Optimal Protein Podcast with Vanessa Spina
Vanessa Spina, a Sports Nutrition Specialist and best-selling author, hosts this podcast focused on optimizing protein intake for metabolic health and fitness. The show features interviews with leading protein scientists, experts, and individuals with inspiring transformation stories. Topics include whole foods nutrition, exercise, and tools for achieving leanness and improved health.
Episodes
PSMF SERIES: Burn More Belly Fat? The Protein Pacing Study Explained
🇺🇸 4th of July Sale Starts Now! Celebrate Independence Day with our biggest sale of the summer! 🎉 Save 40% on: 📘 The PSMF Library ❤️ Tone LUX Red Light Therapy 💨 The Tone Breath Ketone Analyzer Use code: INDEPENDENCEDAY40 ⏰ Limited-time offer. 👉 Shop now at ketogenicgirl.com Welcome back to the Optimal Protein Podcast Summer PSMF Series, where we're exploring the science, history, and practical
The Truth About Menopause, Belly Fat & Insulin Resistance with Cynthia Thurlow
In this episode, Vanessa sits down with bestselling author, nurse practitioner, and Everyday Wellness host Cynthia Thurlow to discuss why women who enter perimenopause with more muscle and better metabolic health often experience a smoother transition. The PSMF Library is officially live 🎉 👉 Check it out here + get 20% off with code VANESSA They explore protein intake, intermittent fasting, testos
PSMF SERIES: PSMF Explained—Burn Fat, Stay Full & Preserve Lean Mass with Dr. David Jockers
Protein-sparing modified fasting (PSMF) has been used for decades as one of the most effective evidence-based approaches for rapid fat loss while preserving lean muscle. But how does it actually work, and who is it best suited for? Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA for 20% off. In this episode, Vanessa sits down with returning guest Dr
The Amino Acid Truth for Fat Loss: Why Protein Labels Are Misleading with Dr. Hans Stein
In this episode, Vanessa Spina interviews Dr. Hans H. Stein, Professor of Animal Sciences at the University of Illinois Urbana-Champaign, about protein quality, amino acid digestibility, and why "grams of protein" on a label do not always reflect what the body can actually use. The PSMF Library is officially live 🎉 👉 Check it out here + get 20% off with code VANESSA . Stein explains why we do not
PSMF SERIES: Burn Stored Body Fat: The Science Behind Protein-Sparing Modified Fasting: Dr. Brian Mowll
In this episode of the Optimal Protein Podcast, Vanessa is joined by Dr. Brian Mowll for a deep dive into protein-sparing modified fasting, or PSMF, as part of the Friday Protein-Sparing Modified Fasting Series. Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA for 20% off. Dr. Mowll explains the origins of PSMF, how it was first developed in clinical
New Research on Muscle, Pregnancy, Menopause & Aging Strong: Dr. Christina Prevett
In this episode of the Optimal Protein Podcast, Vanessa Spina is joined by Dr. Christina Prevett, physiotherapist, researcher, and expert in women's health, strength training, pregnancy, postpartum recovery, and healthy aging. The PSMF Library is officially live 🎉 👉 Check it out here + get 20% off with code VANESSA Dr. Prevett shares why women are not fragile — and why strength training can be one
PSMF SERIES: Protein Sparing Modified Fasting 101: Burn Fat, Preserve Muscle & Break Through Fat Loss Stalls
Welcome to the first episode of the Summer Protein Sparing Modified Fasting Series on the Optimal Protein Podcast. In this episode, Vanessa introduces the science, history, and practical application of protein sparing modified fasting, or PSMF, as a powerful tool for fat loss and body recomposition. Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA fo
Episode #800! Why Low-Carb Burns More Fat in a Calorie Deficit with Dr. Fernando Naclerio
In this fascinating episode of the Optimal Protein Podcast, Vanessa Spina is joined by Dr. Fernando Naclerio, Professor in Strength Training and Sports Nutrition at the University of Greenwich and Centre Lead for the Centre for Exercise Activity and Rehabilitation. Vanessa and Dr. Naclerio dive into a brand new meta-analysis comparing higher-carb and lower-carb diets when calories and protein are
Why Low-Protein Diets Backfire for Fat Loss: Dr. Dan Moore Recap
