Hormones, Metabolism & You!
Your hormones control everything—from energy levels to weight, mood, and overall health. But understanding them shouldn’t feel like decoding a medical textbook. Welcome to Hormones, Metabolism & You!, the podcast where board-certified endocrinologist Dr. Cassie Smith breaks down the science behind your body’s most powerful regulators. Each week, Dr. Smith tackles the real questions about metabolism, weight management, thyroid health, menopause, PCOS, insulin resistance, and more—giving you clear, actionable insights to take charge of your health. Whether you’re struggling with stubborn weight, feeling fatigued, or just want to optimize your well-being, this podcast is your go-to resource for evidence-based advice, practical tips, and expert interviews.
Episodes
125: How to Dementia-Proof Your Brain: Dr. David Perlmutter on Hormones, Gut Health, and Inflammation
What if protecting your brain starts decades before memory problems ever appear? In this conversation, I sit down with neurologist and bestselling author Dr. David Perlmutter to talk about what current research says about dementia prevention, why metabolic health may play a much larger role than many people realize, and why waiting until cognitive symptoms develop may be waiting too long. We get i
124: Heart Disease Myths Exposed: Statins, LDL, Estradiol, Testosterone, & the Truth
Heart disease is still the leading cause of death, yet many people are left wondering whether they're focusing on the right risk factors.
In this episode, I sit down with board-certified cardiac surgeon Dr. Philip Ovadia to discuss how his perspective shifted from treating advanced heart disease in the operating room to helping people prevent it in the first place.
We talk through co
123: Hashimoto’s, Thyroid Labs, and Exercise: Are You Helping Your Body or Stressing It More?
If you have Hashimoto’s and feel like you’re doing everything “right” but somehow feeling worse, this episode is for you. I’m answering your most frequently asked questions about Hashimoto’s, exercise, thyroid labs, thyroid antibodies, medication adjustments, estrogen, and why symptoms don’t always match what your lab work says. Throughout our conversation, I explain why looking at one lab value o
122: Drain Before You Detox: The Missing Link Between Gut Health, Hormones, & Mold Recovery with Marina Ortega (The Poop Fairy)
If you're dealing with constipation, bloating, brain fog, or you feel like every detox protocol makes you feel worse instead of better, this conversation is for you.
In this episode, I'm joined by Marina Ortega, founder of Scottsdale Hydrotherapy and co-founder of Trust Your Gut, to talk about one piece of healing she believes is often overlooked: supporting your body's drainage pathways be
121: Why Successful Men Are Secretly Running Themselves into the Ground: What Every Man and Spouse Needs to Hear
What does it really mean when a man starts feeling constantly exhausted, loses motivation, struggles with brain fog, or notices changes in his physical and sexual health?
In this episode, I sit down with Dr. Stephen Sanders, founder of Whole Men's Health, to talk about why these symptoms deserve more attention and why men's health is about far more than testosterone alone. We discuss the gr
120: From PCOS to PMOS; Why Hormones Are Not the Only Problem
In this interview with Terri DeNeui, we explore why the conversation around PCOS is shifting toward a broader understanding of metabolic health with the emerging term PMOS.
Rather than viewing irregular cycles, infertility, and hormone imbalances as isolated ovarian problems, we discuss how insulin resistance, gut health, inflammation, stress, and lifestyle factors may be driving many of the symp
119: Beyond Sick Care: Why Insurance Isn’t Coming To Save You
For many people, the healthcare system becomes frustrating long before they receive a diagnosis. Symptoms are dismissed, lab work comes back "normal," and the next step is often another prescription rather than a conversation about why those symptoms developed in the first place.
In this episode, I'm joined by board-certified anesthesiologist and hormone optimization specialist Dr. Mike For
118: Stop Starving, Start Healing: The Real Root Cause of Weight Loss Resistance
What if the reason you're struggling with weight, low energy, or hormone symptoms isn't just about eating less and exercising more?
In this episode, I sit down with functional medicine practitioner Dani Conway to talk about the bigger picture of metabolic health. We discuss why so many women are told their lab work is "normal" even when they still feel exhausted, inflamed, or stuck, and why look
117. Perimenopause Is Wild: Symptoms, Support, and What Actually Helps
Perimenopause and menopause affect every woman, yet many are still caught off guard by the wide range of symptoms that can come with this stage of life. In this episode, I sit down with nutritionist, menopause researcher, and author Andrea Donsky to discuss what she's learned from studying thousands of women and why so many continue to feel confused, dismissed, or unsupported when seeking answers.
