Clinical Chemistry Podcast
This free monthly podcast is offered by Clinical Chemistry, the leading forum for peer-reviewed, original research on innovative practices in today's clinical laboratory.
Episodes
Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues
Melissa Ix, Richard Dodel, J Alexander Ross. Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues. Clinical Chemistry, Volume 72, Issue 8, August 2026, Pages 830–844. https://doi.org/10.1093/clinchem/hvag037
Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy
Matthew Lee, Jeffrey A SoRelle, Arun Everest-Dass, David E Gerber, Mitchell S von Itzstein. Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy. Clin Chem 2026; 72(9): 926–47. https://doi.org/10.1093/clinchem/hvag062
Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma
Shengjie Li, Jiazhen Cao, Jun Ren, Kun Chen, Jianing Wu, Yingzhu Li, Yunxiao Song, Chengxun Li, Wenjun Cao, Ming Guan. Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma. Clin Chem 2026; 72(8): 880–92. https://doi.org/10.1093/clinchem/hvag036
Audio Summary September 2026
Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial
Luuk F P Giesen, Jeroen A Roest, Frederique M A Koopman, Martine M L Deckers, Helena Chon, Christian M Hackeng, Jurgen A Riedl, Michiel de Bruin, Brooke M Katzman, Warry van Gelder, Janne Cadamuro, Mads Nybo, Michael A Fouraux, Thijs C van Holten, Robert de Jonge. Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial. Clinical Chemistry, Volume
Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction
Ingar Ziad Restan, Yong Yong Tew, Ole-Thomas Steiro, Ziwen Li, Hilde L Tjora, Jørund Langørgen, Torbjørn Omland, Paul Collinson, Rune Bjørneklett, Kjell Vikenes, Trude Steinsvik, Øyvind Skadberg, Øistein R Mjelva, Alf Inge Larsen, Vernon V S Bonarjee, Nicholas L Mills, Kristin M Aakre. Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial I
Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility
Juexiao Sherry Wang, C J Battey, Kyle Trettin, Ravi Patel, Anu Srinivasan, Janani Saikumar, Divya Kushnoor, Ben F Habermeyer, Sangita Ganesh, Nafei Xu, Nathaniel Friedrich, Summer Pierson, Helen Wan, Heather LaBreche, Genevieve M Gould, Dale Muzzey. Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility. Clinical Chemistry, Volu
Audio Summary August 2026
From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians
Ryan Pearce, Leslie J Donato, Vlad C Vasile, Allan S Jaffe, Jeffrey W Meeusen. From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians. Clinical Chemistry, Volume 72, Issue 7, July 2026, Pages 814–816. https://doi.org/10.1093/clinchem/hvag044
Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis
Anna C H Hoge, Thomas E Grys, Erin H Graf. Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 575–582. https://doi.org/10.1093/clinchem/hvaf187
Audio Summary July 2026
DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping
Ann M Moyer, Emma Lundquist, Emily K Thoreson, Michelle L Kluge, Katrina E Kotzer, Elyse M Love, Heather L Glessner, Sarah K Arneson, Loralie J Langman, Linnea M Baudhuin, John Logan Black. DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 662–669. https://doi.org/10.1093/clinchem/hvag007.
Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions
Lisa A Lansdon, Binu Porath, Mari Mori, David T Miller, Diane Dunham Drexler, Catherine Wattenberg, Morgan Richardson, Robert D Steiner, Peter J Freeman. Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 652–661. https://doi.org/10.1093/clinchem/hvag010
Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine
Patrick M Bossuyt, Tze Ping Loh, Katy Bell, Sally Lord, Andrea R Horvath. Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 546–553. https://doi.org/10.1093/clinchem/hvag014
Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring
Grace Drew, Colleen S Kraft, Nirja Mehta. Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 554–563. https://doi.org/10.1093/clinchem/hvaf156
Audio Summary June 2026
Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?
