Latent Space: The AI Engineer Podcast

Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics Oct 13, 2026 4317 Watch along AIE NYC and join us at AIE CODE in SF next month!This episode includes a live demo of the Taku robot that is best enjoyed on YouTube.Last month, Dyna made waves by announcing Dyna-2, a world-action model pre-trained on one million hours of human video, claiming several new scaling laws on human data across four orders of magnitude. They have now followed up the model with a physical ro

Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub Oct 10, 2026 1916 From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In this special panel moderated by Brandon Anderson, they explore why AlphaFold’s breakthrough was only the beginning, why scaling compute and data alone won’t solve biology, and how the

Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk Oct 8, 2026 5040 It’s hard to believe that Periodic was only launched last September:One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous lab buildout:Most people are familiar with the standard credentials of Liam and Dogus, but we found an incredible “talent slope” while learning more about Periodic, where each successiv

Academia is for Ambition — Alex Zhang, MIT Oct 2, 2026 6088 Last call for regular tickets for AI Engineer NYC! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks!While we tend to cover industry on the pod, every so often we celebrate a clearly emerging superstar PhD. In 2024 we featured Shunyu Yao, who went on to build Operator at OpenAI and is now Chi

Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week Sep 30, 2026 2352 Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Computer Use folks:We are no strangers to learning in public and are no strangers to the stress of getting things wrong when you have a big platform. However, we were at Anthropic for the Computer Use launch, there for Claude Cowork with

Claude Code’s Next Era — Thariq Shihipar, Anthropic Sep 29, 2026 5549 We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York, coming up in 2 weeks!In case you’ve been under a rock, here’s a non-exhaustive list of what Anthropic has been shipping since closing the largest fundraise of all time in May at $47B ARR:* June: Launched Claude Tag and Sonnet 5 and Fable 5* July: Opus 5, /checkup. crossed $65B ARR* Last month: Fable/Myth

OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha Sep 25, 2026 4843 From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers, OpenRouter is one of the clearest bets that the future of AI will be multi-model. In this episode, OpenRouter co-founder & CEO Alex Atallah, with AMP’s Anjney Midha returning with swyx to unpack how OpenRouter emerged from the first wave of Llama, Alpaca, Mistral, and Midjourney,

Runway’s WorldPrompt and the Engineering of Real-Time Worlds Sep 25, 2026 5781 Earlier this month, world model company Runway introduced GWM Worlds 2, a research preview that “turns high-fidelity video and audio generation into real-time interactive simulation.” Runway calls this an “autoregressive diffusion” model; with autoregressive describing how it generates over time.One new feature in particular caught our eye: WorldPrompt, a proposed input format for specifying a gen

🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics) Sep 23, 2026 5518 The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security, then? Clem Delangue argues that cyber-warfare defensive capabilities need to be open and to keep pace with frontier models’ attack capabilitiesRadical Numerics co-founder Eric Nguyen sat down

🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science Sep 22, 2026 7286 How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar, two textbook algorithms, two named asteroids, and an Erdos-Bacon number of 6. This was easily the most fun bio of all the guests we’ve read to date. And the result was an epic and fun chat covering Google’s Empirical Research Assistance (ERA), how AI

Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI Sep 21, 2026 8453 Tickets for AIE NYC now open, and apply for the invite-only AIE CODE. Join us!We have an unusual relationship with today’s guest: for years since coauthoring the InstructGPT paper, Diogo Almeida had been saying that API-available frontier models have been going down the wrong path, everything from the alignment to refusals to reliability perspectives, that we have dropped every mode other than aut

Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC Sep 16, 2026 5174 AIUC first got our attention with the NFDG backing, and have just announced a $40M series A today, with the most impressive industry advisor list we may have ever seen for an early startup behind AIUC-1, their agent standard backed by real insurance:From being Anthropic’s first product hire to building the standards, testing, and insurance infrastructure meant to make frontier AI deployable, Rune

