The Metabolic Classroom with Dr. Ben Bikman
The Metabolic Classroom with Dr. Ben Bikman is a nutrition and lifestyle podcast focused on metabolism, explaining how our bodies use energy and the truth behind why we get sick and fat. Each week, Dr. Ben Bikman shares valuable insights that listeners can apply in their own lives and share with others. The podcast is brought to you by BenBikman.com and InsulinIQ.com.
Episodes
Why Amylin May Be the Most Important Weight Loss Hormone You've Never Heard Of
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Amylin is an insulin-sparing satiety hormone released with insulin that slows digestion, restrains glucagon, and helps reduce post-meal glucose spikes. New amylin-based therapies, especially when combined with GLP-1 drugs, may offe
Why Your Ketone Readings Don’t Match
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comNote:Our friends at SiBio CKM are offering a 5% discount using the code BEN5 at checkout. However, their CKM is not yet available in the United States and Canada. It is currently available in selected countries including the UK, Australi
Why Retatrutide May Outperform GLP-1 Drugs
📢 Ask Dr. Bikman’s Digital Mind (multilingual): https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Retatrutide activates GLP-1, GIP, and glucagon receptors, combining appetite suppression with increased energy expenditure and powerful liver fat reduction. Dr. Bikman argues that its best use is not as a permanent shortcut, but a
Why Tirzepatide Works Better Than GLP-1 Alone
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Tirzepatide activates both GLP-1 and GIP receptors, producing weight loss primarily through appetite suppression, slower gastric emptying, reduced cravings, and improved insulin sensitivity—not by forcing the pancreas to make more
The Hidden Signals That Make Fat Cells Grow
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Nuclear receptors inside fat cells respond to lipid-soluble signals and help determine whether cells become fat cells and how they store energy. Although drugs, dietary fats, cortisol, and environmental chemicals can influence thes
Why Neuropathy Isn’t Just About Blood Sugar
Topic: Peripheral neuropathy is not caused by high glucose alone, but by the combined effects of hyperglycemia, insulin resistance, and glycemic variability. Protecting nerves requires improving insulin sensitivity and reducing glucose swings—not just lowering A1C.Summary: Ben explains why peripheral neuropathy is not simply a “high blood sugar” problem. While hyperglycemia clearly damages nerves,
How Your Brain Talks to Your Pancreas (The Vagus Nerve Explained)
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:The vagus nerve is a major communication line between the brain and abdominal organs, helping regulate liver glucose output, gut-brain signaling, and pancreatic insulin secretion. When this neural system is disrupted—by obesity, in
The Muscle Biology Behind Diabetes Risk
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comSummary:In this lecture, Dr. Ben Bikman explores how skeletal muscle fiber type influences insulin sensitivity and diabetes risk. While muscle is the body’s largest site of insulin-stimulated glucose disposal, not all muscle behaves the
How Insulin May Be Silencing Your GLP-1
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comSummary:GLP-1 has become one of the most talked-about hormones in modern medicine, largely due to the rise of GLP-1 receptor agonist drugs for weight loss. In this lecture, Dr. Ben Bikman shifts the focus from how GLP-1 affects insulin t
Why Creatine Is One of the Most Important Brain Nutrients
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Creatine supports brain function by rapidly regenerating ATP, making it essential for cognitive performance, especially under conditions of stress or low baseline levels. Clinical evidence shows it can improve memory, attention, mo
Why Gum Disease Raises Your Blood Sugar
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comMost people think of gum disease as a local dental issue, but this lecture reveals a much broader and more consequential reality. Dr. Ben Bikman explains how the mouth serves as a gateway to systemic inflammation, particularly when perio
Ivermectin Explained: The Science Behind the Controversy
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Ivermectin is a Nobel Prize-winning drug with emerging evidence showing it influences mitochondria, inflammation, and metabolic signaling pathways such as AMPK and FXR. While most data is still preclinical, its consistent mechanism
