Longevity Roadmap
Dr. Buck Joffrey interviews leading scientists in the field of longevity to discuss cutting-edge research, emerging therapies, and practical strategies for living longer and healthier.
Episodes
169: Protein Folding Errors Contribute to Aging and Disease
In this episode, we are joined by Dr. Judith Frydman to explore proteostasis: the tightly regulated systems that ensure proteins are correctly folded, maintained, and cleared before they become toxic. As these systems degrade with age, misfolded proteins accumulate, cellular signaling falters, and vulnerability to neurodegeneration increases. The discussion centers on why protein folding begins du
168: Best of 2025
Over the past year, we covered a wide range of ground—from clinicians working directly with patients to top scientists studying the underlying biology of aging. This episode is a chance to look back at some of the more interesting conversations we had on Longevity Roadmap in 2025. Looking ahead, there's no sign that the pace is slowing. In longevity, it often feels like every year brings another s
167: Why Bats Don't Age and Why You Should Care with Dr. Emma Teeling
Aging is usually linked to size, metabolism, and inevitable decline—but bats defy all three. In this episode, Dr. Buck Joffrey speaks with Dr. Emma Teeling about why bats are rewriting the rules of longevity science. The discussion explores how bats live far longer than expected for their size while avoiding cancer, immune dysfunction, and chronic inflammation. They examine how stable telomeres, e
166: BioXcellerator - The Cutting Edge of Stem Cell Therapy
Longevity medicine is moving beyond symptom management—and regenerative therapies are forcing a deeper look at how healing actually works. In this episode, Dr. Buck Joffrey speaks with the team at BioXcellerator about what separates rigorous regenerative medicine from hype-driven shortcuts. The conversation focuses on why stem cells aren't about "replacing" tissue, but about directing the body's o
165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Aging begins when cellular quality-control systems lose their precision. In this episode, Professor Ana Maria Cuervo outlines how chaperone-mediated autophagy (CMA)—a selective lysosomal degradation pathway essential for proteostasis—progressively declines with age, triggering downstream failures across neuronal and metabolic tissues. Reduced LAMP2A availability, impaired lysosomal docking, and di
164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray
In this episode, we are joined by Dr. Tony Wyss-Coray to discuss his groundbreaking research on brain resilience and aging. He explains how systemic factors, particularly proteins in the blood, influence cognitive function and the aging process. The discussion covers the role of proteomics, machine learning, and the potential of parabiosis and plasma infusions in developing therapies for age-relat
163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima
In this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline. He begins by outlining how reductions in cytochrome oxidase activity, disruptions in oxidative phosphorylation, and the accumulation of mitochondrial mutations progressively impair neuronal energy metabolism. These metabolic deficits, he explains, often
162: The Habits of Healthy Aging with Dr. Kate Wolin
We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world. From frictionless habit design and daily self-monitoring to movement, sleep, and the muscle-preserving realities of GLP-1s, she reveals the behavioral strategies that truly move the needle on long-term metabolic and
161: The Future of Tissue Regeneration with Dr. Jennifer Elisseeff
In this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine. She explains the shift from using stem cells to focusing on immune cells for tissue repair, the challenges of regenerating cartilage, and the importance of vascularity in tissue health. The discussion also covers the impact of aging on tissue r
160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum
Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging. She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that also exist in humans. The conversation dives into the balance between stress and resilience, the role
159: How DNA Mutations and Epigenetic Drift Cause Aging with Prof. Jan Vijg
This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes. The conversation also touches on the implications of somatic mutations and the future of longevity research, part
158: Sitting Is the New Smoking with Dr. Keith Diaz
In this episode, we are joined by Dr. Keith Diaz to discuss the significant health risks associated with prolonged sitting, likening it to smoking in terms of its dangers. He emphasizes the importance of regular movement, introducing the concept of 'movement snacks'—short bursts of activity that can mitigate the negative effects of sitting. We also cover the physiological mechanisms behind how mov
157: The Role of Surgery in Diabetes and Obesity with Dr. Mitchell Roslin
In this episode, we are joined by Dr. Mitchell Roslin to discuss the complexities of obesity. We explore the role of GLP-1 medications in weight management, the evolution of bariatric surgery, and the innovative SIPS procedure. Dr. Roslin emphasizes that obesity is not merely a result of poor lifestyle choices but involves intricate biological and hormonal mechanisms. He also highlights the imp
156: Investing in the Business of Aging with Dr. Karl Pfleger