Humanity’s Last Invention — Richard Socher of Recursive Sep 14, 2026 5530 At 1:09:00 we talk about the rise of AI x Finance, and AIE NYC is one month away - our hotel block is 97% sold out, get tix & travel ASAP - we will announce speakers from Bridgewater, Ramp, Coatue, Mastercard, Vanguard, Coinbase, Blackrock, Fidelity, Point72, Capital One, JPMC, Wells Fargo, Bloomberg, A24 (yes the movie studio) Labs, Two Sigma, Apollo Global, and more soon!From helping pioneer cor

🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing Aug 26, 2026 5011 A few years ago, Caltech Prof. and co-founder of Accelerated Understanding, Anima Anandkumar set out to develop the first open-source weather model with AI. Talking to experts in the field, she was met with skepticism. Weather is chaotic, physics simulations are hard, have been developed for decades, and require supercomputers, the data just isn’t there. Despite reservations, Anima went forth and

Simulation: the new Scaling Law — Joon Sung Park, Simile AI Aug 21, 2026 4178 When we first dicsussed the Summer of Simulative AI in 2024 we knew it would be a brief summer, but it has recently come back with a vengeance with SimGym in April and now Simile AI’s $2B Series B, backed by GreenOaks and Index Ventures with prominent backers like Fei-Fei Li and Andrej Karpathy, running tens of millions of simulations for Fortune 100 clients like CVS and 85–99% accuracy vs human f

🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery Aug 11, 2026 5719 This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year. OpenAI-backed Chai Discovery (now worth $4B) was somehow at the heart despite being all of 2 years old. The Science team is proud to bring you the first podcast with cofounder Matt McPartlon and product lead Neil Patil to tell the full story! Editor’s note: not

The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten Aug 3, 2026 6089 Watch the full episode on YouTube:We first covered Baseten last year when DeepSeek mania was at peak hype. Now they have raised a monster $13B round and become one of the new cohort of AI Infra decacorns that are (with Nvidia, Intel, and the semis complex) chief beneficiaries of the Inference Inflection. We return to Baseten at the peak of the 2026 edition of Open Weights debate. Ali has published

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI Jul 28, 2026 4168 There are roughly 100x more people who use code than who can write code. As code that “just works” becomes easier to generate, this group may be the biggest prize of all — if you can get the agentic interface right.A key trend we have been tracking over at AINews is the absolute explosion in Codex usage this year, with MAU now up >10x from Jan 2026. Less than two weeks after their July 9th launch,

Inside the Model Factory — Eiso Kant, Poolside AI Jul 23, 2026 6873 In recent months, the open vs closed, and US vs China discussions on model ownership and sovereign/local AI have heated up to a fever pitch. So it is very very good news that Poolside AI are finally emerging with new models, like Laguna S 2.1, that are beating Thinking Machines’ recent release nearly 10 times their size.Poolside’s recent tech report got a lot of praise due to their level of detail

🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist) Jul 21, 2026 5387 Bet on informationIf test loss flatlines after 1.5B parameters while training loss continues to drop as you scale, that tells you that your model is limited by the amount of information in your data.Training on a single, smallish data set exposed an information gap: the 3.1B model falls off the scaling trend. Neither parameters nor compute will improve performance past this wall. For predicting ch

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences Jul 16, 2026 6064 Imagine a dark warehouse. Racks and racks of devices with wires, tubes, and electronics sticking out. The next AI data center? No. This is Lila Sciences‘ dream for the future of science. A dark warehouse full of AI-guided robotics and lab equipment, cranking out new experiments 24/7, building toward a scientific superintelligence.Their automated lab is almost hypnotizing to watch. They have floati

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO Jul 8, 2026 3475 We’ve been running a bit of an Agent Cloud series surveying all the top inference/compute/cloud providers, from Databricks to Daytona to Railway and, even further back, E2B, but we’re excited to conclude this series returning to Modal, which has just raised a monster $355M Series C.The cloud was built for developers. But agents are now changing that.The old infra stack was designed for a human who

