JACC Specialty Journals
American College of Cardiology 1 957 episodes Nov 3, 2026
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
Episodes
Plasma Proteins Associated with Incident Acute Myocardial Infarction in Asians with Type 2 Diabetes | JACC: Asia
Commentary by Dr. Athanasios Sakalidis.
Real-World Evaluation of a Nationally Mandated Risk Stratification Tool for Destination Therapy LVAD in Japan | JACC: Asia
Commentary by Dr. Heerajnarain Bulluck.
Multimodality Imaging-Based Phenotyping and Prognostic Implications of Right Ventricular Involvement in Apical Hypertrophic Cardiomyopathy | JACC: Asia
Commentary by Dr. Milan Prsa.
Osteosarcopenia as a Risk Factor for Atrial Fibrillation: A Multi-Cohort Study | JACC: Asia
Commentary by Dr. Yuhi Fujimoto.
Epidemiological Analysis and 2040 Projections of Atrial Fibrillation and Flutter in Asia | JACC: Asia
Commentary by Dr. Yoshihiro Miyamoto.
Advances in a Capsule: October 2026 | JACC: Advances
Audio Summary of three articles from the October 2026 issue of JACC: Advances.
XGBoost Model with CMR Features for Prognostic Assessment in Patients With ST‑Segment Elevation Myocardial Infarction | JACC: Asia
Commentary by Dr. Yoriyasu Suzuki.
Design and Rationale of GPS-CAD: Global Pretest Probability Study of Coronary Artery Disease | JACC: Asia
Commentary by Dr. Junjie Yang.
Prediction of Paroxysmal Atrial Fibrillation with Incorporating Genomic Information Into AI-Based ECG Analysis | JACC: Asia
Commentary by Dr. Qinkai Yu.
October 2026 Summary | JACC: CardioOncology
Editor-in-Chief Dr. Bonnie Ky introduces the October 2026 issue of JACC: CardioOncology, featuring Part 1 of a special focus on immunology and cardio-oncology. This issue brings together state-of-the-art reviews, primers, original research, and clinical cases examining the immune system's central role in cancer and cardiovascular disease. Topics include the mechanisms and clinical implications of
Fibrotic Rewiring of CD8+ T-cells by Doxorubicin Drives Pathological Remodeling of Cardiac Extracellular Matrix | JACC: CardioOncology
Dr. Caitlin O'Meara discusses a JACC: CardioOncology study showing that doxorubicin reprograms CD8+ T cells into matrix-remodeling T cells (mxT-cells) that produce lysyl oxidase (LOX) and stiffen the cardiac extracellular matrix through HIF1α-P53-TGFβ signaling. She explains how this new immune mechanism of anthracycline cardiotoxicity could lead to therapies that prevent cardiac fibrosis, cardiom
High-Sensitivity Cardiac Troponin T and I Discordance in Patients Receiving Immune Checkpoint Inhibitors | JACC: CardioOncology
Dr. David Austin discusses a JACC: CardioOncology study showing that high-sensitivity cardiac troponin T was elevated in 37.9% of patients starting immune checkpoint inhibitor (ICI) therapy, compared with only 1.8% for high-sensitivity troponin I, a discordance linked to older age, male sex, and kidney dysfunction. He explains what this means for troponin assay selection, baseline testing, and ICI
Inflammatory Cell Profiles in Early- and Late-Manifestation Immune Checkpoint Inhibitor Myocarditis | JACC: CardioOncology
Dr. Cristina Gil-Cruz discusses a JACC: CardioOncology study comparing early- and late-manifestation immune checkpoint inhibitor (ICI) myocarditis, where endomyocardial biopsies showed greater T-cell and macrophage infiltration in early cases despite similar left ventricular ejection fraction and fibrosis. She explains what these inflammatory cell profiles mean for cardio-oncology care, from immun
Impact of Device Position and Aortic Valve Prolapse on Outcomes After Transcatheter VSD Closure | JACC: Asia
Commentary by Dr. Timothy Un.
Prognostic Impact of Residual Thrombus After Aspiration Thrombectomy in ST-Elevation Myocardial Infarction | JACC: Asia
Commentary by Dr. Ziyad Ghazzal.
Sex-Specific Lipid, Apolipoprotein B, and Lipoprotein(a) Responses to Berberine Based on 2 Randomized Placebo-Controlled Trials | JACC: Asia
Commentary by Dr. Yihang Fan.
Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases | JACC: Asia
Commentary by Dr. Hongmei Yan.
Efficacy and Safety of Quarterly Dosing SHR-1918 in Patients With Suboptimally Controlled Hyperlipidemia | JACC: Asia
Commentary by Dr. Xiaojie Xie.