In this solo episode, Vanessa breaks down the biggest takeaways from her conversation with Daniel R. Moore, Professor of Muscle Physiology at the University of Toronto. This episode is a deep dive into muscle protein synthesis, protein intake, fat loss, aging, and why preserving lean mass is one of the most important factors for long-term metabolic health and body composition. Check out the Protei
Why Low-Protein Diets Can Backfire for Fat Loss: Dr. Dan Moore
In this episode, Vanessa sits down with Daniel R. Moore, Professor of Muscle Physiology at the University of Toronto, for a deep dive into protein, muscle protein synthesis, fat loss, and aging. The PSMF Library is officially live 🎉 👉 Check it out here + get 20% off with code VANESSA Dr. Moore explains what muscle protein synthesis actually is, how it's measured in research using metabolic tracers
Maria Emmerich Recap: The Hormone Changes Affecting Fat Loss
Why does fat loss suddenly become harder after 40 — even when women are dieting and exercising? In this Friday solocast recap, Vanessa breaks down the biggest takeaways from her conversation with Maria Emmerich on menopause, hormones, insulin resistance, body composition, HRT, peptides, and metabolic health. Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code V
Maria Emmerich: HRT, Peptides & Why Fat Loss Changes in Menopause
Why does fat loss suddenly become harder in perimenopause and menopause — even when women are dieting and exercising? In this episode, Maria Emmerich joins Vanessa to unpack the hormonal and metabolic shifts driving changes in body composition after 40. The PSMF Library is officially live 🎉 👉 Check it out here + get 20% off with code VANESSA They discuss estrogen and insulin resistance, testostero
New Rapid Fat Loss Study, Menopause Weight Loss Resistance & More: Dr. Bill Campbell Recap
In this Friday deep dive recap, Vanessa Spina breaks down the biggest takeaways from her recent interview with leading body composition researcher Dr. Bill Campbell. 🎉 The Memorial Day Sale starts early! Use code MEMORIALDAY40 for 40% off Tone devices & red light therapy, and MEMORIALDAY25 for 25% off the brand new PSMF Library including the digital download, printed book, and 2 months free commun
New Rapid Fat Loss Study, Menopause Weight Loss Resistance & More | Dr. Bill Campbell
In this episode, Vanessa Spina is joined again by leading body composition scientist Dr. Bill Campbell for a deep dive into menopause, weight loss resistance, rapid fat loss, protein, muscle preservation, and the newest research coming out of his lab. 🎉 The Memorial Day Sale starts early! Use code MEMORIALDAY40 for 40% off Tone devices & red light therapy, and MEMORIALDAY25 for 25% off the brand n
The Muscle-First Approach to Fat Loss, Protein & Healthy Aging - Dr. Antonella Schwarz Recap
In this Friday solo recap, Vanessa breaks down the biggest takeaways from her recent interview with Dr. Antonella Schwarz on why the goal should not simply be to lose weight, but to build and preserve muscle. Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA for 20% off. Vanessa explores the critical difference between weight loss and fat loss, why th
Build Muscle to Burn Fat & Age Better with Dr. Antonella Schwarz
Dr. Antonella Schwarz returns to the Optimal Protein Podcast to discuss her latest study restuls and why building muscle—not simply losing weight—is one of the most powerful things we can do for longevity, metabolic health, and body composition. The PSMF Library is officially live 🎉 👉 Check it out here + get 20% off with code VANESSA In this episode, Vanessa and Dr. Schwarz dive into why the scale
The Real Reason Keto Stops Working for Fat Loss & The Protein Shift That Fixes Keto Fat Loss Stalls (Craig Emmerich Recap)
Why do so many people lose weight at first on keto or carnivore… only to eventually stall or even gain weight? In this Friday recap episode, Vanessa breaks down the biggest takeaways from her interview with Craig Emmerich, co-author of The Art of Metabolic Health. She explains why ketosis alone does not guarantee body fat loss, why high dietary fat can prevent the body from tapping into stored fat
Why You're Not Losing Fat on Keto — and How to Fix It: Craig Emmerich
