Unseen Upside: Investments Beyond Their Returns
Unseen Upside: Investments Beyond Their Returns explores how investment decisions shape future innovations. Host Hillary Ribaudo talks with investors and entrepreneurs about the ways capital can improve lives in unexpected ways. Produced by Cambridge Associates, the show examines investments whose impact goes beyond financial returns. Through these conversations, it highlights the people and ideas driving tomorrow's breakthroughs.
Episodes
S7:EP0 Unseen Upside - Season 7 Trailer
A ship with no crew. New hope for cancer patients. A rethink of the snack aisle.In Season 7 of Unseen Upside, Cambridge Associates meets the founders, doctors, and investorschallenging how things have always been done—from fighting wildfires to building the future ofwomen’s sports.What does it take to back an idea that could change a system and the lives it touches? Find outon Tuesday, Oc
S6:E7 The Portfolio Behind Pearl: Funding a 100-Year Vision
What does it take to build something that lasts for generations?In this special crossover episode from Cambridge Conversations, we explore how bold vision, patient capital, and a deep commitment to community helped transform San Antonio’s Pearl district from a shuttered brewery into a thriving destination.Host Willis Wilson hands the mic to Unseen Upside host Hillary Ribaudo, who travels
S6:E6 Women, Wealth, and Economic Growth
Step into a conversation about the power of investing in women—and the ripple effects that follow.This International Women’s Day, discover how closing the gender gap in leadership and capital unlocks new opportunities, fuels economic growth, and strengthens communities. This discussion goes beyond the numbers; it highlights the stories, challenges, and progress that emerge from supporting
S6:E5 AI & Robotics: Shaping the Future of Work, Mobility, and Medicine
Step into the world of advanced robotics, where AI is transforming how we work, move, and live. Discover how surgical robots, autonomous vehicles, and AI-driven exoskeletons are advancing healthcare, streamlining operations, and restoring independence for individuals. Hear from innovators at Xeno Dynamics, leading investors, and a family whose journey with multiple sclerosis (MS) inspired
S6:E4 AI & Agriculture: Data-Driven Fields, Resilient Futures
Travel to a Vermont dairy farm to see how AI is reshaping agriculture.Learn how data-driven tools are making farming more sustainable and productive, and how companies like Inari Seeds are engineering crops for a changing climate. This episode uncovers the future of food—where technology, tradition, and environmental stewardship meet.Guests include:
Lucas Mann, Co-Founder and Managing Pa
S6:E3 AI & Biotech: Accelerating Breakthroughs in Medicine
Venture into the world of AI-driven drug discovery, where new models are making the process faster, safer, and more ethical.Discover how Axiom’s pioneering technology is helping to eliminate the need for animal model testing, paving the way for more humane and effective drug development. Hear from leaders at Cleveland Clinic and Amplify about how AI is transforming healthcare for patients
S6:E2 AI & Geothermal: The Next Wave of Clean Energy
What happens when AI meets the earth’s natural heat?Join us as we explore how Fervo and global partners are harnessing AI to unlock geothermal energy’s potential—delivering clean, flexible power around the clock. From Houston to the Middle East, we examine the science, policy, and investment trends driving the energy transition, and how geothermal could help power the AI revolution itself
S6:E1 AI & Education: Investing in the Future of Learning
Discover how AI is breaking down barriers to education and tailoring learning experiences for students everywhere.From Duolingo’s global reach to the innovative use of AI in real classrooms at Miss Porter’s School in Connecticut, this episode explores how technology is expanding access, enhancing engagement, and equipping the next generation with essential skills—while ensuring integrity
S6:EP0 Unseen Upside - Season 6 Trailer
Get ready—Season 6 of Unseen Upside launches October 21.This season, we’re taking you behind the scenes to explore how AI is transforming our world. From labs and classrooms to clinics and fields, we’ll follow the capital and uncover how AI is driving the next chapter of human progress.Tune in for episode one on your favorite podcast platform, Tuesday, October 21.
