The a16z Show
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week.
Episodes
Nas, Grandmaster Caz, Steve Stoute & Ben Horowitz on Paying Hip-Hop’s Pioneers Their Due
Ben Horowitz and Erik Torenberg sit down with Nas, Grandmaster Caz, and Steve Stoute for a conversation about the Paid in Full Foundation and its mission to recognize and support the pioneers who built hip-hop.Ben, Nas, and Steve share how the foundation began, why simply giving artists money wasn’t enough, and how the Hip Hop Grandmaster Awards became a way to pair financial support with the reco
What Makes a Consumer AI Product Stick? | Josh Elman
a16z Partner Josh Elman joins Ollie Forsyth on New Economies to discuss the next wave of consumer AI and what separates a product people try once from one that becomes part of their everyday lives.Josh argues that getting attention has actually become easier, but getting consumers to stick is harder than ever. He explains what he looks for in consumer products, why the best ones start with a narro
Databricks CEO on AI Pacing, Cyber Risk, and the Enterprise
Databricks co-founder and CEO Ali Ghodsi joins a16z General Partners Martin Casado and Sarah Wang for a conversation about AI risk, recursive self-improvement, cybersecurity, and what’s actually holding back enterprise adoption.Ali argues that today’s models are already capable enough to automate far more work than most companies are using them for. The bigger problem is context: models haven’t be
The Next Frontier of AI Video Is Control
a16z General Partner Jennifer Li sits down with fal co-founder Gorkem Yurtseven and Head of Engineering Batuhan Taskaya to discuss what changes when generative video becomes fast enough to run in real time.They unpack the technical work behind H3 Max, fal’s post-trained version of MiniMax’s open-weight video model, and how combining model post-training with systems and hardware optimization signif
The AI-Native CRM
a16z’s Alex Rampell and Joe Schmidt sit down with Lightfield co-founder and CEO Keith Peiris to discuss what it takes to rethink the CRM for an AI-native world, and the unusual pivot that got him there.Keith previously built Tome to 25 million users, but eventually walked away from the product after concluding that the underlying technology couldn’t capture enough context about a presenter, their
The Age of Body Futurism | Ruby Justice Thelot
Elena Burger sits down with academic and cyber ethnographer Ruby Justice Thelot to explore the increasingly blurry line between internet culture and the real world, and how to tell the difference between a trend that’s actually changing behavior and one that simply feels enormous online.They use today’s wellness and optimization culture as a case study, from peptides and GLP-1s to protein maxxing,
Greg Brockman on Why OpenAI Says We’re Entering the AGI Era
Ben Horowitz and Erik Torenberg sit down with OpenAI co-founder and President Greg Brockman to discuss why he believes AI has entered a new phase, what OpenAI’s latest models reveal about the path to AGI, and the safety and security challenges that come with increasingly capable systems.Greg explains why computer use represents such an important step for agents, including models that can work cohe
World Models, Robotics, and the Future of 3D AI
World Labs co-founder Justin Johnson joins MTS hosts Theo Jaffee and Sofia Puccini to discuss Atlas, World Labs’ latest world model, and the broader case for AI systems that understand and interact with the physical world.Justin explains how Atlas approaches three core tasks: generating new worlds, reconstructing real environments from images, and simulating how objects or robots might behave with
Why Companies Are Becoming a Series of Loops | Anish Acharya on Lenny’s Podcast
a16z General Partner Anish Acharya joins Lenny Rachitsky on Lenny’s Podcast to discuss why fears of an AI-driven “permanent underclass” may be misplaced, how AI is changing the way companies operate, and why the opportunity may be less about replacing people and more about dramatically expanding what they can build.Anish lays out his idea that companies are becoming a series of loops, with agents
What It Takes to Build a Startup | Andrew Chen & Matt Perault
a16z’s Matt Perault sits down with General Partner and Speedrun lead Andrew Chen on the a16z AI Policy Brief to explore what “Little Tech” actually looks like at the earliest stages, and why the realities of building a two- or three-person startup are often missing from policy debates.Andrew takes us inside Speedrun, where founders are often starting companies from kitchen tables, working with tin
