Sensible Medicine
Common sense and original thinking in bio-medicine A platform for diverse views and debate <br/><br/><a href="https://www.sensible-med.com?utm_medium=podcast">www.sensible-med.com</a>
Episodes
This Fortnight in Medicine XXX
Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trialJohn Mandrola: I am torn on the PolyPill concept This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
This Fortnight in Medicine XXIX
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia* Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysisThe Impact of Midodrine on Guideline-Directed Medical Therapy in Patients Admitted With Systolic Heart Failure This is a public episode. If you'd like to discuss this with other subscribers or get acc
Friday Reflection 62: The Ethics of Telling Patients We Have Nothing Left to Offer
TR is an 88-year-old man who is disabled and in chronic pain from spinal stenosis and knee osteoarthritis. He has multiple other medical issues, including coronary artery disease and COPD.He has been through years of treatment for his knees and back, including physical therapy, multiple joint injections, and an in-office procedure for spinal stenosis. He has been on multiple regimens of oral pain
This Fortnight in Medicine XXVIII
Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults* Prespecified Falsification End Points: Can They Validate True Observational Associations?* Ultrasonography versus Computed Tomography for Suspected NephrolithiasisGLP-1 receptor agonist use and cancer risk in obese nondiabetic adults* Risk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists: A Systematic
This Fortnight in Medicine XXVII
Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-UpGLP-1 Receptor Agonists or SGLT2 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy* Previously discussed on Fornight XXII: Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study This is a public episode. If you'd like to discuss this with
This Fortnight in Medicine XXVI
Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
This Fortnight in Medicine XXV
Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients* Real-World Effectiveness of Nirmatrelvir–Ritonavir Against Severe Outcomes of COVID-19 in Taiwan: A Nationwide Population-Based Cohort StudyThree Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage* Effect of Combination Therapy on Adherence Among US Patients Initiating Therapy for Hypertension: a Coh
This Fortnight in Medicine XXIV
RSV Prefusion F Vaccine for Prevention of Hospitalization in Older AdultsUltrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism* Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus ep
This Fortnight in Medicine XXIII
Dengue Suppression by Male Wolbachia-Infected Mosquitoes* World Mosquito ProgramAntibiotic Therapy for Uncomplicated Acute Appendicitis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
This Fortnight in Medicine XXII
* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study* Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction* Andrew’s previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMIAnd, a bunch of the other studies we discussed.* Complete Revascularizat
This Fortnight in Medicine XXI
Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia: A Retrospective Cohort Study* A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized PatientsEffect of Neuromuscular Warm-up on Injuries in Female Soccer and Basketball Athletes in Urban Public High Schools* Why Are So Many Teen Girls Still Tearing Their A.C.L.s?* Injury prevention programs tha
Going Beyond "AI in Medicine"
Most conversations about “AI in Medicine” bore me. I think this is because either we lack the imagination to consider how AI will change medicine in the next decade, or we are not being specific enough about how small parts of medicine could be productively affected.Dr. Shantanu Nundy, MD, MBA, is a practicing physician whom I like to think of as a serial innovator. He is currently an advisor on a
This Fortnight in Medicine XX
High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults* High-Dose Influenza Vaccine to Reduce Hospitalizations* Efficacy of high-dose versus standard-dose influenza vaccine in older adultsBeta-blockers after myocardial infarction: effects according to sex in the REBOOT trial This is a public episode. If you'd like to discuss this with other subscribers or get access to b
Alternative Modalities for Breast Cancer Screening
Today on the podcast, I am joined by Dr. Jennifer Rusiecki. Dr. Rusiecki is an Associate Professor of Medicine at the University of Chicago. She is the Director of Women’s Health and Gender-Based Care in the internal medicine residency program and the assistant clinic director overseeing gender-based care.Dr. Rusiecki and I discussed the article appraised in the other post today, and also discusse