How Sleep Loss Rewires Your Hunger Hormones
📢 Ask Dr. Bikman’s Digital Mind (multilingual): https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Sleep loss alters key hunger hormones—reducing leptin and increasing ghrelin—while simultaneously activating reward pathways that increase cravings for calorie-dense foods. Because sleep and appetite hormones influence each other
Why Alzheimer’s May Be a Metabolic Disease
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Alzheimer’s disease has traditionally been explained by the buildup of amyloid plaques in the brain, but growing evidence suggests this theory does not fully account for the disease or lead to effective treatments. A metabolic pers
The Personal Fat Threshold Explained and Ethnicity’s Impact
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Metabolic disease is driven more by fat cell size and adipose tissue dysfunction than by total body fat. Ethnicity, genetics, and personal fat storage capacity determine when fat becomes metabolically dangerous.Summary:Dr. Bikman e
How Bile Controls Insulin, GLP-1, and Fat Burning
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Bile acids are powerful hormone-like signaling molecules that regulate liver fat, glucose production, insulin sensitivity, energy expenditure, inflammation, and GLP-1 release through FXR and TGR5 receptors. Gallbladder function and
LDL Isn’t the Problem? The Real Drivers of Heart Disease
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:LDL cholesterol is a weak predictor of heart disease compared to markers of insulin resistance, metabolic syndrome, and the triglyceride-to-HDL ratio. True cardiovascular risk is driven far more by metabolic dysfunction than by cho
Why Exercise Benefits Every Organ — Not Just Muscle
📢 Ask Dr. Bikman’s Digital Mind (multilingual): https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Exercise prompts your muscles to release extracellular vesicles — tiny molecular packages that deliver health-boosting instructions to your brain, liver, fat, and more. These signals improve metabolism, reduce inflammation, and ma
How Glucose Overload Breaks Your Metabolism (And How to Fix It)
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:This episode explores how the NAD⁺/NADH ratio acts as a key metabolic switch, where excess NADH—often driven by high glucose intake—leads to insulin resistance and cellular dysfunction. Ben highlights how lifestyle changes, not sup
Why Your Cells Age (And What You Can Do About It)
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site: https://insuliniq.comTopic:Ben explains how AMPK and mTOR are critical regulators of aging and metabolism, and how their balance can be influenced by diet and lifestyle. Instead of drugs like rapamycin, strategies like carbohydrate restriction and ketosis of
Separating Nicotine from Smoking: Myths, Metabolism, and Medicine
Listen ad-free by becoming an Insider: https://benbikman.comAsk Dr. Bikman’s Digital Mind (multilingual): https://benbikman.com/ben-bikmans-digital-ai-mindDr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comNicotine may not be the addictive villain it's made out to be. When separated from cigarette smoke, it shows surprising anti-inflammatory and neurological potential.Sum
The Hidden Power of Ketones: Fueling + Signaling
Listen ad-free by becoming an Insider: https://www.benbikman.comReferences:For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman’s Digital Mind, ad-free podcast episodes, show notes and references, and online, live Off
GLP-1 Isn’t Enough: Why Glucagon is the Key to Lasting Weight Loss
📢 Ask Dr. Bikman’s Digital Mind (multilingual): https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comIn this lecture, Dr. Ben Bikman explores the misunderstood role of glucagon, insulin’s often-overlooked metabolic counterpart.While insulin encourages fat storage and glucose uptake, glucagon signals the body to mobilize and
Stop Metabolic Inflammation at the Source: Your Gut
📢 Become an Insider: https://benbikman.com📢 Ben’s LPS/Leaky Gut Recommendations: https://us.fullscript.com/plans/insuliniq-leaky-gut-recommendations📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comIn this Metabolic Classroom lecture, Ben explains how lipopolysaccharides (LP
Boost Testosterone Naturally: Mitochondria, Insulin, and Fighting Back