116: What Screen Time Is Really Doing to Your Eyes, Brain, and Stress Levels
One of the most overlooked aspects of health may be influencing how you think, learn, focus, perform, and even respond to stress every single day. In this episode, I sit down with neuro-optometrist Dr. Bryce Appelbaum to explore the difference between eyesight and vision, and why seeing 20/20 doesn't necessarily mean your visual system is functioning optimally. We discuss how the eyes and brain wo
115: PCOS Has a New Name: Why It’s More Than an Ovarian Disorder
In this episode, I explain why PCOS is now better understood as Polyendocrine Metabolic Syndrome (PMOS).
While the traditional name focuses on the ovaries, the reality is that this condition often extends far beyond reproductive health. I discuss why many women with PCOS don't actually have ovarian cysts, how the condition can affect everything from insulin and metabolism to cortisol, inflammatio
114. Why Your Brain Feels Drained... and How to Reset It with Dr. Patrick Porter
In this episode, I sit down with Dr. Patrick Porter, founder of BrainTap and a longtime researcher in brain fitness and human performance, to explore why so many people today are struggling with brain fog, poor focus, low energy, and chronic stress. We discuss the relationship between the brain, gut, and nervous system, and how modern life may be affecting the way we think, feel, and function. Dr.
113: Why Cholesterol Isn’t the Villain and Estrogen Isn’t the Enemy with Dr. Terri DeNeui
For years, cholesterol numbers have been treated as one of the primary indicators of heart health, but are we focusing on the right markers? In this episode, I sit down with Dr. Terri DeNeui to discuss the bigger picture behind cardiovascular risk. We talk through the limitations of looking at LDL cholesterol in isolation, the importance of factors like inflammation, insulin resistance, ApoB, lipo
112: The Birth Control Conversation We Need to Have: Helpful Tool or Hidden Problem?
What if the birth control pill you’ve been told is safe for decades is affecting far more than just pregnancy prevention? In this episode, I sit down with OB-GYN Dr. Johnny Peet for a powerful and nuanced conversation about oral birth control, hormone health, and the risks many women are never fully informed about, especially as they enter their 40s and 50s. We unpack the real differences between
111: Beyond the Labs: The Metabolic Clues Behind Fatigue, Weight Gain & Thyroid Issues
In this conversation, I sit down with Dr. James LaValle to unpack the deeper metabolic patterns driving symptoms like fatigue, thyroid dysfunction, weight gain, hormone imbalances, brain fog, inflammation, and low energy. We dive into why the body cannot be viewed as isolated systems and how stress hormones, insulin, gut health, thyroid function, sex hormones, and inflammation are all deeply conne
110: Is Your Thyroid the Missing Piece? Dr. Amie Hornaman on Energy, Metabolism & Real Answers
In this episode, I sit down with Dr. Amie Hornaman, also known as the Thyroid Fixer, to unpack the real reasons so many people struggle with fatigue, weight gain, brain fog, and hormone imbalances without getting clear answers. We dive into her personal journey of being misdiagnosed multiple times, what finally led her to answers, and why so many patients today are still being overlooked in tradit
109: Why Gut Health Changes Everything: Dr. Vincent Pedre on Healing from the Inside Out
This conversation completely changed the way I think about healing and I know it’s going to shift things for you too. In this episode, I sit down with Dr. Vincent Pedre to unpack why so many people are stuck dealing with fatigue, hormone imbalances, inflammation, brain fog, and digestive issues and why the real answer almost always comes back to the gut. We dive into his personal health journey, h
108: Women, Weightlifting & Longevity: How to Build Muscle, Protect Hormones, and Age Well
If you still think weightlifting is just about aesthetics, this conversation will completely change the way you see your body and your future. In this episode, I sit down with a highly experienced physician assistant and longtime strength training expert to unpack what women have been getting wrong about fitness for decades, especially in perimenopause and beyond. We dive into the real role of mus
107: Why Doing More to Heal Can Backfire | The Cell Danger Response with Dr. Eric Balcavage
In this conversation, I sit down with Dr. Eric Balcavage to unpack what’s really happening beneath the surface when your body feels stuck, overwhelmed, and unable to heal. We dive into the concept of the cell danger response and why so many people today are living in a chronic state of stress at a cellular level without even realizing it. We also explore the gap between traditional and functional
106: Akkermansia: The Metabolism Microbe Every Woman Should Know
What if everything you’ve been told about your metabolism is missing the most important piece? In this episode, I sit down with Dr. Colleen Cutcliffe to uncover the powerful and often overlooked connection between your gut microbiome, your hormones, and your metabolism. We dive into why so many women start experiencing stubborn weight changes, cravings, energy crashes, and insulin resistance, espe
105: It Takes Two to Gaslight with Dr. E: A New Way to Understand Medical Dismissal
