The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey, the Father of Biohacking and creator of Bulletproof Coffee, hosts this masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to upgrade energy, focus, metabolism, and resilience. Guests include world-class scientists, doctors, and innovators discussing mitochondrial health, peptides, hormones, fasting, sleep, and neuroplasticity. The podcast aims to help listeners live longer, stronger, and smarter lives through data-backed human enhancement.
Episodes
Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495
GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracke
90 Days of Full Carnivore: No Plants, No Fiber, Surprising Gut Results | Ben Azadi : 1494
Carnivore Diet, Cholesterol, Gut Bacteria, Microbiome, and Fasting Insulin Results from a 90-Day Self-Experiment What if cutting out fiber entirely actually improved your gut bacteria? This episode breaks down a real 90-day carnivore self-experiment, complete with before and after blood work, stool testing, and continuous glucose data, that cha
Oxytocin: How To Naturally Induce Your MIRACLE Hormone | Anna Cabeca : 1493
Your Hormones Are Killing You: Oxytocin, FSH, and the Anti-Aging Protocol Most Doctors Ignore Your hormones are running your love life, your intuition, your longevity, and your brain, and most doctors are getting it completely wrong. Host Dave Asprey sits down with triple board-certified OBGYN Dr. Anna Cabeca to break down the clinical science of oxytocin, female pleasure, hormonal o
BONUS: The Anti-Aging Molecule Backed by Nobel Prize Research : 1492
You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's just aging. But it’s NOT. Nobel Prize-winning research has identified a single molecule that controls how fast your body breaks down, and more importantly, exactly why yours is being destroyed faster than it's being rebuilt. The fix isn't
Fish Oil Doesn’t Work? Anti-Aging Butterflies, the Ancient Brain Focus Switch, and the Best Brain Diet : 1491
Fish Oil Supplements And Alzheimer’s-Related Decline A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer’s-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer’s risk factor. Researchers confirmed the supplement reached the brain by
The 'Secret Sauce' To A 10/10 Morning Routine : 1490
Most energy drinks trade your long-term health for a short-term jolt. This episode breaks down a smarter approach to energy, one that builds mitochondria function, supports gut health, stabilizes mood, and helps you sleep better at night, all without the crash -Get 15% off your next order at: https://getmte.com/dave Host Dave Asprey sits down with Jeff Boyd, founder and chairman
The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489
Longevity, Trauma Recovery, Circadian Health, Ramadan Fasting & Biohacking Your nervous system may be aging you faster than your diet. Learn how childhood programming, stress, sleep, fasting, resilience, and environment shape longevity, healthspan, metabolism, and human performance, and discover why some of the most powerful upgrades for your biology have nothing to do with
It's Weird, But It Turns On Your Body's Anti-Aging Switch Fast : 1487
Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/If you're eating clean, taking the right supplements, and still feel exhausted and mentally foggy - the problem isn't your protocol. Your body has a built-in cellular cleanup system that determines whether any of those inputs actually work, and right now
Sugar-Free Backlash, Taurine Fail, Copper Brain Therapy, Childhood Biohacking, Strength Training : 1488
Sugar-Free Diets Disrupted Gut Microbiome and Metabolism A 16-week sucrose-free, low-fat diet study presented at ENDO 2026 found mice developed insulin resistance, impaired glucose tolerance, gut microbiome imbalance, intestinal inflammation, and fatty liver disease signs despite no weight gain or calorie difference. Host Dave Asprey breaks down why eliminating sugar entire
BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin : 1486
Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point,
The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher : 1485
Skin Cancer Prevention, Anti-Aging Biohacking, and the Melanoma Detection Gap Most dermatologists are missing melanoma, and a board-certified skin cancer specialist explains exactly why, and what to do about it. This episode covers the detection tool that finds 10 times more melanomas, the real truth about sunscreen chemicals, t
Just 1 Gram Activates Your Deep Focus Switch (Take THIS) : 1484
Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/Over the last 15 years, I’ve built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of d
World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more... : 1483
Semaglutide Slows Biological Aging A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey
Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi : 1482
How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable,
The Foods That Starve Cancer | William Li : 1481
Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your bl
I Drink Fat To Look Shredded (Lost 100lbs) : 1480
I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted.In this video, I break down exactly why adding sugar to your morning coffee is
Putin Longevity, Pancreatic Cancer Cure, AI Therapy, GLP-1 Breast Cancer... : 1479
Pancreatic Cancer Halted by Virus Injection Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's den
How to Get Microplastics Out of Your Body | Mara Labs : 1478
Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows
Peptide Power Without Needles: Smarter Dosing for Longevity | Justin Kirkland : 1477
Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the f
Brain Fog Starts in Your Feet (Scientifically Proven) : 1476
I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires
NASCAR Death, Steroid Olympics, Genetic Age Truth, and Gut Depression... : 1475
Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, brea
Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474
How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and
The Doctor With Answers To Your Mystery Symptoms | Jessica Peatross : 1473
The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for. Watch this episode on YouTube for the full v
The EXACT Japanese Formula To Live Past 100+ (Simple Steps) : 1471
In this video, I break down the exact biological mechanisms keeping men in Okinawa, Japan, physically dominant and mentally sharp past 100. You don't need million-dollar lab work or intense weight training to reverse your biological age. Instead, these centenarians leverage five specific lifestyle protocols to naturally upgrade their biology. I explain the hard science behind how eating t
This Epic Device Gives You A SUPERBRAIN : 1472
Light Therapy, 40Hz Gamma & Brainwave Entrainment: How BrainTap Resets Sleep, Clears Brain Fog, and Boosts Productivity by 26% Your brain is being starved of the one nutrient it needs most, and it is not a supplement, not a nootropic, not a fasting protocol. It is light, and a 40 hertz flicker delivered at the right frequency can break up amyloid plaque, reset
The Biblical Anti-Aging Fruit That Scientists Are Obsessed With : 1470
The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to timeli
How To Hack Your Brain's Missing Youth Molecule | Molly Maloof : 1469
Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Molly
The 4,000-Year-Old Asian Focus Drug That Is Not A Drug : 1468
Most guys over 40 rely on coffee just to survive the day, completely unaware that they are pushing their brains into a frantic, high-stress state that actually destroys deep focus and accelerates cognitive decline. In this video, I reveal the science behind why caffeine is failing you and introduce you to a 4,000-year-old amino acid used by monks to achieve effortless, sustained attention
Semen Switch, Chewing Gum, Creatine Cheat, Cancer Plants, and Bedtime Risk : 1467
One Creatine Dose Kept Sleep-Deprived Brains 12% Sharper A randomized, double-blind crossover trial kept 29 healthy adults awake for 21 hours straight ... half the time on a single moderate dose of creatine (~14g), half the time on placebo ... and found the creatine group held on to up to 12% more cognitive performance across logic, reaction time, and language processing. Host Dave A
Stop Wasting Your Gym Sweat (40 Minutes of This Wins Every Time) | Will Harlow : 1466
If you're over 50 and still doing cardio to stay healthy, you're wasting your time and may actually be making things worse. This episode breaks down the exact movements, supplements, and anti-aging strategies that build real strength, protect your bones, and extend your longevity without spending hours in the gym. Watch this episode on YouTube for
The Real Reason She Loses Interest in Sex | John Gray : 1465
The person you love is either raising your hormones or destroying them, and most people have no idea which one is happening to them. John Gray, the author of one of the most beloved relationship books of all time, returns to reveal how your relational environment directly shapes your biology, and what you can do right now to hack it. Watch this episode on YouTube for the full video e
This Italian Fasting Hack Breaks All The Rules Of Fasting : 1464
If you are constantly bloated, fatigued, and feeling heavy, your gut bacteria have taken over. The standard advice is to just stop eating and do a multi-day water fast. But if your gut is already inflamed, a strict zero-calorie fast will actually spike your cortisol, trigger adrenaline crashes, and blow open the tight junctions in your intestinal wall.In this video, I break down the Itali
Pandemic Fever Is BACK, Testosterone and Brain Tumors, Rabies, and Dog Flu : 1463
*Testosterone Directly Suppresses Brain Tumor Growth in Males by 38% Cleveland Clinic research funded by NIH shows testosterone binds androgen receptors in glioblastoma stem cells — the root of tumor recurrence — and cuts growth by 38% when levels are restored. Dave breaks down why the mainstream framing of testosterone and cancer risk has it backwards, what androgen deprivation ther