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI Jul 1, 2026 6519 This episode has a fun personal twist: There’s a counterfactual world where I was employee #1 at Genesis Molecular AI, the company behind today’s episode. A certain introduction happened a few weeks too late and I had already happily signed at Atomwise, another ML-for-drug-discovery startup. Same problem, different company. I was certain ML was going to transform small molecule drug discovery. Ea

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks Jun 24, 2026 4132 We’re excited to have Databricks join us at AIEWF, among hundreds of the top companies in the AI Engineer ecosystem. LS subscribers can use their discount to get past the late bird pricing and access over $50k in sponsor offers! Everyone is still talking about Satya’s Frontier Ecosystems post, but few have actually built a (now $175 billion) frontier ecosystem and cloud like our guests today.From

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan Jun 22, 2026 3983 AI Engineer World’s Fair regular bird tix will sell out ~today! Join us next week ahead of the Late Bird price hike and get >$40,000 in sponsor credits for attending!Thanks to the US Government issuing an export control directive on Mythos and Fable, the risks of jailbreaks and (industry term) indirect prompt injection are suddenly the talk of the town, though we have been covering AI security for

The Professor of Outputmaxxing — Anjney Midha, AMP Jun 18, 2026 3565 Last 4 days before regular tickets sell out at AI Engineer World’s Fair - this is the single biggest gathering of AI Engineers, Founders, Leaders, and Researchers in the world. Attendees get >$5000 worth of sponsor credits and talk tracks are looking FANTASTIC. Join us!The AI scaling debate always focuses on the question of “how do we get more GPUs?” but the better question may be: how do we make

🔬 The Self-Driving Lab — Joseph Krause, Radical AI Jun 17, 2026 4610 On the Science pod, we’ve been covering a lot of the ground on how AI is revolutionizing STEM, but one of our favorite off the record topics since our launch is which field is harder to accelerate: math, bio, or physics? Today we’re back in Materials Science land with Radical — Unlike biological molecules that can be represented (and predicted!) by token strings, the success of materials involve m

Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs Jun 4, 2026 4539 The new AIEWF website is live! Get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets!Most industry benchmarks compress intelligence and reasoning ability into scores.SWE-Bench Pro, MMLU, Humanity’s Last Exam, etc. These metrics are useful, but don’t always represent the full extent of how a model performs in the real wo

🔬Scaling Past Informal AI - Carina Hong, Axiom Math Jun 3, 2026 5584 In 2025, seven-month-old startup Axiom solved all 12 of the problems Putnam exam (scoring 8/12 in the time limit) a prestigious undergraduate math exam. The 12/12 score is better than the top undergraduates (110/120) and the closest AI system that reported a result (DeepSeek 103/120), although it is unclear what the people and other systems would have scored with more time. Nonetheless, the Putnam

⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build Jun 3, 2026 2338 We’ve informally heard that Satya is a listener to LS for a couple years now, but it was still absolutely surreal to meet him and do a live pod at Build, together with our friends at No Priors, the leading VC AI Podcast that we also greatly admire!We covered the MAI model technical takeaways on yesterday’s AINews, so I will focus our recap of Satya’s main messages around three elements:* Satya’s a

GitHub's plan for Agents — Kyle Daigle, GitHub Jun 2, 2026 5007 I’m excited to work with Microsoft once again as the presenting sponsors of the AI Engineer World’s Fair! We’ll streaming live from MS Build today for a special crossover pod with our friends at No Priors and the one and only Satya Nadella. However we did not hold back with this interview - we asked all the burning questions about uptime and Copilot that we know you have in your minds. Lets go!For

Why Video Agent models are next — Ethan He, xAI Grok Imagine Jun 1, 2026 6206 We’re announcing AIEWF speakers this week! Take the AI Engineering Survey!Today’s guest Ethan first joined us for the LS Paper Club as the lead on NVIDIA Cosmos World Model, but then joined xAI and built Grok Imagine in 3 months:He comes back on Latent Space with some nuclear hot takes: that Video Models primarily get their intelligence from LLMs, not from training on video data, and that the next