Why do so many people lose weight on keto… only to stall—or even gain it back? In this episode, Vanessa sits down with Craig Emmerich to break down one of the biggest misconceptions in fat loss: that simply eating high fat will keep the weight coming off. Together, they unpack why high-fat keto can stall fat loss, how fuel partitioning actually works, and what your body is being driven to burn bas
The Fat Loss Formula: Why Protein + Fiber Work Better Together (Plus How Much Fiber You Actually Need)
You've been told to eat more fiber… But what if that's not why you're still hungry? In this Friday recap, Vanessa breaks down the biggest insights from her conversation with Dr. Joanne Slavin — a leading fiber researcher who still says most people are focusing on the wrong thing for fat loss. This episode unpacks why some "high fiber" diets backfire, what actually controls appetite, and the simple
Fiber Expert Says THIS Matters More for Fat Loss… (It's Not Fiber) | Dr. Joanne Slavin
In this episode, Vanessa sits down with Dr. Joanne Slavin, Professor of Food Science and Nutrition at the University of Minnesota and one of the most highly cited researchers in nutrition science on fiber, satiety and protein. 👉 Extended one more day: The PSMF Library is available at ketogenicgirl.com — use code PSMFLAUNCHDISCOUNT70 to save $70! With decades of research on dietary fiber, satiety,
New Meta-Analysis: The EXACT Protein Intake During Fat Loss for Muscle Preservation
In today's Friday deep dive, Vanessa breaks down one of the most important new studies in fat loss and body recomposition — along with her recent interview with Dr. Eric Helms. This episode explores a cutting-edge meta-regression by Dr. Eric Helms, Dr. Eric Trexler, and Dr. Martin Refalo on protein intake during caloric restriction — and what it means for preserving muscle while losing fat. Last
New Meta-Analysis: How to Burn Fat & Preserve Muscle While Dieting | Dr. Eric Helms
Vanessa Spina is joined by Dr. Eric Helms to break down the latest research on protein intake during fat loss and what it really takes to preserve muscle while dieting. 🔗 PSMF LIBRARY (PRE-ORDER)Time Limited Offer The PSMF Library is officially live for pre-order 🎉 get the LAUNCH discount HERE They discuss Dr. Helms' new meta-regression, whether more protein always leads to better outcomes, how
New Study Changes Everything About Protein, Fat Loss & Muscle: Dr. Carlene Starck Recap!
In this episode, Vanessa breaks down one of the most important conversations on the podcast to date — her interview with Dr. Carlene Starck on newly published research suggesting that protein requirements may be significantly higher than current guidelines. 🔗 PSMF LIBRARY (PRE-ORDER) The PSMF Library is officially live for pre-order 🎉 get the LAUNCH discount HERE Vanessa dives into what this new
New Study: Protein Requirements May Be Too Low — What This Means for Muscle, Fat Loss & Health | Dr. Carlene Starck
In this episode, Vanessa is joined by Dr. Carlene Starck to break down her newly published research on protein and essential amino acid requirements — and why current recommendations may be too low. 🔗 PSMF LIBRARY (PRE-ORDER)Time Limited Offer The PSMF Library is officially live for pre-order 🎉 get the LAUNCH discount HERE They explore how protein needs have traditionally been calculated, what's
The Real Macros Behind the 5 Most Popular Diets — Rating Them for Fat Loss & Muscle Preservation
In today's episode, Vanessa breaks down five of the most popular diet protocols of the last 50 years — and compares them directly to Protein-Sparing Modified Fasting (PSMF) days. 🔗 PSMF LIBRARY (PRE-ORDER) The PSMF Library is officially live for pre-order 🎉 get the LAUNCH discount HERE She unpacks: The Bernstein Diet The Zone Diet (40/30/30) The Ornish Diet (very low fat) The HCG very low
The PSMF Library Is Live! Special Announcement
The PSMF Library is officially live for pre-order — and I'm so excited to finally share this with you! This is a resource I created based on what worked so effectively for me for fat loss and body recomposition — using a structured, high-protein approach instead of trying to restrict calories every single day. Instead of guessing what to eat or constantly starting over, this framework helps you st
Monday Special AMA #22: Fat Loss, Protein & PSMF — Your Top Questions Answered (Part 2 of 2)