Oncologic Benefits and Cardiovascular Risks of Pembrolizumab: Insights From a Nationwide Lung Adenocarcinoma Cohort | JACC: Asia
Commentary by Dr. Koohyar Ahmadzadeh.
Author Interview: Cholesterol Management Gaps Among Patients with Established Coronary Artery Disease Hospitalized for Acute Coronary Events | JACC: Advances
Dinesh Kalra, Todd Villines, and Lisandro Colantonio discuss the importance of this article, what encouraged Dr. Colantonio to conduct this research, and how clinicians can address the concerns patients have.
Association of Implantation Depth with Hemodynamics and Mechanical Consequences in Small Valve-in-Valve TAVR | JACC: Asia
Commentary by Dr. Shinichi Shirai
Comparison of ASCVD Risk Prediction Models in STEMI: Insights from a South Asian Cohort | JACC: Asia
Commentary by Dr. Justin Paul Gnanaraj
Author Interview: Defining Clinically Meaningful Within-Patient Changes in Heart Failure | JACC: Heart Failure
Akshay Desai and Amin Yehya discuss the newest JACC: Heart Failure Position Statement that proposes a pragmatic framework for defining clinically meaningful within-patient changes across heart failure outcomes to improve the patient-centeredness of care during shared decision-making. Learn more about the article: https://www.jacc.org/doi/10.1016/j.jchf.2026.103310
Deep Dive Dialogue: Effect of Evolocumab on Grafts Post-Coronary Artery Bypass Surgery: Post-hoc Analysis of NEWTON-CABG CardioLink-5 | JACC: Advances
Dinesh Kalra, Andrew Choi, and G. B. John Mancini discuss the author group's post hoc analysis of the randomized NEWTON-CABG CardioLink-5 trial.
Issue Summary: September 2026 | JACC: Advances
Audio Summary of three articles from the September 2026 issue of JACC: Advances.
Multimodality Imaging and Pace-Mapping Patterns in Patients With Cardiac Sarcoidosis and Ongoing Inflammation Undergoing Ventricular Tachycardia Ablation | JACC: Clinical Electrophysiology
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study of ventricular tachycardia ablation in patients with active cardiac sarcoidosis. Using integrated FDG-PET and cardiac MRI imaging, the investigators found that VT exit sites were often located in areas of active inflammation, while more proximal circuit sites were associated with scar. Pati
Author Interview: Aortic Stenosis Mortality Across the TAVR Expansion Era, 1999-2024: Rising Mortality in Middle-Aged Adults and a Widening Rural-Urban Gap | JACC: Advances
Nicole Bhave, Ashwini Kerkar, and Ahmed Kamal Siddiqi discuss what inspired this study, differences in mortality trends among age groups, and the most important takeaways from the paper.
Computed Tomography–Defined Ridges and Functional Mapping in Ablation of Postinfarction Ventricular Tachycardia | JACC: Clinical Electrophysiology
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating how CT-defined myocardial ridges and functional mapping can be combined to identify critical ablation targets in post-infarction ventricular tachycardia. The investigators found that VT target sites frequently localized to CT-defined ridges, particularly those associated with pri
Hemodynamic Responses to Exercise and Predictors of Exercise Capacity in Mitral Stenosis: Exercise Catheterization Study | JACC Asia
Commentary by Dr. Jian'an Wang.
Clopidogrel Vs Aspirin Monotherapy for Secondary Prevention After Percutaneous Coronary Intervention: A Nationwide Cohort Study | JACC Asia
Commentary by Dr. Jian'an Wang.
Effect of Colchicine on Left Atrial Mechanics in Rheumatic Heart Disease: COL-RHD A Pilot Trial | JACC Asia
Commentary by Dr. Jian'an Wang.
Long-Term Survival of Balloon Pulmonary Angioplasty for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Multicenter Study | JACC Asia
Commentary by Dr. Jian'an Wang.
The Impact of PCSK9 Inhibitors on Circulatory Inflammation: Mechanisms, Evidence, and Application Prospects | JACC Asia
Commentary by Dr. Jian'an Wang.
Cardiometabolic Multimorbidity and Sympathetic Overactivity: Translational Rationale for Combined Hepatic–Renal Denervation | JACC Asia
Commentary by Dr. Jian'an Wang.
Predictive Value of Imaging-Based Classifications for Conservative Management Failure in Isolated Superior Mesenteric Artery Dissection | JACC Asia
Commentary by Dr. Jian'an Wang.
The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications | JACC Asia
Commentary by Dr. Jian'an Wang.
Vutrisiran in East Asian Patients With Transthyretin Amyloidosis With Cardiomyopathy: Post-Hoc Analysis of HELIOS-B | JACC Asia
Commentary by Dr. Jian'an Wang.