iPhone Poisoning Is REAL: Here's How To Reverse the Hidden Damage | Quantum Upgrade : 1462
What if an invisible field could protect your brain from EMF damage, improve your HRV, accelerate recovery, and optimize your biology without pills, devices, or a single lifestyle change? Host Dave Asprey sits down with Philipp Samor von Holtzendorff-Fehling, founder of Leela Quantum Tech and Quantum Upgrade, to explore one of the most controversial and compelling fron
Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald : 1461
Your biological age can drop by over three years in just eight weeks, and the tools to do it are already in your kitchen. This episode breaks down the cutting-edge science of methylation, polyphenols, Yamanaka mimetics, and epigenetic reprogramming that is rewriting what we know about anti-aging, longevity, and human performance. -Watch this episode on YouTube for the
This 9,000-Year-Old Ritual Cleared 15 Years Of Brain Fog : 1460
I spent fifteen years living with brain fog until I realized the problem wasn’t in my brain, but in a nervous system stuck in a survival mode that pulls energy away from focus and memory. In this video, I explain why "trying harder" or popping supplements rarely works, and instead, I show you the 9,000-year-old ritual of heat and cold that pulls your body out of stress mode so clarity can
Selfies Predict Cancer, Dirty Feed, Bone Vibration, and more... : 1459
This week's stories: *Mud Playgrounds Double Kids' Bacterial Diversity and Spike Immune Genes 30% Finland swapped rubber playground surfaces for natural soil and mud across eight kindergartens — and after just one month, kids in dirt had twice the bacterial species diversity on their skin and a 30% increase in expression of ten immune-related genes. Dave breaks down why your imm
The Strangest Thing I Do Every Morning for 15 Minutes | Brad Pitzele : 1458
Your cells are starving for oxygen, and it's silently driving inflammation, fatigue, brain fog, and accelerated aging. This episode reveals how pairing Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges your mitochondria, reverses pseudo-hypoxia, and unlocks a level of human performance most people never experience. -Save up to $500
How Beef Is Destroying Your Hormones – Cynthia Thurlow : 1457
If you're a woman in your 30s, 40s, or 50s feeling like your body is betraying you, this episode reveals the hormonal, gut, and environmental triggers behind perimenopause that most doctors never address, and exactly what you can do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey
Supercharge Your Immunity In 4 Weeks With THIS Ancient Fruit : 1456
When you hit your 40s, you start catching colds more easily, wounds take longer to heal, and you feel rundown even after a full night's sleep. Your doctor will tell you "it's just aging." They're wrong.It's actually your immune cells suffocating on toxic waste because their power plants—your mitochondria—are breaking down.In this video, I explain the exact biological mechanism behind "imm
Inside Kambo: Poison, Purging, and The People Who Swear By It : 1455
Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme
You've Been Getting Dumber Every Day Since You Turned 30 : 1454
Your brain is aging faster than it should, and most of the decline is self-inflicted. Neuroscientist Dr. Tommy Wood reveals the exact mechanisms driving cognitive decay, and the biohacking strategies backed by hard science that can stop it, reverse it, and future-proof your brain at any age. -Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR Host Dave As
Jason Fung: 3 Rules to Lose 50 Pounds Without Ever Counting a Calorie : 1453
You are not eating because you are hungry. You are eating because you have been trained to, and the food industry designed it that way. This episode dismantles everything you thought you knew about hunger, weight loss, and metabolism, and gives you a science-backed framework to finally stop fighting your own biology. -Watch this episode on YouTube: https://www.youtube.com/
1 Cup Every Morning Helped Me Lose 100 Pounds (Drink THIS) : 1452
I lost 100 pounds, dropped to 4.8% body fat, and my lab tests say I'm biologically in my 30s... at 50 years old. Here's everything I got wrong about weight loss for years, and what actually worked.After 18 months of low-calorie dieting and 700+ hours in the gym with zero fat loss, I discovered the truth about saturated fat, intermittent fasting, and why putting butter in my coffee every m
Flouride and IQ, Sardinemaxxing, At Home Cancer Cure, Hair Loss Fixes, and more... : 1451
This week's stories: ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer*** A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastr
Why I'm Putting 100x Bleach on My Face : 1450
Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home. This episode breaks down hypochlorous acid (HOCl), the compound your white blood cells produce naturally, and why it outperforms Neosporin, hydrogen peroxide, and synthetic antibiotics for everything from cuts and burns to eczema, rosacea, and chronic wounds. -Watch t