📢 To listen ad-free, become an Insider: Ben’s website, https://www.benbikman.com📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comIn this episode Dr. Bikman explores the concept of “male menopause,” more accurately termed andropause. While women experience a dramatic hormonal drop-off due to the depletion of ovarian follicles, men experience a gradual decline in testos
How Omega-3s Supercharge Fat Loss and Muscle Gain
📢 To listen ad-free, become an Insider: Ben’s website, https://www.benbikman.com📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comIn this mini lecture, Dr. Bikman explains the powerful metabolic effects of long-chain omega-3 fatty acids—specifically EPA and DHA—on fat metabolism and muscle growth.Ben starts by clarifying the difference between plant-based ALA and anima
Ketones and Your Heart - How Ketones Protect the Cardiovascular System
Listen Ad-Free: https://benbikman.comIn this Metabolic Classroom mini lecture, Dr. Bikman explores the powerful effects of ketones—particularly beta-hydroxybutyrate (BHB)—on the cardiovascular system. While ketones are typically thought of as a backup fuel, Ben explains how they are, in fact, an adaptive and efficient energy source that can support heart function in both healthy and failing states
Plant Protein vs Animal Protein: What the Science Really Says
Listen Ad-Free: https://benbikman.comIn this mini-lecture, Ben explores the biochemical and physiological differences between plant and animal proteins—avoiding environmental or ethical debates and focusing strictly on metabolism and human health. He breaks down essential amino acids, emphasizing that animal proteins are "complete" sources, while most plant proteins fall short—particularly in leuc
Why Women Enter Ketosis Faster Than Men - What the Science Reveals
📢 Ask Dr. Bikman’s Digital Mind (multilingual):https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this lecture, Dr. Bikman explores how ketogenesis—our body's ability to produce ketones from fat—operates differently in men and women. While the foundational me
How Ketones Help the Brain Recover From Concussions
📢 Ask Dr. Bikman’s Digital Mind: https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this mini lecture Dr. Bikman explores how concussions cause more than just structural damage to the brain—they create a serious metabolic energy crisis.A concussion reduces th
The Power of Plasmalogens: Boost Metabolism & Improve Insulin Sensitivity
📢 Ask Dr. Bikman’s Digital Mind: https://benbikman.com/ben-bikmans-digital-ai-mind📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman explains the crucial role of plasmalogens—a unique type of fat found in the membranes of cells, especially in metabolically active
Ketogenesis & Stress: Can Stress Hormones Actually Be Good For You?
visit: https://www.benbikman.comvisit: https://insuliniq.com In this Metabolic Classroom lecture, Dr. Bikman explores the deep biochemical relationship between stress and ketone production, uncovering how the body interprets stress signals as cues to mobilize fat and create ketones.He explains how stress hormones—like epinephrine, cortisol, glucagon, and growth hormone—aren’t just emergency signal
Why the Glycocalyx is a Hidden Key to Metabolic Health & How to Protect It
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman explores the often-overlooked but metabolically vital glycocalyx—a carbohydrate-rich layer coating nearly every cell in the human body. Far from being just a structural feature, the glycocalyx influences nutrient
The Pancreas: Our Most Underrated Metabolic Organ & Why Its Health is Vital
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this episode of Metabolic Classroom, Ben Bikman takes a detailed look at the pancreas, a small but mighty organ with two major roles—endocrine and exocrine. The endocrine pancreas (just 1–2% of its mass) regulates metabolism by secreting hormones like insul
How Your Nervous System Controls Metabolism: Fight or Flight vs Rest & Digest
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this foundational Metabolic Classroom lecture, Dr. Ben Bikman unpacks the vital role of the autonomic nervous system (ANS) in maintaining health and metabolic balance.The ANS, a part of the peripheral nervous system, regulates involuntary processes such as
Honey & Maple Syrup vs. Sugar: What’s Better for Metabolic Health?
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this episode of the Metabolic Classroom, Dr. Ben Bikman explores whether natural sweeteners like honey and maple syrup might be better metabolic alternatives to table sugar. He begins with a fascinating historical background, including honey’s use as a woun
The Truth About Statins & Women’s Health: Can They Harm More Than They Help?
