Latent Space: The AI Engineer Podcast
Latent Space is a podcast by and for AI engineers, covering foundation models, code generation, multimodality, AI agents, GPU infrastructure, and more. The show features interviews with founders, builders, and thinkers from companies like OpenAI, Anthropic, and Meta, providing insights into cutting-edge AI technology. It aims to give listeners both a definitive take on current trends and an introduction to emerging tools. The podcast has attracted over 10 million readers and listeners in 2025.
Episodes
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
This episode has a fun personal twist: There’s a counterfactual world where I was employee #1 at Genesis Molecular AI, the company behind today’s episode. A certain introduction happened a few weeks too late and I had already happily signed at Atomwise, another ML-for-drug-discovery startup. Same problem, different company. I was certain ML was going to transform small molecule drug discovery. Ea
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
We’re excited to have Databricks join us at AIEWF, among hundreds of the top companies in the AI Engineer ecosystem. LS subscribers can use their discount to get past the late bird pricing and access over $50k in sponsor offers! Everyone is still talking about Satya’s Frontier Ecosystems post, but few have actually built a (now $175 billion) frontier ecosystem and cloud like our guests today.From
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
AI Engineer World’s Fair regular bird tix will sell out ~today! Join us next week ahead of the Late Bird price hike and get >$40,000 in sponsor credits for attending!Thanks to the US Government issuing an export control directive on Mythos and Fable, the risks of jailbreaks and (industry term) indirect prompt injection are suddenly the talk of the town, though we have been covering AI security for
The Professor of Outputmaxxing — Anjney Midha, AMP
Last 4 days before regular tickets sell out at AI Engineer World’s Fair - this is the single biggest gathering of AI Engineers, Founders, Leaders, and Researchers in the world. Attendees get >$5000 worth of sponsor credits and talk tracks are looking FANTASTIC. Join us!The AI scaling debate always focuses on the question of “how do we get more GPUs?” but the better question may be: how do we make
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
On the Science pod, we’ve been covering a lot of the ground on how AI is revolutionizing STEM, but one of our favorite off the record topics since our launch is which field is harder to accelerate: math, bio, or physics? Today we’re back in Materials Science land with Radical — Unlike biological molecules that can be represented (and predicted!) by token strings, the success of materials involve m
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
The new AIEWF website is live! Get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets!Most industry benchmarks compress intelligence and reasoning ability into scores.SWE-Bench Pro, MMLU, Humanity’s Last Exam, etc. These metrics are useful, but don’t always represent the full extent of how a model performs in the real wo
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
In 2025, seven-month-old startup Axiom solved all 12 of the problems Putnam exam (scoring 8/12 in the time limit) a prestigious undergraduate math exam. The 12/12 score is better than the top undergraduates (110/120) and the closest AI system that reported a result (DeepSeek 103/120), although it is unclear what the people and other systems would have scored with more time. Nonetheless, the Putnam
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
We’ve informally heard that Satya is a listener to LS for a couple years now, but it was still absolutely surreal to meet him and do a live pod at Build, together with our friends at No Priors, the leading VC AI Podcast that we also greatly admire!We covered the MAI model technical takeaways on yesterday’s AINews, so I will focus our recap of Satya’s main messages around three elements:* Satya’s a
GitHub's plan for Agents — Kyle Daigle, GitHub
I’m excited to work with Microsoft once again as the presenting sponsors of the AI Engineer World’s Fair! We’ll streaming live from MS Build today for a special crossover pod with our friends at No Priors and the one and only Satya Nadella. However we did not hold back with this interview - we asked all the burning questions about uptime and Copilot that we know you have in your minds. Lets go!For
Why Video Agent models are next — Ethan He, xAI Grok Imagine