CDC Director Jim O'Neill on Fixing America's Broken Food Policy : 1449
The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like. Watch this episode on YouTube for the full video experience: https://www.yout
What Doctor's DON'T Tell You About Megadosing Creatine (Over 40) : 1447
My favorite creatine (discount code DAVETUBE): https://www.qualialife.com/ASPREYRECOMMENDSCreatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity,
Superhuman Contact Lenses, Motivation Supplement Stack, Cat Scratches Cause Brain Fog, Amino Acid Shortening Lifespan, and more... : 1448
This week's stories: *Bartonella Hides in Cat Scratches — and It Might Be Why You Feel Like Garbage A stealth bacterial infection transmitted by everyday cat scratches and flea dirt has been quietly linked to chronic fatigue, brain fog, and neurological symptoms for decades. Dave breaks down how Bartonella slips past standard testing, why it's almost never on a co
Why Doctors Can't Fix Women in 2026 : 1446
Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage. Watch thi
Fix Mitochondria With NASA’s Secret Anti-Aging Superfood : 1442
I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn’t come from a pharmaceutical lab. It came from NASA.Try Danger Coffee: https://dangercoffee.com/dave (Discount Code DAVETUBE)Try Energy Bits: https://energybits.com/discount/daveAstronauts face the harshest environment known to science: space radiation. To keep them alive, NASA
Your AC Is Making You Dumber : 1444
Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots. This episode gives you the full picture on toxic mold, and exactly what to do about it Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave H
Your Doctor Is Wrong About Autism (Here's How To Reverse It) : 1443
Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, what actually triggers it, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen. Host Dave Asprey sits down with Tracy Slepcevic, bestselling autho
Your Organic Protein Powder Is Slowly Killing You : 1441
Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tell you and gives you the tools to stop poisoning yourself every morning. -Watch this episode on YouTube for the full video
This Legal Sleep Powder Beats Melatonin Every Time : 1440
Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves—a state of hypervigilance fueled by stress and blue light. You can take all the m
I Injected Stem Cells Into My Penis (Here's What Happened) : 1439
Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation
Arthur Brooks | Why Your Life Has No Meaning : 1438
What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with
This Popular Fat Loss Shortcut Destroys Your Youth : 1437
Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ a
Give Me 21 Minutes And I'll Give You Perfect Vision Naturally : 1436
Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial
SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor Stats, Colon Cancer Under 50, and more... : 1435
This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker me
Here's Why You Still Feel Like Sh*t After Doing Everything Right... : 1434
Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with McCall McPhers
The Awakening Within Cells: Healing Breakthroughs No One Can Ignore : 1433
What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered. -Watch this episode on YouT
This Nobel Prize Discovery Reverses Aging In 72 Hours : 1432
Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and c
Your Telomeres Are a Lie, Bats Beat Aging, Sleep Meds Ruin Mornings, CO's Silent Kill, and more... : 1431
This week’s stories: Smartphone App Catches What Sleep Trackers Miss A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal t
Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430
Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedar
AI Expert Says: Humans Are Just Mystical Meat Robots : 1429
What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level? -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Tom Griffiths, the
How I Finally FIXED My Terrible Sleep After 18 Years : 1428
Block toxic light with these glasses: https://truedark.com/discount/DAVETUBEThink 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I’ll show you how
WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements : 1427
This week’s stories: Healthy Diets That Offset "Bad Genes" A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect proto
Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426
Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host Dave Asprey and microplastics expert Josephine Musco break down exactly what these particles are doing inside your body and give you a practical, science-backed action plan to detox, protect yourself, and take back control of your biology.&nb
Why Are Hackers Microdosing “Sex Drugs” Now? : 1425
Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. -Watch this episode on YouTube for the full video experience: https://www.youtube.