Andrea L Benedet, Burak Arslan, Kubra Tan, Hanna Huber, Ilaria Pola, Guglielmo Di Molfetta, Hlin Kvartsberg, Anna Orduña Dolado, Shorena Janelidze, Kaj Blennow, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Nicholas J Ashton. Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 3
Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis
Denise M O'Sullivan, Gerwyn M Jones, Manca Zolnir-Dovc, Richard Phillips, Rejoice Arthur, Bariki Mtafya, Daniel Adon Mapamba, Daniela Maria Cirillo, Ewa Augustynowicz-Kopeć, Mei Mei Ho, Belinda Dagg, Sven O Friedrich, Francesca Colavita, Antonella Vulcano, Prince Asare, Dorothy Yeboah-Manu, Timothy D McHugh, Jim F Huggett. Methods to Improve Confidence in the Accuracy of Molecular Testing for Mult
Audio Summary May 2026
Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets
Thomas J S Durant, Seung Joo Lee, Sarah N Dudgeon, Elizabeth Knight, Brent Nelson, H Patrick Young, Lucila Ohno-Machado, Wade L Schulz. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 451–460. https://doi.org/10.1093/clinchem/hvaf192
Scientific Fraud at Scale: Challenges for Trust in Published Data
Preejith P Vachali, Adam J McShane. Scientific Fraud at Scale: Challenges for Trust in Published Data. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 518–519. https://doi.org/10.1093/clinchem/hvag002
Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing
Yusheng Zhu, Jarrett Sell. Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 439–450. https://doi.org/10.1093/clinchem/hvaf155
Endogenous Lithium Levels and Alzheimer Disease
Raymond T Suhandynata, Elizabeth A Bevins, Imir G Metushi. Endogenous Lithium Levels and Alzheimer Disease. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 424–425. https://doi.org/10.1093/clinchem/hvaf174
Audio Summary April 2026
PREEMPT'ing Overreliance on Peripheral Blood-Based ColoRectal Cancer Screening
David H Wang. PREEMPT'ing Overreliance on Peripheral Blood-Based ColoRectal Cancer Screening. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 328–330. https://doi.org/10.1093/clinchem/hvaf137
A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready?
Leslie J Donato. A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready? Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 222–224. https://doi.org/10.1093/clinchem/hvaf101
Audio Summary March 2026
Global IVD: Barriers, Trends, and Future
Min Yu, Zhen Zhao, Dennis J Dietzen, Damien Gruson, Jinjie Hu, Anthony A Killeen, Davide Manissero, Tahir S Pillay. Global IVD: Barriers, Trends, and Future. Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 225–231. https://doi.org/10.1093/clinchem/hvaf184
Uterus Transplantation—Current Evaluation, Monitoring, and Emerging Diagnostics
Andrew Jacques, Giuliano Testa, Massimo Mangiola, Liza Johannesson. Uterus Transplantation—Current Evaluation, Monitoring, and Emerging Diagnostics. Clinical Chemistry, Volume 72, Issue 1, January 2026, Pages 18–26. https://doi.org/10.1093/clinchem/hvaf143
Audio Summary February 2026
Unmet Clinical Needs and Remaining Challenges of Pregnancy Reference Intervals
Vilte E Barakauskas, Samantha Pawer, Wee-Shian Chan, Benjamin P Jung. Unmet Clinical Needs and Remaining Challenges of Pregnancy Reference Intervals. Clinical Chemistry, Volume 72, Issue 1, January 2026, Pages 47–60. https://doi.org/10.1093/clinchem/hvaf150
From Diagnosis to Delivery: A Look at the Continuing Gap in Maternal Testing
Callie Torres, Jeannie Kelly, Ann M Gronowski. From Diagnosis to Delivery: A Look at the Continuing Gap in Maternal Testing. Clinical Chemistry, Volume 72, Issue 1, January 2026, Pages 27–34, https://doi.org/10.1093/clinchem/hvaf109
Audio Summary January 2026
Per se driving under the influence of cannabis statutes and blood delta-9-tetrahydrocannabinol concentrations following short-term cannabis abstinence
Robert L Fitzgerald, Anya Umlauf, Raymond T Suhandynata, David J Grelotti, Marilyn A Huestis, Kyle F Mastropietro, Igor Grant, Thomas D Marcotte. Per Se Driving Under the Influence of Cannabis Statutes and Blood Delta-9-Tetrahydrocannabinol Concentrations following Short-Term Cannabis Abstinence. Clinical Chemistry, Volume 71, Issue 12, December 2025, Pages 1225–1233. https://doi.org/10.1093/clinc
Regulatory Fragmentation in Europe and Its Risks for Patient Access and Safety: Subcontracting Work Flow Steps of In-House Diagnostic Procedures