In Part 2 of this AMA, Vanessa answers your most asked questions on protein, fat loss, muscle, and metabolism — including digestion issues, emotional eating, protein myths, and how to optimize your intake for better body composition results. 📩 Join the waitlist for Vanessa's upcoming Protein-Sparing Modified Fasting Library and receive the special LAUNCH DISCOUNT! Join HERE If you've been struggli
Secrets of Popular Diets: Fasting Mimicking Diet (FMD) — Calories, Macros & the High-Protein Advantage for Fat Loss & Muscle
In this episode, Vanessa breaks down the fasting mimicking diet (FMD) — including the exact calories, macros, and protein intake used in the research — and compares it to higher-protein fat loss approaches like protein-sparing modified fasting (PSMF) days. 📩 Join the waitlist for Vanessa's upcoming Protein-Sparing Modified Fasting Library and receive the special LAUNCH DISCOUNT! Join HERE You'll l
Special AMA #22: Fat Loss, Protein & PSMF: Answering Your Top Questions (Part 1 of 2)
In this AMA episode, Vanessa answers your questions on fat loss, protein intake, PSMF, keto, pregnancy nutrition, and muscle preservation. Topics include perimenopause fat loss, protein timing, ketosis myths, GLP-1 considerations, and how to structure high-protein days for body recomposition. 📩 Join the waitlist for Vanessa's upcoming Protein-Sparing Modified Fasting Library and receive the specia
New Study Changes Everything About Carbs, Fat Loss & Performance (Explained, Dr. Andrew Koutnik Recap)
Vanessa breaks down a groundbreaking new study on carbs, fat loss, metabolism, and performance — and what it means for high protein, low carb, and ketogenic approaches. 📩 Join the waitlist for Vanessa's upcoming Protein-Sparing Modified Fasting Library and receive the special LAUNCH DISCOUNT! Join HERE Vanessa breaks down one of the most important conversations on fat loss, metabolism, and perform
Groundbreaking New Study Changes Everything About Carbs, Fat Loss & Performance | Dr. Andrew Koutnik
Why protein + ketones reduce hunger, how fat-adapted athletes perform without carbs, and what this new study reveals. Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode, Vanessa breaks down one of the most controversial and important new papers in metabolism and sports nutr
Can You Lose Fat Eating MORE Calories? Shocking Protein Studies Explained (Dr. Jose Antonio Recap)
📩 Join the waitlist for Vanessa's upcoming Protein-Sparing Modified Fasting Library and receive the special LAUNCH DISCOUNT! Join HERE What if eating more protein — even more calories — didn't cause fat gain? What if it did the opposite instead? In this episode, Vanessa recaps her conversation with sports nutrition researcher Dr. Jose Antonio, whose groundbreaking studies on protein overfeeding fo
More Protein, More Fat Loss? | Dr. Jose Antonio
In this episode of the Optimal Protein Podcast, Vanessa sits down with sports nutrition scientist Dr. Jose Antonio, one of the world's leading researchers on protein metabolism and body composition. Dr. Antonio is widely known for his groundbreaking protein overfeeding studies, which found that participants consuming extremely high protein diets did not gain body fat — and in some cases actually l
Hormones, Fasting & Fat Loss: Dr. Jason Fung Recap
📩 Join the waitlist for Vanessa's upcoming Protein-Sparing Modified Fasting Library and receive the special LAUNCH DISCOUNT! Join HERE In this episode, Vanessa Spina breaks down the biggest insights from her recent conversation with Dr. Jason Fung, one of the leading voices in fasting and metabolic health. The episode also covers fasting strategies, emerging research on protein-supported fasting a
The NEW Era of Fasting: PSMF vs Water Fasting & The 3 Types of Hunger | Dr. Jason Fung
In this episode, Vanessa is joined by Dr. Jason Fung, author of The Hunger Code, to unpack the hormonal science behind fat loss — and how fasting may be entering a new era. They start with the three types of hunger and why obesity is not simply about willpower, but disrupted hormonal signaling. We break down insulin's role in fat storage, obesity, and how ultra-processed foods blunt satiety hormon
6 Fat Loss Secrets from Elite Athletes: Why They Don't Diet, Eat More Protein & Time Carbs
What do elite athletes do differently when it comes to fat loss? In this episode, Vanessa breaks down the most surprising takeaways from her conversation with sports dietitian Emily Mitchell, who has worked with professional teams including UCLA Athletics, the LA Galaxy, the Clippers, and the Buccaneers. While many people think getting lean requires constant dieting, eliminating carbohydrates, and