In this episode, Dr. Karl Pfleger joins us to discuss the evolving landscape of longevity research and investment. He emphasizes the shift from disease-specific approaches to understanding aging as a multifaceted process that underpins many chronic diseases. Dr. Pfleger outlines his investment strategies in the aging biotech sector, highlighting the importance of addressing various sub-pathologies
155: Can Psilocybin Extend Cellular Lifespan? with Dr. Louise Hecker
In this episode, Dr. Louise Hecker joins us to discuss her groundbreaking research on psilocybin, exploring its potential to extend cellular lifespan and improve health outcomes in aging. We delve into the mechanisms behind psilocybin's effects, findings from animal studies, and the challenges faced in conducting research on this Schedule I substance. Dr. Hecker emphasizes the importance of unders
154: Is Telomere Length Shortening the Master Switch of Aging? with Dr. Bill Andrews
In this episode, Dr. Bill Andrews joins Dr. Buck Joffrey to discuss the critical role of telomeres and telomerase in aging and cellular health. He explains how telomeres shorten with each cell division, leading to aging and cellular senescence. Dr. Andrews emphasizes the importance of inducing telomerase to potentially reverse aging and shares insights from his research on telomerase inducers. He
153: T Cells, Aging, and Extreme Life Extension with Dr. Derya Unutmaz
Dr. Derya Unutmaz joins Dr. Buck Joffrey to discuss the critical role of T cells in the immune system, their changes with aging, and the implications for chronic diseases. He emphasizes the importance of thymus regeneration and the microbiome's influence on health. The discussion also covers advancements in engineering immune cells for cancer treatment and the potential of AI in revolutionizing ag
152: The Role of Vitamin A in Brain Health with Prof. Peter McCaffery
In this episode, Professor Peter McCaffery joins Dr. Buck Joffrey to discuss the multifaceted role of Vitamin A in brain health, particularly its function as a signaling molecule that influences neuroplasticity and cognitive functions. He elaborates on the challenges of Vitamin A supplementation, especially in aging populations, and the implications of retinoic acid signaling in neurodegenerative
151: Does Astaxanthin Increase Longevity? with Dave Watumull
In this episode, Dave Watumull joins Dr. Buck Joffrey to discuss the benefits and mechanisms of astaxanthin, a powerful antioxidant and anti-inflammatory compound. He explains its role in longevity, particularly through the Interventions Testing Program (ITP), where astaxanthin was shown to extend lifespan in male mice by 12%. The discussion also covers the safety profile, bioavailability, and cli
150: The Microbiome's Role in Aging and Healthspan with Dr. Sean Gibbons
Dr. Sean Gibbons joins Dr. Buck Joffrey to discuss the complexities of the gut microbiome, its evolution, and its significant role in health and longevity. He explains how our microbiome is established at birth, how it changes throughout life, and the impact of diet and lifestyle on its composition. The discussion also covers the challenges of modifying the microbiome, the potential of precision n
149: How Dental Health Impacts Longevity with Dr. Ellie Phillips
Dr. Ellie Phillips, DDS, joins Dr. Buck Joffrey to explain how oral pathogens contribute to chronic inflammation and conditions such as cardiovascular disease, Alzheimer's, and adverse pregnancy outcomes. She shares the science behind xylitol, saliva-driven remineralization, and practical strategies for supporting a healthy oral microbiome to reduce systemic risk. Learn more about Dr. Ellie Philli
148: Dr. Kevin J. Tracey - Stimulating the Vagus Nerve to Reduce Inflammation and Improve Healthspan
Dr. Kevin J. Tracey, neurosurgeon, immunologist, and pioneer in bioelectronic medicine, discusses the discovery of the inflammatory reflex and how vagus nerve stimulation can precisely regulate immune activity without immunosuppression. He explains its clinical application in rheumatoid arthritis, potential use in Crohn's disease, multiple sclerosis, and metabolic disorders, and its implications f
147: The Wrong Vitamin E Supplement Can Hurt You with Dr. Barrie Tan
In this conversation, Dr. Barrie Tan joins Dr. Buck Joffrey to discuss the significance of tocotrienols—a lesser-known form of vitamin E—and their potential role in preventing chronic disease and promoting healthy aging. Dr. Tan explains the differences between tocopherols and tocotrienols, the role of vitamin E in human health, and highlights the annatto plant as a key natural source of tocotrien
146: AMA President Dr. Bobby Mukkamala - Healthspan-Centric Medical Care in America
Joining Dr. Buck Joffrey this week, Dr. Bobby Mukkamala shares his journey from aspiring cardiothoracic surgeon to becoming the president of the American Medical Association. He discusses his personal health challenges, including a brain tumor diagnosis, and how it has shaped his perspective on healthcare. The conversation delves into the importance of preventative medicine, the impact of the Flin
145: Why Some Animals Live Longer Than Others with Dr. Steven Austad
In this conversation, Dr. Buck Joffrey and Dr. Steven Austad discusse the biology of aging, the evolutionary aspects of longevity, and the potential for genetic technologies to extend human health span. Dr. Austad emphasizes the complexity of aging, the importance of glucose control, and the need for further research into species that exhibit remarkable longevity. The discussion also touches on th
144: Why the Brain is Especially Vulnerable to Aging with Dr. Julie Andersen