Raymond Nistor-Gallo, Kurt Zatloukal, Karin Schwenoha. Regulatory Fragmentation in Europe and Its Risks for Patient Access and Safety: Subcontracting Work Flow Steps of In-House Diagnostic Procedures. Clinical Chemistry, Volume 71, Issue 12, December 2025, Pages 1202–1211. https://doi.org/10.1093/clinchem/hvaf123
Transdermal GFR Signals a New Horizon in Renal Diagnostics
Vrajesh Pandya. Transdermal GFR Signals a New Horizon in Renal Diagnostics. Clinical Chemistry, Volume 71, Issue 12, December 2025, Pages 1281–1282. https://doi.org/10.1093/clinchem/hvaf106
Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol
Jeffrey W Meeusen, Xin Yi, Steven W Cotten, Jacob B Nielsen, Leslie J Donato, Patricia M Jones, Alagar R Muthukumar, Rafael Zubirán, Alan T Remaley, Jing Cao, Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1138–114
Audio Summary December 2025
Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use
Ruben Y Luo, Priscilla S W Yeung, Morgan W Mann, Lichao Zhang, Yifei K Yang, Andrew N Hoofnagle, Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1111–1124, https://doi.org/10.1093/clinchem/hvaf094
Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making
Nicholas C Spies, Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1178–1179, https://doi.org/10.1093/clinchem/hvaf084
Diagnostic Value of Digital Estimates of Trophoblastic Mosaicism in Genome-Wide Cell-Free Fetal DNA Screening
Risk vs Prevalence: Weighing Routine DPYD Variant Testing Prior to Fluoropyrimidine-Based Chemotherapy
Audio Summary November 2025
Optimizing Estimation: Perspective on Drug Dosing Using New CKD-EPI Equations
Audio Summary October 2025
Utilizing the Stability of Individual Homeostatic Setpoints over Time - A Step Forward on the Path to Personalized Laboratory Medicine
Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic
Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis
Toward Improved Prostate Cancer Screening: Insights from the Göteborg-2 Trial
Audio Summary September 2025
Proteomic Aging Clock Predicts Mortality and Risk of Common Age-Related Diseases
Influence of Macrotroponin on the 99th Percentile Threshold in 2 High-Sensitivity Cardiac Troponin Assays
Pulse Oximeter Performance across Populations with Diverse Skin Tones
Polygenic Effects on Hb A1c May Mask Hyperglycemia and Increase Retinopathy Risk
Audio Summary August 2025
Reducing the Noise in Plasma Metagenomics to Further Define Clinical Utility
Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma
Audio Summary July 2025
Robotic Process Automation in Laboratory Medicine
HOPEing That a PEACEful Resolution for the Clinical Utility of High-Sensitivity Cardiac Troponin in the Ambulatory Setting Will Improve Laboratory Testing
Audio Summary June 2025
The Slow Progress in Developing Better Long-Term Cardiovascular Risk Assessment in Women Continues
Pediatric vaccine-induced antibody thresholds: Rethinking pre-immunosuppression serologic testing and revaccination implications
Reevaluating the threshold for low total testosterone
Help Us to Help You: Recommendations for Continued Enforcement Discretion for Common Infectious Disease Test Modifications under the FDA Final Rule
Audio Summary May 2025
New Clinical Practice Guidelines for Vitamin D Supplementation and Testing
Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations
Cardiac Biomarkers and Malnutrition Incidence in Community-Dwelling Older Adults without Cardiovascular Disease: The Seniors-ENRICA-2 Cohort
Pharmacogenetic Analysis of CYP2C19 for Clopidogrel: Ready for Prime Time
Audio Summary April 2025
A Multianalyte Machine Learning Model to Detect Wrong Blood in Complete Blood Count Tube Errors in a Pediatric Setting
An AI Model (LORIS) to Predict Immune Checkpoint Blockade Response in Cancer: A Clinical Data Science Perspective
Audio Summary March 2025
New American Society of Hematology Thrombophilia Guidelines Could Provoke Surge in Laboratory Testing
Xylazine Pharmacokinetics in Patients Testing Positive for Fentanyl and Xylazine
Rethinking Albuminuria in Low-Risk Patients and a Call for Urine Albumin Standardization
Audio Summary February 2025
From the Perspective of the Child: Ethical Considerations for the Implementation of Genomic Sequencing into Neonatal and Pediatric Care
Overcoming Barriers to Genomic Medicine Implementation
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