S5:E8 Mini Episode | The Story of Saving the American Bison
Once numbering in the tens of millions, the American bison was nearly driven to extinction by the early 1900s. But a coalition of conservationists, Native American communities, and private partners were determined to save the species.Join us for this mini episode of Unseen Upside: Investments Beyond Their Returns, as we share the remarkable story of the bison’s restoration alongside John
S5:E7 Mini Episode | What Inspires Our Guests: Must-Read Books and Podcasts, Pt 2
Summer isn't over just yet--Unseen Upside is bringing you Part 2 of our summer reading list! Tune in as we share more book recommendations from investors and entrepreneurs on the leading edge of healthcare. Check the show notes for links to all the recommendations, and catch up on past episodes in our podcast feed. Stay tuned for Season 6—launching soon.Featured Recommendations:
The Froze
S5:E6 Mini Episode | What Inspires Our Guests: Must-Read Books and Podcasts, Pt 1
As summer heats up, Unseen Upside brings you a special two-part mini-episode packed with inspiration for your reading and listening list. From thought-provoking explorations of social justice and capitalism to the latest in women’s sports and business innovation, this short episode is your guide to what’s fueling the minds and spirits of those driving change in healthcare, housing, and be
S5:E5 The Maternal Health Crisis: Investing for Change
There’s a maternal health crisis in the United States, with high rates of maternal mortality, especially among marginalized communities. But what is being done to improve it? Through conversations with those on the front lines, we uncover the stark health inequities that exist in maternal healthcare and the developments created to tackle them. We also hear from mothers who have firsthand
S5:E4 Digital Health: Transforming Care, Improving Access
How will evolving digital technologies impact healthcare delivery, patient experience, and access to care?According to new venture-backed companies, they can advance health equity, democratize access, and empower individuals to take control of their health journey. Alongside industry pioneers and investors, we explore digital health advancements such as telemedicine, remote monitoring, an
S5:E3 From Barriers to Bridges: Rural Health Access
Join us in Kotzebue, Alaska to explore the issue of rural healthcare and the inequities faced by these communities.We shine a light on innovative solutions aimed at improving rural healthcare delivery, like a program called Siamit that’s connecting cutting-edge medicine from Massachusetts General Hospital (MGH) and Harvard Medical School to the tribal regions of Alaska. We also look at th
S5:E2 Drug Affordability: The High Cost of Healing
Prescription drug prices in the United States are 2.78 times higher than in other developed countries, but why?We untangle the barriers surrounding drug affordability and find out why accessing life-saving medications is costly to so many. Joined by experts, advocates, and one Cystic Fibrosis patient relying on expensive medication to live, we examine the complex factors contributing to t
S5:E1 Investing in Affordable Homes for Healthier Communities
Join us as we head to the Bronx to examine the critical intersection of housing and health and the innovative solutions that are aiming to address the affordable housing crisis in major cities like New York and LA. Through conversations with non-profit leaders and impact investors, we dive into how affordable housing impacts public health and health equity, highlighting the investment str
S5:EP0 Unseen Upside - Season Five Trailer
How does venture capital contribute to advancing health equity and public health? Find out on season five of Unseen Upside, premiering Tuesday, October 8.This season, we dive into how today's investment decisions are shaping tomorrow's innovations in critical areas such as affordable housing, maternal health, drug pricing, and more. Join us for engaging conversations with investors and en
The Decision to Delegate
While we’re busy pulling together stories for the fifth season of Unseen Upside, we thought you might be curious about what it is that Cambridge Associates actually does. In a nutshell, we have the privilege of partnering with some of the world’s top institutional investors—like nonprofits, universities, hospitals, pension plans, and even private families—and we try to help them reach the
S4:E6 AI & Healthcare: The Next Frontier
Artificial intelligence is transforming healthcare, unleashing new investment opportunities. From cancer screening to drug discovery, AI promises to augment clinical decision-making and improve care. We’ll explore the surging ecosystem of medical AI innovations, from the emerging tech landscape to practical deployment. But what are the challenges facing real-world implementation? Which ap
S4:E5 Unlocking the Dark Genome for Lupus and Other Autoimmune Diseases