We’re announcing AIEWF speakers this week! Take the AI Engineering Survey!Today’s guest Ethan first joined us for the LS Paper Club as the lead on NVIDIA Cosmos World Model, but then joined xAI and built Grok Imagine in 3 months:He comes back on Latent Space with some nuclear hot takes: that Video Models primarily get their intelligence from LLMs, not from training on video data, and that the next
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
The new AIEWF website is live! CFPs close in 2 days and we will run our first New Engineer Orientation this weekend, get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets!One of the central tensions in the agents industry is that even while there are major decacorn agent labs like Sierra, Decagon, Notion and Cursor bein
🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “next token” objective: predict the amino acids that have been randomly masked out, based on the context of the rest of the
Giving Agents Computers — Ivan Burazin, Daytona
Take the 2026 AI Engineering Survey and get >$2k in credits and AIE WF tickets!On the product side, everyone is getting Computer - Perplexity, Manus, Cursor, and so on. Meanwhile on the research side, agentic evals like TerminalBench and GDPVal are also assuming computer (Harbor). On both ends, the consolidating LLM OS stack has become a standard toolkit, and Daytona is one of a small set of AI In
Railway: The Agent-Native Cloud — Jake Cooper
Take the 2026 AI Engineering Survey and get >$2k in credits and AIE WF tickets!This was recorded before Railway suffered a major GCP outage on May 19, despite being a multi-AZ, multi-zone mesh ring, with HA fiber interconnects between their Metal GCP AWS, because workload discoverability was unintentionally still tied to GCP. All has been resolved with a post-mortem.Railway did not start as an A
The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
The future of war has been evolving before our eyes in Ukraine, yet the west still plans to fight the last war. In this special episode, guest host Noah Smith (@noahpinion) and Brandon Anderson sit down with Yaroslav Azhnyuk (@YaroslavAzhnyuk), a serial tech founder who went from building PetCube to founding The Fourth Law, one of the world’s most advanced AI-guided drone companies. Over two hours
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
Special discounts up for AIE Melbourne (LS discount) and AIE World’s Fair (group discounts up to 25% - CFPs still open for Autoresearch and Vertical AI) Cya there!Abridge did not start as an “GPT wrapper”. It was founded in 2018, years before the Cambrian explosion of AI application layer companies. OpenAI launched ChatGPT publicly on November 30, 2022 and by then, Abridge had already spent years
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
Some people are going crazy over GPT 5.5. Some people. This is the story of the Jagged Frontier. People who use AI to write emails or even code implementation work find the lift moderate whereas people pushing the limits of the model are figuring out that the limits just moved outwards.Alex Lupsaska has been tracking this limit for a year and a half now. “When GPT5 came out, it was able to reprodu
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
From building Applied Intuition from YC-era autonomy tooling into a $15B physical AI company, Qasar Younis and Peter Ludwig have spent the last decade living through the full arc of autonomy: from simulation and data infrastructure for robotaxi companies, to operating systems for safety-critical machines, to deploying AI onto cars, trucks, mining equipment, construction vehicles, agriculture, defe
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
Today, we check in a year after the first Unsupervised Learning x Latent Space Crossover special to discuss everything that has changed (there is a lot) in the world of AI. This episode was recorded just after AIE Europe, but before the Cursor-xAI deal.Unsupervised Learning is a podcast that interviews the sharpest minds in AI about what’s real today, what will be real in the future and what it me
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Early bird discounts for the San Francisco World’s Fair, the biggest AIE gathering of the year, end today - prices will go up by ~$500 tonight so do please lock in ASAP!From near-universal AI tool adoption inside Shopify to internal systems for ML experimentation, auto-research, customer simulation, and ultra-low-latency search, Mikhail Parakhin joins us for a deep dive into what it actually looks