In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain's heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strate
143: The Longevity Dividend with Prof. Jay Olshansky
In this conversation, Professor S. Jay Olshansky discusses the evolution of aging science, the realistic limits of human life expectancy, and the concept of the Longevity Dividend, which emphasizes the health and economic benefits of modulating the aging process. He also explores the potential of biomarkers in predicting longevity, the societal implications of an aging population, and the ethical
142: The Gut-Muscle Axis with Dr. Michael Lustgarten
In this episode, Dr. Michael Lustgarten discusses his research on the gut microbiome, serum metabolome, and muscle health in older adults. He shares insights from his journey into the world of aging, the importance of data in health optimization, and the emerging concept of the gut-muscle axis. Dr. Lustgarten emphasizes the significance of metabolites in predicting longevity and the need for pe
141: A Thermostat for Your Body Fat with Dr. Stephan J. Guyenet
In this conversation, Dr. Stephan J. Guyenet joins Dr. Buck Joffrey to discuss the complex mechanisms of body fat regulation, focusing on the role of the lipostat and leptin. He explains how the body regulates fatness through hormonal signals and the implications of leptin resistance in obesity. The discussion also covers practical strategies for weight management, the impact of stress and sleep o
140: Inside the Inflammatory Clock - Measuring and Reversing Biological Age with Dr. David Furman
Dr. David Furman and Dr. Buck Joffrey discuss the complexities of immune aging, the role of inflammation in age-related diseases, and how artificial intelligence is being utilized to enhance research in this field. He introduces the concept of the inflammatory age clock, which measures biological aging through immune system signals, and explores potential therapeutic interventions, including nutra
139: Rebuilding the Aging Brain - The Role of Neural Stem Cells with Dr. Tara Walker
In this conversation, Dr. Tara Walker discusses the fascinating topic of adult neurogenesis, the brain's ability to produce new neurons throughout life. She explains how this process is crucial for cognitive function and how it declines with age. The discussion highlights the significant role of exercise in boosting neurogenesis and introduces selenium as a key factor in this process. Dr. Walker a
138: Sleep Impact on Longevity and Health with The Sleep Doctor
Sleep is the secret weapon for a longer, healthier life—and Dr. Michael Breus is here to show you how to use it. In this episode of Longevity Roadmap, Buck Joffrey dives deep into the science of sleep with the world-renowned sleep doctor himself. Discover why sleep is the third pillar of longevity, how REM sleep and deep sleep fuel physical and emotional restoration, and what your chronotype revea
137: Dr. Joan Mannick - Targeting mTOR to Improve Immune Function and Healthspan
What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could e
136: Why is Vitamin D So Important in Health and Longevity? with Dr. Michael Holick
Vitamin D is more than a vitamin—it's a hormone that influences everything from your immune system to cardiovascular health, cognition, and longevity. In this conversation, Dr. Michael Holick breaks down the science of vitamin D synthesis, the truth about sun exposure vs. supplements, and why vitamin D deficiency is far more common—and more dangerous—than most people realize. You'll learn how skin
135: The Aging Brain - From Memory Lapses to Measurable Prevention with Dr. Mitchell Clionsky
Is your memory decline normal—or something more? Clinical neuropsychologist Dr. Mitchell Clionsky breaks down what healthy aging looks like from a cognitive perspective and where concern might be warranted. He introduces the Memory Orientation Screening Test (MOST)—a powerful yet quick tool to assess cognitive health—and shares insights from decades of evaluating memory, dementia, brain injuries,
134: Can You Boost Stem Cells Naturally? with Dr. Christian Drapeau
What if your body already had everything it needs to heal itself—naturally? In this episode, neurophysiologist and stem cell researcher Dr. Christian Drapeau breaks down the science of stem cell therapy, explaining how adult stem cells, embryonic stem cells, and exosomes play a central role in regenerative medicine and longevity. Discover how aging affects the body's ability to mobilize stem cells
133: Can We Reverse Immune System Aging? T Cells, Telomeres, and the Fight Against Senescence with Dr. Alessio Lanna
Is it possible to rejuvenate the immune system as we age? In this episode, Dr. Alessio Lanna breaks down the science of immune aging, focusing on the critical role of T cells, telomere shortening, and senescence. He explains how T cells lose their effectiveness over time—and shares emerging research on how intercellular telomere transfer and the ESMAC complex may help reverse immune senescence. Le
132: Dr. Mark Tarnopolsky's Mitochondrial Cocktail for Cellular Health
Are your mitochondria aging faster than you are? In this episode, Dr. Mark Tarnopolsky breaks down the central role of mitochondria in aging, longevity, and overall metabolic health. Learn how mitochondrial dysfunction drives age-related decline, including neurodegenerative diseases, and what you can do about it. From the paradox of oxidative stress to the risks of overusing antioxidants, this con
131: Matt Kaeberlein - Aging, mTOR, Epigenetic Clocks, and more!
