NIH Collaboratory

Podcast 66: Bringing Context and Clarity to Clinical Trial Research with JAMA+ Trials Aug 17, 2026 00:16:17 Alison Huang and Derek Angus of JAMA+ Trials expand on key takeaways from their recent Grand Rounds presentation, “Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences.”

Podcast 65: Slow Recruitment Mitigation Strategies Jul 30, 2026 00:16:26 Drs. Steven George and Christine Goertz discuss slow recruitment mitigation strategies, one of the small group discussion topics at the NIH Pragmatic Trial Collaboratory's Steering Committee meeting in April 2026. Review the Steering Committee Meeting materials: https://rethinkingclinicaltrials.org/news/april-2026-annual-steering-committee-meeting/

Podcast 64: Death as an Endpoint Jun 22, 2026 00:16:53 Drs. Brad Hammill and Keith Marsolo discuss the use of death as an endpoint, a section in the Living Textbook chapter on Choosing and Specifying Endpoints and Outcomes. Read the chapter: https://rethinkingclinicaltrials.org/chapters/design/choosing-specifying-end-points-outcomes/choosing-and-specifying-endpoints-and-outcomes-introduction/

Podcast 63: Scientific Publishing and AI May 19, 2026 00:16:34 Roy Perlis of Harvard Medical School and JAMA+ AI expands on key takeaways from his recent Grand Rounds presentation, “Keeping a Human in the Loop: Scientific Publishing and AI.”

Podcast 62: Ambient AI to Improve Health Practitioner Well-Being Apr 30, 2026 00:19:15 Majid Afshar and Mary Ryan Baumann discuss the conduct and results of their pragmatic trial.

Podcast 61: Evaluating Analytic Models for IRGT Trials Mar 24, 2026 00:19:08 Drs. Jonathan Moyer and David Murray discuss their recent publication, “Evaluating Analytic Models for Individually Randomized Group Treatment Trials With Complex Clustering in Nested and Crossed Designs.”

Podcast 60: Virtual Vigilance in Decentralized Clinical Trials Feb 18, 2026 00:14:20 Drs. Adrian Hernandez and Christopher Lindsell discuss their recent publication, “Ensuring Virtual Vigilance in Decentralized Clinical Trials," as well as the new Living Textbook Chapter on Decentralized Pragmatic Clinical Trials.

Podcast 59: Gaps and Opportunities in America's Healthcare Landscape Jan 16, 2026 00:14:42 Dr. David Zaas discusses key takeaways from his recent keynote presentation: “Landscape of Healthcare in America: Gaps and Opportunities (That Researchers Need to Hear)."

Podcast 58: INSPIRE Dec 18, 2025 00:18:30 Drs. Shruti Gohil and Jeffrey Guy discuss key takeaways from "INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients," also known as the INSPIRE trial.

Podcast 57: Integrating the BeatPain Study With PRaCTICe, a New Network Research Hub Nov 26, 2025 00:14:13 Drs. Sebastian Tong and Julie Fritz expand on key takeaways from their recent Grand Rounds presentation.

Podcast 56: "Avoiding the Fumble" in Pragmatic Clinical Trials Oct 15, 2025 00:14:48 Dr. Emily O'Brien shares key takeaways from her recent Grand Rounds presentation, "Avoiding the Fumble: Building on a Decade of Lessons from Pragmatic Clinical Trials."

Podcast 55: End-of-Trial Decision-Making Sep 17, 2025 00:20:57 Drs. Greg Simon and Lorella Palazzo discuss their recent Living Textbook Chapter, "End-of-Trial Decision-Making." Read the chapter: https://rethinkingclinicaltrials.org/chapters/dissemination/end-of-trial-decision-making/introduction-end-of-trial-decision-making/

Podcast 54: Disentangling Informing Participants From Obtaining Their Consent Aug 12, 2025 00:12:29 Drs. Pearl O'Rourke and David Wendler discuss their recent publication, "Disentangling Informing Participants From Obtaining Their Consent."