Cost-Effectiveness of TAVI VS Minimally Invasive SAVR for Low-Risk Aortic Stenosis in Japan | JACC Asia
Commentary by Dr. Jian'an Wang.
Novel Transcatheter Edge-to-Edge Repair System for High-Risk Primary Mitral Regurgitation: 2-Year Pivotal Trial Outcomes | JACC Asia
Commentary by Dr. Jian'an Wang.
Patient Characteristics and Diagnosis of Transthyretin Amyloid Cardiomyopathy in Japan: Baseline Analysis of J-COSSA | JACC Asia
Commentary by Dr. Jian'an Wang.
Understanding Outcomes in Hemodialysis Patients Who Underwent Transcatheter Aortic Valve Replacement With the Latest Devices | JACC Asia
Commentary by Dr. Jian'an Wang.
7-Year Outcomes of Balloon-Expandable Versus Self-Expanding Valves in Women Undergoing Transcatheter Aortic Valve Replacement | JACC Asia
Commentary by Dr. Jian'an Wang.
Atrial Fibrillation and Clinical Outcomes Following Mitral Transcatheter Edge-To-Edge Repair According to Mitral Regurgitation Etiology | JACC Asia
Commentary by Dr. Jian'an Wang.
Wearable Electrocardiogram Technologies for the Early Detection of Acute Coronary Syndromes
Commentary by Dr. Jian'an Wang.
Association Between Current of Injury Magnitude and Intraoperative R-Wave Amplitude Fluctuation After Pacing Lead Implantation | JACC Asia
Commentary by Dr. Jian'an Wang.
August 2026 Issue Summary | JACC: Asia
Audio Summary of the August 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
July 2026 Issue Summary | JACC: Asia
Audio Summary of the July 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
Author Interview: Who Will Care for the Heart? Structural Changes in the U.S. Cardiology Workforce, 2005-2023 | JACC: Advances
Author Interview: Clinical Characteristics and Emergency Response to Sudden Cardiac Arrest/Death Secondary to Cardiomyopathies in Young Athletes | JACC: Advances
Matt Martinez and Bradley Petek discuss how the study came about, what results were discovered, and what call to action this study brings.
Prognostic Value of Right Ventricular Circumferential Strain in Patients Undergoing Isolated Tricuspid Valve Surgery | JACC: Asia
Commentary by Dr. Kevin Ka-Ho Kam
Radial Wall Strain for Predicting Severe Dissection After Drug-Coated Balloon | JACC: Asia
Commentary by Dr. Lei Song
Issue Summary: August 2026 | JACC: Advances
Audio Summary of three articles from the August 2026 issue of JACC: Advances.
Author Interview: Opportunistic Genetic Testing for Familial Hypercholesterolemia in Premature Acute Coronary Syndrome: Results of ACCURATE Study | JACC: Advances
Michael Wilkinson, Dinesh Kalra, Liam Brunham, and Robert Rosensen discuss the motivation behind the ACCURATE Study, unmet needs in identifying and treating HeFH, and how future studies can be designed to address the unmet need of identifying patients with HeFH and starting intensive LLT earlier in life.
Author Interview: Social Drivers of Health Advisory: Cardiovascular Disease Projections Through 2050 | JACC: Advances
Dinesh Kalra and Khadijah Breathett discuss the estimated future projections of risk factors for CVD, individual CVD conditions (i.e. heart failure), and total CVD from 2020 to 2050 according to SDOH of the U.S. using the National Health and Nutrition Examination Survey, Medical Expenditure Panel Survey, and U.S. Census.
Computed Tomography–Derived Abrupt Wall-Thickness Transitions as Complementary Markers of Ventricular Tachycardia Substrate in Ischemic Cardiomyopathy
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating whether abrupt wall-thickness transitions on cardiac CT scans can help identify critical ventricular tachycardia (VT) substrate in patients with ischemic cardiomyopathy. The investigators found that these CT-derived structural markers frequently co-localized with VT isthmus bound
Author Interview: INSIGHT Model: Explainable Artificial Intelligence for Real-World EHR-Based Screening of Transthyretin Amyloidosis Cardiomyopathy | JACC: Advances
Dinesh Kalra and Javed Butler discuss the development of an artificial intelligence screening tool to identify high-risk patients who should be considered for diagnostic testing for ATTR-cardiomyopathy (ATTR-CM) from an unselected heart failure (HF) population.
