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Making Sense with Sam Harris

Making Sense with Sam Harris

Sam Harris 494 Episodes Jul 22, 2026

Join neuroscientist, philosopher, and five-time New York Times best-selling author Sam Harris as he explores important and controversial questions about the mind, society, current events, moral philosophy, religion, and rationality—with an overarching focus on how a growing understanding of ourselves and the world is changing our sense of how we should live. Sam is also the creator of the Waking Up app, which offers free subscriptions to anyone who can't afford one and donates a minimum of 10% of profits to effective charities.

Episodes

#486 — Luck All the Way Down
#486 — Luck All the Way Down Jul 22, 2026 21:22 Sam Harris speaks with Kathryn Paige Harden about behavioral genetics, moral luck, and the problem of blame. They discuss Harden's book Original Sin, the controversy over Charles Murray and Ezra Klein, why behavioral genetics remains taboo, the meaning of heritability, nature and nurture as feedback loops, why biological explanations can increase blame, psychopathy as a continuum, a hypothetical c
#485 — The New Science of Cancer
#485 — The New Science of Cancer Jul 14, 2026 01:21:24 Sam Harris speaks with Siddhartha Mukherjee about the science of cancer. They discuss the updated edition of The Emperor of All Maladies, whether cancer is one disease or many, why prevention is so hard, inflammation and air pollution as carcinogens, the myth that cell phones cause cancer, liquid biopsies and Bayesian reasoning, immunotherapy and CAR T cells, drug pricing, the promise of AI in dru
#484 — Artificial Intimacy
#484 — Artificial Intimacy Jul 8, 2026 27:13 Sam Harris speaks with Paul Bloom about our relationships with AI and the future of human connection. They discuss the surprising pace of AI progress, AI companions as a remedy for loneliness, the importance of mattering to other people, digitally resurrecting the dead, whether AI can be conscious, the moral failings of artists, what science actually knows about parenting, the ethics of apology, w
#483 — The Knots We Tie Ourselves Into
#483 — The Knots We Tie Ourselves Into Jul 1, 2026 22:54 Sam Harris speaks with Alain de Botton about the psychology of unhappiness, the secular world's discomfort with ecstasy and ritual, psychedelics as a tool for self-discovery, Freud's legacy, AI as the ultimate mirror, the case against meritocracy, the cancel culture purity trap, the psychological meaning of death, and other topics. If the Making Sense podcast logo in your player is BLACK, you can
#482 — More From Sam: The Iran Deal, College in the AI Age, Mamdani's DSA, and More
#482 — More From Sam: The Iran Deal, College in the AI Age, Mamdani's DSA, and More Jun 25, 2026 21:50 In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss topics from Making Sense Community, including one-world government, the value of a degree as AI reshapes careers, and factory farming ethics, along with Mamdani's DSA-aligned candidates, Trump's humiliating capitulation in the Iran deal, the Tulsi Gabbard guru story, and other topics. If the M
#481 — Sam Harris Receives the 2026 Richard Dawkins Award
#481 — Sam Harris Receives the 2026 Richard Dawkins Award Jun 17, 2026 54:32 Richard Dawkins presents Sam Harris with the 2026 Richard Dawkins Award at a live Center for Inquiry event. After the tribute, the two friends discuss consciousness and epiphenomenalism, AI and the Turing test, the scientific basis of morality, the failures of democracy and Trump's corruption, the role of philosophy, changing deeply held beliefs, Sam's path to meditation, the legacy of Christopher
#480 — The Economics of Everything
#480 — The Economics of Everything Jun 12, 2026 24:30 Sam Harris speaks with economist and Substack writer Noah Smith about the U.S. national debt, wealth inequality, and the economic consequences of AI. They discuss the mechanics of debt and inflation, the case for fiscal austerity, why the U.S. squandered low interest rates, modern monetary theory, how AI may restructure labor and ownership, the anti-billionaire politics of the American left, the d
#479 — When Robots Take Over
#479 — When Robots Take Over Jun 4, 2026 15:05 Sam Harris speaks with Vinod Khosla about AI, economic disruption, and political risk. They discuss the prospect of mass job displacement, a trillion-dollar policy framework to redistribute AI's gains, the failure of the California wealth tax, the corporate capitulation to Trump, Elon Musk's embrace of white nationalist rhetoric, US-China competition, semiconductor dependence, and other topics. If
#478 — The Psychedelic Mind
#478 — The Psychedelic Mind May 29, 2026 30:00 Sam Harris speaks with Robin Carhart-Harris about psychedelic research and its therapeutic potential. They discuss the current state of the field, the FDA denial of MDMA-assisted therapy for PTSD, the critical role of set and setting, risks for vulnerable populations, the REBUS model of how psychedelics work on the brain, the default mode network and ego dissolution, microdosing, the neuroscience
#477 — More From Sam: Iran's Unraveling, The Gaza Information War, AI-Generated Music, and More
#477 — More From Sam: Iran's Unraveling, The Gaza Information War, AI-Generated Music, and More May 26, 2026 21:59 Warning: This episode contains graphic descriptions of violence against civilians during the October 7 attacks (33:49 - 34:35). Listener discretion is advised. In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the Trump administration's bungled Iran campaign, the information war surrounding Gaza and October 7, Nicholas Kristof's disputed New
#476 — The Bittersweet Age
#476 — The Bittersweet Age May 20, 2026 22:46 Sam Harris speaks with Susan Cain about writing, creativity, and what AI means for human culture. They discuss the future of books and reading, the tells AI inherits from good writers, why the advent of AI may spark a revival of the humanities, following your bliss, the ethics of curing sadness, the therapeutic potential of psychedelics, and other topics. If the Making Sense podcast logo in your p
#475 — The Hard Problem of Consciousness
#475 — The Hard Problem of Consciousness May 12, 2026 25:52 Sam Harris speaks with Michael Pollan about consciousness, the mind, and the self. They discuss Pollan's new book, the relationship between consciousness and intelligence, whether consciousness is a product of evolution, the role of psychedelics in consciousness research, AI and the question of machine consciousness, the illusion of the self, and other topics. If the Making Sense podcast logo in y

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