How AI Is Rewriting the Power Law of Venture Capital
a16z’s Jen Kha and David George sit down with Accolade Partners’ Aram Verdiyan to discuss how AI is changing the power law of technology investing, why the largest companies can compound advantages in ways that weren’t possible before, and what that means for how investors construct portfolios.They explore why AI may be much bigger than traditional software, with applications reaching into labor,
Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan
a16z’s Erik Torenberg, Ben Horowitz, and Jennifer Li sit down with Vals founder and CEO Rayan Krishnan to discuss one of AI’s increasingly difficult problems: how do you actually measure whether a model is getting better?As public benchmarks saturate and models get better at optimizing for the tests themselves, Rayan makes the case for independent, continuously evolving evaluations. They unpack wh
OpenAI Researchers on the Future of Mathematical Reasoning
a16z Infra Partner Lisha Li sits down with OpenAI mathematicians Mehtaab Sawhney and Mark Sellke to discuss how quickly AI’s mathematical capabilities are advancing, what recent results reveal about model reasoning, and what happens when AI begins making progress on problems mathematicians have struggled with for decades.Mehtaab and Mark unpack several recent results from OpenAI’s models, includin
Can Open Source Keep AI Power From Concentrating?
MTS host Sophia Dew visits the Open Source AI Summit in San Francisco to ask researchers and founders across the AI stack a central question: can open source prevent AI power from concentrating in the hands of a few companies?Lukasz Kaiser, co-author of Attention Is All You Need, argues that today’s concentration may be a feature of the current technological paradigm rather than a permanent featur
Your AI Doctor Is Coming | Julie Yoo
a16z General Partner Julie Yoo joins MTS host Sophia Dew to explain why she believes healthcare could benefit more from AI than almost any other industry, and why decades of slow technology adoption may actually give healthcare an advantage in the AI era.Julie traces healthcare’s evolution from paper records and fax machines through electronic health records and telehealth, and explains why AI rep
Aaron Levie on Why Open AI Wins
Box co-founder and CEO Aaron Levie joins MTS hosts Theo Jaffee and Sofia Puccini to make the case for open-weight AI, unpack the economics of open versus closed models, and explain why he believes more openness could strengthen rather than undermine the U.S. AI ecosystem.Aaron argues that open models create more use cases, push closed labs to innovate faster, and don't fundamentally change where t
Fei Fei Li: The Race to Build World Models For AI
World Labs co-founders Fei-Fei Li, Justin Johnson, and Ben Mildenhall join a16z General Partner Martin Casado to discuss Atlas, their latest world model, and what it reveals about the pursuit of spatial intelligence.At the center of Atlas is what the team calls “new view prediction”: given images or views of a scene, the model predicts what that environment should look like from a different positi
The $100B Niches Hiding Inside Payments
Erik Torenberg is joined by a16z General Partner Alex Rampell and Affirm Co-Founder and CEO Max Levchin for a conversation on 25 years of fintech, from the early days of digital payments to the origins of Affirm and the next generation of agentic commerce.Max and Alex revisit what surprised them most about how payments evolved, why the card interface has been so difficult to displace, and why even
Inside Moderna’s Personalized Cancer Vaccine
a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Merck’s individualized treatment for melanoma, after more than a decade of work on personalized cancer vaccines.
Stéphane explains how the treatment works by sequencing an individual patient’s tumor and healthy cells, identifying th
Daniel Litt: The Mathematician's Guide to AI
a16z’s Lisha Li sits down with Daniel Litt, Assistant Professor of Mathematics at the University of Toronto, to unpack AI's rapid progress in mathematics, what today's frontier models can actually do, and what they're still missing about the way mathematicians think.
Daniel explains why some recent AI-generated results are genuinely impressive, including an autonomous solution to the Erdős unit di
Gavin Baker: Why AI Demand Is Outrunning Compute Supply
a16z’s David George sits down with Gavin Baker to unpack the state of the AI boom, why demand for intelligence may still be dramatically underestimated, and why the outcome doesn't necessarily have to be winner-take-all.