This Fortnight in Medicine XIX
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical TrialBeta-Blockers after Myocardial Infarction with Normal Ejection Fraction* Should Evidence Come with an Expiration Date? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus e
This Fortnight in Medicine XVIII
No video this week — we had a bit of a computer meltdown — but two interesting articles.As always, thanks for listening. If you have articles you would like us to cover, please send us a suggestion at sensiblemedicine2022@gmail.com.This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with
Friday Reflection 56: Comments that Stuck
In a lifetime of possible memories, only some are accessible. There are a few comments — made by mentors, co-residents, and patients — that have lingered and shaped my medical practice. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
When to treat (or not treat) a high cholesterol
I was shocked at the comments on this post. Many people, some of them I know to be smart, thought I was nuts for suggesting two middle-aged women who had isolated high LDL-C needn’t take meds because their calculated 10-year risk was less than 3% What shocked me is that our guidelines suggest treatment with statins when 10-year risk is ≥ 7.5%. You may not know this but clinicians are supposed to c
This Fortnight in Medicine XVII
Medical Management and Revascularization for Asymptomatic Carotid StenosisVagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trialWe spent quite a bit of time talking about blinding. This is the table on the adequacy of blinding from the supplement. It does seem like blinding was less than perfect. This is a public episode. If you'd like to discu
This Fortnight in Medicine XVI
We try to answer the remainder of your AUA questions. We will be back in the new year with more article discussions!Here are a few of the things we referenced.GDMT Bugs Me: A bit of a rant against the standard of careA Plan to Refocus Primary CareSacrificing patient care for prevention: distortion of the role of general practiceThe Great Colonoscopy DebateArthroscopic Partial Meniscectomy versus S
This Fortnight in Medicine XV
We cover questions from Amy J, Benjamin Hourani, Diana Stiles Friou, Chris Costas, Errol Laurie, Jim Healthy, Elizabeth Fama, Never Dull, Rod Rodriguez, Ellison Burns, David Araujo, and George.We have more to come!One nice reference I found while looking into some of the topics:DMSO Is Not a Cure-All. But the FDA’s Panic Over It Birthed a Myth This is a public episode. If you'd like to discuss thi
This Fortnight in Medicine XIV
Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health recordsComparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease: The PRECISE Randomized Clinical Trial This is a public ep
This Fortnight in Medicine XIII
European Study of Prostate Cancer Screening — 23-Year Follow-upAssociation Between Baseline Diastolic Blood Pressure and the Efficacy of Intensive vs Standard Blood Pressure–Lowering TherapyFurther Reading* Effects of intensive blood-pressure control in type 2 diabetes mellitus* A Randomized Trial of Intensive versus Standard Blood-Pressure ControlSensible Medicine is 100% reader-supported. If you
This Fortnight in Medicine XII
Effects of Intensive Blood Pressure Control in Patients With Frailty: A Post Hoc Analysis From ESPRIT* Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial* Reduction of Antihypertensive Treatment in Nursing Home ResidentsPolysacchar
This Fortnight in Medicine XI
Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults* The Ideal Cholesterol Level ... Depends...And Cannot Be Determined From Observational StudiesStructured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial* Can We Please Stop Asking if Crossword Puzzles Prevent Demen
This Fortnight in Medicine X
Two papers this week, with a bunch of articles that we referenced in the conversation. Also, the last Fortnight podcast was accidentally posted behind a paywall. It is now up and free to listen to. My apologies. Sensible Medicine is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber.Folinic acid improves verbal communication in children with autism and langua
This Fortnight in Medicine IX
We go all observational this week. A look at data suggesting the safety of GLP-1s and a re-examination of data on patient/doctor race concordance/discordance (a topic Adam said we should not study, and then John forces him to).GLP-1 Receptor Agonists and Cancer Risk in Adults With ObesityPhysician–patient racial concordance and newborn mortalityOriginal, 2020 article: Physician–patient racial conc