What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and s
130: Does the Gut Control the Brain? with Dr. Michael Gershon
Dr. Michael Gershon—legendary Columbia professor and author of The Second Brain—joins us to explain why your intestines might just be running the show. From guinea pig guts that "blew back" to the real reason stress wrecks your digestion, this episode dives deep into the mysterious world of the enteric nervous system. Prepare for gut science, serotonin surprises, and a Woody Allen–esque dose of hu
129: Does Too Much Muscle Shorten Your Life? with Dr. Keith Baar
Can muscle growth and longevity coexist? Dr. Keith Baar breaks down the science of exercise, diet, and aging—focusing on the mTOR pathway, muscle hypertrophy, and how resistance vs. endurance training impacts long-term health. Learn how personalized health strategies, isometric exercises, and ketogenic diets influence aging and muscle preservation. This episode is packed with actionable insights f
128: C15 - The Most Underrecognized Anti-Aging Supplement? with Dr. Stephanie Venn-Watson
Could an essential fatty acid discovered in Navy dolphins unlock the secret to healthier aging? In this episode of Longevity Roadmap, Dr. Stephanie Venn-Watson reveals the groundbreaking science behind C15, an essential fatty acid linked to longevity and reduced disease risk. Learn how metabolomics uncovered the connection between higher C15 levels and healthier dolphins—and why this matters for h
127: The Impact of Depression on Longevity and Healthspan with Dr. Peter Franz
Suicide rates are rising—and the impact on longevity is profound. In this eye-opening episode of Longevity Roadmap, Dr. Peter Franz dives deep into the intersection of mental health, suicide prevention, and lifespan. He explores why nearly 50% of Americans experience depression, how loneliness accelerates suicide risk, and why digital interventions offer new hope. We also unpack the demographics m
126: Fahy Protocol - Regrow the Thymus, Reverse Your Age
Can we reverse aging by regenerating the thymus? In this groundbreaking conversation, Dr. Greg Fahy shares his pioneering research on the thymus gland's role in immune function, longevity, and epigenetic age reversal. We dive deep into the TRIM study, which demonstrated for the first time that thymus regeneration in humans is possible—and may even turn back the clock on biological aging. Dr. Fahy
125: Reversing Skin Age - Tackling Senescence with OS-01 with Dr. Carolina Reis Olivera
Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase! Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into the biology of skin aging, the impact of senescent cells, and the cutting-edge strategies OneSkin is u
124: How the Gut Influences Health and Longevity with Dr. Michael Miller and Dr. Jacob Allen
Buck Joffrey welcomes Dr. Michael Miller and Dr. Jacob Allen for an in-depth discussion on gut health and its vital role in overall well-being. They explore the gut microbiome's composition, how diet and lifestyle influence its dynamic nature, and the significance of fermented foods and dietary bioactives. The conversation also tackles the controversial topic of leaky gut syndrome, common misconce
123: What is Metabolic Dysfunction and Why is it Killing Americans with Dr. Robert Lustig
Dr. Robert Lustig joins Buck to discuss the alarming state of metabolic health in America, where only 7% of the population is considered metabolically healthy. He breaks down metabolic dysfunction, linking it primarily to mitochondrial inefficiency, and explains how sugar—especially fructose—plays a major role in various health issues. The conversation explores the dangers of ultra-processed foods
122: How Your Taste Buds Shape Metabolic Health with Dr. Marta Yanina Pepino
In this conversation, Dr. Marta Yanina Pepino discusses her research on taste perception and its implications for metabolic health. She explores how individual differences in taste can influence eating behaviors and obesity risk, the relationship between taste and digestion, and the role of genetics and environment in shaping food preferences. The discussion also covers the potential for dietary i
121: How Long-Lived Species Could Revolutionize Human Aging with Dr. Vera Gorbunova