The Elite Fat Loss Formula: Nutrition Secrets of Elite Athletes
What do elite athletes do differently when it comes to fat loss and body composition? In this episode, Vanessa sits down with Emily Mitchell, RD, CSSD, CDCES — former Director of Sports Nutrition at UCLA Athletics, Sports Performance Dietitian for the LA Galaxy, and current Registered Dietitian at Love.Life — to unpack the real nutrition strategies used at the highest levels of sport. You'll learn
Burn Fat Faster: The Protein Strategy That Changes Everything
Is fasted cardio really better for fat loss? Or could eating protein before your workout actually improve fat burning, muscle retention, and long-term metabolic health — especially for women? In this deep-dive masterclass recap, Vanessa breaks down the science from her interview with exercise physiologist Dr. Katie Hirsch and unpacks the research on: Fasted vs fed training Essential amino acids b
Stop Training Fasted? Protein Timing That Boosts Fat Loss in Women — Dr. Katie Hirsch
Fasted training is one of the most persistent fat-loss myths—and in this episode, Dr. Katie Hirsch breaks down what actually matters for women: training quality, muscle preservation, and metabolic health. We unpack why "burning more fat during a workout" is often the wrong target, and how a small amount of protein (or EAAs) before training can change perceived exertion, improve workout output, and
Protein Fasting: The Upgrade to Intermittent Fasting for Sustainable Fat Loss
Is fasting really the best way to lose fat — or is there a smarter, more strategic approach? In this masterclass episode, Vanessa introduces a powerful new concept: Protein Fasting — a structured approach using PSMF (Protein-Sparing Modified Fast) days to optimize fat loss, suppress appetite naturally, protect muscle, and potentially tap into fasting-like cellular signaling. 🧠 IQBAR – Try the Ulti
Ketosis for Perimenopause: Burn Fat, Fix Blood Sugar & Support Fertility — Dr. Nicole Huffman
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa Perimenopause isn't just about estrogen. If you're eating less, working out more, and still gaining belly fat or losing muscle, the real issue may be metabolic — not hormonal. In this episode, Vanessa sits down with Dr. Nicole Huffman to u
Why Fat Loss Stalls Despite High Protein: Protein That Actually Counts - Dr. Paul Moughan Recap
Start of episode recap is at 13.41 In today's Friday solocast, Vanessa Spina breaks down the biggest takeaways from her interview with Dr. Paul Moughan—one of the world's leading experts on protein quality, amino acid digestibility, and how much of the protein you eat actually becomes usable by the body. If you've ever wondered why fat loss stalls in a deficit, why muscle can drop even when you "h
The Missing Link in Fat Loss: Protein Quality vs Protein Intake — Dr. Paul Moughan
Protein grams don't tell the full story. In this episode, Vanessa Spina is joined by Paul Moughan, a world authority on protein quality and amino acid digestibility, to explore why fat loss can stall and muscle can be lost — even on a high-protein diet. Dr. Moughan, a Distinguished Professor at Massey University and architect of DIAAS, explains why protein absorbed and delivered to muscle matters
Two NEW Studies Change How We Think About Fat Loss & Training + Dr. Arny Ferrando Recap!
Start of Arny Ferrando's episode recap is at 14:00 minutes. In today's Friday solocast, Vanessa Spina recaps her recent interview with Arny Ferrando, one of the world's leading experts on human muscle protein metabolism — and explains why fat loss problems are often muscle problems in disguise. The episode opens with two brand-new studies that challenge common fat-loss assumptions, including new
Protein, Muscle & Women: New Science on Menopause & Body Composition - Dr. Arny Ferrando
In this episode of The Optimal Protein Podcast, Vanessa Spina welcomes back leading muscle metabolism researcher Dr. Arny Ferrando for a deep dive into protein, muscle, and women's physiology across the menopause transition. Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa They explore w