You’ve been told everything is “normal”… but you know something isn’t right. In this episode, I sit down with Dr. Efrat LaMandre to unpack one of the most frustrating and isolating experiences in healthcare today: medical gaslighting. We dive into what it actually is, why it happens more often than we think, and the deeper systemic patterns inside medicine that lead providers to dismiss symptoms w
104: Endometriosis Explained: Symptoms, Treatment, and What You Need to Know
This episode is as raw as it gets as I open up about my personal journey with endometriosis and everything it has taken from me and taught me along the way. I share what it really feels like to live with pain that gets dismissed, the long road to diagnosis, and the emotional and physical toll this condition can have on your body, your relationships, and your future. Through my own story, I break d
103: Stop Blaming Yourself: The ‘Normal Labs’ Trap + The Gut-Hormone Fix
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102: Your Mouth May Be Driving Inflammation - The Hidden Dental Link to Hormones Metabolism and Brain Fog with Dr. Michelle Jorgensen
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey. https://modernendocrinewellness.com/join-gut-health
101: Fix Your Gut, Fix Your Hormones: The Missing Links When Thyroid + Hormones Aren’t Enough
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100: The Most-Shared Episodes on Thyroid, Hormones & Fatigue — The Answers Your Doctor Isn’t Giving You
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99: Thinking About Peptide Therapy or GLP-1s? A Physician’s Safety Checklist for Women in Perimenopause & Menopause
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey. https://modernendocrinewellness.com/join-gut-health
98: Perimenopause: The Gift We Didn’t Ask For and the Health Upgrade We Needed
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97: Why Your Brain Must Feel Safe Before Detox Works: The Neurotoxic Loop of Trauma and Toxins
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96: Ayurveda for Perimenopause & Menopause: Gut Health, Estrobolome Support, and Anti-Inflammatory Spices
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey. https://modernendocrinewellness.com/join-gut-health
95: Why Dieting Fails in Midlife: Hormones, Insulin Resistance + Peptide Therapy
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey. https://modernendocrinewellness.com/join-gut-health
94: Your Labs Are Normal but You Feel Awful - The Hidden Gut Inflammation Blocking Hormone Healing with Josh Dech
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93: Why You Can’t Lose Weight (It’s Your Hormones, Not Your Willpower)
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92: Your Hormones Aren’t the Problem - The Shocking Root Cause Behind Fatigue, Weight Gain, and Brain Fog with Dr. Kelly McCann
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91: You Feel Tired but Labs Look Normal - The Hidden Nitric Oxide Deficiency No One Tests For with Dr. Nathan Bryan
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90: Medicine Is Falling Behind - The Shocking Gaps in Nutrition and Gut Health Training with Dr. Johnny Hadac
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89: The FDA Finally Admits the Truth – The Shocking Correction That Changes Hormone Therapy Forever with Dr. Terri DeNeui
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88: Why Your Thyroid Is in Crisis – The Hidden Triggers Driving Graves Disease with Dr. Eric Osansky
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87: Stop Blaming Age – The Shocking Hidden Causes of Fatigue, Weight Gain, and Mood Swings with McCall McPherson and Dr. Tyna Moore
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86: Your Brain Isn’t Broken – The Fastest Way to Rewire Anxiety and Hormones with Dr. Caroline Leaf
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85: What If Your Migraines Aren’t Just in Your Head? – The Hidden Root Causes with Dr. Meg Mill
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84: Stop Normalizing Painful Periods – How to Finally Fix Hormone Imbalance with Dr. Shawn Tassone
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey. https://modernendocrinewellness.com/join-gut-health
83: Your Gut Is Talking Through Your Skin – The Hidden Root of Eczema & Inflammation with Christa Biegler, RDN
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82: The Keto Truth: Why Flexibility Beats Restriction for Hormone Health with Ben Azadi
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81: Which Gut Type Are You? – The Personalized Blueprint to Heal Hormones and Boost Energy with Dr. Cassie Smith
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80: The Hidden Gut-Hormone Connection – Why You’re Still Tired, Bloated, and Gaining Weight with Dr. Cassie Smith
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79: The Shocking Myths Keeping Women Sick – Perimenopause & Hormone Health Explained with Dr. Mariza Snyder
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78: Are TikTok Health Hacks Harming Your Hormones? – The Truth About Viral Wellness Trends with Dr. Cassie Smith
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey. https://modernendocrinewellness.com/join-gut-health
77: The Diets Were Lying to You! – The Science of Healing Hormones & Metabolism with Kitty Blomfield & Craig McDonald
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey. https://modernendocrinewellness.com/join-gut-health
76: Why We Left Conventional Medicine – The Untold Truth About Healing Hormones & Gut Health with Dustin & Lacy