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
Today, we explain this piece of “clickbait” from our guest!TL;DR: 95% of cancer treatments fail to pass clinical trials, but it may be a matching problem — if we better understood what patients have which tumors which will respond to which treatments, success rates improve dramatically and millions of lives can be saved — with the treatments we ALREADY have.See our full episode dropping today:Why
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
For all those who missed out on London, see you in Miami next week!Notion, the knowledge work decacorn, has been building AI tooling since before ChatGPT, with many hits from Q&A in 2023 and unified AI in 2024 and Meeting Notes in 2025. At the end of their last Make user conference, Ryan Nystrom teased Notion 3.0’s Custom Agents - and they are finally embracing the Agent Lab playbook!Sarah Sachs a
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
We’re proud to release this ahead of Ryan’s keynote at AIE Europe. Hit the bell, get notified when it is live! Attendees: come prepped for Ryan’s AMA with Vibhu after.Move over, context engineering. Now it’s time for Harness engineering and the age of the token billionaires.Ryan Lopopolo of OpenAI is leading that charge, recently publishing a lengthy essay on Harness Eng that has become the talk o
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Fresh off raising a monster $15B, Marc Andreessen has lived through multiple computing platform shifts firsthand, from Mosaic and Netscape to cofounding A16z. In this episode, Marc joins swyx and Alessio in a16z’s legendary Sand Hill Road office to argue that AI is not just another hype cycle, but the payoff of an “80-year overnight success”: from neural nets and expert systems to transformers, re
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
We’ve been on a bit of a mini World Models series over the last quarter: from introducing the topic with Yi Tay, to exploring Marble with World Labs’ Fei-Fei Li and Justin Johnson, to previewing World Models learned from massive gaming datasets with General Intuition’s Pim de Witte (who has now written down their approach to World Models with Not Boring), to discussing the Cosmos World Model with
Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
Mistral has been on an absolute tear - with frequent successful model launches it is easy to forget that they raised the largest European AI round in history last year. We were long overdue for a Mistral episode, and we were very fortunate to work with Sophia and Howard to catch up with Pavan (Voxtral lead) and Guillaume (Chief Scientist, Co-founder) on the occasion of this week’s Voxtral TTS laun
🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
Materials science is the unsung hero of the science world. Behind every physical product you interact was decades of research into getting the properties of materials just right. Your gym clothes contain synthetic fibers developed over decades. The glass screen, diodes, and chip substrate technology needed to read this blog post were only viable due to many teams of material scientists.Our guest P
Dreamer: the Personal Agent OS — David Singleton
Mar 23 update for Latent Spacenauts: this episode was recorded before the Dreamer team announced they were joining Meta Superintelligence Labs, and it turned out to be the last interview they did before the news became public. Consider this a snapshot from just before the transition!In 2024, David Singleton left Stripe and joined forces with Hugo Barra for a buzzy stealth startup named /dev/agents
Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
Claude Cowork came out of an accident.Felix and the Anthropic team noticed something interesting with Claude Code: many users were using it primarily for all kinds of messy knowledge work instead of coding. Even technical builders would use it for lots of non-technical work.Even more shocking, Claude cowork wrote itself. With a team of humans simply orchestrating multiple claude code instances, th
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
Turbopuffer came out of a reading app.In 2022, Simon was helping his friends at Readwise scale their infra for a highly requested feature: article recommendations and semantic search. Readwise was paying ~$5k/month for their relational database and vector search would cost ~$20k/month making the feature too expensive to ship. In 2023 after mulling over the problem from Readwise, Simon decided he w
NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