Autoimmune diseases like lupus impact over 5 million patients globally, but treatment options remain limited. Now, decoding the once mysterious "dark genome" could bring new therapies. Over 90% of our DNA was once considered "junk"—but we’ve learned this dark matter regulates gene expression and human disease. This episode takes you to the pioneers who are unlocking the dark genome's pote
S4:EP4 Appetite for Change: The Obesity Epidemic Meets Biotech
Obesity is a global health crisis, with over 650 million adults affected worldwide. This drives massive economic and disease burdens. Yet new treatment options like GLP-1 drugs offer hope. This episode analyzes the investment landscape and future of obesity therapeutics, focusing on transformational GLP-1 drugs like Ozempic that curb appetite. Join us as we investigate the promise and cha
S4:EP3 Precision Oncology & Advancing Personalized Cancer Care
Precision oncology represents an exciting shift in cancer treatment from a one-size-fits-all approach to personalized care based on each patient's unique cancer and molecular makeup. In this episode, we'll explore how precision oncology is transforming the landscape of cancer care and improving outcomes at leading hospitals like St. Jude Children’s Research Hospital. We'll discuss the lat
S4:EP2 Living Longer But Losing Our Minds: The Alzheimer's Emergency
Thanks to medical advances, we're living longer lives but with that comes rising rates of Alzheimer's disease. Currently 6 million Americans have Alzheimer's, and that could triple by 2050. This episode explores emerging innovations offering hope against neurodegenerative diseases. We'll discuss promising new drugs that could slow cognitive decline and the strides scientists are making to
S4:EP1 Mind Matters: Making Sense of the Mental Health Crisis
The mental health crisis is growing, especially among Gen Z (91% report anxiety or depression). This episode explores innovations in mental healthcare access, new therapeutic approaches for young people and families, and how hospitals are striking creative partnerships to tackle this emergency. Tune in to learn what’s working and showing promise in mental healthcare, glimpses of what the
S4:EP0 Unseen Upside - Season Four Trailer
The future of healthcare is here. Get an an inside look at the innovations transforming lives on season four of Unseen Upside, premiering Tuesday, February 6.
This season, we pull back the curtain on cutting-edge advancements at the intersection of technology and medicine, learn how AI is revolutionizing diagnostics and treatment, discover the potential of GLP-1s to combat obesity, and h
S3:EP5 Can Deep Tech Combat Fast Fashion?
The fashion industry accounts for up to 10% of global carbon dioxide output and roughly 2.6 million tons of clothing returns end up in US landfills each year instead of being resold. Meanwhile, the shipping for these returns account for around 16 million tons of CO2 emissions—and fast fashion is making things worse. But what if deep tech could help to cut down on returns? Amid the rise
S3:EP4 Battery Storage, Renewable Energy & Building a Sustainable Grid
More than two-thirds of our electricity is generated by burning fossil fuels, a major climate change contributor. As such, use of renewable energy is expected to double in the next 15 years. But there’s a catch: the power they generate depends on variable factors like wind and sun, making them too unreliable to power our grid. However, recent battery innovations could be the solution. One
S3:EP3 eVTOLs & Flying Cars
Humans have fantasized about flying cars for decades, but they’ve yet to leave the pages of our sci-fi books...or have they? Join us as we visit Joby Aviation out in Marina, California to witness their eVTOL (electric vertical take-off and landing) aircraft take flight. With plans to operate like ubers in the sky, eVTOLs are the closest thing we have to flying cars—and they could be a com
S3:EP2 CRISPR, Dodo Birds, Woolly Mammoths & Gene Editing
According to scientists, 30,000 species per year are being driven towards extinction and 50% of all species could be extinct by 2050 due to climate change. But what if there was something we could do, in addition to conservation, to change this trajectory? That’s what the scientists and engineers at Colossal Biosciences are working towards: reversing extinction. Using CRISPR and advanced
S3:EP1 Will Fusion Power (or "Stars in a Jar") Replace Fossil Fuels?
Harnessing fusion power has been an elusive goal of physicists and researchers for decades. However, recent scientific advances are helping to make that goal a reality. Described as a star in a bottle, fusion is what powers our sun and stars, offering us the prospect of limitless clean energy. But here on earth, it has presented unresolved engineering challenges—until now. Commonwealth Fu
S3:EP0 Unseen Upside - Season Three Trailer
Season three of Unseen Upside: Investments Beyond Their Returns by Cambridge Associates explores the innovations turning science fiction to fact and the people investing in them. Powered by the global network of Cambridge Associates, discover the investments being made that will redefine our future. Join us to uncover the Unseen Upside.