David and Gavin explore the possibility that frontier labs, open-source models, applications, clouds, and NVIDIA can all capture significant value as AI adoption expands. They dig
Why a16z Launched the Machine Age Fund | Jen Kha
a16z Managing Partner and Head of Global Partnerships Jen Kha joins MTS hosts Theo Jaffee and Sophia Dew to discuss a16z's Machine Age Fund and the investment thesis behind rebuilding the physical infrastructure that powers AI.
Jen explains why chips, networking, memory, cooling, data centers, and other parts of the physical computing stack are becoming investable again after decades in which soft
Why 1,200 AI Agents Started Working Together | Ryan Greenblatt
Ryan Greenblatt, Chief Scientist at Redwood Research, joins MTS host Theo Jaffee to unpack a new independent investigation into the OpenAI Hugging Face hacking incident and what it reveals about how large groups of AI agents behave when they're allowed to coordinate.
Ryan and his collaborators found agents spontaneously organizing through message boards, sharing information, assigning tasks, formi
The Infrastructure Behind the Machine Age
Ben Horowitz, Martin Casado, Raghu Raghuram, and Erik Torenberg discuss the launch of a16z's new Machine Age Fund and the infrastructure buildout behind AI, from chips, memory, and networking to power, cooling, and data centers.
Why a dedicated fund now? The group argues that the bottleneck in AI is increasingly shifting from the models themselves to everything beneath them. Hyperscaler CapEx is s
Inside Cursor: The Anatomy of a Generational Startup
a16z General Partners Martin Casado, Sarah Wang, and Matt Bornstein unpack the story of Cursor: how a small, product-obsessed team entered one of the most competitive markets in technology, took on incumbents with seemingly unbeatable advantages, and repeatedly made decisions that ran against conventional startup wisdom.
They revisit the early bet that the interface between humans and AI would mat
The State of AI: Macro, Apps, and Consumer
Anish Acharya joins Jen Kha to break down the next frontier of AI, from the evolving model landscape and open-source AI to why the application layer, and consumer AI in particular, may be entering a new phase.
Anish explains why he believes there will be multiple winners at the model layer, why traditional moats like network effects, scale, and brand still matter, and how companies can choose betw
The New Economics of AI | Martin Casado & Steven Sinofsky
a16z General Partners Martin Casado and Erik Torenberg are joined by Board Partner Steven Sinofsky to explore what recent breakthroughs in AI and mathematics tell us about where the technology is headed, and whether some of the basic assumptions that have governed computing for decades are starting to break.
Martin and Steven debate whether AI's progress in mathematics represents a genuine leap in
Why Medical AI Needs a Referee | Protege's Engy Ziedan
Daisy Wolf and Eva Steinman are joined by Engy Ziedan, co-founder and Chief Scientific Officer of Protege, to discuss why medical AI has a measurement problem, and why scoring well on a benchmark doesn't necessarily mean a model is ready for the hospital.
Engy explains why healthcare AI needs independent evaluations that go beyond static exams and measure how models actually perform in real-world
Martin Casado on Where the Value Is Going in AI
Martin Casado joins MTS hosts Theo Jaffee and Sophia Dew to unpack where value is actually accruing in AI, why this technology cycle looks fundamentally different from previous waves, and whether the frontier labs will ultimately capture most of the market.
Martin explains why AI has turned venture into a scale-up capital game, where small teams can productively deploy extraordinary amounts of mon
Microsoft's Deputy CISO on Securing AI Agents
a16z's Joel De La Garza is joined by Aaron Zollman, Deputy CISO at Microsoft Gaming, to discuss how security teams can embrace AI agents without losing control.