Creatine, Fat Cells & Body Recomposition: New Science You Haven't Heard — Dr. Scott Forbes
Most people think creatine only affects muscle strength and performance. But what if creatine also plays a role inside fat cells themselves—and could subtly influence fat loss and body recomposition? In this episode of the Optimal Protein Podcast, Vanessa Spina I recaps the key takeaways from the interview with Dr. Scott Forbes, focusing on fat loss, body recomposition, muscle preservation, protei
Body Recomposition vs Weight Loss: What Fat Loss Science Reveals — Dr. Scott Forbes
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa Most fat-loss advice focuses on the scale — but what if that's the wrong metric entirely? In this episode, Vanessa Spina is joined by Dr. Scott Forbes, exercise physiologist and professor at Brandon University, whose research challenges ma
The Fat Loss Hormone: New Science on Leptin + a 7-Day Leptin Reset Protocol
Skip to the start of the recap: 13:41 In today's Friday solo episode of The Optimal Protein Podcast, Vanessa breaks down the science of leptin — the hormone that determines whether your body will burn fat or protect it. Leptin isn't just about appetite. It's a metabolic permission signal, and when leptin signaling is disrupted, fat loss can stall even in a calorie deficit. 🧠 IQBAR – Try the Ultima
Light, Leptin & Fat Loss: How Circadian Biology Controls Metabolism — Dr. Catherine Clinton
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode, I'm joined by Dr. Catherine Clinton to explore how circadian biology, light exposure, and cellular electrical charge regulate metabolism, hormones, and fat loss — often beyond calories alone. We discuss how morning light i
Lose Fat Without Losing Muscle, PSMF VS Low Calorie, Protein Quality, Seed Oils vs Butter & Recovery Science —Recap of Dr. Nick Barringer
Skip to the start of the recap: 11:40 In today's solo recap, Vanessa unpacks the most important takeaways from her conversation with Dr. Nick Barringer—former U.S. Army officer, researcher, and Registered Dietitian—whose work with tactical athletes and elite military populations reveals what really happens to the body during fat loss, stress, and recovery. This episode explores why so many people
How To Lose Fat Without Losing Muscle, Seed Oils vs Butter, Surprising New Research on Collagen for Mood & Recovery — Dr. Nick Barringer
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode of the Optimal Protein Podcast, Vanessa is joined by Dr. Nick Barringer, former U.S. Army officer, researcher, Registered Dietitian, and Chief Academic Officer at Lionel University. Dr. Barringer has led cutting-edge resear
The New Protein Guidelines, Weight Loss Drugs & Fat Regain + Carb Tolerance & Fat Loss — Dr. Gabrielle Lyon Recap
Skip to the start of the episode: 11:52 In today's Friday solo recap on the Optimal Protein Podcast, I break down the most important takeaways from my recent conversation with Dr. Gabrielle Lyon — and why this episode has major implications for fat loss, metabolic health, and women's body composition. 🧠 IQBAR – Try the Ultimate Sampler Pack: IQBARs, IQMIX, and IQJOE! Text VANESSA to 64000 for a 20
Fat Loss, Midlife Metabolism & Why Muscle Is the Missing Link: Dr. Gabrielle Lyon
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode of the Optimal Protein Podcast, I'm joined by Dr. Gabrielle Lyon to break down the muscle-centered strategy every woman needs for fat loss, metabolic health, and long-term strength. We unpack why muscle — not hormones alone
2026 Goal Setting Masterclass: How to Set Health & Body Recomposition Goals You'll Actually Achieve
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa Most people don't fail at their goals because they lack discipline — they fail because they were never taught how to set goals that actually work. In this New Year solo episode, Vanessa shares a powerful, step-by-step goal-setting mastercl
2025's Biggest Body Recomposition, Fat Loss & Protein Breakthroughs
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In today's episode, I'm continuing our Best of 2025 series with a powerful follow-up to Friday's episode. Instead of an interview, this is a curated masterclass pulling together the most important breakthroughs of 2025 in body recompositio
A Personal Announcement + The 5 BIGGEST TAKEAWAYS & Studies From 2025!