In this episode, Dr. Vera Gorbunova unpacks the secrets of nature's longest-lived species—like the naked mole rat and bowhead whale—to uncover the biological mechanisms that keep them healthier for longer. We explore the role of DNA repair, transposable elements, and epigenetics in aging and what these discoveries could mean for human longevity. From mitochondrial function to promising interventio
120: Andrea Maier's Personalized Approach to Longevity Medicine with Prof. Andrea B. Maier
Buck Joffrey interviews Professor Andrea B. Maier, a leading expert in geroscience and healthy aging. They discuss the evolution of longevity research, the importance of distinguishing between lifespan and healthspan, and the biological mechanisms of aging. Professor Maier emphasizes the need for precision medicine in interventions and the challenges of supplement quality. They also explore future
119: What is NAD and How to Boost It for Longevity with Dr. Nicola Conlon
In this conversation, Buck and Dr. Nicola Conlon delve into the significance of NAD (Nicotinamide Adenine Dinucleotide) in aging and longevity. Dr. Conlon explains the role of NAD in cellular energy production, its decline with age, and the consequences of this decline on cellular repair and overall health. They discuss the importance of NAD in activating sirtuins, which are crucial for longevity,
118: Live to 100 - How To Build Your Personal Blue Zone with Dan Buettner
Buck and Nikki sit down with Dan Buettner, creator of the Netflix series Live to 100: Secrets of the Blue Zones, to explore the wisdom of the world's longest-lived populations. They dive into the lifestyle, diet, and environmental factors that contribute to longevity, and how you can engineer these principles to extend your healthy lifespan.
117: Best of Longevity Junky 2024
This week on Longevity Roadmap, Buck showcases standout moments from Longevity Junky—another health-focused podcast he co-hosts with actress and model Nikki Leigh. Designed for a broader audience, Longevity Junky makes longevity concepts accessible while delivering valuable insights. Tune in for a curated selection of engaging topics, complete with Buck's commentary, offering fresh perspectives no
116: Martin Gibala - The Value of HIIT for Longevity and Healthspan
Buck Joffrey interviews Martin Gibala, a professor at McMaster University, about High-Intensity Interval Training (HIIT) and its benefits. They discuss the definition of HIIT, its physiological mechanisms, and how it compares to traditional exercise. The conversation also covers the implications of HIIT for different populations, its connection to VO2 max and longevity, practical applications in d
115: Dr. Ellen Langer - The Mind-Body Connection
In this wholesome conversation, Buck and Dr. Ellen Langer discuss the profound connection between the mind and body, emphasizing the importance of mindfulness in health and aging. She shares insights from her groundbreaking studies, including the counterclockwise study, which demonstrated that altering one's mindset can lead to significant health improvements. The discussion also explores how perc
114: Traditional Lab Studies Can Miss Deadly Disease
In this episode, Buck Joffrey discusses the importance of going beyond the normal scope of testing when it comes to lipid profiles and cardiovascular health management. He emphasizes the significance of understanding cholesterol particles, particularly APO-B, and lipoprotein(a), in assessing heart disease risk. He also highlights preventative strategies to optimize health and mitigate risks associ
113: Lipid Management with Coronary Artery Disease and e2/e4 Genotype
In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for p
Giveaway: $2500 Full-Body MRI
Hey Sapio Fans, I've got something really exciting for you today—a chance to win a full-body MRI worth $2,500! This giveaway comes from my new podcast, Longevity Junky (that's junky with a Y). It's a fun, insightful show I co-host with actress Nikki Leigh, where we dive into cutting-edge advancements in health and longevity. This week's episode is all about full-body MRIs from Prenuvo, a gr
112: Longevity Escape Velocity with Aubrey de Grey
An interview with Aubrey de Grey, a founding father of the longevity movement—the man who coined the phrase 'Longevity Escape Velocity.' Aubrey discusses the transformative potential of damage repair, stem cell therapies, and advancements that are turning science fiction into reality. From reversing cellular damage to extending health spans by decades, this conversation unpacks his cutting-edge re
🎁 The Gift of Longevity – Black Friday & Cyber Monday Special!