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75: From ER to Root-Cause Medicine – How Functional Care Transforms Patients’ Lives with Sommer Hood
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74: Your Gut Could Be the Root Cause – The Shocking Link Between Digestion, Mood & Weight with Sarah Nitterauer
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73: Your Gut Runs the Show – The Shocking Truth About Microbes, Hormones & Health with Kiran Krishnan
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72: From Birth Control to Muscle Building – The Best Holistic Fixes for PCOS with Dr. Naji Abou-Ali
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71: Can Plants Activate Stem Cells? – The Shocking Science Behind Self-Healing & Longevity with Ryan Riley
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70: Fix What Doctors Can’t – The Shocking Power of Functional Health Coaching with Vince Pitstick
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69: Bloated Again? – The Shocking Truth About Digestion & Simple Fixes with Dr. Heather Finley
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68: Feeling Off in Your 30s, 40s or 50s? – The Best Time to Start Hormone Therapy with Dr. Terri DeNeui
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67: Fasting Was Wrecking My Hormones – The Shocking Truth About Burnout & Stress with Shana Hussin
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66: Struggling to Conceive? – The Top Fertility Killers You’re Overlooking with Dr. Kelsey Duncan
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65: This Hidden Toxin Is Wrecking Your Gut and Brain – The Shocking Link to Chronic Illness with Dr. Jill Carnahan
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64: Forgotten Children! – The Shocking Reality of Young Caregivers & How to Protect Their Future with Connie Siskowski, RN, PhD
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63: Unlocking the Mystery of Chronic Fatigue: A Holistic Approach to Healing
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62: The Ultimate Guide to Healing Your Gut and Balancing Your Hormones!
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61: The Shocking Truth About Energy, Fatigue & Chronic Disease – Boost Mitochondrial Power with Dr. Bruce Hoffman
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60: Is Your Home Making You Sick? The Hidden Dangers of Poor Air Quality
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59: Misdiagnosed? – The Unbelievable PCOS Myths Destroying Your Metabolism (and How to Fix Them) with Tallene Hacatoryan & Sirak
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58: Are We Treating Menopause All Wrong? – The Shocking HRT Fix That Preserves Muscle & Metabolism with Dr. Jordan Robertson
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57: Fix PCOS, Thyroid & Infertility Without Medication – The Most Overlooked Strategy with Tamar Samuels
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56: Clean Eating for Kids: Why Gut Health Matters More Than You Think with Madeline Lauf
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55: Toxic Truth: How Mold, Metals & Water Are Wrecking Your Hormones – with Dr. Jaban Moore
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54: This Could Be Lyme, Not Menopause! – The Shocking Misdiagnosis Costing Women Their Sanity with Dr Myriah Hinchey
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53: Gut Health - The Key To Raising Happy and Healthy Kids with Dr. Elisa Song
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52: Think It's Your Thyroid? It's Probably This – The #1 Hormone Women Are Missing with Dr. Tyna Moore
In this powerhouse episode of Hormones, Metabolism & You, Dr. Cassie Smith sits down with the incomparable Dr. Tyna Moore—naturopathic physician, chiropractor, podcast host, and metabolic health disruptor—to dig deep into hormone health, microdosing GLP-1s, gut health, pain, muscle, alcohol, and more.
This episode is a must-listen if you’ve ever been confused by hormone therapy, overwhelmed by
51: Are You Eating Your Way to Anxiety? Let’s Talk Mental Health!
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50: Stem Cells, Skincare & Scar-Free Facelifts with Dr. Nathan Newman
In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith welcomes Dr. Nathan Newman, a leading expert in stem cell science, beauty, and regenerative medicine. Dr. Newman is the pioneer behind the Stem Cell Lift, a revolutionary scar-free facelift technique. He shares groundbreaking insights on the power of stem cells—not just for aesthetics but for healing joints, autoimmune conditions,
49: Why You’re Aging Faster Than You Should—And How Hormones Can Fix It! with Dr. Beth McDougall
In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith sits down with Dr. Beth McDougall, a pioneer in integrative and functional medicine, to discuss the profound impact of hormones on brain health, anxiety, depression, and longevity. They dive deep into how bioidentical hormone therapy (HRT) not only supports cognitive function but also reduces all-cause mortality and improves qualit
48: The Truth About Supplements for Hormonal Health with Shawn Wells
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47: Is Your Lack of Sleep Making You Fat? with Dr. Audrey Wells
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46: The Hidden Dangers of Breast Implants: Exploring the Connection to Autoimmune Conditions with Dr. Robert Whitfield
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