Friday Reflection 53: Eradicating the Very Important Patient from the Medical Ecosystem
NT is a 55-year-old man admitted to the general medicine service with cellulitis of his left leg. When the attending sees him the morning after admission, he notices the patient’s “Medical Center Trustee” hospital ID on his bedside table. After gathering a history and examining the leg, the attending leaves the room. In the hallway, he crosses paths with the hospital president, who is there to mak
Friday Reflection 52: The Three Worst Phone Calls of My Career
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
This Fortnight in Medicine VIII
Last week, John was at the European Society of Cardiology conference in Madrid, and Adam was at the Preventing Overdiagnosis 2025 International Conference in Oxford. A conversation about what we learned.Digitoxin in Patients with Heart Failure and Reduced Ejection FractionBeta-Blockers Post-MI: A Clear Clinical MessageAspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulatio
This Fortnight in Medicine VII
Metformin for Treatment of Knee Osteoarthritis in Patients With Overweight or ObesityOnce-Weekly Semaglutide in Persons with Obesity and Knee OsteoarthritisSemaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Friday Reflection 50: The Look
TR is a 72-year-old woman, a retired executive, who had been in excellent health until she began experiencing exertional dyspnea and palpitations. After waiting out the symptoms for about a month, she called and made an appointment to see her primary care doctor. The day before her appointment, she awoke unable to move her entire right side. With difficulty, she reached for her phone and called he
This Fortnight in Medicine VI
A “manel” reviewing trials and studies that explore the benefits and harms of hormone replacement therapy.The Women’s Health Initiative* Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial* The Women's Health Initiative Randomized Trials and Clinical Practice: A Review* The Women’s Health In
This Fortnight in Medicine V
Primary Articles* As-Needed Albuterol–Budesonide in Mild Asthma* Early versus Later Anticoagulation for Stroke with Atrial FibrillationReferenced Articles * Albuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma* Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects: Systematic Review and Meta-regression Analysis This is a public episode. If you'd like to
This Fortnight in Medicine IV
Primary articles discussed:* First myocardial infarction: risk factors, symptoms, and medical therapy* Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use DisorderA Randomized Clinical TrialArticles referenced:* Pharmacotherapy for Alcohol Use Disorder: A Systematic Review and Meta-Analysis* General health checks in adults for reducing morbidity and mortality
Friday Reflection 49: The Patients of 12 Reisman
A visit brings back the memories of patients and the lessons they taught. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
This Fortnight in Medicine III
No association between preprocedural fasting and witnessed pulmonary aspiration: A systematic review and meta-analysisHere are a couple of other older articles to give you the history of preprocedural fasting. Reducing the Risk of Acid Aspirations During Cesarean SectionFasting from midnight — the history behind the dogmaCT Angiography, Healthy Lifestyle Behaviors, and Preventive Therapy This is a
This Fortnight in Medicine II
This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber.Clinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal CancerIf you want a deeper dive into cancer screening, we have covered the topic a lot on Sensible Medicine. There is a video debate Vinay, John, and Adam had about colon cancer screening. We also posted
This Fortnight in Medicine
We are beginning a new series today. John and Adam will discuss a couple of articles we found interesting. Please let us know your thoughts. This week:Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated SteatohepatitisTiotropium Initiation and Dementia Risk in Chronic Obstructive Pulmonary Disease This is a public episode. If you'd like to discuss this with other subscribers or get ac
Ask Us Anything
This is a long one! 83 minutes. This is the second podcast in which we answer questions from a our “ask us anything” post. We recorded this one before our most recent podcast — kind of like Abbey Road and Let it Be — so we were still graced by Vinay’s presence. In fact, we recorded it in his studio. We still have about a half dozen questions to answer; we will cover those on an upcoming podcast.