Join Kyle, Nader, Vibhu, and swyx live at NVIDIA GTC next week!Now that AIE Europe tix are ~sold out, our attention turns to Miami and World’s Fair!The definitive AI Accelerator chip company has more than 10xed this AI Summer:And is now a $4.4 trillion megacorp… that is somehow still moving like a startup. We are blessed to have a unique relationship with our first ever NVIDIA guests: Kyle Kranen
Cursor's Third Era: Cloud Agents
All speakers are announced at AIE EU, schedule coming soon. Join us there or in Miami with the renowned organizers of React Miami! Singapore CFP also open!We’ve called this out a few times over in AINews, but the overwhelming consensus in the Valley is that “the IDE is Dead”. In November it was just a gut feeling, but now we actually have data: even at the canonical “VSCode Fork” company, people a
Every Agent Needs a Box — Aaron Levie, Box
The reception to our recent post on Code Reviews has been strong. Catch up!Amid a maelstrom of discussion on whether or not AI is killing SaaS, one of the top publicly listed SaaS companies in the world has just reported record revenues, clearing well over $1.1B in ARR for the first time with a 28% margin. As we comment on the pod, Aaron Levie is the rare public company CEO equally at home in both
METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
This is a free preview of a paid episode. To hear more, visit www.latent.spaceAIE Europe CFP and AIE World’s Fair paper submissions for CAIS peer review are due TODAY - do not delay! Last call ever.We’re excited to welcome METR for their first LS Pod, hopefully the first of many:METR are keepers of currently the single most infamous chart in AI:But every Latent Space reader should be sophisticated
[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
Swyx joined SAIL! Thank you SAIL Media, Prof. Tom Yeh, 8Lee, Hamid Bagheri, c9n, and many others for tuning into SAIL Live #6 with Nathan Lambert and Sebastian Raschka, PhD. Sharing here for the LS paid subscribers.We covered: This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.latent.space/subscribe
🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
Editor’s note: CuspAI raised a $100m Series A in September and is rumored to have reached a unicorn valuation. They have all-star advisors from Geoff Hinton to Yann Lecun and team of deep domain experts to tackle this next frontier in AI applications.In this episode, Max Welling traces the thread connecting quantum gravity, equivariant neural networks, diffusion models, and climate-focused materia
Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis
This is a free preview of a paid episode. To hear more, visit www.latent.spaceFirst speakers for AIE Europe and AIEi Miami have been announced. If you’re in Asia/Aus, come by Singapore and Melbourne. AI Engineering is going global!One year ago today, Anthropic launched Claude Code, to not much fanfare:The word of mouth was incredibly strong however, and so we were glad to be one of the first podca
⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
Olivia Watkins (Frontier Evals team) and Mia Glaese (VP of Research at OpenAI, leading the Codex, human data, and alignment teams) discuss a new blog post (https://openai.com/index/why-we-no-longer-evaluate-swe-bench-verified/) arguing that SWE-Bench Verified—long treated as a key “North Star” coding benchmark—has become saturated and highly contaminated, making it less useful for measuring real c
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
Tickets for AIEi Miami and AIE Europe are live, with first wave speakers announced!From pioneering software-defined networking to backing many of the most aggressive AI model companies of this cycle, Martin Casado and Sarah Wang sit at the center of the capital, compute, and talent arms race reshaping the tech industry. As partners at a16z investing across infrastructure and growth, they’ve watche
Owning the AI Pareto Frontier — Jeff Dean
From rewriting Google’s search stack in the early 2000s to reviving sparse trillion-parameter models and co-designing TPUs with frontier ML research, Jeff Dean has quietly shaped nearly every layer of the modern AI stack. As Chief AI Scientist at Google and a driving force behind Gemini, Jeff has lived through multiple scaling revolutions from CPUs and sharded indices to multimodal models that rea
🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