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this important Metabolic Classroom lecture, Dr. Bikman examines the use of statins in women, particularly for primary prevention of cardiovascular disease.While statins are widely prescribed to lower LDL cholesterol and ApoB levels, Ben highlights research
Can You Build Muscle on a Low-Carb Ketogenic Diet? What the Science Says
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comDuring this mini lecture, Dr. Bikman tackles the popular misconception that building muscle requires carbohydrates and insulin spikes. He begins by reframing insulin's role—not as a muscle-building hormone, but primarily as an anti-catabolic signal that helps
What Migraine Sufferers Need to Know About Metabolism & Insulin Resistance
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comThis week’s Metabolic Classroom lecture is a deep dive into the metabolic roots of migraines—a condition that affects millions but is rarely discussed through the lens of insulin resistance and energy dysregulation.Dr. Bikman explains that migraines are more t
The Real Cause of Fat Gain: Genetics, Hormones, and Insulin
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman explains how rare genetic forms of obesity—known as monogenic obesity—reveal deep insights into how the body stores fat and why the “calories in, calories out” model falls short.He introduces three genetic condit
Yerba Mate and Metabolism: What the Science Says
In this Metabolic Classroom, Ben explores the fascinating metabolic effects of yerba mate, a traditional South American tea that’s gaining attention in scientific circles. Yerba mate contains a synergistic mix of bioactive compounds, including xanthines (like caffeine), chlorogenic acid, and saponins—all of which contribute to its wide-ranging health benefits. Dr. Bikman explains how this unique b
The Link Between Muscle Loss, Aging and Obesity: Anabolic Resistance Explained w/Dr. Ben Bikman
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Ben explores the concept of anabolic resistance—the body’s reduced ability to build and maintain muscle in response to stimuli like protein intake and resistance training.This phenomenon, often associated with aging,
The Sugar Diet: What the Science Really Says
📢 Visit Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this episode of the Metabolic Classroom, Dr. Ben Bikman explores a surprising and controversial dietary trend: the “sugar diet.”Despite its name, this diet isn’t built around candy and soda. Instead, it promotes a very high intake of simple carb
An Alternative View of T1DM
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this lecture, Ben challenges the conventional insulin-centric model of type 1 diabetes by introducing the “bi-hormonal hypothesis” proposed by Dr. Roger Unger.While insulin deficiency is a defining feature of T1DM, Dr. Bikman emphasizes the overlooked
Nitrates and Nitrites: Villain or Metabolic Hero?
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comThis Metabolic Classroom lecture explores the often misunderstood world of nitrates and nitrites—compounds historically feared due to their association with processed meats.Dr. Bikman presents a balanced examination of their biological role, historical u
Menopause, Ketones, and Metabolism: A Strategy Explained
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comThis Metabolic Classroom lecture with Dr. Bikman explores how the loss of estradiol during menopause affects five key metabolic systems: the brain, muscles, mitochondria, fat tissue, and inflammation.Each of these systems relies on estradiol for optimal
How the MTHFR Gene Affects Our Metabolic Health
📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman explores the MTHFR gene and how common mutations can affect overall metabolic health. Ben explains the biochemical role of the MTHFR enzyme in the methylation cycle, its influence on homocysteine levels, an
Creatine Demystified: Brain, Muscle & Metabolic Benefits
📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman breaks down the true nature and benefits of creatine—a molecule often misunderstood as merely a muscle-building supplement. Creatine plays a critical role in cellular energy production by helping regenerate ATP, especially
Can Nattokinase Improve Heart & Metabolic Health?
📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this Metabolic Classroom lecture, Dr. Bikman dives into the science behind nattokinase, an enzyme derived from natto—a fermented soybean staple in Japan. Nattokinase has gained attention for its cardiovascular benefits, especially its ability to dissolve blood clots.