Aaron shares Microsoft's experience with OpenClaw, from the initial instinct to ban it to figuring out how to make it safe to use. They unpack what agents mean for identity, permissions, containerization, and monitoring, as well as how AI
How Global Networks Are Reshaping Startup Success
Elena Burger is joined by a16z’s Angela Strange and Gabriel Vasquez to discuss the rise of the "borderless founder": entrepreneurs who bring the networks and insights of their home markets together with the talent, capital, and speed of Silicon Valley to build global companies.
Angela and Gabriel trace how a16z's international investing efforts grew from early work in Latin America into a broader
How Whatnot Built a Global Marketplace
a16z General Partner David George is joined by Grant LaFontaine, co-founder of Whatnot, to unpack how a marketplace that started with collectibles evolved into one of the world's leading live shopping platforms.
Grant traces the company's origins from selling Pokémon cards online as a kid to discovering live commerce by watching Whatnot's earliest customers hack together sales on social media. The
How Do You Defend Against AI That Can Hack?
a16z's Joel De La Garza is joined by Nick Warner of Neo and Max Pollard of Cotool to discuss what happens when cybersecurity tools built to defend against humans and malware suddenly have to contend with AI agents. As frontier models become more capable of finding and exploiting vulnerabilities, many of the assumptions underlying traditional security are beginning to break.
They explore why guardr
Stripe’s AI Strategy: Build More, Not Less
a16z General Partner David George is joined by Will Gaybrick, President of Product & Business at Stripe, to discuss how AI is changing the way Stripe builds products, organizes teams, and thinks about the future of internet commerce. Stripe has evolved from a payments company into a multi-product financial infrastructure platform, while a new generation of AI companies is growing and monetizing fa
Ben Horowitz and Travis Kalanick on Building Again
Ben Horowitz, Travis Kalanick, and Erik Torenberg take the stage at Atoms' launch event for a candid fireside conversation about entrepreneurship, company building, and why Kalanick believes the next industrial revolution will be powered by AI.
They revisit pivotal moments from Uber's history, including the decision not to acquire Lyft, lessons from scaling one of the world's fastest-growing compa
The Two Ways to Sell AI: Lighthouse or Landgrab?
Elena Burger is joined by a16z's Andy McCall and Joe Schmidt to break down two very different ways AI startups can go to market: the lighthouse and the landgrab. Should founders win a handful of marquee customers whose credibility unlocks an entire industry, or move quickly across a broad market where the ROI already speaks for itself?
Drawing on Joe's Lighthouse or Landgrab framework and Andy's e
Garry Tan on Taste, Agents and Founder Ambition
Anish Acharya is joined by Garry Tan, President and CEO of Y Combinator, for a conversation about how AI is rewriting the startup playbook, why founders should be more ambitious than ever, and what two decades of Silicon Valley booms, busts, and missed opportunities have taught Garry about building what's next.
Garry reflects on turning down an early opportunity to join Palantir, why chasing what'
The CISO Playbook for AI Agents | Datadog
a16z's Joel De La Garza is joined by Emilio Escobar, Chief Information Security Officer at Datadog, to discuss what it takes to secure a company where nearly every employee is using AI and more than 4,000 engineers are working with coding agents. Rather than trying to block new tools, Emilio explains why Datadog chose to embrace AI early and build the security infrastructure needed to use it safel
The Self-Improving Company | Kavak's AI Playbook
Angela Strange and Gabriel Vasquez are joined by Alejandro Maza Ayala, Chief Product & AI Officer at Kavak, to unpack how the Latin American used-car marketplace rebuilt itself around AI agents, with 96% of customer interactions and 95% of transactions now handled by agents.
