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Precision Pathology Podcast (P³)

Perelman School of Medicine, Pathology & Laboratory Medicine 10 Episodes Jul 17, 2026

The Precision Pathology Podcast (P³) is a monthly interview series hosted by Dr. George J. Netto, Chair of Pathology at the University of Pennsylvania. Each episode features conversations with global thought leaders on cutting-edge research in pathology and biomedical science. Topics include digital pathology, single-cell and spatial omics, and multiplex biomarker assessment, with a focus on precision diagnostics and therapeutics.

Episodes

How CAR T-Cell Therapy Enabled Kidney Transplants for Highly Sensitized Patients Jul 17, 2026 00:25:44 This episode explains how a novel CAR T-cell approach made kidney transplantation possible for patients previously considered unmatched, and why that could change outcomes for people waiting on dialysis. Dr. Vijay Bhoj, MD, PhD, assistant professor of pathology and cellular immunotherapy at the University of Pennsylvania, walks through the phase 1, multi-institutional trial that combined CD19 and

Leveraging the Million Veteran Program Dataset to Bring a Prostate Genomic Risk to the Clinic: the ProGRESS study Jun 16, 2026 00:25:08 In this episode, we discuss the recent publication in Nature Cancer by Jason L. Vassy et al. on building a personalized genomic risk model to enhance precision in prostate cancer screening. Guest Kara Maxwell, MD, PhD, from the University of Pennsylvania, explains how the PCARE test combines a polygenic risk score with genetic ancestry and family history to guide PSA decisions in clinical care. Yo

GLP-1 Receptor Agonists and Cancer Risk Reduction: What is the Verdict? May 27, 2026 00:36:21 Glucagon-like peptide 1 receptor agonists (GLP1RAs) are widely used to treat type 2 diabetes mellitus (T2DM) and obesity. Given that T2DM and obesity are associated with a higher risk of cancer, the potential of GLP1RAs use to reduce cancer risk is of great interest. Professor Edoardo Mannucci from the University of Florence, Italy, discusses his recent publication in Nature Reviews Clinical Oncol

Intercepting Pancreatic Cancer: KRAS Inhibitors in Action Apr 28, 2026 00:21:13 Ben Stanger, MD, Hannah Weiss Professor of Oncology at the University of Pennsylvania, discusses his team's groundbreaking study on the use of KRAS-targeted small molecules to eliminate pancreatic cancer precursor lesions (PanIN) in a preclinical mouse model. The tremendous clinical implications of intercepting cancer development using novel pharmacologic agents are highlighted. View Dr. Stanger's

Cutting Edge Technologies Unlocking Barrett's Esophagus Clonal Cell States Feb 10, 2026 00:26:53 In this episode, Dr. Sydney Shaffer shares her expertise on cutting-edge technologies, including single-cell and spatial transcriptomics, and their significance for understanding cancer biology. The guest discusses these tools in the context of her recent Nature Communications publication (https://doi.org/10.1038/s41467-025-66302-w), which provides a single-cell view of cell dynamics in Barrett’s

Revolutionizing CNS Tumor Diagnostics: Intraoperative Methylation Profiling! Dec 23, 2025 00:22:07 Join Dr. George Netto as he discusses with Professor Felix Sahm, an international expert from Heidelberg University, his team's innovative multi-center study on intraoperative molecular profiling of central nervous system tumors (CNS). Learn how rapid methylation profiling could change the landscape of diagnostics and management of brain neoplasms. Don't miss this enlightening discussion!#Neuropat

A Second Look at the Impact of TERTp Mutation on Meningioma Grade Nov 21, 2025 00:18:08 Join Dr. George Netto and Dr. Matija Snuderl of Langone Health at NY University as they discuss the significance of TERT promoter mutations in meningiomas and their implications for patient prognosis. This conversation sheds light on the need for reevaluation of molecular biomarkers in the grading of Meningiomas.#Meningioma#MolecularDiagnostics#TERTPromoter#Pathology#CancerResearch#TumorGrade

AI-Driven Biomarkers for Antibody-Drug Conjugates (ADC) Oct 20, 2025 00:19:53 In this episode, I discuss with Dr. Salgado, Co-Chair of the International Immuno-Oncology Biomarkers Working Group, his editorial (https://doi.org/10.1016/j.ccell.2025.03.020) on the recent Cancer Cell study by Ding Ma et al, presenting a predictive AI model for HER2-targeting ADC efficacy, incorporating immune system components, hormone receptor status, clinical staging, and HER2+ cell proportio

Introduction to Precision Pathology Podcast Aug 27, 2025 00:02:54 Introducing P³ PodcastWelcome to P³, our new podcast series on Precision Pathology, created and hosted by Dr. George J. Netto, the Simon Flexner Professor and Chair of Pathology and Laboratory Medicine at the University of Pennsylvania in Philadelphia, PA.In each episode, Dr. Netto will share his perspective on the latest discoveries in precision medicine through informal conversations with accom

Pathology Foundation Model for Lung Cancer Bio-Marker Detection Aug 27, 2025 00:18:25 Rapid and accurate assessment of EGFR mutations in lung adenocarcinoma is critical for the management of NSCLC patients. PCR-based assays provide rapid results but with reduced accuracy compared with next-generation sequencing and can exhaust the increasingly valuable small amount of biopsy tissue available for predictive biomarkers. Computational biomarkersLeveraging modern foundation models may

Precision Pathology Podcast (P³)

Episodes

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