The China Study Revisited - Science vs. Storytelling
📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.comand/or📢 Become an Insider, Ben’s website: https://www.benbikman.comIn this episode of The Metabolic Classroom, Dr. Bikman critically examines the claims made in The China Study, a popular book advocating for a plant-based diet based on correlational data from the China-Cornell-Oxford Project. While the book suggests that animal protein
Does the HCG Diet Actually Work? What the Studies Really Say
📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider on Ben’s website: https://www.benbikman.comDuring this Metabolic Classroom lecture, Dr. Bikman unpacks the history, claims, and science behind the controversial HCG diet.Originally popularized in the 1950s by Dr. Albert Simeons, the diet pairs daily HCG hormone injections with an extremely low-calorie diet (around 5
How Lectins Disrupt Insulin, Gut Health, and Immunity
📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.com📢 Become an Insider on Ben’s website: https://www.benbikman.comIn this lecture, Dr. Bikman introduces lectins as harmful plant-derived proteins often found in carbohydrate-rich foods like legumes, grains, and nightshades. While these molecules serve as plant defense mechanisms, in humans they can bind to gut lining cells, disrupting ti
How Lipoprotein Lipase (LPL) Determines Where Your Body Stores Fat
In this Metabolic Classroom lecture, Dr. Bikman dives into the central metabolic role of lipoprotein lipase (LPL)—a largely unsung but crucial enzyme that governs whether fat is burned or stored and even where it accumulates in the body.LPL is anchored to capillary walls in tissues like fat, muscle, heart, and lactating mammary glands. It acts as a metabolic gatekeeper, hydrolyzing triglycerides f
The Metabolic Effects of Fluoride
Dr. Ben Bikman opens this lecture with a comprehensive overview of fluoride’s history in public health, highlighting its original role in preventing dental cavities. However, he shifts the focus to its lesser-known systemic effects, particularly on metabolic health.Ben emphasizes emerging evidence that chronic exposure to fluoride—from water, toothpaste, and other products—can disrupt fat cell fun
How Fat Hormones Affect Appetite, Inflammation, and Heart Health
In this Metabolic Classroom lecture, Dr. Ben Bikman explores the critical yet often overlooked role of fat tissue as an endocrine organ, not just a passive energy storage site.Fat secretes dozens of bioactive hormones, collectively called adipokines, that influence everything from appetite and insulin sensitivity to inflammation and cardiovascular risk. He focuses primarily on leptin, adiponectin,
Cortisol & Insulin Resistance: How Cortisol Drives Fat Gain & Carb Cravings
This week, Dr. Bikman dives deep into the metabolic role of cortisol, the body’s primary glucocorticoid. He explains that while cortisol is essential for survival—mobilizing energy during fasting or stress—chronically elevated levels can wreak metabolic havoc.Cortisol is produced by the adrenal cortex under direction from the hypothalamic-pituitary-adrenal (HPA) axis. Its main role is to ensure en
“Fast” vs. “Slow” Insulin Resistance: The Two Paths Explained
In this lecture, Dr. Bikman presents a framework for understanding the two primary patterns of insulin resistance onset—what he terms “fast” and “slow” insulin resistance.“Fast” insulin resistance happens quickly and can often be reversed just as rapidly. It’s typically triggered by three major factors: elevated insulin (from frequent carb consumption), stress hormones like cortisol and epinephrin
Cold Therapy & Metabolism, Metabolic Health Benefits of Ice Baths and Shivering
During this week’s Metabolic Classroom lecture, Ben explores the metabolic power of cold therapy, explaining how brief, controlled exposure to cold can significantly enhance metabolic function.He starts with a deep dive into brown adipose tissue (BAT), which is rich in mitochondria and burns calories to generate heat. Cold exposure activates BAT through norepinephrine, leading to mitochondrial unc
Seed Oils and Insulin Resistance: What the Science Really Says
During this week’s Metabolic Classroom lecture, Dr. Ben Bikman explores the connection between seed oils—specifically linoleic acid—and insulin resistance, a growing area of interest and controversy in the metabolic health world.Ben begins by detailing the historical rise of seed oils like soybean, corn, sunflower, and canola oil in the human diet. Once used for industrial purposes, they have now
Fat Metabolism Deep Dive: Saturated, Mono, and Poly Fats Explained
(📢 NOTE: We apologize for the sound glitch starting at 2 minutes. Dr. Bikman’s lectures are recorded LIVE, and our production team didn’t want to interrupt him. 🙂 )Dr. Ben Bikman’s Metabolic Classroom lecture this week explores fat metabolism and the differences between saturated, monounsaturated, and polyunsaturated fats. He begins by explaining that fat is more than just stored energy—it serves
Could We Use GLP-1 Drugs like Ozempic & Mounjaro Better? A Smarter Weight Loss Strategy
In this Metabolic Classroom lecture, Dr. Bikman explores GLP-1 receptor agonists (such as Ozempic and Mounjaro) and how to use them more effectively.Ben first explains how GLP-1 is naturally produced in the gut and helps regulate glucagon suppression, slows gastric emptying, and promotes satiety. However, he highlights research showing that individuals with obesity have a blunted GLP-1 response to
Natural Ways to Boost GLP-1
For this week’s Metabolic Classroom lecture, Dr. Bikman focuses on natural ways to boost GLP-1 (Glucagon-Like Peptide-1), a powerful gut hormone involved in appetite control, blood sugar regulation, and metabolic health.Ben begins by explaining that GLP-1 is secreted in response to food intake, influencing glucagon suppression, slowing gastric emptying, and activating satiety centers in the brain.