Alejandro explains why Kavak decided that simply giving employees AI tools wasn't enough, and instead redesigned the company
The Reality of AI-Powered Cyberattacks | Truffle Security & Socket
Joel De La Garza is joined by Dylan Ayrey, co-founder and CEO of Truffle Security, and Feross Aboukhadijeh, founder and CEO of Socket, to discuss one of the biggest shifts happening in cybersecurity: AI models are no longer just finding vulnerabilities—they're exploiting them. As frontier models become increasingly capable of hacking, software security, supply chain attacks, and cyber defense are
The Engine Powering Open-Source AI
Elena Burger and Matt Bornstein are joined by Simon Mo, co-founder and CEO of Inferact, the open-source inference engine powering many of today's most advanced AI applications. Together, they explore how open-source AI evolved from a research project into critical infrastructure, why inference has become one of the most important layers of the AI stack, and what it takes to bring frontier intellig
Three Startups Reinventing Critical Infrastructure
This week, a16z American Dynamism Films premiered three short documentaries highlighting companies tackling some of America's biggest industrial challenges: Ulysses, Mariana Materials, and Radiant. Before watching those films, we're revisiting conversations with the founders behind each company.
You'll hear Will O'Brien explain why autonomous underwater robots could unlock a new era of ocean explo
OpenAI's Joshua Achiam: Did We Already Reach AGI?
Theo Jaffee is joined by Joshua Achiam, Chief Futurist at OpenAI, for a conversation on AI cybersecurity, frontier model capabilities, and why he believes society may have already crossed the threshold into an AGI-era without fully recognizing it.
They discuss AI's rapidly advancing cyber capabilities, state-sponsored hacking, model jailbreaks, recursive self-improvement, and what happens when AI
Ruby Thelot on Internet Culture, AI, and the Future of Taste
Sophia Dew and Sofia Puccini are joined by Ruby Thelot, designer, artist, cyberethnographer, professor at NYU, and founder of 13101401, for a wide-ranging conversation about internet culture, AI, digital communities, and how technology is reshaping the way we relate to one another.
Drawing on years of research into online behavior, Ruby explains how digital cultures form, why algorithms shape more
Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation
Marc Andreessen, Chris Dixon, and Robert Hackett discuss one of the most consequential policy debates facing the crypto industry: the push for comprehensive U.S. market structure legislation and what regulatory clarity could mean for innovation, financial markets, and America's technological leadership.
They explore the CLARITY Act, stablecoins, securities law, consumer protection, and why both bu
How Enterprise AI Really Gets Deployed
Sarah Wang and Kimberly Tan are joined by Jesse Zhang and Ashwin Sreenivas, co-founders of Decagon, to discuss the evolution of enterprise AI agents, why the company increasingly relies on open-source models, and how it is helping some of the world’s largest companies deploy AI in production.
Decagon has become one of the fastest-growing AI companies by building agents that automate customer suppo
AI for America's Small Businesses | Lassie
Alex Rampell and Olivia Moore speak with Lassie cofounders Steijn Pelle and Frédéric Renken about bringing AI to one of the most overlooked parts of the economy: small businesses.
Inspired by time spent working inside dental practices, Pelle and Renken set out to automate the administrative work that keeps healthcare providers away from patients. They discuss how AI agents are changing billing, in
AI Micro Dramas, Generative Media, and the Future of Creativity
Justine Moore, partner at Andreessen Horowitz, joins New Economies to explore the rapid evolution of generative media and why AI-native content is reaching an inflection point. They discuss the rise of AI micro-dramas, how creators are building entirely new forms of entertainment, and why the biggest opportunities may lie not in replacing Hollywood—but in expanding who gets to create.
They also co
Fei-Fei Li on Spatial Intelligence and Robotics
Last week, World Labs announced its acquisition of SceniX, bringing together two teams working on one of AI's biggest unsolved problems: how to give machines a true understanding of the physical world.
Martin Casado sits down with Fei-Fei Li, co-founder and CEO of World Labs, creator of ImageNet, and pioneer of spatial intelligence, alongside Yunzhu Li, co-founder of SceniX and assistant professor
Steven Sinofsky: AI Doesn't Need New Rules Yet
Steven Sinofsky joins Theo Jaffee and Sofia Puccini for a conversation on AI regulation, open-source models, and what history can teach us about technological revolutions. Drawing on decades of experience leading products at Microsoft, Sinofsky argues that governments are rushing to regulate AI before they fully understand the technology, risking innovation in the process.