Vinay at FDA; what's next for Sensible Medicine; ask us anything answers
John and Adam discuss our hopes for Vinay’s tenure at the FDA and how we intend to keep Sensible Medicine a vibrant place on Substack, a place where we will continue to showcase a range of ideas and opinions about all things bio-medicine. We also answer some of the questions from our recent “ask us anything” post. This is a public episode. If you'd like to discuss this with other subscribers or ge
Friday Reflection 48: Linguistics, Diagnosis, and Medical Error
FH is a 66-year-old woman who comes in for an urgent visit because she has been feeling woozy for two days. She is very anxious, almost distraught, because she thinks these symptoms are the same as the ones that her sister had before she died of a hemorrhagic stroke.Sensible Medicine is a reader-supported publication. If you appreciate our work, consider becoming a free or paid subscriber.A few ye
A Conversation with Professor Jeffrey Flier Regarding Changes in NIH Funding
Professor Jeffrey Flier is a distinguished service professor and Higginson Professor of Physiology and Medicine at Harvard Medical School. He is the former dean of Harvard Medical School. We talked about the recent (and sudden) change in NIH funding. First a note on Professor Flier. He is not a normal medical school dean. He is active online. He speaks candidly, often critically. He and Vinay wrot
RFK Jr hearings/ Eulogy Values & NIH delays
We are back with a riveting discussion This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
A Conversation with Michael Easter from the TWO/PERCENT
I recently recorded a conversation with Michael Easter from the TWO/PERCENT, a Substack and podcast. Michael offers “practical, accurate, and useful health, performance, and mindset information,” and in a space where there is a lot of drive, I find him remarkably thoughtful.Our conversation is on the podcast feed. Below are my notes for our conversation with links to many of the things we discusse
Friday Reflection 47: Patients Make the Hardest Decisions
Doctors often get credit (or blame) for having to make difficult, life-and-death decisions. But really, it is all of us, when we are patients, who make the bravest decisions that carry the highest stakes. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
A conversation with Margaret McCartney, MD, PhD regarding evidence-based medicine and conflicts of interest
I have long followed the work of Dr. Margaret McCartney. She is a general practitioner in Glasgow, Scotland, writer, public speaker, and now PhD. She is a fierce advocate for evidence-based medicine. She holds highly skeptical views of screening for disease—which, to my surprise is quite common in the UK. Her recently finished PhD sought empirical evidence regarding declaration of conflicts of int
UCSF hematology oncology interest group
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Adam Cifu Interviewed by Michael Easter on the TWO/PERCENT Substack and Podcast
I had the pleasure of being interviewed by Michael Easter. Michael is behind the TWO/PERCENT Substack where he offers “practical, accurate, and useful health, performance, and mindset information.” I’ve listened to, and read, a bunch of Michael’s content. Not only is it enjoyable but it seems, well, sensible. Our conversation was inspired by my Coming Out Against the Healthy Lifestyle post. I hope
A live taping from Wash U, a Sensible Medicine discussion
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
MAHA and Medical Conservatism
What does our philosophy have to do with RFK Jr and MAHA? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Systematic reviews 101
4 mistakes people make in systematic reviews This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Ask me anything
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Friday Reflection 45: Patients
The woman with palpitations.The man with whom you used to joke and trade barbs who now sits silently, absent, while you talk to his wife.The woman whose depression dominates every visit; her depression being the one problem she refuses to address.The man whose joy and charisma makes every visit an absolute pleasure, despite his painful disability about which you can really do nothing.The man who n
Sensible medicine ask us anything part 2
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Ask us anything podcast
This podcast is one of three we will be posting to answer the questions that came to us in response to this post. We had a nice set of questions so we will certainly be doing it again. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Back to Sleep Series in Audio Format
I learned a lot from Elizabeth Fama’s multipart series on the back-to-sleep recommendation for infants. She agreed to put the entire series into an audio file. Here you go. JMM Sensible Medicine is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or
Friday Reflection 44: Diagnostic Enigma
Ask general internists what they love about their field, and they are likely to talk about long-term relationships with patients and the pleasure of solving clinical puzzles. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
How can we do better as a county hospital?