This podcast features Gabriele Corso and Jeremy Wohlwend, co-founders of Boltz and authors of the Boltz Manifesto, discussing the rapid evolution of structural biology models from AlphaFold to their own open-source suite, Boltz-1 and Boltz-2. The central thesis is that while single-chain protein structure prediction is largely “solved” through evolutionary hints, the next frontier lies in modeling
The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI
From Palantir and Two Sigma to building Goodfire into the poster-child for actionable mechanistic interpretability, Mark Bissell (Member of Technical Staff) and Myra Deng (Head of Product) are trying to turn “peeking inside the model” into a repeatable production workflow by shipping APIs, landing real enterprise deployments, and now scaling the bet with a recent $150M Series B funding round at a
🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White
Editor’s note: Welcome to our new AI for Science pod, with your new hosts RJ and Brandon! See the writeup on Latent.Space (https://Latent.Space) for more details on why we’re launching 2 new pods this year. RJ Honicky is a co-founder and CTO at MiraOmics (https://miraomics.bio/), building AI models and services for single cell, spatial transcriptomics and pathology slide analysis. Brandon Anderson
Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay
From shipping Gemini Deep Think and IMO Gold to launching the Reasoning and AGI team in Singapore, Yi Tay has spent the last 18 months living through the full arc of Google DeepMind’s pivot from architecture research to RL-driven reasoning—watching his team go from a dozen researchers to 300+, training models that solve International Math Olympiad problems in a live competition, and building the i
Brex’s AI Hail Mary — With CTO James Reggio
From building internal AI labs to becoming CTO of Brex, James Reggio has helped lead one of the most disciplined AI transformations inside a real financial institution where compliance, auditability, and customer trust actually matter.We sat down with Reggio to unpack Brex’s three-pillar AI strategy (corporate, operational, and product AI) [https://www.brex.com/journal/brex-ai-native-operations],
Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith
Happy New Year! You may have noticed that in 2025 we had moved toward YouTube as our primary podcasting platform. As we’ll explain in the next State of Latent Space post, we’ll be doubling down on Substack again and improving the experience for the over 100,000 of you who look out for our emails and website updates!We first mentioned Artificial Analysis in 2024, when it was still a side project in
[State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena
We are reupping this episode after LMArena announced their fresh Series A (https://www.theinformation.com/articles/ai-evaluation-startup-lmarena-valued-1-7-billion-new-funding-round?rc=luxwz4), raising $150m at a $1.7B valuation, with $30M annualized consumption revenue (aka $2.5m MRR) after their September evals product launch.—-From building LMArena in a Berkeley basement to raising $100M and be
[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton
From undergraduate research seminars at Princeton to winning Best Paper award at NeurIPS 2025, Kevin Wang, Ishaan Javali, Michał Bortkiewicz, Tomasz Trzcinski, Benjamin Eysenbach defied conventional wisdom by scaling reinforcement learning networks to 1,000 layers deep—unlocking performance gains that the RL community thought impossible. We caught up with the team live at NeurIPS to dig into the s
[State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang
From creating SWE-bench in a Princeton basement to shipping CodeClash, SWE-bench Multimodal, and SWE-bench Multilingual, John Yang has spent the last year and a half watching his benchmark become the de facto standard for evaluating AI coding agents—trusted by Cognition (Devin), OpenAI, Anthropic, and every major lab racing to solve software engineering at scale. We caught up with John live at Neu
[State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI
From pre-training data curation to shipping GPT-4o, o1, o3, and now GPT-5 thinking and the shopping model, Josh McGrath has lived through the full arc of OpenAI’s post-training evolution—from the PPO vs DPO debates of 2023 to today’s RLVR era, where the real innovation isn’t optimization methods but data quality, signal trust, and token efficiency. We sat down with Josh at NeurIPS 2025 to dig into
[State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor
From Berkeley robotics and OpenAI’s 2017 Dota-era internship to shipping RL breakthroughs on GPT-4o, o1, and o3, and now leading model development at Cursor, Ashvin Nair has done it all. We caught up with Ashvin at NeurIPS 2025 to dig into the inside story of OpenAI’s reasoning team (spoiler: it went from a dozen people to 300+), why IOI Gold felt reachable in 2022 but somehow didn’t change the wo
[State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify
From investing through the modern data stack era (DBT, Fivetran, and the analytics explosion) to now investing at the frontier of AI infrastructure and applications at Amplify Partners, Sarah Catanzaro has spent years at the intersection of data, compute, and intelligence—watching categories emerge, merge, and occasionally disappoint. We caught up with Sarah live at NeurIPS 2025 to dig into the st
One Year of MCP — with David Soria Parra and AAIF leads from OpenAI, Goose, Linux Foundation
One year ago, Anthropic launched the Model Context Protocol (MCP)—a simple, open standard to connect AI applications to the data and tools they need. Today, MCP has exploded from a local-only experiment into the de facto protocol for agentic systems, adopted by OpenAI, Microsoft, Google, Block, and hundreds of enterprises building internal agents at scale. And now, MCP is joining the newly formed
Steve Yegge's Vibe Coding Manifesto: Why Claude Code Isn't It & What Comes After the IDE
Note: Steve and Gene’s talk on Vibe Coding and the post IDE world was one of the top talks of AIE CODE: From building legendary platforms at Google and Amazon to authoring one of the most influential essays on AI-powered development (Revenge of the Junior Developer, quoted by Dario Amodei himself), Steve Yegge has spent decades at the frontier of software engineering—and now he’s leading the charg
⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI
From the frontlines of OpenAI’s Codex and GPT-5 training teams, Bryan and Bill are building the future of AI-powered coding—where agents don’t just autocomplete, they architect, refactor, and ship entire features while you sleep. We caught up with them at AI Engineer Conference right after the launch of Codex Max, OpenAI’s newest long-running coding agent designed to work for 24+ hours straight, m
SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)
As with all demo-heavy and especially vision AI podcasts, we encourage watching along on our YouTube (and tossing us an upvote/subscribe if you like!)From SAM 1’s 11-million-image data engine to SAM 2’s memory-based video tracking, MSL’s Segment Anything project has redefined what’s possible in computer vision. Now SAM 3 takes the next leap: concept segmentation—prompting with natural language lik
⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security
Note: this is Pliny and John’s first major podcast. Voices have been changed for opsec.From jailbreaking every frontier model and turning down Anthropic’s Constitutional AI challenge to leading BT6, a 28-operator white-hat hacker collective obsessed with radical transparency and open-source AI security, Pliny the Liberator and John V are redefining what AI red-teaming looks like when you refuse to
AI to AE's: Grit, Glean, and Kleiner Perkins' next Enterprise AI hit — Joubin Mirzadegan, Roadrunner
Glean started as a Kleiner Perkins incubation and is now a $7B, $200m ARR Enterprise AI leader. Now KP has tapped its own podcaster to lead it’s next big swing.From building go-to-market the hard way in startups (and scaling Palo Alto Networks’ public cloud business) to joining Kleiner Perkins to help technical founders turn product edge into repeatable revenue, Joubin Mirzadegan has spent the las
The Future of Email: Superhuman CTO on Your Inbox As the Real AI Agent (Not ChatGPT) — Loïc Houssier
From applied cryptography and offensive security in France’s defense industry to optimizing nuclear submarine workflows, then selling his e-signature startup to Docusign (https://www.docusign.com/company/news-center/opentrust-joins-docusign-global-trust-network and now running AI as CTO of Superhuman Mail (Superhuman, recently acquired by Grammarly https://techcrunch.com/2025/07/01/grammarly-acqui
World Models & General Intuition: Khosla's largest bet since LLMs & OpenAI
From building Medal into a 12M-user game clipping platform with 3.8B highlight moments to turning down a reported $500M offer from OpenAI (https://www.theinformation.com/articles/openai-offered-pay-500-million-startup-videogame-data) and raising a $134M seed from Khosla (https://techcrunch.com/2025/10/16/general-intuition-lands-134m-seed-to-teach-agents-spatial-reasoning-using-video-game-clips/) t
After LLMs: Spatial Intelligence and World Models — Fei-Fei Li & Justin Johnson, World Labs