Study takeaways start at 18:00 mark Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this special end-of-year solo episode, Vanessa shares a brief personal announcement, followed by the five biggest scientific takeaways from 2025 that reshaped how she thinks about fat loss, longevity
Gut Health, Hormones & Midlife Weight Gain — What Women Need to Know: Cynthia Thurlow, NP
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode of the Optimal Protein Podcast, Vanessa is joined by Cynthia Thurlow, nurse practitioner, bestselling author, and women's health expert, for a deep dive into why fat loss and muscle maintenance become more challenging durin
The New Peptide Science: Reversing Skin Aging, Senescent "Zombie" Cells, Collagen Breakdown & Inflammation — Dr. Alessandra Zonari
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa What if the real driver of skin aging isn't wrinkles or sun damage — but "zombie" senescent cells hiding in your skin? In this episode of the Optimal Protein Podcast, Vanessa sits down with Dr. Alessandra Zonari, PhD — a stem cell biologis
Why You Can't Diet Forever: Study Results From 10,000 People Who Kept the Weight Off
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa Why do so many people lose weight — only to regain it later? In this episode of The Optimal Protein Podcast, Vanessa Spina sits down with Dr. Holly Wyatt, physician, endocrinologist, and longtime researcher with the National Weight Control
BREAKING NEWS EXPLAINED: Your Metabolism Isn't "Capped" — What the New Study REALLY Shows
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa For nearly a decade, many of us have believed that calorie burn eventually plateaus—that once you move enough, your body quietly compensates and stops burning more energy. That belief has shaped how we diet, how we train, and even whether
BREAKING: Your Body Burns More Calories Than We Thought — Dr. Howard on the Groundbreaking Study Rewriting Metabolism
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In today's episode, Vanessa sits down with Dr. Howard, the lead author of a brand-new PNAS study that is challenging one of the most widely accepted ideas in human metabolism. For years, many scientists believed that our bodies operate wit
Shocking New Research on Creatine & Collagen: What Women Need to Know - Benefits, Dosing & More!
In today's episode, Vanessa reveals the shocking new human research on two of the most powerful and science-backed supplements for women's fat loss, muscle tone, metabolic health, skin rejuvenation, and longevity: creatine and collagen. You'll discover why creatine is no longer just a gym supplement, and how groundbreaking new data shows collagen may actually influence biological age. This episode
Is Intermittent Fasting Sabotaging Your Muscle? The Truth About IF, Carbs & Recovery- Dr. Cas Fuchs
NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with taurine. Get 20% off at puori.com/VANESSA In this science-packed episode, Dr. Cas Fuchs breaks down the surprising ways intermittent fasting, under-fueling, cold plunges, and low glycogen can quietly sabotage your muscle, strength, and body recomposition goals. We unc
Why I Quit Intermittent Fasting & Lost 13+ Lbs of Fat — What I'm Doing Instead
🔥 BLACK FRIDAY IS HERE — 30% OFF SITEWIDE! My biggest sale of the year is live! Get 30% OFF all Tone Devices, red light panels, masks, and more at KetogenicGirl.com with code BF2025. 👉 Shop the sale HERE In this episode, Vanessa reveals why she quit intermittent fasting after nearly a decade — and how she went on to lose 13+ pounds of fat by switching to a completely different approach that's supp
Fat Loss for Women: What Actually Works — with Dr. Shawn Arent
🔥 BLACK FRIDAY IS HERE — 30% OFF SITEWIDE! My biggest sale of the year is live! Get 30% OFF all Tone Devices, red light panels, masks, and more at KetogenicGirl.com with code BF2025. 👉 Shop the sale HERE OneSkin is powered by the breakthrough peptide OS-01, the first ingredient proven to reduce skin's biological age. I use the OS-01 Face and Eye formulas daily—they've transformed my skin's smoothn
Stop Midlife Belly Fat: The New Science on Protein & Perimenopause (Dr. Hannah Cabre Recap)
Here it is 🖤 BIOptimizers Black Friday: Get 25% off + exclusive free gifts now through Dec 3 on favorites like Magnesium Breakthrough and MassZymes. 👉 bioptimizers.com/vanessa Code: VANESSA Don't miss the year's biggest savings! In today's Friday solo episode, I'm recapping one of my favorite conversations on women's health, metabolism, and body composition with Dr. Hannah Cabré — postdoctoral res
Muscle Loss, Belly Fat & Perimenopause: What's REALLY Happening & How to Fix It: Dr. Hannah Cabre
NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with taurine. Get 20% off at puori.com/VANESSA In today's episode, we take a powerful deep dive into women's metabolism during perimenopause and midlife with Dr. Hannah Cabré, postdoctoral fellow at Pennington Biomedical Research Center and 2025 Fellow of the Year. We brea
Part 2: PSMF Ask Me Anything: Rapid Fat Loss, Protein to Protect Muscle, Fat and Carb Re-Feeds & Hormones