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray May 28, 2026 4082 The new AIEWF website is live! CFPs close in 2 days and we will run our first New Engineer Orientation this weekend, get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets!One of the central tensions in the agents industry is that even while there are major decacorn agent labs like Sierra, Decagon, Notion and Cursor bein

🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub May 27, 2026 4212 Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “next token” objective: predict the amino acids that have been randomly masked out, based on the context of the rest of the

Giving Agents Computers — Ivan Burazin, Daytona May 21, 2026 4227 Take the 2026 AI Engineering Survey and get >$2k in credits and AIE WF tickets!On the product side, everyone is getting Computer - Perplexity, Manus, Cursor, and so on. Meanwhile on the research side, agentic evals like TerminalBench and GDPVal are also assuming computer (Harbor). On both ends, the consolidating LLM OS stack has become a standard toolkit, and Daytona is one of a small set of AI In

Railway: The Agent-Native Cloud — Jake Cooper May 20, 2026 5314 Take the 2026 AI Engineering Survey and get >$2k in credits and AIE WF tickets!This was recorded before Railway suffered a major GCP outage on May 19, despite being a multi-AZ, multi-zone mesh ring, with HA fiber interconnects between their Metal GCP AWS, because workload discoverability was unintentionally still tied to GCP. All has been resolved with a post-mortem.Railway did not start as an A

The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion May 18, 2026 7168 The future of war has been evolving before our eyes in Ukraine, yet the west still plans to fight the last war. In this special episode, guest host Noah Smith (@noahpinion) and Brandon Anderson sit down with Yaroslav Azhnyuk (@YaroslavAzhnyuk), a serial tech founder who went from building PetCube to founding The Fourth Law, one of the world’s most advanced AI-guided drone companies. Over two hours

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge May 14, 2026 3920 Special discounts up for AIE Melbourne (LS discount) and AIE World’s Fair (group discounts up to 25% - CFPs still open for Autoresearch and Vertical AI) Cya there!Abridge did not start as an “GPT wrapper”. It was founded in 2018, years before the Cambrian explosion of AI application layer companies. OpenAI launched ChatGPT publicly on November 30, 2022 and by then, Abridge had already spent years

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI May 5, 2026 5511 Some people are going crazy over GPT 5.5. Some people. This is the story of the Jagged Frontier. People who use AI to write emails or even code implementation work find the lift moderate whereas people pushing the limits of the model are figuring out that the limits just moved outwards.Alex Lupsaska has been tracking this limit for a year and a half now. “When GPT5 came out, it was able to reprodu

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition Apr 27, 2026 4341 From building Applied Intuition from YC-era autonomy tooling into a $15B physical AI company, Qasar Younis and Peter Ludwig have spent the last decade living through the full arc of autonomy: from simulation and data infrastructure for robotaxi companies, to operating systems for safety-critical machines, to deploying AI onto cars, trucks, mining equipment, construction vehicles, agriculture, defe

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026) Apr 23, 2026 3292 Today, we check in a year after the first Unsupervised Learning x Latent Space Crossover special to discuss everything that has changed (there is a lot) in the world of AI. This episode was recorded just after AIE Europe, but before the Cursor-xAI deal.Unsupervised Learning is a podcast that interviews the sharpest minds in AI about what’s real today, what will be real in the future and what it me

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO Apr 22, 2026 4345 Early bird discounts for the San Francisco World’s Fair, the biggest AIE gathering of the year, end today - prices will go up by ~$500 tonight so do please lock in ASAP!From near-universal AI tool adoption inside Shopify to internal systems for ML experimentation, auto-research, customer simulation, and ultra-low-latency search, Mikhail Parakhin joins us for a deep dive into what it actually looks