Fei-Fei Li and Justin Johnson are cofounders of World Labs, who have recently launched Marble (https://marble.worldlabs.ai/), a new kind of generative “world model” that can create editable 3D environments from text, images, and other spatial inputs. Marble lets creators generate persistent 3D worlds, precisely control cameras, and interactively edit scenes, making it a powerful tool for games, fi
⚡️ 10x AI Engineers with $1m Salaries — Alex Lieberman & Arman Hezarkhani, Tenex
Alex Lieberman and Arman Hezarkani, co-founders of Tenex, reveal how they’re revolutionizing software consulting by compensating AI engineers for output rather than hours—enabling some engineers to earn over $1 million annually while delivering 10x productivity gains. Their company represents a fundamental rethinking of knowledge work compensation in the age of AI agents, where traditional hourly
Anthropic, Glean & OpenRouter: How AI Moats Are Built with Deedy Das of Menlo Ventures
Deedy Das, Partner at Menlo Ventures, returns to Latent Space to discuss his journey from Glean to venture capital, the explosive rise of Anthropic, and how AI is reshaping enterprise software and coding. From investing in Anthropic early on when they had no revenue to managing the $100M Ontology Fund, Das shares insider perspectives on the fastest-growing software company in history and what’s ne
⚡ Inside GitHub’s AI Revolution: Jared Palmer Reveals Agent HQ & The Future of Coding Agents
Jared Palmer, SVP at GitHub and VP of CoreAI at Microsoft, joins Latent Space for an in-depth look at the evolution of coding agents and modern developer tools. Recently joining after leading AI initiatives at Vercel, Palmer shares firsthand insights from behind the scenes at GitHub Universe, including the launch of Agent HQ which is a new collaboration hub for coding agents and developers.This ep
⚡ [AIE CODE Preview] Inside Google Labs: Building The Gemini Coding Agent — Jed Borovik, Jules
Jed Borovik, Product Lead at Google Labs, joins Latent Space to unpack how Google is building the future of AI-powered software development with Jules. From his journey discovering GenAI through Stable Diffusion to leading one of the most ambitious coding agent projects in tech, Borovik shares behind-the-scenes insights into how Google Labs operates at the intersection of DeepMind’s model developm
⚡️ Ship AI recap: Agents, Workflows, and Python — w/ Vercel CTO Malte Ubl
In this conversation with Malte Ubl, CTO of Vercel (http://x.com/cramforce), we explore how the company is pioneering the infrastructure for AI-powered development through their comprehensive suite of tools including workflows, AI SDK, and the newly announced agent ecosystem. Malte shares insights into Vercel’s philosophy of “dogfooding” - never shipping abstractions they haven’t battle-tested the
Why RL Won — Kyle Corbitt, OpenPipe (acq. CoreWeave)
In this deep dive with Kyle Corbitt, co-founder and CEO of OpenPipe (recently acquired by CoreWeave), we explore the evolution of fine-tuning in the age of AI agents and the critical shift from supervised fine-tuning to reinforcement learning. Kyle shares his journey from leading YC’s Startup School to building OpenPipe, initially focused on distilling expensive GPT-4 workflows into smaller, cheap
DevDay 2025: Apps SDK, Agent Kit, MCP, Codex and why Prompting is More Important than Ever
At OpenAI DevDay, we sit down with Sherwin Wu and Christina Huang from the OpenAI Platform Team to discuss the launch of AgentKit - a comprehensive suite of tools for building, deploying, and optimizing AI agents. Christina walks us through the live demo she performed on stage, building a customer support agent in just 8 minutes using the visual Agent Builder, while Sherwin shares insights on how
Taste is your Moat (Dylan Field of Figma)
Dylan Field (CEO Figma) on how they are letting designers build with Figma Make, how Figma can be the context repository for aesthetic in the age of vibe coding, and why design is your only differentiator now.Full show notes: https://www.latent.space/p/figma This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.latent.space/subscr
Amp: The Emperor Has No Clothes
Quinn Slack (CEO) and Thorsten Ball (Amp Dictator) from SourceGraph join the show to talk about Amp Code, how they ship 15x/day with no code reviews, and why subagents and prompt optimizers aren’t a promising direction for coding agents.Amp Code: https://ampcode.com/Latent Space: https://latent.space/Full Video EpisodeTimestamps00:00 Introduction00:41 Transition from Cody to Amp03:18 The Importanc