A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424
What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most
Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423
This week’s stories: Sinclair’s This Is the Test: Are we about to see age reversal in humans? At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an
The Secret to Staying DANGEROUS After 50 : 1422
Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/ Host Dave Asprey
The Home Laser That Reverses Skin Age By 20 Years : 1421
Your skin is not just a cosmetic surface. It’s a living organ that responds to signals, and the right light signal can flip your biology into repair mode. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from LYMA by using code ‘DAVE-10’ at: https://lyma.life/ -Offer not valid on LYMA La
I Tested The Most Dangerous Viral Brain Hack : 1420
Most people try to fix brain fog and focus issues with caffeine or nootropics, but those approaches only mask the problem.This video explains that brain fog begins when the brain’s energy system—its mitochondria—starts to fail, long before any obvious signs of aging appear.Modern stress, poor sleep, artificial light, toxins, and blood sugar swings quietly drain this energy and reduce the
Plastic in Your Testicles, AI Sleep Scans, The 29% Weight Loss Drug : 1419
This episode covers: • Microplastics Are Destroying Male Fertility and Metabolism New research is putting microplastics in a category most men still are not taking seriously: direct reproductive and hormone risk. A 2024 study detected microplastics in every human testicle examined, with polyethylene and PVC among the most common polymers. PVC is especially relevan
Change Your Morning, Change Your Life – Hal Elrod : 1418
Meet a man who makes miracles happen. Today, we revist my conversation with Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle Equation. After overcoming multiple near-death experiences and financial hardships, Hal channeled his adversity into helping others overcome their own challenges. His Miracle Morning approach
The Secret to Looking Younger is in Mushrooms (And Chocolate?) : 1417
Your gray hair, thinning lashes, brain fog, and that low energy feeling after 30 might all trace back to one thing: falling NAD and stressed mitochondria. This episode breaks down what actually happens inside your cells as NAD declines, and what you can do about it using specific compounds from mushrooms, olive oil, and even chocolate. -Watch this episode on YouTube for the
Low Testosterone Starts In Your Eyes (Avoid This Before Bed) : 1416
https://truedark.com/discount/DAVETUBEMost people believe testosterone declines simply because of age. That explanation is easy, familiar, and wrong. Testosterone is not primarily controlled by how hard you train, how clean you eat, or how stressed you feel during the day.It is controlled by what happens in your brain at night. This video explains how sleep architecture works, why deep sl
Jet Lag Superdrug, 25% Dementia Drop, Coffee Brain Aging, Kratom Shakeup : 1415
This episode covers: • Mic-628 Could Reset Your Body Clock and Cut Jet Lag in Half A new circadian drug candidate, Mic-628, has demonstrated the ability to shift the body’s internal clock and significantly reduce jet-lag recovery time in early human studies. In controlled simulations, participants experienced faster realignment of their sleep-wake cycles and improved d
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