Podcast 53: Healthcare Data Interoperability and Standardization for Research Jul 30, 2025 00:12:13 Drs. Lesley Curtis and Keith Marsolo discuss the new learning module "Healthcare Data Interoperability and Standardization for Research."

Podcast 52: Making Pragmatic Trials More Pragmatic Jun 24, 2025 00:14:03 Drs. Rich Platt, Hayden Bosworth, and Greg Simon consider how to make pragmatic trials more pragmatic.

Podcast 51: ACP PEACE May 16, 2025 00:19:56 Dr. James Tulsky and Dr. Angelo Volandes discuss "Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly," also known as the ACP PEACE trial.

Podcast 50: Waiver of Consent Jul 11, 2024 00:16:05 Dr. Pearl O'Rourke and Dr. Stephanie Morain discuss waiver or alteration of informed consent for minimal risk clinical investigations.

Podcast 49: Public-Private Partnerships in the Trustworthy Health AI Ecosystem Jun 25, 2024 00:21:28 Dr. Michael Pencina and Dr. Brian Anderson discuss Public-Private Partnerships in the Trustworthy Health AI Ecosystem.

Podcast 48: Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial Dec 1, 2023 00:22:58 Dr. Harlan M. Krumholz and the PaxLC research team discuss Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial.

Podcast 47: BeatPain Utah Jul 18, 2023 00:10:12 Dr. Julie Fritz discusses "BeatPain Utah: Partnering with Community Health Centers Within a Socio-Technical Framework."

Podcast 46: All of Us Research Program Jun 23, 2023 00:15:36 Dr. Joshua Denny discusses the All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine.

Podcast 45: From Observational Studies to Pragmatic Clinical Trials: Research in PCORnet® Apr 21, 2023 00:17:51 Drs. Russell Rothman and Erin Holve discuss a decade of research in PCORnet®.

Podcast 44: The Heartline Trial: A New Paradigm in Conducting Virtual Clinical Trials Mar 8, 2023 00:12:58 Dr. Michael Gibson discusses The Heartline Trial and a new paradigm in conducting virtual clinical trials.

Podcast 43: Ethical Considerations for Vulnerable Populations in Pragmatic Clinical Trials Feb 6, 2023 00:15:00 This podcast continues the discussion with Dr. Emily Largent as she discusses ethical considerations for vulnerable populations participating in pragmatic clinical trials.

Podcast 42: FDA Draft Guidance on Real-World Evidence Jul 14, 2022 00:27:48 Dr. John Concato discusses the 2021 FDA draft guidance on real-world evidence.

Podcast 41: Searching for a Unicorn: Selecting Outcomes for Outpatient Trials Jan 25, 2022 00:12:57 Dr. Christopher Lindsell discusses research outcomes and the importance of choosing the correct outcome.

Podcast 40: Survivor Corps: Long-Term COVID-19 Patient Engagement Aug 16, 2021 00:17:32 This podcast continues the discussion with Diana Berrent, JD, and Nick Guthe, founder and member of Survivor Corps, and Natalie Lambert, PhD, of the Indiana University School of Medicine, as they describe best practices for medical professionals treating patients experiencing debilitating effects of COVID-19.

Podcast 39: Inclusion of Diverse Participants in Pragmatic Clinical Trials Aug 4, 2021 00:15:56 Dr. Boineau moderates a discussion with Drs. Chambers, Curtis, O'Brien, Weber, and Zimmerman about increasing diverse participation in pragmatic clinical trials.

Podcast 38: Online Recruitment in the Era of COVID-19: Pitfalls and Progress Jun 1, 2021 00:12:52 This podcast continues the discussion with Dr. Adrian Hernandez and Dr. Megan L. Ranney about using digital technologies in clinical trials and best practices for online participant recruitment.

Podcast 37: Data and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The Challenges Mar 31, 2021 00:12:26 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez speaks with Dr. Susan Ellenberg of the University of Pennsylvania about the challenges encountered by the Data and Safety Monitoring Board overseeing a group of COVID-19 vaccine trials under the National Institutes of Health.