How Bilirubin Affects Fat Burning, Inflammation & Metabolic Health
Dr. Bikman’s lecture this week explores the metabolic roles of bilirubin, a molecule typically associated with liver disease and jaundice but now emerging as a key player in metabolism, oxidative stress, and fat regulation.Bilirubin is produced from the breakdown of red blood cells and is transported to the liver, where it undergoes conjugation to become water-soluble and is then excreted into bil
Peptides & Metabolism - Fat Loss, Muscle Growth, and Hormones Explained
Dr. Bikman’s Metabolic Classroom lecture this week explores peptides and their effects on metabolism, fat loss, muscle growth, and overall health.Ben begins by defining peptides as short chains of amino acids that act as signaling molecules in the body. While some peptides occur naturally, others are synthetically developed for therapeutic purposes. He explains that peptides are gaining popularity
Acne & Insulin Resistance: Why Your Diet Matters More Than You Think
Learn more about becoming an Insider: https://www.benbikman.comIn this week’s lecture, Dr. Bikman explores the metabolic origins of acne, challenging the conventional view that acne is purely a skin issue. While acne is often attributed to excess oil production, clogged pores, bacteria, and inflammation, Ben highlights how metabolic factors—especially insulin—play a significant role.Insulin direct
How ADHD Medications Affect Fat Burning, Insulin & Brain Health
Learn more about becoming an Insider: https://www.benbikman.comIn this week’s episode of the Metabolic Classroom lectures, Dr. Ben Bikman explores the metabolic impact of ADHD medications and whether ADHD itself has metabolic roots.Ben explains how stimulant medications (like Adderall and Ritalin) primarily work by increasing dopamine and norepinephrine, enhancing focus but also suppressing appeti
GLP-1 Medications Explained: Benefits, Risks, and What You Need to Know
Learn more about becoming an Insider: https://www.benbikman.comDr. Bikman’s Metabolic Classroom lecture this week explores the physiological role and implications of GLP-1 (glucagon-like peptide-1) and the GLP-1 receptor agonist drugs used for type 2 diabetes management and weight loss.Ben begins by explaining GLP-1 as a hormone produced in the intestines in response to food. It plays a vital role
Metabolic Surgeries: How Bariatric Procedures Work, Their Benefits and Risks
Learn more about becoming an Insider: https://www.benbikman.comThis week, Dr. Bikman’s lecture focuses on metabolic surgeries (also called bariatric surgeries), their mechanisms, and their impacts on weight loss and metabolic health.Ben begins by explaining the qualifications for these surgeries, which often serve as a last resort for individuals with severe obesity or comorbidities like type 2 di
How Autophagy Protects Your Cells and Boosts Longevity
In this Metabolic Classroom lecture, Dr. Bikman delves into the fascinating metabolic process of autophagy, the body’s natural recycling system that maintains cellular health by breaking down and reusing damaged components.Ben explains how autophagy is essential for replacing malfunctioning organelles and proteins, thereby preventing diseases such as neurodegenerative disorders, cardiovascular con
The Metabolic Consequences of Poor Sleep
Learn more about becoming an Insider on our website: https://www.benbikman.comDr. Benjamin Bikman delves into the profound relationship between sleep and metabolic health, emphasizing the critical role sleep plays in maintaining insulin sensitivity and overall metabolic function.Ben explains that deep sleep is a restorative phase during which the body repairs cells, regulates hormones, and improve
The Unexpected Link Between Salt Regulating Hormones and Metabolic Health
We sincerely apologize! During the livestream recording, we experienced some technical difficulties between 07:15 to 08:50. Thanks for your patience and understanding.Learn more about becoming an Insider on our website: https://www.benbikman.comDuring The Metabolic Classroom lecture this week, Dr. Bikman dives into the intricate relationship between salt- and water-regulating hormones and metaboli
Hypertension Medications and Metabolic Health