Here it is 🖤 BIOptimizers Black Friday: Get 25% off + exclusive free gifts now through Dec 3 on favorites like Magnesium Breakthrough and MassZymes. 👉 bioptimizers.com/vanessa Code: VANESSA Don't miss the year's biggest savings! This is Part Two of our PSMF Ask Me Anything series! In this episode, Vanessa answers your most practical and frequently asked questions about how to implement a Protein-S
PSMF Ask Me Anything: Rapid Fat Loss, Protein to Protect Muscle, Fat and Carb Re-Feeds & Hormones (Part 1)
In this Ask Me Anything episode, Vanessa breaks down your most common questions about the Protein-Sparing Modified Fast (PSMF) — one of the most powerful evidence-based tools for rapid fat loss and muscle preservation. NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with taurine. Get 20% off at puori.com/VANESSA You'll
Burn Fat, Keep Muscle: Inside the Science of the Protein-Sparing Modified Fast
Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa In this solo episode, Vanessa Spina breaks down the science and strategy behind one of the most effective tools for rapid fat loss and muscle preservation — the Protein-Sparing Modified Fast (PSMF). Following her in-depth interview
How to Lose 10–20 Pounds of Fat in 30 Days: The Protein-Sparing Modified Fast Explained with Dr. David Jockers
Learn how to lose 10–20 pounds of fat in one month—without losing muscle or wrecking your hormones. Dr. David Jockers joins Vanessa to break down the Protein-Sparing Modified Fast (PSMF): the macros, meals, training, and refeed strategy that make this rapid fat-loss reset both safe and effective. NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohyd
How to Eat for Fat Loss Without Losing Muscle: What Science Says About Protein, Fasting & EAAs (Dr. David Church Recap)
Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa In this solocast episode, Vanessa breaks down the latest research from Dr. David Church — a rising leader in protein metabolism — to reveal exactly how to eat for fat loss without losing muscle. Discover how stable isotope tracer s
The Science of Fat Loss & Muscle Retention — Dr. David Church on Protein Timing, EAAs, and Creatine
NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with taurine. Get 20% off at puori.com/VANESSA In this masterclass episode, Vanessa sits down with Dr. David Church, one of the most exciting young researchers in protein metabolism and a mentee of Dr. Arny Ferrando and Dr. Robert Wolfe. Together, they break down the lates
How to Maintain Fat Loss: The Studies & Science Behind Long-Term Success
Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa What separates people who keep fat off from those who regain it? In this episode, Vanessa Spina breaks down the latest research on long-term fat loss maintenance — including insights from one of the world's most respected obesity a
The Real Secret to Fat Loss Maintenance: Insights from 30 Years of Research with Dr. James Hill
NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with taurine. Get 20% off at puori.com/VANESSA In today's episode, Vanessa sits down with one of the most influential figures in obesity and metabolism research — Dr. James Hill, Professor of Nutrition Sciences at the University of Alabama at Birmingham and co-founder of t
How Women Should Eat Protein for Muscle, Fat Loss & Longevity — Backed by Science
Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa In this solo episode, Vanessa breaks down her in-depth conversation with Dr. Emily Lantz, a leading researcher in protein metabolism and muscle physiology. Discover why eating around 30 g of high-quality protein at each meal may be
Fat Loss without Muscle Loss: The Science of Refeeds, Protein & Recomposition with Dr. Escalante
NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with taurine. Get 20% off at puori.com/VANESSA Can you really lose fat without losing muscle? Vanessa sits down with Dr. Guillermo Escalante, physique competitor and sports nutrition researcher, to reveal the science of doing exactly that. Learn how high-protein diets and
Why Women Need Creatine: Fat Loss, Metabolism & Cognitive Benefits Backed by Science — and How to Choose Clean, Pure Supplements with Oliver Amdrup-Chamby
In this powerful educational episode, Vanessa sits down with Oliver Amdrup-Chamby, CEO and Co-Founder of Puori, for an in-depth masterclass on the supplements most overlooked—yet most transformative—for women's health: creatine and omega-3s. Drawing on the latest scientific research and insights from world-leading muscle and metabolism experts, Vanessa and Oliver unpack: ✅ Why creatine is a founda
The Science of 30/30/30 Protein Meals: Burn Fat & Build Muscle - Dr. Emily Lantz
Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In this episode, Vanessa sits down with Dr. Emily Lantz, Assistant Professor at the University of Texas Medical Branch and mentee of the late Profes
New Study! Belly Fat Drops Faster on High-Protein — With Autophagy Still Active
Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa In today's solocast, we break down a brand new clinical trial that tested whether a high-protein diet really shuts down autophagy — and what it means for fat loss and body composition. For years, many believed that eating more prot
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