They discuss the "precau
Ben Horowitz: The Fight Over Open Source AI
Ben Horowitz joins Theo Jaffee and Sofia Puccini to discuss one of the biggest debates in AI today: the future of open-source models. They examine the growing push to restrict open models, why Ben believes open source is critical for security, innovation, and competition, and what happens if a handful of frontier labs come to dominate the AI ecosystem.
They also discuss distillation, AI monopolies
Sriram Krishnan on Open Source AI's Biggest Week Yet
Sriram Krishnan joins Theo Jaffee and Sofia Puccini just after concluding his tenure as Senior White House Policy Advisor on AI to discuss one of the biggest weeks yet for open-source AI. They unpack the rapid release of models including Kimi K3 and Qwen, why open models are putting pressure on frontier labs, and what it means for pricing, competition, and the future of AI infrastructure.
They als
Building the Physical AI Stack | Travis Kalanick on TBPN
Travis Kalanick joins TBPN to discuss Atoms, his vision for industrial AI, and why he believes the biggest opportunities in AI lie beyond software.
He explains how Atoms is bringing autonomy to mining, logistics, and food production, why robotics will reshape physical industries, and how lower costs and greater automation could unlock entirely new economic opportunities. Travis also reflects on ra
Travis Kalanick Is Back | Building the Future of Industrial AI
Travis Kalanick, Ben Horowitz, and Erik Torenberg reunite to reflect on Uber's early days, the investment that almost happened, and why Kalanick believes the next great technology opportunity lies beyond software.
They discuss the lessons of building Uber, the value of founder-led companies, and why Kalanick spent nearly eight years quietly building Atoms before stepping back into the spotlight.
T
Why Physical AI Is the Next Frontier | Applied Intuition
Applied Intuition has spent the past decade building the software that powers intelligent machines, from passenger vehicles and trucks to defense systems, mining equipment, and industrial robots.
In this conversation, Marc Andreessen and Erik Torenberg sit down with Applied Intuition cofounders Qasar Younis and Peter Ludwig to discuss the emergence of physical AI and the company's latest launch, D
Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition
As governments weigh new restrictions on frontier AI models, one question is becoming increasingly important: what role should open source play in the future of artificial intelligence?
Theo Jaffee and Sofia Puccini speak with Hugging Face CEO Clément Delangue about AI regulation, open source safety, model routing, and why he believes competition—not consolidation—is essential for the industry's f
Amjad Masad on Going Direct, Building Replit, and the Future of Software
Recorded live at the New Media Summit, Erik Torenberg sits down with Replit founder and CEO Amjad Masad to discuss founder-led storytelling, building in public, and the role of media in company building.
Masad reflects on Replit’s decade-long journey, including the years before the company’s recent breakout growth, and explains why communicating a vision can be just as important as executing on it
Replay 2025: David Sacks on AI, Crypto, and America's Technology Future
As part of our summer replay series, we're revisiting one of our most-discussed conversations from the past year.
David Sacks joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to discuss the intersection of AI, crypto, regulation, and American competitiveness.
The conversation explores the Trump administration's approach to AI and crypto policy, open source AI, export controls, energy and in
From the Archive: Can Anyone Catch NVIDIA? | The Future of Chips and Infrastructure
As part of our summer replay series, we're revisiting one of our favorite conversations on the future of AI infrastructure.
SemiAnalysis founder Dylan Patel joins Erin Price-Wright, Guido Appenzeller, and Erik Torenberg to examine the rapidly evolving economics of AI hardware, from GPUs and custom silicon to data centers, power, and the global race for compute.
The conversation explores NVIDIA's c
Is AI a Bubble? | Gavin Baker on Data Centers, GPUs, and the AI Economy
As part of our summer replay series, we're revisiting one of the standout conversations from Runtime, a16z's conference on AI infrastructure and the future of computing.
Gavin Baker, Managing Partner and CIO of Atreides Management, joins David George to examine the biggest questions surrounding today's AI investment cycle. Is AI a bubble? What does the unprecedented buildout of data centers, GPUs,
Before Blockchains, There Was State Machine Replication
Every blockchain today relies on replication techniques first developed in the 1980s by researchers who weren't thinking about cryptocurrencies at all.