This Black Friday and Cyber Monday, I want to share something truly meaningful—the opportunity to invest in your health or the health of someone you love. The Longevity Roadmap Course has already transformed lives, uncovering critical health issues and empowering participants to reverse conditions like borderline diabetes and optimize their health. It's no exaggeration to say this course has alrea
111: Nanoparticles in Neurodegenerative Disease Treatment
Buck interviews Mark Mortenson and Rob Etherington from Clene Nanomedicine, discussing their innovative approach to treating neurodegenerative diseases using clean surface nanocrystals. They delve into the science behind nanoparticles, their role in enhancing mitochondrial function, and the mechanisms of neurorepair. They also cover clinical applications, safety considerations, and the challenges
110: Unique Framework for Nutrition and Longevity with Dr. David Raubenheimer and Prof. Stephen Simpson
In this episode, Buck dives into the groundbreaking work of Dr. David Raubenheimer and Professor Stephen Simpson, renowned nutritional scientists from the University of Sydney. They unpack the "Geometric Framework for Nutrition," a holistic and visual approach that examines how nutrients interact to shape health and aging. From protein leverage to balancing macronutrients for longevity, this conve
109: Red Light in Mitochondrial Health with Prof. Glen Jeffery
Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for i
108: Diving Deep on Lipids and Heart Disease with Dr. Dennis Hughes
Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced u
Do You Have Your Longevity Roadmap?
107: Longevity Supplements - The Novos Approach
Dr. Diogo Barardo, Director of Research and Development at Novos, joins Buck to discuss Novos' innovative approach to longevity supplements, unpacking the differences between biological and epigenetic aging and the impact of the Drug Age database. He details how Novos evaluates compounds for safety and efficacy, the unique ingredients in their flagship NovoScore, and the promising role
106: Nitric Oxide - The X Factor in Longevity? with Dr. Nathan Bryan
Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body's nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there's a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the r
105: Understanding Heart Rate Variability with Dr. Torkil Færø
Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body's autonomic nervous system balance, showing how lifestyle factors, particularly chr
104: The Real Science Behind Mitochondrial Health
Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressin
103: Microplastics and Your Health - One More Thing to Worry About
Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, as well as practical steps to minimize exposure to microplas
102: Everything You've Been Told About Fat Loss is a Lie – Layne Norton Exposes the Truth
In this episode of Longevity Junky, Buck and Nikki tackle one of the most contentious and polarizing areas of longevity, diet with Bio Layne founder Dr. Layne Norton. Learn more about BioLayne and Dr. Layne Norton: https://biolayne.com/coach/layne-norton/ Full episode in video available on YouTube: https://www.youtube.com/channel/UCh6LlBjtOy7lldU7Ldjw0cw Questions? Send us a message at: www.longev
101: Can we see mental illness on brain scans?
Buck introduces his brand new podcast, Longevity Junky. In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of bra
100: What is Flow?
Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and
99: What is a Retinal Detachment? A First Person Narrative
Buck shares his recent experience with a retinal tear and detachment, emphasizing the importance of early diagnosis and treatment to prevent permanent vision loss. He explains the anatomy of the eye, the process of vitreous detachment, and the symptoms of retinal tear and detachment. Buck also discusses the risk factors for these conditions, including high myopia and previous eye surgery. He descr
98: Big Tech's Vision of an Aging Population
Buck discusses the role of big Tech and the elderly with Keren Etkin, founder of TheGerontechnologist.com. Discussion includes the role of robots, implications for social interaction, as well as the additional opportunities for founders to take advantage of the coming geriatric storm. 01:04 Current Tech for Aging 05:17 Tech for Social-Emotional Support 09:03 The Driving Force Behind the Develo
97: Buck's Boston Heart Cholesterol Balance Test
Link to Buck's Results: https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing Section 1: Overview of Cholesterol Metabolism Cholesterol in the Body: Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production. It is produced endogenously in th
96: Cardiovascular Risk Management: Calcium Scores, Lp(a), and Colchicine
Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine
95: What is Atherosclerosis and How to Prevent it
This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their asso
94: Intermittent vs Prolonged Fasting
Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each.
93: Alzheimer's Disease vs Age-Related Cognitive Decline
Buck interviews Dr. Ken Frumkin on his own journey of aging and cognitive decline.
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