Learn more about becoming an Insider on our website: https://www.benbikman.comThis week in The Metabolic Classroom lecture, Ben focuses on the relationship between hypertension medications and metabolic health, providing a critical examination of their mechanisms and metabolic implications.He begins by highlighting the role of insulin resistance as a common root cause of both hypertension and meta
Thyroid Health and Low-Carb Diets: What Lower T3 Really Means
This week in The Metabolic Classroom, Ben explores the effects of a ketogenic diet on thyroid function, addressing concerns that lower thyroid hormone levels observed during the diet may indicate dysfunction.Dr. Bikman begins by explaining the hypothalamic-pituitary-thyroid (HPT) axis, a regulatory system that controls thyroid hormone production. The thyroid gland produces two primary hormones, T3
Hormone Replacement Therapy in Women: Metabolic Benefits and Misunderstood Risks
In this week’s episode of The Metabolic Classroom, Dr. Bikman delivers a comprehensive lecture on hormone replacement therapy (HRT), focusing on its role in addressing metabolic health challenges faced by women during menopause.The loss of estradiol causes fat to redistribute from healthier storage areas, like the hips and thighs, to the abdominal region, where larger fat cells become more insulin
Nicotine and Insulin Resistance: What You Should Understand About the Connection
During Dr. Ben Bikman’s latest episode of The Metabolic Classroom lectures, Ben explores the metabolic effects of nicotine, emphasizing its influence beyond its addictive properties and its association with lung health and its connection to insulin resistance.Nicotine, a naturally occurring alkaloid found primarily in tobacco plants, is widely consumed through various products such as cigarettes,
Oxalates and Metabolic Health: How and Why Antinutrients From Plants Can Be Harmful
For The Metabolic Classroom lecture this week, Dr. Bikman explores the often-overlooked effects of oxalates on human health, with a focus on their impact on metabolic, kidney, cardiovascular, gut, and joint health.Oxalates are natural compounds found in various plants, including leafy greens like spinach and kale, as well as certain nuts, seeds, grains, and legumes. They serve as a defense mechani
Microplastics & Metabolic Health: The Surprising Connection with Dr. Ben Bikman
During this week’s episode of The Metabolic Classroom, Dr. Bikman discusses the impact of microplastics on metabolic health, focusing on their effects on fat cells, insulin resistance, and blood vessel health.Microplastics—tiny plastic particles under five millimeters—are now ubiquitous in our environment, entering the body through food, water, air, and skin products. Their pervasiveness poses ser
Using a Continuous Glucose Monitor (CGM) to Help You Improve Insulin Sensitivity
This week’s episode of The Metabolic Classroom focuses on the potential of continuous glucose monitors (CGMs) as a valuable tool not only for individuals with diabetes but also for anyone interested in gaining deeper insights into their metabolic health.CGMs, which measure glucose levels continuously by detecting interstitial glucose, provide real-time feedback on how diet, exercise, stress, and s
Glucosamine and Metabolic Health: What You Need to Know with Dr. Ben Bikman
In the recording of today’s livestream episode of The Metabolic Classroom, Dr. Ben Bikman explores glucosamine’s impact on both joint and metabolic health.Glucosamine, commonly used as a supplement to alleviate joint pain, especially in osteoarthritis, is an amino sugar that plays a role in cartilage formation. However, its effectiveness in improving joint health is debated, with some studies sugg
Hyperglycemia Explained: The Consequences of High Blood Sugar and Why It Matters with Dr. Ben Bikman
In this episode of The Metabolic Classroom, Dr. Ben Bikman explores the metabolic implications of hyperglycemia, the condition of elevated blood glucose levels. He focuses on both the chronic effects, like those seen in diabetes, and the acute effects of glucose spikes, even from short-term dietary indulgences. Hyperglycemia, while often linked to insulin resistance and diabetes, also has a range
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