In this episode, Tim Roughgarden speaks with MIT professor and Turing Award winner Barbara Liskov, one of the pioneers of programming languages, fault tolerance, and distributed systems. Joined by a16z crypto research partner Ittai Abraham, they tr
How Bitcoin Rewired a Classic Computer Science Problem
We're excited to share a special feed drop from The a16z Crypto Show.
In the first episode of First Principles: The Scientific Roots of Blockchain Technology, Tim Roughgarden and Ittai Abraham trace the decades of computer science research that laid the foundation for modern blockchains.
Long before Bitcoin, researchers were studying one of distributed computing's hardest challenges: how independe
Mark Zuckerberg & Priscilla Chan: How AI Will Help Cure Disease
As part of our summer replay series, we're revisiting one of our favorite conversations from the past year.
Mark Zuckerberg and Dr. Priscilla Chan join Ben Horowitz, Vineeta Agarwala, and Erik Torenberg to discuss the Chan Zuckerberg Initiative's ambitious effort to help cure, prevent, and manage disease by the end of the century.
Rather than funding individual breakthroughs, CZI is focused on bui
Adam Neumann: This Is How You Build Iconic Companies
Adam Neumann joins Marc Andreessen, Ben Horowitz, and Erik Torenberg for a candid conversation about entrepreneurship, failure, and building Flow.
Neumann reflects on his childhood, military service, immigration to the United States, the rise and fall of WeWork, and what he learned from one of the most scrutinized founder journeys in technology. He explains why Flow is focused on rethinking housin
Is Software Losing Its Head?
Seema Amble, Steven Sinofsky, and Elena Burger unpack one of the biggest questions facing enterprise software: what happens when AI agents become the primary users of software instead of humans?
The conversation explores the rise of "headless" software, why APIs and agentic workflows are reshaping enterprise applications, and whether traditional SaaS products are becoming systems of record rather
Don’t Follow Your Passion | Ben Horowitz’s Advice for New Graduates
In this commencement address to Columbia University's Fu Foundation School of Engineering and Applied Science Class of 2015, Ben Horowitz challenges some of the most common advice given to graduates.
Rather than urging students to “follow their passion,” Horowitz argues that people should focus on developing their strengths and making meaningful contributions to the world. Drawing on stories from
a16z Goes Global: Why American Tech Must Lead the World
Ben Horowitz is joined by Anne Neuberger, Raghu Raghuram, and Jen Kha to discuss a16z's expanding international strategy and the growing role technology plays in economic growth, national security, and global partnerships.
The conversation explores why America's technology leadership matters beyond Silicon Valley, how AI is reshaping relationships between governments and the private sector, and wh
Outsmarting Uber: Why Bolt Wins in Europe
What does it take to build a global mobility company from a country of just 1.3 million people?
Markus Villig, founder and CEO of Bolt, joins the show to share how he scaled from Estonia to 50+ countries, navigating early scrappy days, a near-bankruptcy from expanding too fast, and the hard-won lessons behind Bolt’s capital-efficient growth.
They also discuss building in Europe vs. the U.S., compe
Rick Rubin on AI, Creativity, and The Way of Code
Rick Rubin joins Marc Andreessen, Ben Horowitz, Anjney Midha, and Erik Torenberg to discuss creativity, artificial intelligence, and his book The Way of Code, which reimagines the Tao Te Ching for the age of AI.
The conversation explores vibe coding, remix culture, artistic process, entrepreneurship, and what AI changes, and doesn't change, about creativity. Rubin argues that AI is best understood
Building AI for Creators | Luma & Phota Labs
Yoko Li speaks with Luma's Head of Applied Research Matt Tancik and Phota Labs cofounder and CTO Zach Xia about how AI is changing creativity, photography, and the tools people use to make art.