S2:EP5 Space: Zero Gravity Space Factories
We’ve all dreamt of traveling to outer space and recently, that dream has been more tangible than ever. But for those of us without a seat on the next rocket, how will space innovation improve our lives here on Earth? It turns out that the microgravity environment of orbit provides manufacturing capabilities that aren’t possible on earth. It allows us to create things—think artificial org
S2:EP4 Water: Carbon Sinking Kelp Farms
Oceans make up 72% of the earth’s surface and have absorbed around 40% of carbon emissions since 1840. As such, investors are increasingly putting capital to work in ocean-based businesses to both mitigate climate change and enhance the Blue Economy—but how? In this episode, we visit Running Tide in Portland, ME to see this concept in action. They use advanced aquatic growing systems and
S2:EP3 Fire: Net-Zero Plasma Diamonds
Fire is often a marker associated with the worst effects of climate change. But what if fire could actually be harnessed to help reverse it? In this episode, we meet Diamond Foundry, a company revolutionizing the diamond industry with their affordable, lab-created diamonds—free from the myriad of problems associated with the mining process. We’ll learn about the social and environmental i
S2:EP2 Air: Planting 20M Trees by 2030
For most of human history, we’ve been cutting down trees. However, the acceleration of carbon credit markets and the societal demand for climate solutions are pushing us to re-think our relationship with them. So how can investors earn a compelling return from planting trees while helping to sequester carbon and increase biodiversity? We’ll travel to Broadclyst, England to experience the
S2:EP1 Earth: Mushrooms and the Future of Meat
Livestock take up nearly 80% of global agricultural land yet produce only 20% of the world’s supply of calories—so how can we make feeding people more efficient? In this season two premiere of Unseen Upside, we visit an alternative protein company in Boulder, Colorado called Meati. There, we explore how a nutrient-rich fungi called mycelium is changing the game when it comes to protein co
S2:EP0 Unseen Upside - Season Two Trailer
Season two of the Unseen Upside podcast by Cambridge Associates explores elements of our natural world—and beyond—with the innovators and investors aiming to enhance and protect our future. Powered by the global network of Cambridge Associates, host Luke Charest will explore the investments being made that will improve our lives in unexpected ways. Join us to uncover the Unseen Upside.
S1:EP5 Consumer Brands: Why Do We Buy?
Consumers are demanding more from brands than ever before, but how are brands rising to the occasion? In this episode of Unseen Upside, Cambridge Associates’ Global Head of Private Investments, Andrea Auerbach, looks at how technology, coupled with evolving consumer preferences, are impacting how both startups and incumbent brands market themselves. We also speak with Jenny Gyllander, Fou
S1:EP4 Digital Health: How Is Tech Revolutionizing Healthcare?
In this episode of Unseen Upside, we look at how technology is transforming healthcare for both the provider and the patient—and making it more equitable. Sami Inkinen, CEO and Co-Founder of Virta Health will discuss how his company is treating and reversing diabetes through an app on your phone. We also speak with Jasmine Richards, Cambridge Associates' Head of Diverse Manager Research;
S1:EP3 Crypto: How Are Artists Leveraging NFTs?
In this episode of Unseen Upside, we’ll explore how non-fungible tokens (NFTs)—and the blockchain technology that supports them—are enabling a revolution in how artists and creators earn a living. You’ll hear from Cambridge Associates’ Joe Marenda and Kenneth Tom; Dawn Harflinger, President & CEO of Queen Lili`uokalani Trust in Hawaii; Maria Shen, Partner at Electric Capital; and Coop
S1:EP2 Digital Infrastructure: Where Does the Internet Come From?
Now more than ever, we rely on high-speed internet to power our work and personal lives—but where does it come from? In this episode of Unseen Upside, we visit Cambridge Associates’ Minesh Mashru in Amsterdam to discuss digital infrastructure and the investments being made in fiber optic cables. We’ll also meet Simon Soder, a Partner at Antin Infrastructure Partners in Paris, Aaron Werley
S1:EP1 Impact Investing: How Is Tech Making Food Systems More Sustainable?
In this season one premiere of Unseen Upside, we take you to the Foster Brothers Dairy Farm in Middlebury, Vermont to explore impact investing through the lens of precision agriculture and sustainable farming—and specifically, how technology is changing food systems for the better. In this episode, we talk with farmers George and Jeremy Foster, Sam Kass, a Partner at Acre Venture Partners
S1:EP0 Introducing Unseen Upside
Cambridge Associates’ inaugural podcast season explores the tech changing our daily lives and the people who invest in it. How we invest today drives tomorrow’s innovations. Through conversations with investors and early adopters, explore how investment decisions have the potential to improve our daily lives in unexpected ways. Powered by the network of Cambridge Associates, host Luke Cha
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