Podcast 36: Beyond Politics: Promoting COVID Vaccination in the United States Mar 3, 2021 00:13:26 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez speaks with Dr. Kevin Schulman of Stanford about strategies for promoting widespread COVID-19 vaccination in the United States.

Podcast 35: HERO-TOGETHER Jan 21, 2021 00:11:41 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez speaks with Dr. Emily O'Brien of the Duke Clinical Research Institute about the HERO-TOGETHER study that is evaluating how people do over time after receiving the COVID-19 vaccine.

Podcast 34: Lessons from Virtual Trials in Time of a Pandemic Nov 12, 2020 00:20:18 This podcast follows the conversation between Dr. David Boulware and Dr. Adrian Hernandez as they discuss the complexities of conducting virtual clinical trials during the COVID-19 pandemic.

Podcast 33: The Democratization of Medicine Aug 18, 2020 00:18:43 This podcast follows the conversation between Dr. C. Michael Gibson and Dr. Adrian Hernandez as they discuss how open access, patient empowerment, social media, and digital health are transforming clinical trials.

Podcast 32: Reflection on Advances at the Intersection of Digital Health, EHRs, and PCTs Jul 8, 2020 00:28:28 This podcast, led by Wendy Weber, ND, PhD, MPH, features a reflective conversation with Lesley Curtis, PhD, Patrick Heagerty, PhD, and Keith Marsolo, PhD, focused on the Grand Rounds EHR workshop series, “Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials.”

Podcast 31: Real World Evidence: Contemporary Experience and Future Directions Jun 25, 2020 00:16:59 This episode of the NIH Collaboratory Grand Rounds podcast follows the conversation on Electronic Health Records (EHRs) between Dr. Lesley Curtis and Dr. Joshua C. Denny, Chief Executive Officer of the All of Us Research Program. The discussion covers questions on Dr. Denny’s early experience with EHRs, his journey on working with All of US and EHRs, and how the program is addressing the impact of

Podcast 30: Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem? May 15, 2020 00:18:25 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Lesley Curtis speaks with Dr. Robert Califf, Head of Strategy and Policy at Verily Life Sciences and Google Health about whether the COVID-19 crisis can lead to reformation of the current healthcare delivery system. This discussion follows Dr. Califf's keynote presentation of a Grand Rounds Series titled Advances at the Intersectio

Podcast 29: Creating a Learning Health System Through Randomization Mar 20, 2020 00:17:00 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez speaks with Dr. Leora Horwitz of NYU Langone Health about creating a Learning Health System through randomization.

Podcast 28: Using Nudges to Improve the Delivery of Health Care Feb 20, 2020 00:12:15 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez speaks with Dr. Mitesh Patel of University of Pennsylvania about using nudges in a healthcare system to “steer medical decision-making toward higher value and improved patient outcomes.”

Podcast 27: It’s Time to Learn From Patients Like Mine Dec 12, 2019 00:12:56 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez sits down with Dr. Nigam Shah of Stanford University to discuss an informatics service called “Green Button,” which searches across diagnosis and procedure codes, concepts extracted from clinical notes, laboratory test results, vital signs, as well as visit types and duration of inpatient stays, to ultimately compa

Podcast 26: Playing with FHIR–Innovative Use Cases for the New REDCap EHR Integration Module Nov 27, 2019 00:16:54 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez sits down with Dr. Paul Harris to discuss REDCap integration with Fast Healthcare Interoperability Resources (FHIR). In the discussion, Harris covers past challenges of Electronic Health Record and Electronic Data Capture integration, progress in development of a new model, and current adopters of FHIR.

Podcast 25: Preparing for Clinical Trial Data Sharing and Re-use: The New Reality for Researchers Oct 3, 2019 00:15:13 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez sits down with Drs. Rebecca Li and Frank Rockhold to discuss clinical trial data sharing and re-use. In the discussion, Li and Rockhold highlight benefits, potential fears, and the future of data sharing and open science as well as Vivli, a global clinical research data sharing platform.