My lecture to the cancer care staff at a county hospital. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Friday Reflection 43: The Absence of Reassuring Counterfactuals in Clinical Medicine
Even when a decision is clear, and things turn out badly, the lack of a counterfactual allows endless second guessing. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
What Medical School Looks For and What Medical School Should Look For
I discuss how medical students are selected, and perhaps how they should be selected. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
The Retirement of Dr. Mark Siegler
Remarks about a model clinician. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Friday Reflection 42: Patient Approaches to a Doctor’s Visit
It would be foolish to argue that doctors are unaffected by how they are treated by patients. Their treatment may not affect the care they deliver and only affect how they feel at the end of the day. It is probably impossible to know. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
A Discussion with Professor Venk Murthy on Coronary Artery Disease
When I type the words coronary artery disease I bet that you picture angiograms with stenotic lesions—blockages in colloquial language. Indeed a high grade plaque from atherosclerosis in the inside of a coronary artery can limit flow to the heart muscle. But. But. Not as much as you think. You know why? Because there is something called the coronary microcirculation. Before blood gets to the beati
Impella, Mammograms and Med School Fails Students
VP fixed the audio This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Fear and Opioids in Academic Medicine
Regard for power implies disregard for those without power; part 3 This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
A discussion with interventional cardiologist Dr David Cohen on medical evidence, TAVR and stroke prevention
David Cohen is one of the smartest docs on Twitter. I learned a bunch talking with him. The procedure called transcatheter aortic valve implantation or TAVR is a damn miracle. In days of old, a heart surgeon would have to saw open the chest and cut out the heavily calcified immobile aortic valve and sew in a new one. I watched a case as a young doctor and came away shocked that patients survive th
Adam and I discuss the week's medical news
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Cifu, Prasad, Mandrola
A spirited discussion of craziness in medicine This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Friday Reflection #39: What to Expect When You Are Aging
MM is 94 years old. Her only active medical issues are hypertension and vitamin D deficiency. She takes only 20 mg of lisinopril and 1000 units of vitamin D3 each day. She has no cognitive decline and gardens every day if the Chicago weather allows. Her Friday afternoon appointment is the doctor’s last of the week.Sensible Medicine is a reader-supported publication. If you appreciate our work, con
A Novel Approach to AF Ablation
A few short words about our conversation: Two decades have passed and electrophysiologists have learned little about how to ablate atrial fibrillation. Now, and then, we simply ablate circles around the orifices of the pulmonary veins. This works reasonably well. But we don’t—exactly—know why it works. For instance, some patients have total elimination of AF, but when they are restudied, they have
Video version of our podcast
We discuss the state of medical education, Harvard music video, causal language at JAMA and more This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Cifu, Mandrola, Prasad
Video will be available to paid subscribers This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
A Discussion with Dr. Dena Zeraatkar regarding analytic flexibility in observational studies
Gosh was this a great conversation about her recent paper on specification curve analysis of nutritional observational studies. Here is Dr. Zeraatkar’s bio:Dena Zeraatkar, PhD is an Assistant Professor in the Departments of Anesthesia and Health Research Methods, Evidence, and Impact (HEI) at McMaster University. She earned her doctoral degree at McMaster University in the Health Research Methodol
Friday Reflection 38: Yesterday’s Solutions; Today’s Problems
The Thomas Sowell quote, “On closer scrutiny, it turns out that many of today's problems are a result of yesterday's solutions” has been ringing in my head a lot lately. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Yet Another Excellent Explainer About P-Values in Randomized Trials
Gosh was I lucky to speak with Professor Erik Van Zwet from Leiden University in the Netherlands. He is the first author on a recent NEJM Evidence paper looking at more than 23,000 trials in the Cochrane Database. (I linked to an URL that should get by the paywall.) There are technical aspects of this paper. We hit on some (not a lot) of them. The gist of it though is really important when we look
Friday Reflection 37: Why I Teach (acceptable and less acceptable reasons)
Why have I been committed to medical education? Some of the reasons are admirable but not terribly novel. Others are a bit hard to admit, but just as true. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Friday Reflection 36: Why Don’t Doctors Want to See Patients?
Friday Reflection 35: Why Don’t Doctors Want to See Patients?I was asked “Why is it that doctors don’t want to see patients?” and I could not answer the question. Fourteen months later, here is my response. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
New Austrian Study Shows Boosters do NOT reduce COVID19 deaths in people who had COVID
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Math Professor Ben Recht and I Discuss P-values and Confidence Intervals
Ben Recht is a professor at UC Berkeley. You know, the place that has all those parking spaces for the Nobel laureates. He understands the innards of math. And that is exactly why he explained that doctors who use evidence don’t have to get bogged down in technicalities. I reached out to Ben to discuss a complicated but provocative statistical paper in NEJM evidence. But we mostly talk basics. Ben
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