Context Engineering for Agents - Lance Martin, LangChain
Lance: https://www.linkedin.com/in/lance-martin-64a33b5/How Context Fails: https://www.dbreunig.com/2025/06/22/how-contexts-fail-and-how-to-fix-them.htmlHow New Buzzwords Get Created: https://www.dbreunig.com/2025/07/24/why-the-term-context-engineering-matters.htmlContent Engineering: https://rlancemartin.github.io/2025/06/23/context_engineering/ https://docs.google.com/presentation/d/16aaXLu40Gu
Better Data is All You Need — Ari Morcos, Datology
Our chat with Ari shows that data curation is the most impactful and underinvested area in AI. He argues that the prevailing focus on model architecture and compute scaling overlooks the “bitter lesson” that “models are what they eat.” Effective data curation—a sophisticated process involving filtering, rebalancing, sequencing (curriculum), and synthetic data generation—allows for training models
The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)
We first had Nathan on to give us his RLHF deep dive when he was joining AI2, and now he’s back to help us catch up on the evolution to RLVR (Reinforcement Learning with Verifiable Rewards), first proposed in his Tulu 3 paper. While RLHF remains foundational, RLVR has emerged as a powerful approach for training models on tasks with clear success criteria and using verifiable, objective functions a
AI is Eating Search
ChatGPT handles 2.5B prompts/day and is on track to match Google’s daily searches by end of 2026. AI agents don’t browse like us—they crave queryable, chunkable data for tools like ChatGPT & Perplexity. A new industry is being born, some are calling it AI SEO, others GEO, but what is clear is that it drives amazing results. Businesses are seeing 2-4x higher conversion from visitors coming from AI
Cline: the open source coding agent that doesn't cut costs
Saoud Rizwan and Pash from Cline joined us to talk about why fast apply models got bitter lesson’d, how they pioneered the plan + act paradigm for coding, and why non-technical people use IDEs to do marketing and generate slides.Full writeup: https://www.latent.space/p/clineX: https://x.com/latentspacepodFull Video EpisodeTimestamps00:00 - Introductions 01:35 - Plan and Act Paradigm 05:37 - Model
Personalized AI Language Education — with Andrew Hsu, Speak
Speak (https://speak.com) may not be very well known to native English speakers, but they have come from a slow start in 2016 to emerge as one of the favorite partners of OpenAI, with their Startup Fund leading and joining their Series B and C as one of the new AI-native unicorns, noting that “Speak has the potential to revolutionize not just language learning, but education broadly”.Today we spea
AI Video Is Eating The World — Olivia and Justine Moore, a16z
When the first video diffusion models started emerging, they were little more than just “moving pictures” - still frames extended a few seconds in either direction in time. There was a ton of excitement about OpenAI’s Sora on release through 2024, but so far only Sora-lite has been widely released. Meanwhile, other good videogen models like Genmo Mochi, Pika, MiniMax T2V, Tencent Hunyuan Video, an
Information Theory for Language Models: Jack Morris
Our last AI PhD grad student feature was Shunyu Yao, who happened to focus on Language Agents for his thesis and immediately went to work on them for OpenAI. Our pick this year is Jack Morris, who bucks the “hot” trends by -not- working on agents, benchmarks, or VS Code forks, but is rather known for his work on the information theoretic understanding of LLMs, starting from embedding models and la
Scaling Test Time Compute to Multi-Agent Civilizations — Noam Brown, OpenAI
Solving Poker and Diplomacy, Debating RL+Reasoning with Ilya, what’s *wrong* with the System 1/2 analogy, and where Test-Time Compute hits a wallFull Video EpisodeTimestamps00:00 Intro – Diplomacy, Cicero & World Championship 02:00 Reverse Centaur: How AI Improved Noam’s Human Play 05:00 Turing Test Failures in Chat: Hallucinations & Steerability 07:30 Reasoning Models & Fast vs. Slow Thinking Par
The Utility of Interpretability — Emmanuel Amiesen
Emmanuel Amiesen is lead author of “Circuit Tracing: Revealing Computational Graphs in Language Models” (https://transformer-circuits.pub/2025/attribution-graphs/methods.html ), which is part of a duo of MechInterp papers that Anthropic published in March (alongside https://transformer-circuits.pub/2025/attribution-graphs/biology.html ).We recorded the initial conversation a month ago, but then he
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