Podcast 24: Digital in Trials: Improving Participation and Enabling Novel Endpoints Aug 21, 2019 00:10:20 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Kevin Weinfurt sits down with Craig Lipset to discuss the role and impact of digital in trials and its various roles. In the discussion, Lipset highlights displacement and its impact on traditional research models, the concept of digital twins, and opportunities that stakeholders have to address the barriers that exist for to meani

Grand Rounds August 2, 2019: AI and the Future of Psychiatry Aug 7, 2019 00:59:33 Dr. Murali Doraiswamy discusses potential uses of artificial intelligence technologies in the field of mental health. (Audio track of the webinar.)

Podcast 23: Good Clinical Practice Guidance & Pragmatic Trials in the Learning Health System Jun 25, 2019 00:10:05 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez sits down with Dr. Rob Mentz to discuss balancing Good Clinical Practice Guidance and Pragmatic Trials in the Learning Health System. In the discussion, Dr. Mentz covers key challenges with good clinical practice (GCP), input from Dr. Rob Califf and others, and suggestions on how the scientific community should add

Podcast 22: Development of Harmonized Outcome Measures for Use in Research and Clinical Practice Apr 23, 2019 00:14:51 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez sits down with Dr. Elise Berliner and Michelle Leavy to discuss the Development of Harmonized Outcome Measures for Use in Research and Clinical Practice. In the discussion, Dr. Berliner and Leavy explain the outcome measures framework and harmonizing outcomes in specific clinical areas.

Podcast 21: The Pragmatic Airway Resuscitation Trial (PART) Feb 18, 2019 00:17:40 Podcast 21: The Pragmatic Airway Resuscitation Trial (PART) by NIH Pragmatic Trials Collaboratory

Podcast 20: Perinatal Outcomes Associated with a Major Change in Gestational Diabetes Screening Jan 28, 2019 00:09:38 Podcast 20: Perinatal Outcomes Associated with a Major Change in Gestational Diabetes Screening by NIH Pragmatic Trials Collaboratory

Podcast 19: Validating a Computable Phenotype Dec 5, 2018 00:11:04 Podcast 19: Validating a Computable Phenotype by NIH Pragmatic Trials Collaboratory

Podcast 18: Data Linkage Within, Across, and Beyond PCORnet Nov 19, 2018 00:12:34 Podcast 18: Data Linkage Within, Across, and Beyond PCORnet by NIH Pragmatic Trials Collaboratory

Podcast 17: MDEpiNet RAPID and SPEED Projects Nov 7, 2018 00:10:50 Renee Mitchell, Terrie Reed, and Roseann White discuss the Medical Device Epidemiology Network’s RAPID and SPEED projects.

Podcast 16: Returning Individual Research Results to Participants Oct 1, 2018 00:14:43 Podcast 16: Returning Individual Research Results to Participants by NIH Pragmatic Trials Collaboratory

Podcast 15: Digital Pragmatic Clinical Trial for Identifying Underdiagnosed Atrial Fibrillation Aug 7, 2018 00:13:31 Steve Steinhubl, Director of Digital Media, Scripps RTI,discusses a digital & pragmatic clinical trial that explores under diagnosed Atrial Fibrillation in large health population.

Podcast 14: Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing Jul 19, 2018 00:11:24 In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Michelle Mello discusses a study she and Dr. Steven Goodman recently conducted to determine how clinical trial participants think about having their participant-level data widely shared. In her discussion with Dr. Lesley Curtis, Dr. Mello discusses study results, what she found most surprising, and how the study revealed takeaways

Podcast 13: Rethinking University Research with State Data (Aaron McKethan, PhD) Jul 10, 2018 00:12:40 Podcast 13: Rethinking University Research with State Data (Aaron McKethan, PhD) by NIH Pragmatic Trials Collaboratory

Podcast 12: Exploring What is Possible with High-Quality Data. Examples from Flatiron Health Jun 27, 2018 00:11:46 Podcast 12: Exploring What is Possible with High-Quality Data. Examples from Flatiron Health by NIH Pragmatic Trials Collaboratory