The conversation explores the evolving relationship between artists and AI, from image generation and personalization to creative workflows, controllability, and agentic design tools.
They discuss personal
Beyond P(doom): Marc Andreessen - Betting on America
Marc Andreessen joins CSIS's Navin Girishankar for a wide-ranging conversation on artificial intelligence, productivity growth, industrial policy, and America's technological future.
Andreessen argues that while AI has already begun reshaping the economy, the largest impacts are still ahead. He explores how AI could dramatically expand access to expertise, improve productivity, and transform indus
AI Is Crossing the Frontier of Human Knowledge | Kevin Weil
Kevin Weil, the previous CPO & Vice President of Science at OpenAI, joins Speedrun to discuss the future of AI, scientific discovery, and startup building.
After helping build products at Twitter, Instagram, and Facebook, Weil is now focused on one of AI's most ambitious applications: accelerating science itself. He explains why modern AI models are beginning to solve problems that sit beyond the
Marc Andreessen on AI, Technology, and the Future of Humanity
Michael Malice sits down with Marc Andreessen to discuss artificial intelligence, technological progress, economic growth, and the future of human flourishing.
Drawing on decades of experience spanning the birth of the commercial internet through today’s AI boom, Andreessen argues that many of the most common fears about technology are rooted in a misunderstanding of how innovation creates opportu
What Happens to Design After AI?
Anish Acharya speaks with Microsoft VP of Design John Maeda and Impeccable founder and CEO Paul Bakaus about how AI is changing the practice of design.
The conversation explores the relationship between design and technology, the rise of AI-powered creative tools, and whether automation raises the floor, the ceiling, or both. Maeda and Bakaus discuss software craftsmanship, taste, creative judgmen
What’s Next for Consumer AI? | Josh Elman Joins a16z
Anish Acharya sits down with Josh Elman to discuss the future of consumer technology and Josh's decision to join a16z.
Over the past two decades, Elman has helped shape some of the most important consumer technology products and companies, including LinkedIn, Facebook, Twitter, Robinhood, Discord, Musical.ly, TikTok, and Apple. Drawing on those experiences, he reflects on how technology has evolve
Jake Paul & Anti Fund: From Creator to Investor
Jake Paul and Geoff Woo join the podcast to announce Anti Fund’s new $100 million growth fund and discuss the evolution of their investment strategy.
The conversation covers the fund’s portfolio, including investments in companies such as SpaceX, OpenAI, Anthropic, Anduril, Cognition, Etched, and Modal, as well as the lessons they’ve learned backing founders and identifying emerging technologies.
The New Rules of Media | Marc Andreessen & Ben Horowitz
Recorded live at the New Media Summit, Marc Andreessen, Ben Horowitz, Erik Torenberg, and Gaby Goldberg discuss how media, communication, and influence are changing in the internet era.
The conversation explores the shift from legacy media to creator-led platforms, why authenticity has become a competitive advantage, and how founders can build audiences by communicating directly with customers, em
The Fintech Playbook for Latin America
Angela Strange and Gabriel Vásquez speak with Addi founder and CEO Santiago Suárez about building one of Latin America's largest financial platforms.
What began as a buy now, pay later product has evolved into a broader ecosystem spanning payments, commerce, logistics, and now banking. Serving millions of consumers and tens of thousands of merchants, Addi sits at the intersection of financial serv
Jack Altman on Product-Market Fit
Jack Altman joins Speedrun to discuss product-market fit, customer feedback, hiring, fundraising, and the realities of building an enduring company.
Drawing on his experience building Lattice from startup to multi-billion-dollar company, Altman explains how founders should think about customer requests, when to pivot, and why some of the hardest decisions come from balancing conviction with market
AI, Design, and the Power of Open Models
Yoko Li and Justine Moore speak with Ideogram founder and CEO Mohammad Norouzi about image generation models, design workflows, and the evolving relationship between AI and creative work.
The conversation covers Ideogram's decision to release an open-weight model, the challenges of generating text and layouts within images, and why controllability has become an increasingly important area of resea