Feasibility and Safety of Strategic Multielectrode Positioning Guided by S3 Protocol for Hemodynamically Unstable Ventricular Tachycardia: The S3-STaMP Project | JACC: Clinical Electrophysiology
Francis E. Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses the S3-STaMP study, which evaluated a novel mapping strategy for patients with hemodynamically unstable ventricular tachycardia (VT). The investigators found that STaMP mapping, guided by the S3 functional mapping protocol, rapidly identified critical VT circuit pathways in nearly three-quarters of patients an
August 2026 Issue Summary | JACC: CardioOncology
Dr. Ky's August 2026 Issue Summary.
Hemoglobin Decline After Oral Anticoagulation Initiation and Subsequent Cancer Detection in Patients with Atrial Fibrillation | JACC: CardioOncology
Commentary by Dr. Duk-Woo Park.
Divergent effects of GnRH agonist and GnRH antagonist treatment on platelet activity and transcriptome | JACC: CardioOncology
Commentary by Dr. Deng Ye on behalf of Leilei Cheng.
A Simple Clinical Risk Score to Improve Prediction of Anthracycline-Induced Cardiotoxicity | JACC: CardioOncology
Commentary by Dr. Joshua Levenson.
Cardiovascular-Kidney-Metabolic Syndrome Staging and Cancer Risk: Insights from Proteomic and Metabolomic Mediators | JACC: CardioOncology
Commentary by Dr. Adithya Yadalam.
Burden and Risk Factors of Cardiovascular Diseases in Asia, 1990–2021: An Analysis for GBD 2021 | JACC: Asia
Commentary by Dr. Kevin Tang.
Chinese Population-Wide Lipid Trajectories From Age 20 to 85: Sex- and Adiposity-Specific Patterns | JACC: Asia
Commentary by Dr. Kevin Tang.
New 10-Year Atherosclerosis Cardiovascular Disease Risk Score for Asian and American Indian Women Service Members | JACC: Asia
Commentary by Dr. Fu-Zong WU.
Association Between Serum Atherogenic Index and Cardiovascular Disease in Early Adulthood: A Cohort Study | JACC: Asia
Commentary by Dr. Xin Zhou.
Burden of Cardiovascular Disease in Asian Countries, 1990-2021 | JACC: Asia
Commentary by Dr. Hyeon Chang Kim.
High Voltage, High Stakes: Assessing Cardiovascular Effects of Electromagnetic Fields From Electric Vehicles | JACC: Asia
Commentary by Dr. Łukasz Kuźma.
Holistic Lifestyle Framework to Longitudinally Evaluate Cardiovascular Disparities and Post-Diagnosis Changes Among Older Thai Adults | JACC: Asia
Commentary by Dr. Ekamol Tantisattamo.
Cardiorespiratory Fitness Reference Standards and Prognostic Stratification in Chinese Patients With Cardiovascular Disease | JACC: Asia
Commentary by Dr. Barry Franklin.
Infective Endocarditis of Transcatheter Aortic Valve Replacement and Transcatheter Edge to Edge Repair Devices | JACC: Advances
Nicole Bhave, Michael Reardon, and Joe Aoun discuss what inspired their paper, the unique microbiology of TAVR endocarditis, and a challenging endocarditis case example.
Tailoring Antiplatelet Therapy Duration After PFO Closure: Insights from the PROLONG Registry | JACC: Advances
Akl Fahed and Carlo Gaspardone discuss the impact of APT duration on long-term outcomes after PFO closure.
Safety and Efficacy of a Novel Rotational Atherectomy System in Coronary Calcifications: The CORECT Trial | JACC: Asia
Commentary by Dr. Kenichi Sakakura.
Long-Term Impact of Clinical Obesity on Heart Failure Development and Prognosis: New Insights | JACC: Asia
Commentary by Dr. Cheng Liu.
Association Between Complete Right Bundle Branch Block and Vascular Endothelial Function | JACC: Asia
Commentary by Dr. Alena Shantsila.
Blood Pressure Reduction Effects of Salt Substitutes in Different Application Settings: A Meta-Analysis of Randomized Controlled Trials | JACC: Asia
Commentary by Dr. Chi Chiu Wang.
Prognostic Value of Periprocedural Pulmonary Artery Pulsatility Index in Patients After Transcatheter Aortic Valve Replacement | JACC: Asia
Commentary by Dr. Sung-Han Yoon.
Multicenter Experience of Aortic Valve Leaflet Modification in TAVR: From the Asia-Pacific Electrosurgery Working Group | JACC: Asia
Commentary by Dr. Yuxin He.
Understanding Outcomes in Hemodialysis Patients Who Underwent Transcatheter Aortic Valve Replacement With the Latest Devices | JACC: Asia
Commentary by Dr. Raffi Bekeredjian.
Cost-Effectiveness of TAVI VS Minimally Invasive SAVR for Low-Risk Aortic Stenosis in Japan | JACC: Asia
Commentary by Dr. Jae-Sik Jang.
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