Podcast 11: Launching NESTcc to Improve use of Real-World Evidence in Medical Device Ecosystem May 21, 2018 00:09:17 Podcast 11: Launching NESTcc to Improve use of Real-World Evidence in Medical Device Ecosystem by NIH Pragmatic Trials Collaboratory

Podcast 10: OHDSI: Drawing Reproducible Conclusions from Observational Clinical Data Apr 16, 2018 00:11:24 In this episode of the Collaboratory Grand Rounds podcast, Dr. George Hripcsak, Chair of the Bioinformatics Department at Columbia University, discusses the Observational Health Data Sciences and Informatics (OHDSI) Program with moderator Dr. Adrian Hernandez. He describes the Program's vision to create accessible and reliable clinical evidence by gathering the clinical data of millions of patien

Podcast 9: Data Science in the Era of Data Ubiquity Apr 11, 2018 00:15:39 Moderator Dr. Adrian Hernandez speaks with Duke Forge Director Dr. Robert Califf about the opportunities and challenges for data science in an era where data is everywhere. Now that mobile phones and other portable electronic devices provide people with access to large amounts of data day or night, Dr. Califf addresses how researchers and health systems can ensure that accurate health information

Podcast 8: Clinicians' Views on Participating in CER/PCOR Mar 22, 2018 00:15:20 Dr. Sean Tunis and Ellen Tambor discuss with moderator Dr. Kevin Weinfurt their findings on clinician attitudes towards research participation, and how and when to best engage them. They describe the need for involving clinicians in the planning of study design, and in closing feedback loops after studies are completed, in order to build clinicians’ trust that research does lead to quality improve

Podcast 7: Considerations for the Return of Genomic Results Feb 19, 2018 00:08:12 Dr. Andrew Faucett of Geisinger describes the considerations for the return of genomic results to patients.

Podcast 6: IMPACT-AFib: A Randomized Trial Using the Sentinel Initiative Platform Jan 22, 2018 00:08:04 Drs. Richard Platt and Christopher Granger speak with moderator Dr. Adrian Hernandez about the IMPACT-AFib atrial fibrillation trial and the role of the FDA’s Sentinel Inititative. In this trial, researchers used Sentinel pharmacy data to find eligible patients with at least one oral anticoagulation prescription fill, and the speakers describe how the platform provided them with an efficient and

Podcast 1: Preprints: What, Why Not, and How Jan 22, 2018 00:11:26 Dr. Harlan Krumholz of Yale University Medical Center speaks with the NIH Collaboratory’s Dr. Adrian Hernandez about the ways preprint servers can help accelerate scientific progress through greater access to research results.

Podcast 5: Data and Safety Monitoring in Pragmatic Clinical Trials Jan 3, 2018 00:10:36 Dr. Greg Simon, principal investigator of the Suicide Prevention Outreach Trial (SPOT), and Susan Ellenberg, a member of the Collaboratory Regulatory/Ethics Core, speak with moderator Dr. Adrian Hernandez about the factors that determine the need for a Data and Safety Monitoring Board (DSMB) in pragmatic trials.

Podcast 4: Moderators' Edition Jan 3, 2018 00:10:29 Drs. Adrian Hernandez and Kevin Weinfurt, two NIH Collaboratory Co-PIs and podcast moderators, discuss their predictions and hopes for the NIH Collaboratory in the next year.

Podcast 3: Bringing Machine Learning to the Point of Care to Improve Suicide Prevention Jan 3, 2018 00:09:20 Dr. Greg Simon of the Kaiser Permanente Washington Health Research Institute speaks with the NIH Collaboratory’s Dr. Lesley Curtis about the integration of machine learning into suicide prevention.

Podcast 2: Health is More than Healthcare Jan 3, 2018 00:11:44 Dr. Karen DeSalvo, former acting Assistant Secretary for Health and Human Services, speaks with the NIH Collaboratory’s Dr. Kevin Weinfurt about the factors other than healthcare systems than impact the health of our communities.

Episodes

Recommended