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik Apr 20, 2026 5121 Today, we explain this piece of “clickbait” from our guest!TL;DR: 95% of cancer treatments fail to pass clinical trials, but it may be a matching problem — if we better understood what patients have which tumors which will respond to which treatments, success rates improve dramatically and millions of lives can be saved — with the treatments we ALREADY have.See our full episode dropping today:Why

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion Apr 15, 2026 4637 For all those who missed out on London, see you in Miami next week!Notion, the knowledge work decacorn, has been building AI tooling since before ChatGPT, with many hits from Q&A in 2023 and unified AI in 2024 and Meeting Notes in 2025. At the end of their last Make user conference, Ryan Nystrom teased Notion 3.0’s Custom Agents - and they are finally embracing the Agent Lab playbook!Sarah Sachs a

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony Apr 7, 2026 4363 We’re proud to release this ahead of Ryan’s keynote at AIE Europe. Hit the bell, get notified when it is live! Attendees: come prepped for Ryan’s AMA with Vibhu after.Move over, context engineering. Now it’s time for Harness engineering and the age of the token billionaires.Ryan Lopopolo of OpenAI is leading that charge, recently publishing a lengthy essay on Harness Eng that has become the talk o

Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different" Apr 3, 2026 4580 Fresh off raising a monster $15B, Marc Andreessen has lived through multiple computing platform shifts firsthand, from Mosaic and Netscape to cofounding A16z. In this episode, Marc joins swyx and Alessio in a16z’s legendary Sand Hill Road office to argue that AI is not just another hype cycle, but the payoff of an “80-year overnight success”: from neural nets and expert systems to transformers, re

Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun Apr 2, 2026 4007 We’ve been on a bit of a mini World Models series over the last quarter: from introducing the topic with Yi Tay, to exploring Marble with World Labs’ Fei-Fei Li and Justin Johnson, to previewing World Models learned from massive gaming datasets with General Intuition’s Pim de Witte (who has now written down their approach to World Models with Not Boring), to discussing the Cosmos World Model with

Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample Mar 30, 2026 2928 Mistral has been on an absolute tear - with frequent successful model launches it is easy to forget that they raised the largest European AI round in history last year. We were long overdue for a Mistral episode, and we were very fortunate to work with Sophia and Howard to catch up with Pavan (Voxtral lead) and Guillaume (Chief Scientist, Co-founder) on the occasion of this week’s Voxtral TTS laun

🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik Mar 24, 2026 2114 Materials science is the unsung hero of the science world. Behind every physical product you interact was decades of research into getting the properties of materials just right. Your gym clothes contain synthetic fibers developed over decades. The glass screen, diodes, and chip substrate technology needed to read this blog post were only viable due to many teams of material scientists.Our guest P

Dreamer: the Personal Agent OS — David Singleton Mar 20, 2026 3815 Mar 23 update for Latent Spacenauts: this episode was recorded before the Dreamer team announced they were joining Meta Superintelligence Labs, and it turned out to be the last interview they did before the news became public. Consider this a snapshot from just before the transition!In 2024, David Singleton left Stripe and joined forces with Hugo Barra for a buzzy stealth startup named /dev/agents

Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop Mar 17, 2026 5219 Claude Cowork came out of an accident.Felix and the Anthropic team noticed something interesting with Claude Code: many users were using it primarily for all kinds of messy knowledge work instead of coding. Even technical builders would use it for lots of non-technical work.Even more shocking, Claude cowork wrote itself. With a team of humans simply orchestrating multiple claude code instances, th

Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer Mar 12, 2026 3632 Turbopuffer came out of a reading app.In 2022, Simon was helping his friends at Readwise scale their infra for a highly requested feature: article recommendations and semantic search. Readwise was paying ~$5k/month for their relational database and vector search would cost ~$20k/month making the feature too expensive to ship. In 2023 after mulling over the problem from Readwise, Simon decided he w

NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo) Mar 10, 2026 5017 Join Kyle, Nader, Vibhu, and swyx live at NVIDIA GTC next week!Now that AIE Europe tix are ~sold out, our attention turns to Miami and World’s Fair!The definitive AI Accelerator chip company has more than 10xed this AI Summer:And is now a $4.4 trillion megacorp… that is somehow still moving like a startup. We are blessed to have a unique relationship with our first ever NVIDIA guests: Kyle Kranen

Cursor's Third Era: Cloud Agents Mar 6, 2026 3999 All speakers are announced at AIE EU, schedule coming soon. Join us there or in Miami with the renowned organizers of React Miami! Singapore CFP also open!We’ve called this out a few times over in AINews, but the overwhelming consensus in the Valley is that “the IDE is Dead”. In November it was just a gut feeling, but now we actually have data: even at the canonical “VSCode Fork” company, people a

Every Agent Needs a Box — Aaron Levie, Box Mar 5, 2026 4618 The reception to our recent post on Code Reviews has been strong. Catch up!Amid a maelstrom of discussion on whether or not AI is killing SaaS, one of the top publicly listed SaaS companies in the world has just reported record revenues, clearing well over $1.1B in ARR for the first time with a 28% margin. As we comment on the pod, Aaron Levie is the rare public company CEO equally at home in both

METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity Feb 27, 2026 3374 This is a free preview of a paid episode. To hear more, visit www.latent.spaceAIE Europe CFP and AIE World’s Fair paper submissions for CAIS peer review are due TODAY - do not delay! Last call ever.We’re excited to welcome METR for their first LS Pod, hopefully the first of many:METR are keepers of currently the single most infamous chart in AI:But every Latent Space reader should be sophisticated

[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka Feb 26, 2026 3137 Swyx joined SAIL! Thank you SAIL Media, Prof. Tom Yeh, 8Lee, Hamid Bagheri, c9n, and many others for tuning into SAIL Live #6 with Nathan Lambert and Sebastian Raschka, PhD. Sharing here for the LS paid subscribers.We covered: This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.latent.space/subscribe

🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI Feb 25, 2026 2036 Editor’s note: CuspAI raised a $100m Series A in September and is rumored to have reached a unicorn valuation. They have all-star advisors from Geoff Hinton to Yann Lecun and team of deep domain experts to tackle this next frontier in AI applications.In this episode, Max Welling traces the thread connecting quantum gravity, equivariant neural networks, diffusion models, and climate-focused materia

Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis Feb 24, 2026 7453 This is a free preview of a paid episode. To hear more, visit www.latent.spaceFirst speakers for AIE Europe and AIEi Miami have been announced. If you’re in Asia/Aus, come by Singapore and Melbourne. AI Engineering is going global!One year ago today, Anthropic launched Claude Code, to not much fanfare:The word of mouth was incredibly strong however, and so we were glad to be one of the first podca

⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data Feb 23, 2026 1572 Olivia Watkins (Frontier Evals team) and Mia Glaese (VP of Research at OpenAI, leading the Codex, human data, and alignment teams) discuss a new blog post (https://openai.com/index/why-we-no-longer-evaluate-swe-bench-verified/) arguing that SWE-Bench Verified—long treated as a key “North Star” coding benchmark—has become saturated and highly contaminated, making it less useful for measuring real c

Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z Feb 19, 2026 3318 Tickets for AIEi Miami and AIE Europe are live, with first wave speakers announced!From pioneering software-defined networking to backing many of the most aggressive AI model companies of this cycle, Martin Casado and Sarah Wang sit at the center of the capital, compute, and talent arms race reshaping the tech industry. As partners at a16z investing across infrastructure and growth, they’ve watche

Owning the AI Pareto Frontier — Jeff Dean Feb 12, 2026 5011 From rewriting Google’s search stack in the early 2000s to reviving sparse trillion-parameter models and co-designing TPUs with frontier ML research, Jeff Dean has quietly shaped nearly every layer of the modern AI stack. As Chief AI Scientist at Google and a driving force behind Gemini, Jeff has lived through multiple scaling revolutions from CPUs and sharded indices to multimodal models that rea

🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery Feb 12, 2026 4867 This podcast features Gabriele Corso and Jeremy Wohlwend, co-founders of Boltz and authors of the Boltz Manifesto, discussing the rapid evolution of structural biology models from AlphaFold to their own open-source suite, Boltz-1 and Boltz-2. The central thesis is that while single-chain protein structure prediction is largely “solved” through evolutionary hints, the next frontier lies in modeling

The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI Feb 6, 2026 4081 From Palantir and Two Sigma to building Goodfire into the poster-child for actionable mechanistic interpretability, Mark Bissell (Member of Technical Staff) and Myra Deng (Head of Product) are trying to turn “peeking inside the model” into a repeatable production workflow by shipping APIs, landing real enterprise deployments, and now scaling the bet with a recent $150M Series B funding round at a

🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White Jan 28, 2026 4436 Editor’s note: Welcome to our new AI for Science pod, with your new hosts RJ and Brandon! See the writeup on Latent.Space (https://Latent.Space) for more details on why we’re launching 2 new pods this year. RJ Honicky is a co-founder and CTO at MiraOmics (https://miraomics.bio/), building AI models and services for single cell, spatial transcriptomics and pathology slide analysis. Brandon Anderson

Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay Jan 23, 2026 5525 From shipping Gemini Deep Think and IMO Gold to launching the Reasoning and AGI team in Singapore, Yi Tay has spent the last 18 months living through the full arc of Google DeepMind’s pivot from architecture research to RL-driven reasoning—watching his team go from a dozen researchers to 300+, training models that solve International Math Olympiad problems in a live competition, and building the i

Brex’s AI Hail Mary — With CTO James Reggio Jan 17, 2026 4406 From building internal AI labs to becoming CTO of Brex, James Reggio has helped lead one of the most disciplined AI transformations inside a real financial institution where compliance, auditability, and customer trust actually matter.We sat down with Reggio to unpack Brex’s three-pillar AI strategy (corporate, operational, and product AI) [https://www.brex.com/journal/brex-ai-native-operations],

Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith Jan 8, 2026 4704 Happy New Year! You may have noticed that in 2025 we had moved toward YouTube as our primary podcasting platform. As we’ll explain in the next State of Latent Space post, we’ll be doubling down on Substack again and improving the experience for the over 100,000 of you who look out for our emails and website updates!We first mentioned Artificial Analysis in 2024, when it was still a side project in

[State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena Jan 6, 2026 1442 We are reupping this episode after LMArena announced their fresh Series A (https://www.theinformation.com/articles/ai-evaluation-startup-lmarena-valued-1-7-billion-new-funding-round?rc=luxwz4), raising $150m at a $1.7B valuation, with $30M annualized consumption revenue (aka $2.5m MRR) after their September evals product launch.—-From building LMArena in a Berkeley basement to raising $100M and be

[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton Jan 2, 2026 1699 From undergraduate research seminars at Princeton to winning Best Paper award at NeurIPS 2025, Kevin Wang, Ishaan Javali, Michał Bortkiewicz, Tomasz Trzcinski, Benjamin Eysenbach defied conventional wisdom by scaling reinforcement learning networks to 1,000 layers deep—unlocking performance gains that the RL community thought impossible. We caught up with the team live at NeurIPS to dig into the s

[State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang Dec 31, 2025 1065 From creating SWE-bench in a Princeton basement to shipping CodeClash, SWE-bench Multimodal, and SWE-bench Multilingual, John Yang has spent the last year and a half watching his benchmark become the de facto standard for evaluating AI coding agents—trusted by Cognition (Devin), OpenAI, Anthropic, and every major lab racing to solve software engineering at scale. We caught up with John live at Neu

