian'an Wang.
Comparison of Flow Ratio Derived From IVUS With CAG in Complex Lesions: Correlation With FFR | JACC Asia
Commentary by Dr. Jian'an Wang.
CRP Cutoff Value in East Asians With Coronary Heart Disease: A Systematic Review and Meta-Analysis | JACC Asia
Commentary by Dr. Jian'an Wang.
Validation and Recalibration of PCE, China-PAR and PREVENT Models for Estimating ASCVD Risk in China | JACC Asia
Commentary by Dr. Jian'an Wang.