[State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI Dec 31, 2025 1654 From pre-training data curation to shipping GPT-4o, o1, o3, and now GPT-5 thinking and the shopping model, Josh McGrath has lived through the full arc of OpenAI’s post-training evolution—from the PPO vs DPO debates of 2023 to today’s RLVR era, where the real innovation isn’t optimization methods but data quality, signal trust, and token efficiency. We sat down with Josh at NeurIPS 2025 to dig into

[State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor Dec 30, 2025 2713 From Berkeley robotics and OpenAI’s 2017 Dota-era internship to shipping RL breakthroughs on GPT-4o, o1, and o3, and now leading model development at Cursor, Ashvin Nair has done it all. We caught up with Ashvin at NeurIPS 2025 to dig into the inside story of OpenAI’s reasoning team (spoiler: it went from a dozen people to 300+), why IOI Gold felt reachable in 2022 but somehow didn’t change the wo

[State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify Dec 30, 2025 1722 From investing through the modern data stack era (DBT, Fivetran, and the analytics explosion) to now investing at the frontier of AI infrastructure and applications at Amplify Partners, Sarah Catanzaro has spent years at the intersection of data, compute, and intelligence—watching categories emerge, merge, and occasionally disappoint. We caught up with Sarah live at NeurIPS 2025 to dig into the st

One Year of MCP — with David Soria Parra and AAIF leads from OpenAI, Goose, Linux Foundation Dec 27, 2025 5958 One year ago, Anthropic launched the Model Context Protocol (MCP)—a simple, open standard to connect AI applications to the data and tools they need. Today, MCP has exploded from a local-only experiment into the de facto protocol for agentic systems, adopted by OpenAI, Microsoft, Google, Block, and hundreds of enterprises building internal agents at scale. And now, MCP is joining the newly formed

Steve Yegge's Vibe Coding Manifesto: Why Claude Code Isn't It & What Comes After the IDE Dec 26, 2025 2244 Note: Steve and Gene’s talk on Vibe Coding and the post IDE world was one of the top talks of AIE CODE: From building legendary platforms at Google and Amazon to authoring one of the most influential essays on AI-powered development (Revenge of the Junior Developer, quoted by Dario Amodei himself), Steve Yegge has spent decades at the frontier of software engineering—and now he’s leading the charg

⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI Dec 26, 2025 1665 From the frontlines of OpenAI’s Codex and GPT-5 training teams, Bryan and Bill are building the future of AI-powered coding—where agents don’t just autocomplete, they architect, refactor, and ship entire features while you sleep. We caught up with them at AI Engineer Conference right after the launch of Codex Max, OpenAI’s newest long-running coding agent designed to work for 24+ hours straight, m

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow) Dec 18, 2025 4503 As with all demo-heavy and especially vision AI podcasts, we encourage watching along on our YouTube (and tossing us an upvote/subscribe if you like!)From SAM 1’s 11-million-image data engine to SAM 2’s memory-based video tracking, MSL’s Segment Anything project has redefined what’s possible in computer vision. Now SAM 3 takes the next leap: concept segmentation—prompting with natural language lik

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security Dec 16, 2025 2440 Note: this is Pliny and John’s first major podcast. Voices have been changed for opsec.From jailbreaking every frontier model and turning down Anthropic’s Constitutional AI challenge to leading BT6, a 28-operator white-hat hacker collective obsessed with radical transparency and open-source AI security, Pliny the Liberator and John V are redefining what AI red-teaming looks like when you refuse to

AI to AE's: Grit, Glean, and Kleiner Perkins' next Enterprise AI hit — Joubin Mirzadegan, Roadrunner Dec 12, 2025 4183 Glean started as a Kleiner Perkins incubation and is now a $7B, $200m ARR Enterprise AI leader. Now KP has tapped its own podcaster to lead it’s next big swing.From building go-to-market the hard way in startups (and scaling Palo Alto Networks’ public cloud business) to joining Kleiner Perkins to help technical founders turn product edge into repeatable revenue, Joubin Mirzadegan has spent the las

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